JP2020512381A - アメントフラボンの安定度が向上された透明または半透明の化粧料組成物 - Google Patents
アメントフラボンの安定度が向上された透明または半透明の化粧料組成物 Download PDFInfo
- Publication number
- JP2020512381A JP2020512381A JP2019553568A JP2019553568A JP2020512381A JP 2020512381 A JP2020512381 A JP 2020512381A JP 2019553568 A JP2019553568 A JP 2019553568A JP 2019553568 A JP2019553568 A JP 2019553568A JP 2020512381 A JP2020512381 A JP 2020512381A
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- Prior art keywords
- amentoflavone
- cosmetic composition
- agent
- transparent
- stability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Images
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Abstract
Description
洗浄した卷柏420kgを準備し、これをエタノールに浸漬し、室温で7日間抽出した後、250メッシュ(3μm)濾紙で濾過した。次に、60℃で濃縮させた後、これを水に溶解させ、酢酸エチル(EtOAc)で3回抽出した。酢酸エチル層を分離した後、これを60℃で濃縮させ、シリカ粉末を含むカラムでアメントフラボンが溶離されるまで分離した(ヘキサン:酢酸エチル=1:1で溶離)。分離されたアメントフラボン画分を60℃で濃縮させ、エタノールに溶解させた後、0.45μmの濾紙で濾過した。これを再び60℃で濃縮させ、30℃で24時間真空乾燥させて粉末状態の卷柏抽出物1kgを製造した。
天然高分子から由来したオリゴマー構造体であるキトサン及びヒアルロン酸で疎水性空洞構造を形成させ、卷柏抽出物を前記空洞構造に封入させることにより水溶化アメントフラボン−オリゴマー複合体を製造した。具体的には、キトサン及びヒアルロン酸を6:1の重量比で混合し、水に完全に溶解させて空洞構造が形成されたオリゴマー構造体を製造し、卷柏抽出物粉末を徐々に添加して卷柏抽出物に含有されたアメントフラボンがオリゴマー構造体の疎水性空洞構造に封入されるようにした後、反応液を濾過または遠心分離してオリゴマー構造体に封入されていない残余の卷柏抽出物を除去し、残余物が除去された反応液から水と有機溶媒を除去した後、乾燥して水溶化アメントフラボン−オリゴマー複合体を製造した。このとき、温度40〜50℃、pH6.5〜7.5に維持しながら製造した。
下記表1の組成に応じて構成成分を混合してミキサーで30分以上十分に混合し、完全に溶解させて実施例1〜4及び比較例1〜7を製造し、下記表1の含有量の単位は、第2剤の全体重量に対する該当成分の重量%である。
下記表2の組成に応じて水溶性パーツに該当する成分は、ミキサーを利用して蒸溜水に溶解及び分散させ、可溶化パーツに該当する成分は、別にミキサーを利用して溶解させた後、溶解された可溶化パーツ成分を溶解及び分散された水溶性パーツ成分に添加及び混合して、実施例5〜7及び比較例8を製造し、下記表2の含有量の単位は、第1剤の全体重量に対する該当成分の重量%である。
前記実施例1〜4及び比較例1〜7の4週加速安定度を比較評価するために、−15℃、5℃、室温、30℃、45℃、60℃の恒温槽(Incubator、 Jisico社)に保管し、毎週室温に復元した後、再び保管する方法で4週次加速安定度を確認した。試験結果は、表3に示された通りである。
前記実施例1〜4及び比較例1〜7の25℃及び40℃におけるそれぞれの力価安定度を評価するために、高速液体クロマトグラフィー(High Performance Liquid Chromatography、HPLC)を使用し、測定機器の仕様、測定条件及び測定結果は、下記表4に示した。
前記実施例5〜7または比較例8と実施例1とを、それぞれ重量を基準として5:1の混合比で混合した後、それぞれの4週次及び8週次加速安定度を評価するために、前記試験例1と同じ方法で加速安定度を確認した。4週次加速安定度評価試験結果は、下記の表5に、8週次加速安定度評価試験結果は、図1に示した。
前記実施例5〜7または比較例8と実施例1とを、それぞれ重量を基準として5:1の混合比で混合した後、それぞれの力価安定度を評価するために、前記試験例2と同じ仕様及び測定条件のHPLCを使用して力価安定度を評価した。試験結果は、下記表6に示した。
Claims (14)
- 溶解強化剤(hydrotrope)を含有する第1剤;及び
アメントフラボンと、前記アメントフラボンを安定化させるための多価アルコールとを含有する第2剤を含み、
前記第1剤及び第2剤は、2液タイプ容器にそれぞれ保管されて使用前混合されることを特徴とする、アメントフラボンの安定度が向上された透明または半透明の化粧料組成物。 - 前記溶解強化剤は、ナイアシンアミド(niacinamide)、カフェイン(caffeine)、ピロリドンカルボン酸ナトリウム(sodium pyrrolidone carbonic acid)、サリチル酸ナトリウム(sodium salicylate)、ウレア(urea)、ヒドロキシエチルウレア(hydroxyethyl urea)及びD−パンテノール(D−panthenol)の中から選択された少なくとも1つ以上であることを特徴とする、請求項1に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
- 前記アメントフラボンは、卷柏抽出物内に含有されたものを使用することを特徴とする、請求項1に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
- 前記アメントフラボンは、親水性天然高分子から由来したオリゴマー構造体の空洞構造に封入されて水溶化(water−soluble)アメントフラボン−オリゴマー複合体の形態で含有されることを特徴とする、請求項1に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
- 前記アメントフラボンは、前記水溶化アメントフラボン−オリゴマー複合体の全体重量対比7.6〜9.2重量%の量で前記空洞構造に封入されることを特徴とする、請求項4に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
- 前記水溶化アメントフラボン−オリゴマー複合体は、前記第2剤の全体重量対比0.2〜30重量%の量で含有されることを特徴とする、請求項4に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
- 前記水溶化アメントフラボン−オリゴマー複合体は、前記化粧料組成物の全体重量対比0.1〜5重量%の量で含有されることを特徴とする、請求項4に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
- 前記多価アルコールは、炭素数3個〜6個の2価または3価アルコールであることを特徴とする、請求項1に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
- 前記多価アルコールは、プロパンジオール(propanediol)及びブタンジオール(butanediol)のうちの少なくとも1つ以上であることを特徴とする、請求項1に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
- 前記アメントフラボンは、前記第2剤の全体重量対比0.0152〜2.76重量%の量で含有されることを特徴とする、請求項1に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
- 前記アメントフラボンは、前記化粧料組成物の全体重量対比0.0076〜0.46重量%の量で含有されることを特徴とする、請求項1に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
- 前記第1剤及び第2剤の混合比は、重量を基準として1〜6:1であることを特徴とする、請求項1に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
- 前記第2剤は、蒸溜水またはグリセリンをさらに含むことを特徴とする、請求項1に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
- 前記蒸溜水またはグリセリンは、前記第2剤の全体重量対比0重量%超過〜30重量%以下の量で含有されることを特徴とする、請求項13に記載のアメントフラボンの安定度が向上された透明または半透明の化粧料組成物。
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US11298307B2 (en) | 2022-04-12 |
KR102552770B1 (ko) | 2023-07-10 |
CN110475538A (zh) | 2019-11-19 |
JP7080247B2 (ja) | 2022-06-03 |
US20200054540A1 (en) | 2020-02-20 |
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