JP7353980B2 - 高含量の生体接着物質を有する電界紡糸繊維を調製する方法 - Google Patents

高含量の生体接着物質を有する電界紡糸繊維を調製する方法 Download PDF

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JP7353980B2
JP7353980B2 JP2019560457A JP2019560457A JP7353980B2 JP 7353980 B2 JP7353980 B2 JP 7353980B2 JP 2019560457 A JP2019560457 A JP 2019560457A JP 2019560457 A JP2019560457 A JP 2019560457A JP 7353980 B2 JP7353980 B2 JP 7353980B2
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eudragit
bioadhesive
fibers
fiber
copolymer
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JP2020506307A5 (enExample
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イェンス ハンセン，
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アフリックス セラピューティクス アー／エス
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/02—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • D01F6/16—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polymers of unsaturated carboxylic acids or unsaturated organic esters, e.g. polyacrylic esters, polyvinyl acetate
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/02—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • D01F6/26—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from other polymers
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
    • D01F6/62—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters
    • D01F6/625—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters derived from hydroxy-carboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
    • C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Textile Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Artificial Filaments (AREA)
  • Nonwoven Fabrics (AREA)
JP2019560457A 2017-01-23 2018-01-22 高含量の生体接着物質を有する電界紡糸繊維を調製する方法 Active JP7353980B2 (ja)

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Application Number Priority Date Filing Date Title
DKPA201770043 2017-01-23
DKPA201770043 2017-01-23
PCT/DK2018/050010 WO2018133910A1 (en) 2017-01-23 2018-01-22 Method for preparing electrospun fibers with a high content of a bioadhesive substance

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JP2020506307A JP2020506307A (ja) 2020-02-27
JP2020506307A5 JP2020506307A5 (enExample) 2021-03-04
JP7353980B2 true JP7353980B2 (ja) 2023-10-02

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US (1) US11045430B2 (enExample)
EP (1) EP3570822B1 (enExample)
JP (1) JP7353980B2 (enExample)
KR (1) KR102595001B1 (enExample)
CN (1) CN110290783A (enExample)
AU (1) AU2018209592B2 (enExample)
BR (1) BR112019014732A2 (enExample)
CA (1) CA3050026A1 (enExample)
DK (1) DK3570822T3 (enExample)
ES (1) ES2874787T3 (enExample)
IL (1) IL268185B2 (enExample)
MX (1) MX387268B (enExample)
RU (1) RU2019126497A (enExample)
WO (1) WO2018133910A1 (enExample)

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IL291842A (en) * 2014-06-10 2022-06-01 Afyx Therapeutics As Compositions comprising electrohydrodynamically obtained fibres for administration of specific dosages of an active substance to skin or mucosa
BR112019014236A2 (pt) 2017-01-23 2020-03-17 Afyx Therapeutics A/S Método para a fabricação de um produto de duas camadas à base de fibras eletrofiadas
CA3157209A1 (en) 2019-10-08 2021-04-15 Afyx Therapeutics A/S Compositions for the delivery of proteins
ES2876401B2 (es) 2020-05-11 2024-04-05 Bioinicia S L Parches auto-adhesivos de fibras para la liberación controlada de bioactivos
WO2023094457A1 (en) 2021-11-23 2023-06-01 Afyx Therapeutics A/S Mucosal patches and methods of use thereof
KR102965449B1 (ko) 2022-11-18 2026-05-15 한국생산기술연구원 다공성 폴리 유산 미세섬유 및 이의 제조방법
EP4773947A1 (en) 2023-09-06 2026-07-15 Afyx Development A/S Compositions and methods for treating and preventing oral cancer
KR20250066118A (ko) 2023-11-06 2025-05-13 한국생산기술연구원 두가지 기능성 물질이 담지된 다공성 셀룰로오스 아세테이트 섬유 구조체 및 이의 제조방법
KR102987082B1 (ko) * 2023-11-14 2026-07-09 지에이치신소재 주식회사 용융 전기방사 나노섬유 제조장치
KR102980636B1 (ko) * 2024-03-28 2026-06-23 주식회사 아이메디텍 의료용 나노섬유 방사용액 제조방법 및 이에 의한 의료용 나노섬유 방사용액
KR102987083B1 (ko) * 2024-12-05 2026-07-09 지에이치신소재 주식회사 섬유간 접착력을 개선시킨 용융 전기방사 나노섬유 제조장치
CN120960179B (zh) * 2025-09-04 2026-06-12 苏州禾川化学技术服务有限公司 一种可降解纳米纤维素缓释载药薄膜的制备方法

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JP2009041117A (ja) 2007-08-06 2009-02-26 Nisshinbo Ind Inc 多糖類ナノファイバー
JP2013544259A (ja) 2010-11-26 2013-12-12 ユニバーシティ・オブ・ジ・ウィトウォーターズランド・ヨハネスブルク 医薬投与形態
JP2016536305A (ja) 2013-10-25 2016-11-24 コンティプロ ビオテック スポレチノスト エス ルチェニム オメゼニム ヒアルロン酸をベースとする化粧品組成物，その調製法及び使用
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WO2015189212A1 (en) 2014-06-10 2015-12-17 Dermtreat Aps Compositions comprising electrohydrodynamically obtained fibres for administration of specific dosages of an active substance to skin or mucosa

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AU2018209592A1 (en) 2019-07-25
ES2874787T3 (es) 2021-11-05
IL268185A (en) 2019-09-26
AU2018209592B2 (en) 2024-03-21
DK3570822T3 (da) 2021-07-26
NZ755185A (en) 2025-06-27
EP3570822B1 (en) 2021-05-05
KR20190126306A (ko) 2019-11-11
KR102595001B1 (ko) 2023-10-26
RU2019126497A (ru) 2021-02-24
IL268185B2 (en) 2024-01-01
BR112019014732A2 (pt) 2020-03-10
WO2018133910A1 (en) 2018-07-26
US20190254986A1 (en) 2019-08-22
IL268185B1 (en) 2023-09-01
MX2019008155A (es) 2019-11-07
US11045430B2 (en) 2021-06-29
MX387268B (es) 2025-03-18
CA3050026A1 (en) 2018-07-26
EP3570822A1 (en) 2019-11-27
RU2019126497A3 (enExample) 2021-05-26
JP2020506307A (ja) 2020-02-27
CN110290783A (zh) 2019-09-27

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