JP2018518459A5 - - Google Patents
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- JP2018518459A5 JP2018518459A5 JP2017556587A JP2017556587A JP2018518459A5 JP 2018518459 A5 JP2018518459 A5 JP 2018518459A5 JP 2017556587 A JP2017556587 A JP 2017556587A JP 2017556587 A JP2017556587 A JP 2017556587A JP 2018518459 A5 JP2018518459 A5 JP 2018518459A5
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- JP
- Japan
- Prior art keywords
- molecule comprises
- immunomodulatory molecule
- ccl19
- optionally
- ccl21
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 230000002519 immonomodulatory effect Effects 0.000 claims description 118
- 210000004027 cell Anatomy 0.000 claims description 67
- 102100036842 C-C motif chemokine 19 Human genes 0.000 claims description 60
- 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 claims description 60
- 102100036846 C-C motif chemokine 21 Human genes 0.000 claims description 59
- 101000713085 Homo sapiens C-C motif chemokine 21 Proteins 0.000 claims description 59
- 102000013462 Interleukin-12 Human genes 0.000 claims description 58
- 108010065805 Interleukin-12 Proteins 0.000 claims description 58
- 102100023700 C-C motif chemokine 16 Human genes 0.000 claims description 57
- 101000978375 Homo sapiens C-C motif chemokine 16 Proteins 0.000 claims description 57
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 37
- 108010002350 Interleukin-2 Proteins 0.000 claims description 35
- 239000000203 mixture Substances 0.000 claims description 33
- 150000007523 nucleic acids Chemical group 0.000 claims description 26
- 108091033319 polynucleotide Proteins 0.000 claims description 22
- 102000040430 polynucleotide Human genes 0.000 claims description 22
- 239000002157 polynucleotide Substances 0.000 claims description 22
- 102000000588 Interleukin-2 Human genes 0.000 claims description 21
- 239000000427 antigen Substances 0.000 claims description 20
- 102000036639 antigens Human genes 0.000 claims description 20
- 108091007433 antigens Proteins 0.000 claims description 20
- 108010029697 CD40 Ligand Proteins 0.000 claims description 18
- 102100032937 CD40 ligand Human genes 0.000 claims description 18
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 18
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 18
- 102000003812 Interleukin-15 Human genes 0.000 claims description 18
- 108090000172 Interleukin-15 Proteins 0.000 claims description 18
- 108010042215 OX40 Ligand Proteins 0.000 claims description 18
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 claims description 18
- 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 claims description 17
- 102100035283 Tumor necrosis factor ligand superfamily member 18 Human genes 0.000 claims description 17
- 102000039446 nucleic acids Human genes 0.000 claims description 17
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 239000013598 vector Substances 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 231100000053 low toxicity Toxicity 0.000 claims description 13
- 101000638251 Homo sapiens Tumor necrosis factor ligand superfamily member 9 Proteins 0.000 claims description 12
- 102000003810 Interleukin-18 Human genes 0.000 claims description 12
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims description 12
- 230000000295 complement effect Effects 0.000 claims description 10
- 229920001184 polypeptide Polymers 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
- 238000002560 therapeutic procedure Methods 0.000 claims description 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 9
- 201000011510 cancer Diseases 0.000 claims description 8
- 230000002435 cytoreductive effect Effects 0.000 claims description 8
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims description 6
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 6
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 6
- 150000001413 amino acids Chemical group 0.000 claims description 6
- 238000002512 chemotherapy Methods 0.000 claims description 6
- 210000003527 eukaryotic cell Anatomy 0.000 claims description 6
- 238000001959 radiotherapy Methods 0.000 claims description 6
- 230000011664 signaling Effects 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 4
- 230000003115 biocidal effect Effects 0.000 claims description 4
- 230000000139 costimulatory effect Effects 0.000 claims description 4
- 238000000315 cryotherapy Methods 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 4
- 229910021641 deionized water Inorganic materials 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- 238000011534 incubation Methods 0.000 claims description 4
- 210000000822 natural killer cell Anatomy 0.000 claims description 4
- 231100000331 toxic Toxicity 0.000 claims description 4
- 230000002588 toxic effect Effects 0.000 claims description 4
- 230000002463 transducing effect Effects 0.000 claims description 4
- 239000013603 viral vector Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 3
- 239000003550 marker Substances 0.000 claims description 3
- 241000283690 Bos taurus Species 0.000 claims description 2
- 241000282465 Canis Species 0.000 claims description 2
- 108091035707 Consensus sequence Proteins 0.000 claims description 2
- 241000283073 Equus caballus Species 0.000 claims description 2
- 241000282324 Felis Species 0.000 claims description 2
- BCCRXDTUTZHDEU-VKHMYHEASA-N Gly-Ser Chemical compound NCC(=O)N[C@@H](CO)C(O)=O BCCRXDTUTZHDEU-VKHMYHEASA-N 0.000 claims description 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 2
- 210000004102 animal cell Anatomy 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 210000001236 prokaryotic cell Anatomy 0.000 claims description 2
- 230000001177 retroviral effect Effects 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 238000004246 ligand exchange chromatography Methods 0.000 claims 30
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000008102 immune modulation Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000001018 virulence Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 102100030703 Interleukin-22 Human genes 0.000 description 6
- 239000003242 anti bacterial agent Substances 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562155296P | 2015-04-30 | 2015-04-30 | |
| US62/155,296 | 2015-04-30 | ||
| PCT/US2016/030248 WO2016176639A1 (en) | 2015-04-30 | 2016-04-29 | Secretory tnt car cell immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018518459A JP2018518459A (ja) | 2018-07-12 |
| JP2018518459A5 true JP2018518459A5 (https=) | 2019-04-18 |
Family
ID=57199395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556587A Pending JP2018518459A (ja) | 2015-04-30 | 2016-04-29 | 分泌性ｔｎｔ ｃａｒ細胞免疫療法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20180291089A1 (https=) |
| EP (1) | EP3288568A4 (https=) |
| JP (1) | JP2018518459A (https=) |
| CN (1) | CN107635569A (https=) |
| AU (1) | AU2016255535A1 (https=) |
| CA (1) | CA2984180A1 (https=) |
| IL (1) | IL255280A0 (https=) |
| WO (1) | WO2016176639A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108064176A (zh) * | 2015-04-22 | 2018-05-22 | 库瑞瓦格股份公司 | 用于治疗肿瘤疾病的含有rna的组合物 |
| US20220348633A1 (en) * | 2015-06-25 | 2022-11-03 | Icell Gene Therapeutics Llc | COMPOUND CHIMERIC ANTIGEN RECEPTOR (cCAR) TARGETING MULTIPLE ANTIGENS, COMPOSITIONS AND METHOD OF USE THEREOF |
| AU2017335634A1 (en) | 2016-09-27 | 2019-03-14 | Cero Therapeutics, Inc. | Chimeric engulfment receptor molecules |
| CA3039797A1 (en) * | 2016-10-11 | 2018-04-19 | Minerva Biotechnologies Corporation | Humanized anti-muc1* antibodies and use of cleavage enzyme |
| EP3548055A4 (en) | 2016-12-02 | 2020-08-19 | University of Southern California | SYNTHETIC IMMUNE RECEPTORS AND THEIR PROCESSES FOR USE |
| EP3567049A4 (en) | 2016-12-28 | 2020-08-26 | Green Cross Lab Cell Corporation | CHEMERICAL ANTIGENIC RECEPTOR AND NATURAL KILLER CELLS EXPRESSING THE SAME |
| CN118374493A (zh) * | 2017-05-17 | 2024-07-23 | 西雅图儿童医院（Dba西雅图儿童研究所） | 生成哺乳动物t细胞活化诱导型合成启动子(syn+pro)以改善t细胞疗法 |
| CN111201035A (zh) * | 2017-06-19 | 2020-05-26 | 梅迪塞纳医疗股份有限公司 | Il-2超激动剂、激动剂及其融合体的用途和方法 |
| EP4714966A2 (en) | 2017-09-26 | 2026-03-25 | Cero Therapeutics Holdings, Inc. | Chimeric engulfment receptor molecules and methods of use |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| KR102774451B1 (ko) | 2017-11-14 | 2025-02-28 | 앱클론(주) | 항-her2 항체 또는 그의 항원 결합 단편, 및 이를 포함하는 키메라 항원 수용체 |
| EP3714042A4 (en) * | 2017-11-22 | 2021-08-04 | La Jolla Institute for Allergy and Immunology | USE AND PRODUCTION OF MODIFIED IMMUNE CELLS |
| EP3753952A4 (en) * | 2017-12-13 | 2022-04-13 | XDCExplorer (Shanghai) Co., Ltd. | EGFRVIII ANTIBODY AND CONJUGATE, AND METHODS FOR ITS PRODUCTION AND USE |
| EP3774906A1 (en) | 2018-03-28 | 2021-02-17 | Cero Therapeutics, Inc. | Chimeric tim4 receptors and uses thereof |
| MX2020010241A (es) | 2018-03-28 | 2020-10-16 | Cero Therapeutics Inc | Composiciones de inmunoterapia celular y usos de las mismas. |
| CN108641000A (zh) * | 2018-04-26 | 2018-10-12 | 上海怡豪生物科技有限公司 | 肝癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108641001A (zh) * | 2018-04-26 | 2018-10-12 | 上海怡豪生物科技有限公司 | 结肠癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108659133A (zh) * | 2018-04-26 | 2018-10-16 | 上海怡豪生物科技有限公司 | 肺癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108864289A (zh) * | 2018-04-26 | 2018-11-23 | 上海怡豪生物科技有限公司 | 胃癌的双靶点car-t治疗载体及其构建方法和应用 |
| CA3100446A1 (en) * | 2018-05-15 | 2019-11-21 | Carsgen Therapeutics Co., Ltd. | Genetically engineered cell and application thereof |
| JP7241161B2 (ja) | 2018-08-01 | 2023-03-16 | イミュニティーバイオ、インコーポレイテッド | 細胞免疫療法の安定した遺伝子改変のための、ホーミング受容体又はサイトカインとキメラ抗原受容体とを含むクアドリシストロニックシステム |
| CN113272318A (zh) * | 2018-09-05 | 2021-08-17 | 孔锡卿 | 用于实体癌的嵌合抗原受体和表达嵌合抗原受体的t细胞 |
| WO2020057641A1 (zh) * | 2018-09-20 | 2020-03-26 | 科济生物医药（上海）有限公司 | 表达有趋化因子的细胞及用途 |
| US20210338729A1 (en) * | 2018-10-12 | 2021-11-04 | Icell Gene Therapeutics Llc | CHIMERIC ANTIGEN RECEPTORS (CARs) COMPOSITIONS AND METHODS OF USE THEREOF |
| CN110818803B (zh) * | 2019-07-24 | 2023-01-03 | 浙江启新生物技术有限公司 | 分泌表达il15ra-il15融合蛋白、ccl21趋化因子的嵌合抗原受体-t细胞及应用 |
| WO2021057906A1 (zh) * | 2019-09-25 | 2021-04-01 | 科济生物医药（上海）有限公司 | 表达il-15的免疫效应细胞 |
| CN110684739B (zh) * | 2019-11-11 | 2022-05-27 | 深圳市体内生物医药科技有限公司 | 一种嵌合抗原受体t细胞及其应用 |
| US11230699B2 (en) | 2020-01-28 | 2022-01-25 | Immunitybio, Inc. | Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors |
| AU2021296822A1 (en) * | 2020-06-23 | 2023-02-02 | The General Hospital Corporation | Tunneling nanotube cells and methods of use thereof for delivery of biomolecules |
| CN112608902B (zh) * | 2020-12-21 | 2024-07-02 | 广东昭泰细胞生物科技有限公司 | 一种第四代car-t细胞及其应用 |
| WO2022220648A1 (ko) * | 2021-04-15 | 2022-10-20 | 주식회사 유틸렉스 | Hla-dr 특이적 키메라 항원 수용체 및 이의 용도 |
| US20240366762A1 (en) * | 2021-04-28 | 2024-11-07 | Sanquin IP B.V. | Chimeric fc-alpha receptors and uses thereof |
| CN115725504A (zh) * | 2021-08-26 | 2023-03-03 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9814383D0 (en) * | 1998-07-02 | 1998-09-02 | Cambridge Antibody Tech | Improvements relating to antibodies |
| CN1883454A (zh) * | 2006-06-01 | 2006-12-27 | 复旦大学 | 一种肿瘤坏死靶向单抗预定位脂质体给药系统及其应用 |
| CN101028525B (zh) * | 2006-09-01 | 2010-12-08 | 上海美恩生物技术有限公司 | 肿瘤细胞核单抗在物理治疗实体瘤中作为增效剂的用途 |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| CN103304669A (zh) * | 2012-03-12 | 2013-09-18 | 复旦大学 | 人源化肿瘤免疫细胞因子tntil2及其制备方法和用途 |
| CN113684185A (zh) * | 2013-02-26 | 2021-11-23 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
-
2016
- 2016-04-29 EP EP16787271.2A patent/EP3288568A4/en not_active Withdrawn
- 2016-04-29 WO PCT/US2016/030248 patent/WO2016176639A1/en not_active Ceased
- 2016-04-29 CN CN201680031760.6A patent/CN107635569A/zh active Pending
- 2016-04-29 CA CA2984180A patent/CA2984180A1/en not_active Abandoned
- 2016-04-29 AU AU2016255535A patent/AU2016255535A1/en not_active Abandoned
- 2016-04-29 US US15/570,747 patent/US20180291089A1/en not_active Abandoned
- 2016-04-29 JP JP2017556587A patent/JP2018518459A/ja active Pending
-
2017
- 2017-10-26 IL IL255280A patent/IL255280A0/en unknown
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