JP2020509756A5 - - Google Patents
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- JP2020509756A5 JP2020509756A5 JP2019549389A JP2019549389A JP2020509756A5 JP 2020509756 A5 JP2020509756 A5 JP 2020509756A5 JP 2019549389 A JP2019549389 A JP 2019549389A JP 2019549389 A JP2019549389 A JP 2019549389A JP 2020509756 A5 JP2020509756 A5 JP 2020509756A5
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- JP
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- Prior art keywords
- e100ff
- antibody
- antibody according
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- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001413 amino acids Chemical class 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 8
- 230000035772 mutation Effects 0.000 claims 8
- 235000001014 amino acid Nutrition 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 5
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- 230000002378 acidificating effect Effects 0.000 claims 3
- 239000012636 effector Substances 0.000 claims 3
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 3
- 230000007935 neutral effect Effects 0.000 claims 3
- 230000004962 physiological condition Effects 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 102000008055 Heparan Sulfate Proteoglycans Human genes 0.000 claims 2
- 229920002971 Heparan sulfate Polymers 0.000 claims 2
- 108090000054 Syndecan-2 Proteins 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 239000000611 antibody drug conjugate Substances 0.000 claims 2
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 2
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 210000000440 neutrophil Anatomy 0.000 claims 2
- 210000005259 peripheral blood Anatomy 0.000 claims 2
- 239000011886 peripheral blood Substances 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 102100032530 Glypican-3 Human genes 0.000 claims 1
- 101001014668 Homo sapiens Glypican-3 Proteins 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000004236 Ponceau SX Substances 0.000 claims 1
- 208000003874 Simpson-Golabi-Behmel syndrome Diseases 0.000 claims 1
- 230000006044 T cell activation Effects 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000017455 cell-cell adhesion Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023002879A JP7573659B2 (ja) | 2017-03-14 | 2023-01-12 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
| JP2024179648A JP2025023919A (ja) | 2017-03-14 | 2024-10-15 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471196P | 2017-03-14 | 2017-03-14 | |
| US62/471,196 | 2017-03-14 | ||
| US201862636746P | 2018-02-28 | 2018-02-28 | |
| US62/636,746 | 2018-02-28 | ||
| PCT/US2018/022230 WO2018169993A1 (en) | 2017-03-14 | 2018-03-13 | Antibodies binding to vista at acidic ph |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023002879A Division JP7573659B2 (ja) | 2017-03-14 | 2023-01-12 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020509756A JP2020509756A (ja) | 2020-04-02 |
| JP2020509756A5 true JP2020509756A5 (enExample) | 2021-04-30 |
| JP7211961B2 JP7211961B2 (ja) | 2023-01-24 |
Family
ID=63522565
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019549389A Active JP7211961B2 (ja) | 2017-03-14 | 2018-03-13 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
| JP2023002879A Active JP7573659B2 (ja) | 2017-03-14 | 2023-01-12 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
| JP2024179648A Pending JP2025023919A (ja) | 2017-03-14 | 2024-10-15 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023002879A Active JP7573659B2 (ja) | 2017-03-14 | 2023-01-12 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
| JP2024179648A Pending JP2025023919A (ja) | 2017-03-14 | 2024-10-15 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11603406B2 (enExample) |
| EP (1) | EP3595720A4 (enExample) |
| JP (3) | JP7211961B2 (enExample) |
| KR (2) | KR20240151866A (enExample) |
| CN (2) | CN110740749B (enExample) |
| AU (2) | AU2018236218B2 (enExample) |
| BR (1) | BR112019019108A2 (enExample) |
| CA (1) | CA3054067A1 (enExample) |
| CL (2) | CL2019002610A1 (enExample) |
| CO (1) | CO2019010943A2 (enExample) |
| IL (2) | IL326895A (enExample) |
| MX (1) | MX2024003316A (enExample) |
| MY (1) | MY200609A (enExample) |
| PE (2) | PE20250933A1 (enExample) |
| SG (1) | SG11201907848YA (enExample) |
| TW (3) | TWI825010B (enExample) |
| WO (1) | WO2018169993A1 (enExample) |
| ZA (1) | ZA201905525B (enExample) |
Families Citing this family (32)
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| EP4793360A2 (en) | 2006-03-31 | 2026-08-19 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| TW201920257A (zh) | 2008-04-11 | 2019-06-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗原結合分子 |
| TWI654203B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| SG10201609665PA (en) | 2011-02-25 | 2017-01-27 | Chugai Pharmaceutical Co Ltd | FcɣRIIb-SPECIFIC Fc ANTIBODY |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| KR20210074395A (ko) | 2011-11-30 | 2021-06-21 | 추가이 세이야쿠 가부시키가이샤 | 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약 |
| EP4624490A3 (en) | 2012-02-09 | 2025-11-05 | Chugai Seiyaku Kabushiki Kaisha | Modified fc region of antibody |
| CA2865158C (en) | 2012-02-24 | 2022-11-01 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting disappearance of antigen via fc.gamma.riib |
| TWI855488B (zh) | 2012-08-24 | 2024-09-11 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| ES2812208T3 (es) * | 2013-03-14 | 2021-03-16 | Bristol Myers Squibb Co | Combinación de un agonista de DR5 y un antagonista de anti-PD-1 y métodos de uso |
| SG11201508170TA (en) | 2013-04-02 | 2015-11-27 | Chugai Pharmaceutical Co Ltd | Fc REGION VARIANT |
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| EA201791366A1 (ru) | 2014-12-19 | 2018-02-28 | Чугаи Сейяку Кабусики Кайся | Антитела к c5 и способы их применения |
| CN114773469B (zh) | 2015-02-05 | 2025-12-19 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| EP3394098A4 (en) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | ANTI-MYOSTATIN ANTIBODIES AND METHOD OF USE |
| CN109071631B (zh) | 2016-03-14 | 2023-07-14 | 奥斯陆大学 | 具有改变的FcRn结合的工程化免疫球蛋白 |
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| US11220550B2 (en) | 2017-05-25 | 2022-01-11 | Bristol-Myers Squibb Company | Antagonistic anti-CD40 antibodies and methods of antagonizing CD40 activity |
| SG11202008593PA (en) | 2018-03-21 | 2020-10-29 | Five Prime Therapeutics Inc | ANTIBODIES BINDING TO VISTA AT ACIDIC pH |
| US20190300610A1 (en) * | 2018-03-29 | 2019-10-03 | Hummingbird Bioscience Pte. Ltd. | Vista antigen-binding molecules |
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| AU2019301120A1 (en) | 2018-07-11 | 2021-02-25 | Bristol-Myers Squibb Company | Antibodies binding to VISTA at acidic pH |
| KR20250024129A (ko) * | 2018-07-20 | 2025-02-18 | 피에르 파브르 메디카먼트 | Vista의 수용체 |
| AR117091A1 (es) | 2018-11-19 | 2021-07-07 | Bristol Myers Squibb Co | Anticuerpos monoclonales antagonistas contra cd40 y sus usos |
| CA3149719A1 (en) * | 2019-09-19 | 2021-03-25 | Bristol-Myers Squibb Company | Antibodies binding to vista at acidic ph |
| BR112022012010A2 (pt) | 2019-12-18 | 2022-08-30 | Hoffmann La Roche | Anticorpos, ácido nucleico isolado, célula hospedeira, formulação farmacêutica, uso do anticorpo, método de produção de um anticorpo, método de tratamento de um indivíduo que tem câncer e método de tratamento de um indivíduo que tem uma doença inflamatória ou autoimune |
| BR112023016533A2 (pt) * | 2021-02-18 | 2023-11-21 | Kineta Inc | Anticorpos antivista e usos dos mesmos |
| EP4373848A2 (en) | 2021-07-22 | 2024-05-29 | University of Dundee | Therapeutic muteins |
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2018
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- 2018-03-13 KR KR1020247033048A patent/KR20240151866A/ko active Pending
- 2018-03-13 AU AU2018236218A patent/AU2018236218B2/en active Active
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- 2018-03-13 WO PCT/US2018/022230 patent/WO2018169993A1/en not_active Ceased
- 2018-03-13 KR KR1020197029923A patent/KR102715540B1/ko active Active
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