JP2020511974A5 - - Google Patents

Info

Publication number

JP2020511974A5

JP2020511974A5 JP2019552866A JP2019552866A JP2020511974A5 JP 2020511974 A5 JP2020511974 A5 JP 2020511974A5 JP 2019552866 A JP2019552866 A JP 2019552866A JP 2019552866 A JP2019552866 A JP 2019552866A JP 2020511974 A5 JP2020511974 A5 JP 2020511974A5

Authority

JP

Japan

Prior art keywords

fructose

tagatose

epimerase

seq

coli

Prior art date

2018-03-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 101710157736 ATP-dependent 6-phosphofructokinase Proteins 0.000 description 9
• 101710200244 ATP-dependent 6-phosphofructokinase isozyme 2 Proteins 0.000 description 9
• 230000000694 effects Effects 0.000 description 7
• 241000588724 Escherichia coli Species 0.000 description 6
• 239000002773 nucleotide Substances 0.000 description 6
• 125000003729 nucleotide group Chemical group 0.000 description 6
• 108090000790 Enzymes Proteins 0.000 description 5
• 102000004190 Enzymes Human genes 0.000 description 5
• 241001198387 Escherichia coli BL21(DE3) Species 0.000 description 5
• 244000005700 microbiome Species 0.000 description 4
• LKDRXBCSQODPBY-OEXCPVAWSA-N D-tagatose Chemical compound OCC1(O)OC[C@@H](O)[C@H](O)[C@@H]1O LKDRXBCSQODPBY-OEXCPVAWSA-N 0.000 description 3
• 229930091371 Fructose Natural products 0.000 description 3
• 239000005715 Fructose Substances 0.000 description 3
• 102000001253 Protein Kinase Human genes 0.000 description 3
• BGWGXPAPYGQALX-VANKVMQKSA-N alpha-D-tagatofuranose 6-phosphate Chemical compound OC[C@]1(O)O[C@H](COP(O)(O)=O)[C@H](O)[C@@H]1O BGWGXPAPYGQALX-VANKVMQKSA-N 0.000 description 3
• BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 description 3
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
• 229910052799 carbon Inorganic materials 0.000 description 2
• 238000000034 method Methods 0.000 description 2
• 239000000758 substrate Substances 0.000 description 2
• 230000001131 transforming effect Effects 0.000 description 2
• IUKHSWVQCORLGA-AYXADEGOSA-N (3s,4r,5r)-1,3,4,5,6-pentahydroxyhexan-2-one Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO.OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO IUKHSWVQCORLGA-AYXADEGOSA-N 0.000 description 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 241000633183 Anaerolinea Species 0.000 description 1
• 241000410435 Anaerolinea thermophila Species 0.000 description 1
• 241000894006 Bacteria Species 0.000 description 1
• 241001135722 Dictyoglomus sp. Species 0.000 description 1
• 108091000080 Phosphotransferase Proteins 0.000 description 1
• 241000339824 Thermoanaerobacter indiensis Species 0.000 description 1
• 241000186338 Thermoanaerobacter sp. Species 0.000 description 1
• 241000208189 Thermobifida halotolerans Species 0.000 description 1
• 241001633114 Thermobifida sp. Species 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 125000003275 alpha amino acid group Chemical group 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 238000006345 epimerization reaction Methods 0.000 description 1
• 239000013604 expression vector Substances 0.000 description 1
• BJHIKXHVCXFQLS-UYFOZJQFSA-N fructose group Chemical group OCC(=O)[C@@H](O)[C@H](O)[C@H](O)CO BJHIKXHVCXFQLS-UYFOZJQFSA-N 0.000 description 1
• XPYBSIWDXQFNMH-PQLUHFTBSA-N keto-D-tagatose 1,6-bisphosphate Chemical compound OP(=O)(O)OC[C@@H](O)[C@H](O)[C@H](O)C(=O)COP(O)(O)=O XPYBSIWDXQFNMH-PQLUHFTBSA-N 0.000 description 1
• 102000020233 phosphotransferase Human genes 0.000 description 1
• 239000002157 polynucleotide Substances 0.000 description 1
• 102000040430 polynucleotide Human genes 0.000 description 1
• 108091033319 polynucleotide Proteins 0.000 description 1
• 229920001184 polypeptide Polymers 0.000 description 1
• 108090000765 processed proteins & peptides Proteins 0.000 description 1
• 102000004196 processed proteins & peptides Human genes 0.000 description 1
• 108090000623 proteins and genes Proteins 0.000 description 1
• 230000003362 replicative effect Effects 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 230000005030 transcription termination Effects 0.000 description 1
• 239000013598 vector Substances 0.000 description 1
• 108700026220 vif Genes Proteins 0.000 description 1