CN110167936A - 氮杂茚并异喹啉化合物及其用途 - Google Patents

氮杂茚并异喹啉化合物及其用途 Download PDF

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Publication number
CN110167936A
CN110167936A CN201780083073.3A CN201780083073A CN110167936A CN 110167936 A CN110167936 A CN 110167936A CN 201780083073 A CN201780083073 A CN 201780083073A CN 110167936 A CN110167936 A CN 110167936A
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CN
China
Prior art keywords
optionally substituted
substituents
group
hydrogen
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780083073.3A
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English (en)
Chinese (zh)
Inventor
M·S·库什曼
P·王
Y·G·波米耶
M·S·A·艾尔萨伊德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Health Research Institutes
Purdue Research Foundation
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National Health Research Institutes
Purdue Research Foundation
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Filing date
Publication date
Application filed by National Health Research Institutes, Purdue Research Foundation filed Critical National Health Research Institutes
Publication of CN110167936A publication Critical patent/CN110167936A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201780083073.3A 2016-12-22 2017-12-19 氮杂茚并异喹啉化合物及其用途 Pending CN110167936A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662437777P 2016-12-22 2016-12-22
US62/437,777 2016-12-22
PCT/US2017/067206 WO2018118852A1 (en) 2016-12-22 2017-12-19 Azaindenoisoquinoline compounds and uses thereof

Publications (1)

Publication Number Publication Date
CN110167936A true CN110167936A (zh) 2019-08-23

Family

ID=62627773

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780083073.3A Pending CN110167936A (zh) 2016-12-22 2017-12-19 氮杂茚并异喹啉化合物及其用途

Country Status (6)

Country Link
US (1) US10875860B2 (https=)
EP (1) EP3558993A4 (https=)
JP (1) JP7182548B2 (https=)
CN (1) CN110167936A (https=)
CA (1) CA3047992A1 (https=)
WO (1) WO2018118852A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020023700A2 (en) * 2018-07-25 2020-01-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services OXYNITIDINE DERIVATIVES USEFUL AS INHIBITORS OF TOPOISOMERASE IB (Top1) AND TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101674832A (zh) * 2007-02-28 2010-03-17 伊诺泰克制药公司 茚并异喹啉酮类似物及其使用方法
US20140018360A1 (en) * 2012-07-13 2014-01-16 Mark S. Cushman Azaindenoisoquinoline topoisomerase i inhibitors
US20140187547A1 (en) * 2012-07-13 2014-07-03 Purdue Research Foundation Azaindenoisoquinoline topoisomerase i inhibitors
US20160229888A1 (en) * 2005-11-14 2016-08-11 Purdue Research Foundation N-substituted indenoisoquinolines and syntheses thereof
US20160318946A1 (en) * 2011-05-25 2016-11-03 Purdue Research Foundation Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase i inhibitors

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Publication number Priority date Publication date Assignee Title
JPH0692410B2 (ja) 1988-08-30 1994-11-16 キッセイ薬品工業株式会社 新規なベンゾフロキノリン誘導体
CA2347100C (en) 1998-10-14 2010-12-14 Purdue Research Foundation Novel indenoisoquinolines as antineoplastic agents
US20030096833A1 (en) 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
EP1453812B1 (en) 2001-11-14 2008-08-20 Rutgers, The State University Cytotoxic agents
AU2002364953A1 (en) 2001-11-14 2003-06-17 Edmond J. Lavoie Topoisomerase poison agents
EP1646388A4 (en) 2003-05-12 2007-04-18 Purdue Research Foundation CYTOTOXIC INDENO AND ISOINDOLOISOCHINOLONE
EP1735281A4 (en) 2004-03-17 2009-11-04 Purdue Research Foundation Synthesis of Indinoisoquinoline Compounds and Their Use
US7495100B2 (en) 2004-05-07 2009-02-24 Purdue Research Foundation Synthesis of indenoisoquinolines
CA2629530C (en) 2005-11-14 2014-07-08 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services N-substituted indenoisoquinolines and syntheses thereof
WO2008076767A1 (en) 2006-12-13 2008-06-26 Purdue Research Foundation Chemotherapeutic flavonoids, and syntheses thereof
WO2009140467A1 (en) 2008-05-15 2009-11-19 Purdue Research Foundation Oxobenzindolizinoquinolines and uses thereof
WO2011094416A1 (en) 2010-01-27 2011-08-04 Purdue Research Foundation Substituted norindenoisoquinolines, syntheses thereof, and methods of use
US9073920B2 (en) 2010-08-17 2015-07-07 Purdue Research Foundation Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor
US9328073B2 (en) 2011-05-25 2016-05-03 Purdue Research Foundation Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors
US8912213B2 (en) 2012-04-13 2014-12-16 Purdue Research Foundation Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors
EP2882714B1 (en) 2012-08-08 2019-11-13 Merck Patent GmbH (aza-)isoquinolinone derivatives
WO2015069766A1 (en) 2013-11-06 2015-05-14 Purdue Research Foundation Dupa-indenoisoquinoline conjugates

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160229888A1 (en) * 2005-11-14 2016-08-11 Purdue Research Foundation N-substituted indenoisoquinolines and syntheses thereof
CN101674832A (zh) * 2007-02-28 2010-03-17 伊诺泰克制药公司 茚并异喹啉酮类似物及其使用方法
US20160318946A1 (en) * 2011-05-25 2016-11-03 Purdue Research Foundation Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase i inhibitors
US20140018360A1 (en) * 2012-07-13 2014-01-16 Mark S. Cushman Azaindenoisoquinoline topoisomerase i inhibitors
US20140187547A1 (en) * 2012-07-13 2014-07-03 Purdue Research Foundation Azaindenoisoquinoline topoisomerase i inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DANIEL E. BECK等: "Discovery of Potent Indenoisoquinoline Topoisomerase I Poisons Lacking the 3 ‑ Nitro Toxicophore", 《J. MED. CHEM.》 *
DANIEL E. BECK等: "Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons", 《BIO ORGANIC & MEDIC INAL CHEMISTRY》 *
EVGENY KISELEV等: "Optimization of the Lactam Side Chain of 7‑ Azaindenoisoquinoline Topoisomerase I Inhibitors and Mechanism of Action Studies in Cancer Cells", 《J. MED. CHEM.》 *
MOHAMED S.A.ELSAYED等: "Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I", 《J.MED.CHEM.》 *

Also Published As

Publication number Publication date
JP2020506886A (ja) 2020-03-05
JP7182548B2 (ja) 2022-12-02
CA3047992A1 (en) 2018-06-28
WO2018118852A1 (en) 2018-06-28
US10875860B2 (en) 2020-12-29
EP3558993A1 (en) 2019-10-30
US20200095243A1 (en) 2020-03-26
EP3558993A4 (en) 2020-05-06

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Application publication date: 20190823