JP2013509481A - オリゴマー複合体の形成による難溶性/不溶性活性物質の可溶化方法 - Google Patents
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Abstract
本発明の主要構成は、2種類の新水性天然高分子由来のオリゴマーを混合して水で溶解させて、空洞構造の形成されたオリゴマー複合体を製造する第1工程と、前記オリゴマー複合体に難溶性/不溶性物質を添加して、オリゴマー複合体の疎水性の空洞構造にそれを封入する第2工程とを含むことを特徴とする。
Description
以下、実施例によって本発明をさらに詳述するが、下記の実施例は本発明を例示するためのものであり、本発明の範囲がこれらに限定されるものではない。
蒸溜水156gに下記表1の割合によって天然高分子オリゴマーのうち一つを選択して添加し、反応温度を40ないし50℃に維持し、pH調節剤を用いてpH 5ないし8に維持し、完全に溶解するまで撹拌してオリゴマー水溶液を形成する。
対照群例1ないし12において対照群の粉末製造時、エラグ酸を天然高分子オリゴマーが溶解した溶液に添加して混合した後、遠心分離の際に沈殿物を乾燥させて不溶性沈殿物の重量を測定した。
天然高分子来由のオリゴマーの適用
蒸溜水156gに、下記の表3、表4、表5の割合によって2種類の天然高分子オリゴマーを混合し、反応温度を40ないし50℃に維持し、pH調節剤を用いてpH5ないし8に維持しつつ、完全に溶解するまで撹拌してオリゴマー複合体を形成する。
(実施例121ないし138)
難溶性/不溶性物質を含むオリゴマー複合体の製造
表6示すように、天然高分子オリゴマーのうちデキストリン及びマルトデキストリンを所定の割合で蒸溜水に入れて40ないし50℃に維持し、pH調節剤を用いてpH 5ないし8に維持して、完全に溶解するまで撹拌してオリゴマー複合体を形成した。形成されたオリゴマー複合体溶液を40ないし50℃、pH 6.5ないし7.5に維持した。所定量の難溶性/不溶性物質を単純添加するか、または有機溶媒に1ないし50%の濃度に溶解させた後、オリゴマー複合体の溶液に徐々に添加して、オリゴマー複合体の疎水性の空洞構造に封入した。反応液を遠心分離または濾過して、封入されずに除去された難溶性/不溶性物質の重量を測定し、有機溶媒が添加された実験群は、蒸溜器を用いてエタノールなどの有機溶媒を蒸溜し、凍結乾燥器を用いて粉末化して難溶性/不溶性物質を含むオリゴマー複合体を製造した。
実施例1ないし138において、難溶性/不溶性物質を封入したオリゴマー複合体の製造時、難溶性/不溶性物質を2種類の天然高分子オリゴマー複合体が溶解した溶液に添加して混合した後、遠心分離または濾過時沈殿物を乾燥して不溶性沈殿物の重量を測定した。
前記表7、表8、及び表9の結果のように、2種類の天然高分子オリゴマーを適用した実施例の場合、難溶性/不溶性物質をオリゴマー複合体溶液に添加して封入した後に反応液を遠心分離する際に、沈殿物がほとんど発生せず、大部分オリゴマー複合体に封入されたことが分かった。
Claims (8)
- 2種類の新水性天然高分子由来のオリゴマーを混合して水に溶解させて、空洞構造の形成されたオリゴマー複合体を製造する第1工程と、
前記オリゴマー複合体に難溶性/不溶性物質を添加して、オリゴマー複合体の疎水性の空洞構造にそれを封入する第2工程と、を含むことを特徴とするオリゴマー複合体の形成による難溶性/不溶性活性物質の可溶化方法。 - 前記第2工程以後に反応液を濾過または遠心分離することにより、オリゴマー複合体に封入されていない残りの難溶性/不溶性物質を除去する第3工程と、残留物が除去された反応液から水及び有機溶媒(使用した場合)を除去して乾燥する第4工程とをさらに含むことを特徴とする請求項1に記載のオリゴマー複合体の形成による難溶性/不溶性活性物質の可溶化方法。
- 前記天然高分子由来のオリゴマーは、キサンタンゴム、アカシア・ゴム、グアーガム、アラビア・ゴム、寒天、アルギン酸、キトサン、ペクチン、カルボキシアルキルセルロース、マルトデキストリン、デキストリン、ヒアルロン酸などのうち選択された2つであることを特徴とする請求項1に記載のオリゴマー複合体の形成による難溶性/不溶性活性物質の可溶化方法。
- 前記難溶性/不溶性物質は、アメントフラボン、エラグ酸、アピゲニン、ベルゲニン、ジオスメチン、ユニベスチン、レスベラトロル、イソフラボン、カテキンのようなポリフェノール類と、サリチル酸、アルファリポ酸、カフェイン、トコフェロール、ドコサヘキサエン酸(DHA)、エイコサペンタエン酸(EPA)、共役リノール酸(CLA)のようなオイル性の脂肪酸類、イチョウの葉抽出物、紅参抽出物、ポリフェノール類を含む天然抽出物類などのうち選択される何れか一つであることを特徴とする請求項1に記載のオリゴマー複合体の形成による難溶性/不溶性活性物質の可溶化方法。
- 前記天然高分子オリゴマーは、総重量に対して1:1ないし1:10重量部で添加され、20ないし80℃で混合することを特徴とする請求項1に記載のオリゴマー複合体の形成による難溶性/不溶性活性物質の可溶化方法。
- 前記難溶性/不溶性物質を総固形物の重量部を基準に0.1ないし99重量%で添加され、20ないし80℃で混合されることを特徴とする請求項1に記載のオリゴマー複合体の形成による難溶性/不溶性活性物質の可溶化方法。
- 前記第2工程では、前記難溶性/不溶性物質を有機溶媒に溶解させて添加することを特徴とする請求項1に記載のオリゴマー複合体の形成による難溶性/不溶性活性物質の可溶化方法。
- 前記有機溶媒は、メタノール、エタノール、アセトン、テトラヒドロフラン(THF)、アセトニトリル(AN)のうち選択された何れか一つであることを特徴とする請求項7に記載のオリゴマー複合体の形成による難溶性/不溶性活性物質の可溶化方法。
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PCT/KR2010/007066 WO2011071239A2 (ko) | 2009-12-09 | 2010-10-15 | 올리고머 복합체의 형성을 통한 난/불용성 활성물질의 가용화 방법 |
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JP2020512381A (ja) * | 2017-03-31 | 2020-04-23 | アモーレパシフィック コーポレーションAmorepacific Corporation | アメントフラボンの安定度が向上された透明または半透明の化粧料組成物 |
US11298307B2 (en) | 2017-03-31 | 2022-04-12 | Amorepacific Corporation | Transparent or semitransparent cosmetic composition having enhanced amentoflavone stability |
JP7080247B2 (ja) | 2017-03-31 | 2022-06-03 | アモーレパシフィック コーポレーション | アメントフラボンの安定度が向上した透明または半透明の化粧料組成物 |
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WO2011071239A3 (ko) | 2011-11-03 |
KR20110065055A (ko) | 2011-06-15 |
EP2511345A2 (en) | 2012-10-17 |
EP2511345B1 (en) | 2018-12-19 |
US9139703B2 (en) | 2015-09-22 |
EP2511345A4 (en) | 2014-07-23 |
US20120219604A1 (en) | 2012-08-30 |
KR101138258B1 (ko) | 2012-04-24 |
JP5629327B2 (ja) | 2014-11-19 |
WO2011071239A2 (ko) | 2011-06-16 |
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