JP7182548B2 - アザインデノイソキノリン化合物およびその使用 - Google Patents

アザインデノイソキノリン化合物およびその使用 Download PDF

Info

Publication number
JP7182548B2
JP7182548B2 JP2019534676A JP2019534676A JP7182548B2 JP 7182548 B2 JP7182548 B2 JP 7182548B2 JP 2019534676 A JP2019534676 A JP 2019534676A JP 2019534676 A JP2019534676 A JP 2019534676A JP 7182548 B2 JP7182548 B2 JP 7182548B2
Authority
JP
Japan
Prior art keywords
mmol
compound
optionally substituted
compounds
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019534676A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020506886A (ja
JP2020506886A5 (https=
Inventor
クッシュマン，マーク，エス．
ワン，ピン
ポミエ，イヴ，ジョージ
エルサイード，ムハンマド，エス．エー．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institutes of Health NIH
Original Assignee
National Institutes of Health NIH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institutes of Health NIH filed Critical National Institutes of Health NIH
Publication of JP2020506886A publication Critical patent/JP2020506886A/ja
Publication of JP2020506886A5 publication Critical patent/JP2020506886A5/ja
Application granted granted Critical
Publication of JP7182548B2 publication Critical patent/JP7182548B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2019534676A 2016-12-22 2017-12-19 アザインデノイソキノリン化合物およびその使用 Active JP7182548B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662437777P 2016-12-22 2016-12-22
US62/437,777 2016-12-22
PCT/US2017/067206 WO2018118852A1 (en) 2016-12-22 2017-12-19 Azaindenoisoquinoline compounds and uses thereof

Publications (3)

Publication Number Publication Date
JP2020506886A JP2020506886A (ja) 2020-03-05
JP2020506886A5 JP2020506886A5 (https=) 2021-01-21
JP7182548B2 true JP7182548B2 (ja) 2022-12-02

Family

ID=62627773

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019534676A Active JP7182548B2 (ja) 2016-12-22 2017-12-19 アザインデノイソキノリン化合物およびその使用

Country Status (6)

Country Link
US (1) US10875860B2 (https=)
EP (1) EP3558993A4 (https=)
JP (1) JP7182548B2 (https=)
CN (1) CN110167936A (https=)
CA (1) CA3047992A1 (https=)
WO (1) WO2018118852A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020023700A2 (en) * 2018-07-25 2020-01-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services OXYNITIDINE DERIVATIVES USEFUL AS INHIBITORS OF TOPOISOMERASE IB (Top1) AND TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010520220A (ja) 2007-02-28 2010-06-10 イノテック ファーマシューティカルズ コーポレイション インデノイソキノリノン類似体およびその使用方法
US20140018360A1 (en) 2012-07-13 2014-01-16 Mark S. Cushman Azaindenoisoquinoline topoisomerase i inhibitors
US20140187547A1 (en) 2012-07-13 2014-07-03 Purdue Research Foundation Azaindenoisoquinoline topoisomerase i inhibitors
US20160229888A1 (en) 2005-11-14 2016-08-11 Purdue Research Foundation N-substituted indenoisoquinolines and syntheses thereof
US20160318946A1 (en) 2011-05-25 2016-11-03 Purdue Research Foundation Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase i inhibitors

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0692410B2 (ja) 1988-08-30 1994-11-16 キッセイ薬品工業株式会社 新規なベンゾフロキノリン誘導体
CA2347100C (en) 1998-10-14 2010-12-14 Purdue Research Foundation Novel indenoisoquinolines as antineoplastic agents
US20030096833A1 (en) 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
EP1453812B1 (en) 2001-11-14 2008-08-20 Rutgers, The State University Cytotoxic agents
AU2002364953A1 (en) 2001-11-14 2003-06-17 Edmond J. Lavoie Topoisomerase poison agents
EP1646388A4 (en) 2003-05-12 2007-04-18 Purdue Research Foundation CYTOTOXIC INDENO AND ISOINDOLOISOCHINOLONE
EP1735281A4 (en) 2004-03-17 2009-11-04 Purdue Research Foundation Synthesis of Indinoisoquinoline Compounds and Their Use
US7495100B2 (en) 2004-05-07 2009-02-24 Purdue Research Foundation Synthesis of indenoisoquinolines
CA2629530C (en) 2005-11-14 2014-07-08 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services N-substituted indenoisoquinolines and syntheses thereof
WO2008076767A1 (en) 2006-12-13 2008-06-26 Purdue Research Foundation Chemotherapeutic flavonoids, and syntheses thereof
WO2009140467A1 (en) 2008-05-15 2009-11-19 Purdue Research Foundation Oxobenzindolizinoquinolines and uses thereof
WO2011094416A1 (en) 2010-01-27 2011-08-04 Purdue Research Foundation Substituted norindenoisoquinolines, syntheses thereof, and methods of use
US9073920B2 (en) 2010-08-17 2015-07-07 Purdue Research Foundation Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor
US9328073B2 (en) 2011-05-25 2016-05-03 Purdue Research Foundation Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors
US8912213B2 (en) 2012-04-13 2014-12-16 Purdue Research Foundation Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors
EP2882714B1 (en) 2012-08-08 2019-11-13 Merck Patent GmbH (aza-)isoquinolinone derivatives
WO2015069766A1 (en) 2013-11-06 2015-05-14 Purdue Research Foundation Dupa-indenoisoquinoline conjugates

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160229888A1 (en) 2005-11-14 2016-08-11 Purdue Research Foundation N-substituted indenoisoquinolines and syntheses thereof
JP2010520220A (ja) 2007-02-28 2010-06-10 イノテック ファーマシューティカルズ コーポレイション インデノイソキノリノン類似体およびその使用方法
US20160318946A1 (en) 2011-05-25 2016-11-03 Purdue Research Foundation Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase i inhibitors
US20140018360A1 (en) 2012-07-13 2014-01-16 Mark S. Cushman Azaindenoisoquinoline topoisomerase i inhibitors
US20140187547A1 (en) 2012-07-13 2014-07-03 Purdue Research Foundation Azaindenoisoquinoline topoisomerase i inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry ，2016年，24(7)，1469-1479
C.G.WERMUTH，最新創薬化学，上巻，1998年，p.375-80
Journal of Medicinal Chemistry ，2014年，57(4)，1289-1298
Journal of Medicinal Chemistry ，2015年，58(9)，3997-4015

Also Published As

Publication number Publication date
JP2020506886A (ja) 2020-03-05
CA3047992A1 (en) 2018-06-28
CN110167936A (zh) 2019-08-23
WO2018118852A1 (en) 2018-06-28
US10875860B2 (en) 2020-12-29
EP3558993A1 (en) 2019-10-30
US20200095243A1 (en) 2020-03-26
EP3558993A4 (en) 2020-05-06

Similar Documents

Publication Publication Date Title
EP3092236B1 (en) Novel glutaminase inhibitors
EP1725565B1 (en) Fused heterotricyclic compounds as inhibitors of 17b-hydroxysteroid dehydrogenase 3
IL257886A (en) History of imidazo [5,4-c] quinoline and imidazo [5,4-c] [5,1] naphthyridine as lrrk2 inhibitors
CA2936550C (en) Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
EP4282864A1 (en) Cdk6/dyrk2 dual-target inhibitor, and preparation method therefor and use thereof
JP7663968B2 (ja) Ｗｄｒ５阻害剤及び調節剤
EP3967682A1 (en) Bisheterocyclic carbonyl substituted dihydropyrazole compound, preparation method therefor and pharmaceutical use thereof
JP2022517085A (ja) ハロゲン化アリルアミン系化合物及びその適用
EP1610790A2 (en) Anticancer compounds
KR20180039117A (ko) 아릴-치환된 디히드로퀴놀리논, 그의 제조법 및 제약으로서의 그의 용도
JP7182548B2 (ja) アザインデノイソキノリン化合物およびその使用
CN109476649B (zh) 五元杂环类化合物及其制备方法、药物组合物和用途
CN114075218B (zh) Usp7抑制剂
JP2024517867A (ja) Ｗｄｒ５阻害剤およびモジュレーター
US10759795B2 (en) Aza-A-ring indenoisoquinoline topoisomerase I poisons
CN120230084A (zh) 一种tdg抑制剂化合物及其用途
CN121930241A (zh) 依喜替康衍生物及其制备方法和应用
CN115806553A (zh) 杂环并内酰胺类衍生物、其制备方法及含有该衍生物的药物组合物在医药上的应用
CN120574234A (zh) 具有透脑功能的高选择性parp1抑制剂
JP2019506410A (ja) 抗癌剤インドテカンおよびインジミテカンのプロドラッグ
TW202235074A (zh) 多環類激酶抑制劑
CN104119343A (zh) 2-三氟甲基噻二唑类化合物及其用途
CN109928998A (zh) 一种含螺环基团的吡咯并[2,3-d]嘧啶化合物及其制备方法
HK1228906B (en) Novel glutaminase inhibitors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201203

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20201203

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20211028

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20211102

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220131

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20220517

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220908

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20220908

C11 Written invitation by the commissioner to file amendments

Free format text: JAPANESE INTERMEDIATE CODE: C11

Effective date: 20220920

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20221006

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20221011

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20221115

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20221121

R150 Certificate of patent or registration of utility model

Ref document number: 7182548

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250