JP2020506307A5 - - Google Patents
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- Publication number
- JP2020506307A5 JP2020506307A5 JP2019560457A JP2019560457A JP2020506307A5 JP 2020506307 A5 JP2020506307 A5 JP 2020506307A5 JP 2019560457 A JP2019560457 A JP 2019560457A JP 2019560457 A JP2019560457 A JP 2019560457A JP 2020506307 A5 JP2020506307 A5 JP 2020506307A5
- Authority
- JP
- Japan
- Prior art keywords
- fiber
- bioadhesive
- substance
- concentration
- hydrophilic polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000835 fiber Substances 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 43
- 239000000227 bioadhesive Substances 0.000 claims description 39
- 239000000203 mixture Substances 0.000 claims description 31
- 239000000126 substance Substances 0.000 claims description 28
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 21
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 21
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 15
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 15
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 15
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 12
- 229920001223 polyethylene glycol Polymers 0.000 claims description 12
- 229940088679 drug related substance Drugs 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 8
- 150000001298 alcohols Chemical class 0.000 claims description 8
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 8
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 8
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 8
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 8
- 239000003246 corticosteroid Substances 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 6
- 229920006243 acrylic copolymer Polymers 0.000 claims description 6
- 229920000058 polyacrylate Polymers 0.000 claims description 6
- 239000001856 Ethyl cellulose Substances 0.000 claims description 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 5
- 229920001249 ethyl cellulose Polymers 0.000 claims description 5
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 5
- 230000003352 fibrogenic effect Effects 0.000 claims description 5
- 230000002209 hydrophobic effect Effects 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 4
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims description 4
- 229920001661 Chitosan Polymers 0.000 claims description 4
- 244000007835 Cyamopsis tetragonoloba Species 0.000 claims description 4
- 229920002307 Dextran Polymers 0.000 claims description 4
- 229920003134 Eudragit® polymer Polymers 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 229920002148 Gellan gum Polymers 0.000 claims description 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- 102000004856 Lectins Human genes 0.000 claims description 4
- 108090001090 Lectins Proteins 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 229920002807 Thiomer Polymers 0.000 claims description 4
- 229940072056 alginate Drugs 0.000 claims description 4
- 235000010443 alginic acid Nutrition 0.000 claims description 4
- 229920000615 alginic acid Polymers 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 4
- 229940124599 anti-inflammatory drug Drugs 0.000 claims description 4
- 235000010418 carrageenan Nutrition 0.000 claims description 4
- 239000000679 carrageenan Substances 0.000 claims description 4
- 229920001525 carrageenan Polymers 0.000 claims description 4
- 229940113118 carrageenan Drugs 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- 239000002523 lectin Substances 0.000 claims description 4
- 229920000609 methyl cellulose Polymers 0.000 claims description 4
- 239000001923 methylcellulose Substances 0.000 claims description 4
- 229920001277 pectin Polymers 0.000 claims description 4
- 239000001814 pectin Substances 0.000 claims description 4
- 235000010987 pectin Nutrition 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 4
- 238000001523 electrospinning Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 229960004703 clobetasol propionate Drugs 0.000 claims 3
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 229920001610 polycaprolactone Polymers 0.000 claims 3
- 230000005684 electric field Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000009987 spinning Methods 0.000 claims 2
- 239000002245 particle Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201770043 | 2017-01-23 | ||
| DKPA201770043 | 2017-01-23 | ||
| PCT/DK2018/050010 WO2018133910A1 (en) | 2017-01-23 | 2018-01-22 | Method for preparing electrospun fibers with a high content of a bioadhesive substance |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506307A JP2020506307A (ja) | 2020-02-27 |
| JP2020506307A5 true JP2020506307A5 (enExample) | 2021-03-04 |
| JP7353980B2 JP7353980B2 (ja) | 2023-10-02 |
Family
ID=58536695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019560457A Active JP7353980B2 (ja) | 2017-01-23 | 2018-01-22 | 高含量の生体接着物質を有する電界紡糸繊維を調製する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11045430B2 (enExample) |
| EP (1) | EP3570822B1 (enExample) |
| JP (1) | JP7353980B2 (enExample) |
| KR (1) | KR102595001B1 (enExample) |
| CN (1) | CN110290783A (enExample) |
| AU (1) | AU2018209592B2 (enExample) |
| BR (1) | BR112019014732A2 (enExample) |
| CA (1) | CA3050026A1 (enExample) |
| DK (1) | DK3570822T3 (enExample) |
| ES (1) | ES2874787T3 (enExample) |
| IL (1) | IL268185B2 (enExample) |
| MX (1) | MX387268B (enExample) |
| RU (1) | RU2019126497A (enExample) |
| WO (1) | WO2018133910A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2950821C (en) * | 2014-06-10 | 2024-02-06 | Dermtreat Aps | Compositions comprising electrohydrodynamically obtained fibres for administration of specific dosages of an active substance to skin or mucosa |
| ES2887977T3 (es) | 2017-01-23 | 2021-12-29 | Afyx Therapeutics As | Método para la fabricación de un producto de dos capas a base de fibras electrohiladas |
| JP2022552832A (ja) | 2019-10-08 | 2022-12-20 | アフリックス セラピューティクス アー／エス | タンパク質の送達のための組成物 |
| ES2876401B2 (es) * | 2020-05-11 | 2024-04-05 | Bioinicia S L | Parches auto-adhesivos de fibras para la liberación controlada de bioactivos |
| JP2024542227A (ja) | 2021-11-23 | 2024-11-13 | アフリックス デベロップメント アー／エス | 粘膜パッチおよびその使用方法 |
| KR20240073700A (ko) | 2022-11-18 | 2024-05-27 | 한국생산기술연구원 | 다공성 폴리 유산 미세섬유 및 이의 제조방법 |
| WO2025051337A1 (en) | 2023-09-06 | 2025-03-13 | Afyx Development A/S | Compositions and methods for treating and preventing oral cancer |
| KR20250066118A (ko) | 2023-11-06 | 2025-05-13 | 한국생산기술연구원 | 두가지 기능성 물질이 담지된 다공성 셀룰로오스 아세테이트 섬유 구조체 및 이의 제조방법 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2134635Y (zh) | 1992-08-18 | 1993-05-26 | 许竞新 | 具有连续响声的印刷鞭炮 |
| DE4337152A1 (de) | 1993-10-30 | 1995-05-04 | Merck Patent Gmbh | Verfahren zur Herstellung von wäßrigen Chitosan-Lösungen und -Gelen |
| US6753454B1 (en) | 1999-10-08 | 2004-06-22 | The University Of Akron | Electrospun fibers and an apparatus therefor |
| JP2003521493A (ja) | 2000-01-28 | 2003-07-15 | スミスクライン・ビーチャム・コーポレイション | 電気紡糸された医薬組成物 |
| WO2002076425A2 (en) | 2001-03-22 | 2002-10-03 | Battelle (Memorial Institute) | Manufacturing dissolvable dosage forms |
| US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
| US6585997B2 (en) | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
| US7309498B2 (en) | 2001-10-10 | 2007-12-18 | Belenkaya Bronislava G | Biodegradable absorbents and methods of preparation |
| US20030017208A1 (en) | 2002-07-19 | 2003-01-23 | Francis Ignatious | Electrospun pharmaceutical compositions |
| TW200410714A (en) | 2002-08-07 | 2004-07-01 | Smithkline Beecham Corp | Electrospun amorphous pharmaceutical compositions |
| AU2003265446A1 (en) | 2002-08-13 | 2004-02-25 | Medtronic, Inc. | Active agent delivery system including a hydrophilic polymer, medical device, and method |
| KR100564366B1 (ko) | 2003-11-19 | 2006-04-07 | 재단법인서울대학교산학협력재단 | 나노 섬유형 부직포를 이용한 조직 재생용 차폐막 및 그의 제조 방법 |
| JP4526851B2 (ja) | 2004-03-31 | 2010-08-18 | 明彦 谷岡 | 多糖類のナノスケールの繊維および成形体 |
| EP1796822A4 (en) | 2004-10-06 | 2008-09-17 | Res Foundation Suny | INTENSE FLOW FILTRATION MEDIA WITH LOW ENCRYPTION |
| US7390760B1 (en) | 2004-11-02 | 2008-06-24 | Kimberly-Clark Worldwide, Inc. | Composite nanofiber materials and methods for making same |
| WO2006106514A2 (en) | 2005-04-06 | 2006-10-12 | Nicast Ltd. | Electrospun dosage form and method of producing the same |
| US20100190254A1 (en) | 2006-12-05 | 2010-07-29 | Nanyang Technological University | Three-dimensional porous hybrid scaffold and manufacture thereof |
| JP2009041117A (ja) | 2007-08-06 | 2009-02-26 | Nisshinbo Ind Inc | 多糖類ナノファイバー |
| JP5600005B2 (ja) | 2007-09-05 | 2014-10-01 | 太陽化学株式会社 | 水溶性電界紡糸シート |
| EP2271301A4 (en) | 2008-03-27 | 2014-07-02 | Agigma Inc | METHOD AND COMPOSITIONS FOR THE DELIVERY OF FUNDS |
| US8361492B2 (en) | 2008-04-29 | 2013-01-29 | Ocugenics, LLC | Drug delivery system and methods of use |
| WO2010099292A2 (en) | 2009-02-25 | 2010-09-02 | North Carolina State University | Biodegradable drug or other active delivery system |
| US20110111012A1 (en) | 2009-11-12 | 2011-05-12 | Hemcon Medical Technologies, Inc. | Nanomaterial wound dressing assembly |
| EP2646006B1 (en) | 2010-11-26 | 2015-02-25 | University Of The Witwatersrand, Johannesburg | A pharmaceutical dosage form |
| CN102251317B (zh) * | 2011-05-18 | 2013-01-16 | 东华大学 | 一种药物释放可控的电纺纤维的制备方法 |
| US20130295143A1 (en) | 2012-05-02 | 2013-11-07 | Massachusetts Institute Of Technology | Electroprocessing of active pharmaceutical ingredients |
| WO2014066297A1 (en) | 2012-10-22 | 2014-05-01 | North Carolina State University | Nonwoven fiber materials |
| US9393216B2 (en) | 2012-11-06 | 2016-07-19 | University Of Washington Through Its Center For Commercialization | Vaginal matrices: nanofibers for contraception and prevention of HIV infection |
| EP2810645B1 (en) | 2013-06-06 | 2017-05-24 | A. Sezai Sarac | New Drug Delivery System |
| EP2813212A1 (en) | 2013-06-10 | 2014-12-17 | Zentiva, a.s. | Drug formulation using API in nanofibers |
| CZ308492B6 (cs) | 2013-10-25 | 2020-09-23 | Contipro A.S. | Kosmetická kompozice na bázi kyseliny hyaluronové, způsob její přípravy a použití |
| CA2935237A1 (en) * | 2014-01-15 | 2015-07-23 | University Of Guelph | Compositions and methods to encapsulate and control release of volatile organic compounds for increasing shelf-life of perishable products |
| CN107106720B (zh) | 2014-06-05 | 2020-06-16 | 约翰内斯堡威特沃特斯兰德大学 | 一种伤口敷料 |
| CA2950821C (en) | 2014-06-10 | 2024-02-06 | Dermtreat Aps | Compositions comprising electrohydrodynamically obtained fibres for administration of specific dosages of an active substance to skin or mucosa |
| US20160166959A1 (en) * | 2014-12-12 | 2016-06-16 | The Board Of Trustees Of The Leland Stanford Junior University | Air filter for high-efficiency pm2.5 capture |
| MX391778B (es) | 2015-11-19 | 2025-03-21 | Dermtreat Aps | Composición farmacéutica que comprende fibras obtenidas electrohidrodinámicamente y que tiene tiempo de residencia mejorado en el sitio de aplicación. |
-
2018
- 2018-01-22 AU AU2018209592A patent/AU2018209592B2/en active Active
- 2018-01-22 DK DK18702052.4T patent/DK3570822T3/da active
- 2018-01-22 WO PCT/DK2018/050010 patent/WO2018133910A1/en not_active Ceased
- 2018-01-22 KR KR1020197024907A patent/KR102595001B1/ko active Active
- 2018-01-22 IL IL268185A patent/IL268185B2/en unknown
- 2018-01-22 JP JP2019560457A patent/JP7353980B2/ja active Active
- 2018-01-22 BR BR112019014732-2A patent/BR112019014732A2/pt not_active Application Discontinuation
- 2018-01-22 CN CN201880007823.3A patent/CN110290783A/zh active Pending
- 2018-01-22 MX MX2019008155A patent/MX387268B/es unknown
- 2018-01-22 EP EP18702052.4A patent/EP3570822B1/en active Active
- 2018-01-22 ES ES18702052T patent/ES2874787T3/es active Active
- 2018-01-22 CA CA3050026A patent/CA3050026A1/en active Pending
- 2018-01-22 RU RU2019126497A patent/RU2019126497A/ru unknown
-
2019
- 2019-04-26 US US16/395,956 patent/US11045430B2/en active Active
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