JP2020506886A5 - - Google Patents
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- Publication number
- JP2020506886A5 JP2020506886A5 JP2019534676A JP2019534676A JP2020506886A5 JP 2020506886 A5 JP2020506886 A5 JP 2020506886A5 JP 2019534676 A JP2019534676 A JP 2019534676A JP 2019534676 A JP2019534676 A JP 2019534676A JP 2020506886 A5 JP2020506886 A5 JP 2020506886A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- pharmaceutical composition
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 101710183280 Topoisomerase Proteins 0.000 claims 2
- 102100024579 Tyrosyl-DNA phosphodiesterase 1 Human genes 0.000 claims 2
- 101710205182 Tyrosyl-DNA phosphodiesterase 1 Proteins 0.000 claims 2
- 102100024578 Tyrosyl-DNA phosphodiesterase 2 Human genes 0.000 claims 2
- 101710205181 Tyrosyl-DNA phosphodiesterase 2 Proteins 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 0 CC(*)C*N(C(c(c(C1=O)c2)ncc2OC)=C1c1ccc(*)cc11)C1=O Chemical compound CC(*)C*N(C(c(c(C1=O)c2)ncc2OC)=C1c1ccc(*)cc11)C1=O 0.000 description 1
- JKHAGQZCIAFTOX-UHFFFAOYSA-N CCCSC(N)=N Chemical compound CCCSC(N)=N JKHAGQZCIAFTOX-UHFFFAOYSA-N 0.000 description 1
- BAUWRHPMUVYFOD-UHFFFAOYSA-N CN(CC1)CCC1O Chemical compound CN(CC1)CCC1O BAUWRHPMUVYFOD-UHFFFAOYSA-N 0.000 description 1
- PVOAHINGSUIXLS-UHFFFAOYSA-N CN1CCNCC1 Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 1
- SJRJJKPEHAURKC-UHFFFAOYSA-N CN1CCOCC1 Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 1
- MCTWTZJPVLRJOU-UHFFFAOYSA-N C[n]1cncc1 Chemical compound C[n]1cncc1 MCTWTZJPVLRJOU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437777P | 2016-12-22 | 2016-12-22 | |
| US62/437,777 | 2016-12-22 | ||
| PCT/US2017/067206 WO2018118852A1 (en) | 2016-12-22 | 2017-12-19 | Azaindenoisoquinoline compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506886A JP2020506886A (ja) | 2020-03-05 |
| JP2020506886A5 true JP2020506886A5 (https=) | 2021-01-21 |
| JP7182548B2 JP7182548B2 (ja) | 2022-12-02 |
Family
ID=62627773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019534676A Active JP7182548B2 (ja) | 2016-12-22 | 2017-12-19 | アザインデノイソキノリン化合物およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10875860B2 (https=) |
| EP (1) | EP3558993A4 (https=) |
| JP (1) | JP7182548B2 (https=) |
| CN (1) | CN110167936A (https=) |
| CA (1) | CA3047992A1 (https=) |
| WO (1) | WO2018118852A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020023700A2 (en) * | 2018-07-25 | 2020-01-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | OXYNITIDINE DERIVATIVES USEFUL AS INHIBITORS OF TOPOISOMERASE IB (Top1) AND TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1) |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0692410B2 (ja) | 1988-08-30 | 1994-11-16 | キッセイ薬品工業株式会社 | 新規なベンゾフロキノリン誘導体 |
| AU765135B2 (en) | 1998-10-14 | 2003-09-11 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Novel indenoisoquinolines as antineoplastic agents |
| US20030096833A1 (en) | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| ES2311639T3 (es) | 2001-11-14 | 2009-02-16 | Rutgers, The State University | Agentes citotoxicos. |
| ATE390923T1 (de) | 2001-11-14 | 2008-04-15 | Univ Rutgers | Topoisomerase-giftmittel |
| WO2004100891A2 (en) | 2003-05-12 | 2004-11-25 | Purdue Research Foundation | Cytotoxic indeno and isoindoloisoquinolones |
| EP1735281A4 (en) | 2004-03-17 | 2009-11-04 | Purdue Research Foundation | Synthesis of Indinoisoquinoline Compounds and Their Use |
| US7495100B2 (en) | 2004-05-07 | 2009-02-24 | Purdue Research Foundation | Synthesis of indenoisoquinolines |
| US9399660B2 (en) * | 2005-11-14 | 2016-07-26 | Purdue Research Foundation | N-substituted indenoisoquinolines and syntheses thereof |
| CA2629530C (en) | 2005-11-14 | 2014-07-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | N-substituted indenoisoquinolines and syntheses thereof |
| WO2008076767A1 (en) | 2006-12-13 | 2008-06-26 | Purdue Research Foundation | Chemotherapeutic flavonoids, and syntheses thereof |
| KR20090115879A (ko) * | 2007-02-28 | 2009-11-09 | 이노텍 파마슈티컬스 코포레이션 | 인데노이소퀴놀리논 유사체와 이의 이용 방법 |
| WO2009140467A1 (en) | 2008-05-15 | 2009-11-19 | Purdue Research Foundation | Oxobenzindolizinoquinolines and uses thereof |
| EP2528440A4 (en) | 2010-01-27 | 2013-08-07 | Purdue Research Foundation | SUBSTITUTED NORINDEN ISOCHINOLINE, SYNTHESIS THEREOF AND METHOD OF USE THEREOF |
| US9073920B2 (en) | 2010-08-17 | 2015-07-07 | Purdue Research Foundation | Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor |
| US9328073B2 (en) | 2011-05-25 | 2016-05-03 | Purdue Research Foundation | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors |
| US9682990B2 (en) * | 2011-05-25 | 2017-06-20 | Purdue Research Foundation | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors |
| US8912213B2 (en) | 2012-04-13 | 2014-12-16 | Purdue Research Foundation | Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors |
| US8686146B2 (en) * | 2012-07-13 | 2014-04-01 | Purdue Research Foundation | Azaindenoisoquinoline topoisomerase I inhibitors |
| US9034870B2 (en) | 2012-07-13 | 2015-05-19 | Purdue Research Foundation | Azaindenoisoquinoline topoisomerase I inhibitors |
| KR102083154B1 (ko) | 2012-08-08 | 2020-03-02 | 메르크 파텐트 게엠베하 | （아자―）이소퀴놀리논 유도체 |
| WO2015069766A1 (en) | 2013-11-06 | 2015-05-14 | Purdue Research Foundation | Dupa-indenoisoquinoline conjugates |
-
2017
- 2017-12-19 CN CN201780083073.3A patent/CN110167936A/zh active Pending
- 2017-12-19 JP JP2019534676A patent/JP7182548B2/ja active Active
- 2017-12-19 US US16/471,945 patent/US10875860B2/en active Active
- 2017-12-19 CA CA3047992A patent/CA3047992A1/en active Pending
- 2017-12-19 WO PCT/US2017/067206 patent/WO2018118852A1/en not_active Ceased
- 2017-12-19 EP EP17882353.0A patent/EP3558993A4/en active Pending
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