JP2020512284A5 - - Google Patents
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- Publication number
- JP2020512284A5 JP2020512284A5 JP2019530043A JP2019530043A JP2020512284A5 JP 2020512284 A5 JP2020512284 A5 JP 2020512284A5 JP 2019530043 A JP2019530043 A JP 2019530043A JP 2019530043 A JP2019530043 A JP 2019530043A JP 2020512284 A5 JP2020512284 A5 JP 2020512284A5
- Authority
- JP
- Japan
- Prior art keywords
- intracellular signaling
- domain
- signaling domain
- intracellular
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662438106P | 2016-12-22 | 2016-12-22 | |
| US62/438,106 | 2016-12-22 | ||
| PCT/US2017/067830 WO2018119198A1 (en) | 2016-12-22 | 2017-12-21 | Compositions and methods for modulating the immune system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020512284A JP2020512284A (ja) | 2020-04-23 |
| JP2020512284A5 true JP2020512284A5 (https=) | 2021-02-04 |
Family
ID=62627209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530043A Pending JP2020512284A (ja) | 2016-12-22 | 2017-12-21 | 免疫系調節組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20190330306A1 (https=) |
| EP (1) | EP3525805A4 (https=) |
| JP (1) | JP2020512284A (https=) |
| KR (1) | KR20190096969A (https=) |
| CN (1) | CN110267666A (https=) |
| AU (1) | AU2017382243A1 (https=) |
| CA (1) | CA3038150A1 (https=) |
| IL (1) | IL266386A (https=) |
| MX (1) | MX2019006852A (https=) |
| WO (1) | WO2018119198A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9687510B2 (en) * | 2014-09-04 | 2017-06-27 | The Johns Hopkins University | Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions |
| CN107995913B (zh) | 2015-05-18 | 2022-02-11 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| FI3909972T3 (fi) | 2015-06-19 | 2024-05-03 | Sebastian Kobold | Pd1-cd28-fuusioproteiineja ja niiden käyttö lääkkeessä |
| US11851491B2 (en) | 2016-11-22 | 2023-12-26 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| US20200370013A1 (en) * | 2019-05-20 | 2020-11-26 | The Trustees Of The University Of Pennsylvania | Engineered Expression of Cell Surface and Secreted Sialidase by CAR T Cells for Increased Efficacy in Solid Tumors |
| WO2022211376A1 (ko) * | 2021-04-01 | 2022-10-06 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
| KR20220144000A (ko) * | 2021-04-16 | 2022-10-26 | 주식회사 이뮤노로지컬디자이닝랩 | Programmed death-ligand 1(PD-L1)에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도 |
| CN117279931A (zh) * | 2021-05-07 | 2023-12-22 | 基因医疗免疫疗法有限责任公司 | Prame特异性t细胞受体与嵌合共刺激受体的组合 |
| CA3240185A1 (en) * | 2021-12-06 | 2023-06-15 | Vycellix, Inc. | Chimeric switch receptors in nk cells |
| WO2025056659A1 (en) * | 2023-09-15 | 2025-03-20 | Medigene Immunotherapies Gmbh | T-CELL RECEPTOR VARIANT AGAINST mKRAS7-16 G12V AND G12C |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3549611B1 (en) * | 2011-07-29 | 2021-06-30 | The Trustees of the University of Pennsylvania | Switch costimulatory receptors |
| TW201446794A (zh) * | 2013-02-20 | 2014-12-16 | Novartis Ag | 利用抗－ｃｄ１２３嵌合抗原受體工程化ｔ細胞之初級人類白血病有效靶向 |
| US10023626B2 (en) * | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| ES2781175T3 (es) * | 2014-07-31 | 2020-08-31 | Novartis Ag | Subconjunto optimizado de células T que contienen un receptor de antígeno quimérico |
| US9687510B2 (en) * | 2014-09-04 | 2017-06-27 | The Johns Hopkins University | Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions |
| US20180334490A1 (en) * | 2014-12-03 | 2018-11-22 | Qilong H. Wu | Methods for b cell preconditioning in car therapy |
| KR20170093248A (ko) * | 2014-12-19 | 2017-08-14 | 다나-파버 캔서 인스티튜트 인크. | 탄산무수화효소 ix 특이적 키메라 항원 수용체 및 이의 사용 방법 |
| CA2978186A1 (en) * | 2015-03-05 | 2016-09-09 | Fred Hutchinson Cancer Research Center | Immunomodulatory fusion proteins and uses thereof |
| RU2749113C2 (ru) * | 2015-04-22 | 2021-06-04 | Куревак Аг | Содержащая рнк композиция для лечения опухолевых заболеваний |
| WO2016179319A1 (en) * | 2015-05-04 | 2016-11-10 | Cellerant Therapeutics, Inc. | Chimeric antigen receptors with ctla4 signal transduction domains |
| CA2991040A1 (en) * | 2015-06-29 | 2017-01-05 | The Johns Hopkins University | Immune checkpoint chimeric receptors therapy |
| CN105153315B (zh) * | 2015-10-09 | 2019-04-02 | 重庆精准生物技术有限公司 | 免疫抑制受体联合肿瘤抗原嵌合受体及其应用 |
| EP3433269B1 (en) * | 2016-03-23 | 2023-09-27 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins of pd-1 and 4-1bb |
-
2017
- 2017-12-21 JP JP2019530043A patent/JP2020512284A/ja active Pending
- 2017-12-21 KR KR1020197014105A patent/KR20190096969A/ko not_active Withdrawn
- 2017-12-21 MX MX2019006852A patent/MX2019006852A/es unknown
- 2017-12-21 WO PCT/US2017/067830 patent/WO2018119198A1/en not_active Ceased
- 2017-12-21 EP EP17885380.0A patent/EP3525805A4/en not_active Withdrawn
- 2017-12-21 CA CA3038150A patent/CA3038150A1/en not_active Abandoned
- 2017-12-21 US US16/471,854 patent/US20190330306A1/en not_active Abandoned
- 2017-12-21 AU AU2017382243A patent/AU2017382243A1/en not_active Abandoned
- 2017-12-21 CN CN201780079696.3A patent/CN110267666A/zh active Pending
-
2019
- 2019-05-01 IL IL266386A patent/IL266386A/en unknown