JP2018537399A5 - - Google Patents
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- Publication number
- JP2018537399A5 JP2018537399A5 JP2018510074A JP2018510074A JP2018537399A5 JP 2018537399 A5 JP2018537399 A5 JP 2018537399A5 JP 2018510074 A JP2018510074 A JP 2018510074A JP 2018510074 A JP2018510074 A JP 2018510074A JP 2018537399 A5 JP2018537399 A5 JP 2018537399A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- immunoglobulin
- chain variable
- variable region
- region sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562214605P | 2015-09-04 | 2015-09-04 | |
| US62/214,605 | 2015-09-04 | ||
| PCT/US2016/050213 WO2017041001A2 (en) | 2015-09-04 | 2016-09-02 | Insulin immunoglobulin fusion proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537399A JP2018537399A (ja) | 2018-12-20 |
| JP2018537399A5 true JP2018537399A5 (https=) | 2019-10-03 |
| JP6951825B2 JP6951825B2 (ja) | 2021-10-20 |
Family
ID=58188627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510074A Active JP6951825B2 (ja) | 2015-09-04 | 2016-09-02 | インスリン免疫グロブリン融合タンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10501546B2 (https=) |
| EP (1) | EP3344278A4 (https=) |
| JP (1) | JP6951825B2 (https=) |
| KR (1) | KR20180039726A (https=) |
| CN (1) | CN108348581B (https=) |
| AU (1) | AU2016315889A1 (https=) |
| CA (1) | CA2996716A1 (https=) |
| HK (1) | HK1258125A1 (https=) |
| WO (1) | WO2017041001A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6951825B2 (ja) | 2015-09-04 | 2021-10-20 | ザ スクリプス リサーチ インスティテュート | インスリン免疫グロブリン融合タンパク質 |
| EP3845240B1 (en) * | 2018-09-12 | 2024-11-06 | Amphastar Nanjing Pharmaceuticals, Inc. | Pro-insulin aspart structure and method for preparing insulin aspart |
| US12077568B2 (en) * | 2018-10-01 | 2024-09-03 | University Of Houston System | Engineered active single-polypeptide chain insulin analogs |
| US20210403575A1 (en) * | 2018-10-22 | 2021-12-30 | Shanghai Yichen Biomed Co. Ltd | Bispecific antibody |
| TWI844709B (zh) * | 2019-07-31 | 2024-06-11 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| CN110684082B (zh) * | 2019-10-08 | 2021-12-10 | 江苏诺泰澳赛诺生物制药股份有限公司 | Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途 |
| CN111041025B (zh) | 2019-12-17 | 2021-06-18 | 深圳市瑞吉生物科技有限公司 | 基于结合N-乙酰半乳糖胺多肽的mRNA靶向分子及其制备方法 |
| CN111744019B (zh) | 2020-07-01 | 2023-08-04 | 深圳瑞吉生物科技有限公司 | 基于甘露糖的mRNA靶向递送系统及其应用 |
| WO2022114908A1 (ko) * | 2020-11-27 | 2022-06-02 | (주)디앤디파마텍 | 비오틴 모이어티, 지방산 모이어티 또는 이의 조합이 결합된 생리활성 물질 접합체의 경구 제형 |
| EP4252780A4 (en) * | 2020-11-27 | 2026-04-15 | D&D Pharmatech Inc | A conjugated biologically active material having a biotin fraction, a fatty acid fraction, or a combination of these coupled to it |
| WO2025098472A1 (zh) * | 2023-11-08 | 2025-05-15 | 北京拓界生物医药科技有限公司 | 融合蛋白及其医药用途 |
| WO2025210538A1 (en) * | 2024-04-02 | 2025-10-09 | Biohaven Therapeutics Ltd. | Bifunctional degraders |
| CN118834293B (zh) * | 2024-08-06 | 2025-09-19 | 扬州大学 | 一种基于h5n8亚型禽流感病毒na的单克隆抗体及其应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5470582A (en) | 1992-02-07 | 1995-11-28 | Syntex (U.S.A.) Inc. | Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles |
| US6372716B1 (en) | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
| US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US6566329B1 (en) | 1999-06-28 | 2003-05-20 | Novo Nordisk A/S | Freeze-dried preparation of human growth hormone |
| IL155812A0 (en) | 2000-12-07 | 2003-12-23 | Lilly Co Eli | Glp-1 fusion proteins |
| HUE026260T2 (en) | 2003-11-21 | 2016-06-28 | Ucb Biopharma Sprl | A method for treating multiple sclerosis by inhibiting IL-17 activity |
| EP1702069A2 (en) | 2004-01-05 | 2006-09-20 | EMD Lexigen Research Center Corp. | Interleukin-12 targeted to oncofoetal fibronectin |
| US7871632B2 (en) | 2004-07-12 | 2011-01-18 | Adventrx Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
| CA2600929A1 (en) * | 2005-03-04 | 2006-09-14 | Biogen Idec Ma Inc. | Methods of humanizing immunoglobulin variable regions through rational modification of complementarity determining residues |
| US20110135725A1 (en) | 2005-05-23 | 2011-06-09 | Sdg, Inc. | Lipid Construct for Delivery of Insulin to a Mammal |
| WO2007064911A1 (en) * | 2005-12-02 | 2007-06-07 | Biogen Idec Inc. | Anti-mouse cd20 antibodies and uses thereof |
| WO2008043033A2 (en) | 2006-10-04 | 2008-04-10 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| JP5676849B2 (ja) | 2006-10-20 | 2015-02-25 | 中外製薬株式会社 | 抗ｈｂ−ｅｇｆ抗体を有効成分として含む癌治療剤 |
| FR2929509B1 (fr) | 2008-04-02 | 2011-01-21 | Lvmh Rech | L'utilisation de glycosides d'alkyle ou de melanges de glycosides d'alkyle en tant qu'agents destines a inhiber la croissance microbienne, et compositions contenant lesdits glycosides d'alkyle. |
| EP2296692A4 (en) | 2008-04-22 | 2012-06-06 | Univ Case Western Reserve | ISOFORM-SPECIFIC INSULIN ANALOG |
| EP2166021A1 (en) * | 2008-09-16 | 2010-03-24 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
| WO2010129304A2 (en) | 2009-04-27 | 2010-11-11 | Oncomed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| US20130129723A1 (en) | 2009-12-29 | 2013-05-23 | Emergent Product Development Seattle, Llc | Heterodimer Binding Proteins and Uses Thereof |
| WO2011086143A2 (en) | 2010-01-14 | 2011-07-21 | Glaxo Group Limited | Liver targeting molecules |
| AR081066A1 (es) | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
| TWI560199B (en) * | 2010-08-31 | 2016-12-01 | Sanofi Sa | Peptide or peptide complex binding to α2 integrin and methods and uses involving the same |
| AU2013228317A1 (en) | 2012-03-06 | 2014-10-23 | National Cancer Center | Pharmaceutical composition for treating cancer |
| US9518112B2 (en) | 2012-03-08 | 2016-12-13 | Ludwig Institute For Cancer Research Ltd | TGF-β1 specific antibodies and methods and uses thereof |
| CA2878626A1 (en) | 2012-08-09 | 2014-02-13 | Roche Glycart Ag | Asgpr antibodies and uses thereof |
| US9273093B2 (en) | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
| SG11201606761RA (en) | 2014-02-21 | 2016-09-29 | Ecole Polytecnique Federale De Lausanne Epfl Epfl Tto | Glycotargeting therapeutics |
| WO2015143091A1 (en) | 2014-03-19 | 2015-09-24 | Genzyme Corporation | Site-specific glycoengineering of targeting moieties |
| JP6951825B2 (ja) | 2015-09-04 | 2021-10-20 | ザ スクリプス リサーチ インスティテュート | インスリン免疫グロブリン融合タンパク質 |
-
2016
- 2016-09-02 JP JP2018510074A patent/JP6951825B2/ja active Active
- 2016-09-02 CA CA2996716A patent/CA2996716A1/en not_active Abandoned
- 2016-09-02 US US15/756,296 patent/US10501546B2/en active Active
- 2016-09-02 EP EP16843113.8A patent/EP3344278A4/en not_active Withdrawn
- 2016-09-02 HK HK19100415.6A patent/HK1258125A1/zh unknown
- 2016-09-02 AU AU2016315889A patent/AU2016315889A1/en not_active Abandoned
- 2016-09-02 CN CN201680063883.8A patent/CN108348581B/zh active Active
- 2016-09-02 KR KR1020187008446A patent/KR20180039726A/ko not_active Ceased
- 2016-09-02 WO PCT/US2016/050213 patent/WO2017041001A2/en not_active Ceased
-
2019
- 2019-10-24 US US16/663,239 patent/US11421033B2/en active Active
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