JP2020513804A5 - - Google Patents
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- Publication number
- JP2020513804A5 JP2020513804A5 JP2019549574A JP2019549574A JP2020513804A5 JP 2020513804 A5 JP2020513804 A5 JP 2020513804A5 JP 2019549574 A JP2019549574 A JP 2019549574A JP 2019549574 A JP2019549574 A JP 2019549574A JP 2020513804 A5 JP2020513804 A5 JP 2020513804A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding fragment
- tau
- pharmaceutical composition
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000004064 dysfunction Effects 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022164041A JP2022191383A (ja) | 2017-03-16 | 2022-10-12 | 抗ｐｈｆ－タウ抗体及びその使用 |
| JP2024055230A JP2024088689A (ja) | 2017-03-16 | 2024-03-29 | 抗ｐｈｆ－タウ抗体及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762472214P | 2017-03-16 | 2017-03-16 | |
| US62/472,214 | 2017-03-16 | ||
| PCT/US2018/022782 WO2018170351A1 (en) | 2017-03-16 | 2018-03-16 | Anti-phf-tau antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022164041A Division JP2022191383A (ja) | 2017-03-16 | 2022-10-12 | 抗ｐｈｆ－タウ抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020513804A JP2020513804A (ja) | 2020-05-21 |
| JP2020513804A5 true JP2020513804A5 (https=) | 2021-04-15 |
| JP7159185B2 JP7159185B2 (ja) | 2022-10-24 |
Family
ID=63521020
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019549574A Active JP7159185B2 (ja) | 2017-03-16 | 2018-03-16 | 抗ｐｈｆ－タウ抗体及びその使用 |
| JP2022164041A Withdrawn JP2022191383A (ja) | 2017-03-16 | 2022-10-12 | 抗ｐｈｆ－タウ抗体及びその使用 |
| JP2024055230A Withdrawn JP2024088689A (ja) | 2017-03-16 | 2024-03-29 | 抗ｐｈｆ－タウ抗体及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022164041A Withdrawn JP2022191383A (ja) | 2017-03-16 | 2022-10-12 | 抗ｐｈｆ－タウ抗体及びその使用 |
| JP2024055230A Withdrawn JP2024088689A (ja) | 2017-03-16 | 2024-03-29 | 抗ｐｈｆ－タウ抗体及びその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US10766953B2 (https=) |
| EP (1) | EP3596119A4 (https=) |
| JP (3) | JP7159185B2 (https=) |
| KR (2) | KR102597462B1 (https=) |
| CN (2) | CN117209599A (https=) |
| AR (1) | AR111288A1 (https=) |
| AU (1) | AU2018234709B2 (https=) |
| CA (1) | CA3055598A1 (https=) |
| CL (1) | CL2019002566A1 (https=) |
| EA (1) | EA201992038A1 (https=) |
| IL (2) | IL268700B2 (https=) |
| JO (1) | JOP20180021A1 (https=) |
| MA (1) | MA47789A (https=) |
| MX (2) | MX2019010922A (https=) |
| MY (1) | MY205672A (https=) |
| PH (1) | PH12019501973A1 (https=) |
| SG (1) | SG11201907754RA (https=) |
| TW (1) | TWI771389B (https=) |
| UA (1) | UA128385C2 (https=) |
| UY (2) | UY37635A (https=) |
| WO (1) | WO2018170351A1 (https=) |
| ZA (2) | ZA202101318B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9371376B2 (en) * | 2011-12-20 | 2016-06-21 | Janssen Biotech, Inc. | Anti-PHF-tau antibodies and their uses |
| CA2902026C (en) | 2013-03-13 | 2023-08-29 | Prothena Biosciences Limited | Tau immunotherapy |
| EP3452507B1 (en) | 2016-05-02 | 2022-10-19 | Prothena Biosciences Limited | Tau immunotherapy |
| CA3022515A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| BR112019017021A2 (pt) | 2017-02-17 | 2020-04-14 | Denali Therapeutics Inc | anticorpos anti-tau e métodos de uso dos mesmos |
| CN110881274B (zh) | 2017-05-02 | 2024-11-15 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| EP3697814A1 (en) | 2017-10-16 | 2020-08-26 | Eisai R&D Management Co., Ltd. | Anti-tau antibodies and uses thereof |
| CA3093200A1 (en) | 2018-03-05 | 2019-09-12 | Janssen Pharmaceutica Nv | Anti-phf-tau antibodies and uses thereof |
| EP3935083A4 (en) | 2019-03-03 | 2022-11-30 | Prothena Biosciences Limited | Antibodies recognizing tau |
| MX2021014473A (es) * | 2019-05-31 | 2022-01-06 | Lilly Co Eli | Compuestos y metodos dirigidos a la tau humana. |
| JP7181438B2 (ja) * | 2019-08-06 | 2022-11-30 | アプリノイア セラピューティクス リミテッド | 病理学的タウ種に結合する抗体及びその使用 |
| MX2022012628A (es) * | 2020-04-08 | 2023-01-11 | Janssen Biotech Inc | Anticuerpos anti-phf-tau y usos de estos. |
| CN116348769A (zh) * | 2020-07-14 | 2023-06-27 | 詹森药业有限公司 | 用于检测tau蛋白病或淀粉样蛋白形成性疾病的基于血液的测定 |
| EP4232472A1 (en) * | 2020-10-26 | 2023-08-30 | JANSSEN Pharmaceutica NV | Method of safe administration of anti-tau antibody |
| WO2022090158A1 (en) * | 2020-10-26 | 2022-05-05 | Janssen Pharmaceutica Nv | Methods of reducing tau in human subjects |
| WO2022176959A1 (en) * | 2021-02-19 | 2022-08-25 | Eisai R&D Management Co., Ltd. | Anti-pt217 tau antibody |
| IL307170A (en) | 2021-03-26 | 2023-11-01 | Janssen Biotech Inc | Anti-tau antibodies and their uses |
| US20250034559A1 (en) | 2021-11-17 | 2025-01-30 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
| CN117003863A (zh) * | 2022-04-28 | 2023-11-07 | 厦门大学 | 针对p-tau 217的抗体及其用途 |
| CA3266790A1 (en) | 2022-09-15 | 2024-03-21 | Voyager Therapeutics, Inc. | TAU PROTEIN BINDING COMPOUNDS |
| CN116948024B (zh) * | 2023-09-14 | 2024-02-06 | 北京凯祥弘康生物科技有限公司 | 抗Tau蛋白的捕获抗体 |
| CN116948023B (zh) * | 2023-09-14 | 2024-02-09 | 北京凯祥弘康生物科技有限公司 | Tau蛋白抗体及其应用 |
| WO2025122634A1 (en) | 2023-12-05 | 2025-06-12 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| DK0610330T3 (da) | 1991-10-25 | 1998-01-26 | Innogenetics Nv | Monoklonale antistoffer mod microtubulus-associeret protein tau |
| DK0737208T3 (da) | 1993-12-21 | 2006-11-27 | Innogenetics Nv | Monoklonale antistoffer, der er specifikke for PHF-tau, hybridomaer, der secernerer dem, og antigen-genkendelse for disse antistoffer og deres anvendelsesmuligheder |
| EP0772634B1 (en) | 1994-07-29 | 2003-03-12 | Innogenetics N.V. | Monoclonal antibodies specific for an epitope of a particular subclass or form of phosphorylated tau, hybridomas secreting them, antigen recognition of these antibodies and their applications |
| MXPA05000511A (es) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| EP1590369B1 (en) * | 2003-01-24 | 2016-03-16 | Applied Molecular Evolution, Inc. | Human il-1 beta antagonists |
| CA2548817A1 (en) | 2003-12-04 | 2005-06-23 | Xencor, Inc. | Methods of generating variant proteins with increased host string content and compositions thereof |
| EP1720908A2 (en) * | 2004-02-17 | 2006-11-15 | Absalus, Inc. | Super-humanized antibodies against respiratory syncytial virus |
| US20070048785A1 (en) | 2004-06-09 | 2007-03-01 | Lin Laura L | Anti-IL-13 antibodies and complexes |
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| EP2057193B1 (en) | 2006-08-04 | 2013-12-18 | Novartis AG | Ephb3-specific antibody and uses thereof |
| JP2010235447A (ja) | 2007-07-30 | 2010-10-21 | Igaku Seibutsugaku Kenkyusho:Kk | 炎症性サイトカインの抑制剤 |
| JP2012505654A (ja) | 2008-10-14 | 2012-03-08 | ヤンセン バイオテツク，インコーポレーテツド | 抗体をヒト化及び親和性成熟する方法 |
| DK2356270T3 (da) * | 2008-11-07 | 2016-12-12 | Fabrus Llc | Kombinatoriske antistofbiblioteker og anvendelser deraf |
| US9968574B2 (en) | 2009-05-15 | 2018-05-15 | The University Of Kentucky Research Foundation | Treatment of MCI and Alzheimer's disease |
| CA3239368A1 (en) | 2009-06-10 | 2010-12-16 | New York University | Immunological targeting of pathological tau proteins |
| US8609097B2 (en) | 2009-06-10 | 2013-12-17 | Hoffmann-La Roche Inc. | Use of an anti-Tau pS422 antibody for the treatment of brain diseases |
| US8912355B2 (en) | 2009-09-29 | 2014-12-16 | University Of Ottawa Heart Institute | Linoleic phospholipids and uses thereof for inhibiting inflammatory and neurodegenerative processes |
| ES2826883T3 (es) | 2009-10-14 | 2021-05-19 | Janssen Biotech Inc | Métodos de maduración por afinidad de anticuerpos |
| CN102884085B (zh) * | 2010-04-09 | 2016-08-03 | Aveo制药公司 | 抗erbb3抗体 |
| ES2548686T3 (es) | 2010-10-07 | 2015-10-20 | Ac Immune S.A. | Anticuerpos que reconocen fosfo-Tau |
| BR112013008765B8 (pt) | 2010-10-11 | 2023-05-02 | Biogen Idec Int Neuroscience Gmbh | Anticorpos monoclonais anti-tau humano isolados ou um fragmento de ligação à tau dos mesmos, métodos de preparação dos mesmos, polinucleotídeo ou polinucleotídeos, vetor ou vetores, composição, método in vitro de diagnóstico ou monitoramento da progressão de uma tauopatia neurodegenerativa em um indivíduo humano, método in vitro para diagnosticar uma tauopatia neurodegenerativa em um indivíduo humano, e kit útil para o diagnóstico de uma tauopatia neurodegenerativa |
| US9371376B2 (en) * | 2011-12-20 | 2016-06-21 | Janssen Biotech, Inc. | Anti-PHF-tau antibodies and their uses |
-
2018
- 2018-03-15 TW TW107108890A patent/TWI771389B/zh active
- 2018-03-16 KR KR1020197028728A patent/KR102597462B1/ko active Active
- 2018-03-16 EA EA201992038A patent/EA201992038A1/ru unknown
- 2018-03-16 US US15/923,011 patent/US10766953B2/en active Active
- 2018-03-16 AR ARP180100620A patent/AR111288A1/es unknown
- 2018-03-16 SG SG11201907754RA patent/SG11201907754RA/en unknown
- 2018-03-16 UY UY0001037635A patent/UY37635A/es not_active Application Discontinuation
- 2018-03-16 IL IL268700A patent/IL268700B2/en unknown
- 2018-03-16 WO PCT/US2018/022782 patent/WO2018170351A1/en not_active Ceased
- 2018-03-16 UA UAA201910307A patent/UA128385C2/uk unknown
- 2018-03-16 EP EP18767083.1A patent/EP3596119A4/en active Pending
- 2018-03-16 AU AU2018234709A patent/AU2018234709B2/en active Active
- 2018-03-16 CN CN202310854848.XA patent/CN117209599A/zh active Pending
- 2018-03-16 IL IL310464A patent/IL310464A/en unknown
- 2018-03-16 MX MX2019010922A patent/MX2019010922A/es unknown
- 2018-03-16 CA CA3055598A patent/CA3055598A1/en active Pending
- 2018-03-16 MY MYPI2019005282A patent/MY205672A/en unknown
- 2018-03-16 KR KR1020237037321A patent/KR102695287B1/ko active Active
- 2018-03-16 CN CN201880018431.7A patent/CN110799531B/zh active Active
- 2018-03-16 JP JP2019549574A patent/JP7159185B2/ja active Active
- 2018-03-16 MA MA047789A patent/MA47789A/fr unknown
- 2018-03-18 JO JOP/2018/0021A patent/JOP20180021A1/ar unknown
-
2019
- 2019-08-28 PH PH12019501973A patent/PH12019501973A1/en unknown
- 2019-09-09 CL CL2019002566A patent/CL2019002566A1/es unknown
- 2019-09-13 MX MX2024015440A patent/MX2024015440A/es unknown
-
2020
- 2020-08-06 US US16/986,615 patent/US11365244B2/en active Active
-
2021
- 2021-02-26 ZA ZA2021/01318A patent/ZA202101318B/en unknown
-
2022
- 2022-05-18 US US17/747,785 patent/US20230047413A1/en not_active Abandoned
- 2022-10-12 JP JP2022164041A patent/JP2022191383A/ja not_active Withdrawn
-
2023
- 2023-12-12 ZA ZA2023/11412A patent/ZA202311412B/en unknown
-
2024
- 2024-03-29 JP JP2024055230A patent/JP2024088689A/ja not_active Withdrawn
- 2024-07-19 UY UY0001040829A patent/UY40829A/es unknown
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