JP2020506243A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020506243A5 JP2020506243A5 JP2019563650A JP2019563650A JP2020506243A5 JP 2020506243 A5 JP2020506243 A5 JP 2020506243A5 JP 2019563650 A JP2019563650 A JP 2019563650A JP 2019563650 A JP2019563650 A JP 2019563650A JP 2020506243 A5 JP2020506243 A5 JP 2020506243A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- influenza
- composition according
- virus
- naphthamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000712461 unidentified influenza virus Species 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 16
- 241000712431 Influenza A virus Species 0.000 claims description 8
- 230000009385 viral infection Effects 0.000 claims description 8
- 241000197306 H1N1 subtype Species 0.000 claims description 4
- 241000252870 H3N2 subtype Species 0.000 claims description 4
- 241001473385 H5N1 subtype Species 0.000 claims description 4
- 241000713196 Influenza B virus Species 0.000 claims description 4
- 230000010076 replication Effects 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- 239000003443 antiviral agent Substances 0.000 claims description 3
- WVROWPPEIMRGAB-UHFFFAOYSA-N bit225 Chemical compound C1=NN(C)C=C1C1=CC=CC2=CC(C(=O)NC(N)=N)=CC=C12 WVROWPPEIMRGAB-UHFFFAOYSA-N 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 206010022000 influenza Diseases 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- 241000713297 Influenza C virus Species 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229960003752 oseltamivir Drugs 0.000 claims description 2
- VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims description 2
- XRQDFNLINLXZLB-CKIKVBCHSA-N peramivir Chemical compound CCC(CC)[C@H](NC(C)=O)[C@@H]1[C@H](O)[C@@H](C(O)=O)C[C@H]1NC(N)=N XRQDFNLINLXZLB-CKIKVBCHSA-N 0.000 claims description 2
- 229960001084 peramivir Drugs 0.000 claims description 2
- 229960001028 zanamivir Drugs 0.000 claims description 2
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 17
- 102000004310 Ion Channels Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2017900385 | 2017-02-08 | ||
| AU2017900385A AU2017900385A0 (en) | 2017-02-08 | Methods of treating influenza | |
| PCT/AU2018/050085 WO2018145148A1 (en) | 2017-02-08 | 2018-02-07 | Methods of treating influenza |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506243A JP2020506243A (ja) | 2020-02-27 |
| JP2020506243A5 true JP2020506243A5 (enExample) | 2021-03-11 |
| JP7019727B2 JP7019727B2 (ja) | 2022-02-15 |
Family
ID=63106827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019563650A Active JP7019727B2 (ja) | 2017-02-08 | 2018-02-07 | インフルエンザの治療方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10918623B2 (enExample) |
| EP (1) | EP3579833B1 (enExample) |
| JP (1) | JP7019727B2 (enExample) |
| KR (1) | KR102607599B1 (enExample) |
| CN (1) | CN110325187B (enExample) |
| AU (1) | AU2018218179B2 (enExample) |
| BR (1) | BR112019016316A2 (enExample) |
| CA (1) | CA3052503A1 (enExample) |
| ES (1) | ES2910136T3 (enExample) |
| MX (1) | MX387115B (enExample) |
| RU (1) | RU2769317C2 (enExample) |
| SG (1) | SG11201907034PA (enExample) |
| WO (1) | WO2018145148A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME01924B (me) | 2010-07-22 | 2015-05-20 | Gilead Sciences Inc | Metode i jedinjenja za lečenje infekcija izazvanih Paramyxoviridae virusom |
| TWI698444B (zh) | 2014-10-29 | 2020-07-11 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
| ES2918585T3 (es) | 2015-09-16 | 2022-07-19 | Gilead Sciences Inc | Métodos para el tratamiento de infecciones por el virus Arenaviridae |
| CN110869028B (zh) | 2017-03-14 | 2023-01-20 | 吉利德科学公司 | 治疗猫冠状病毒感染的方法 |
| WO2018204198A1 (en) | 2017-05-01 | 2018-11-08 | Gilead Sciences, Inc. | Crystalline forms of (s) 2 ethylbutyl 2 (((s) (((2r,3s,4r,5r) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| US10675296B2 (en) | 2017-07-11 | 2020-06-09 | Gilead Sciences, Inc. | Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections |
| JP2023512656A (ja) | 2020-01-27 | 2023-03-28 | ギリアード サイエンシーズ， インコーポレイテッド | ＳＡＲＳ ＣｏＶ－２感染を治療するための方法 |
| WO2021183750A2 (en) | 2020-03-12 | 2021-09-16 | Gilead Sciences, Inc. | Methods of preparing 1'-cyano nucleosides |
| US11701372B2 (en) | 2020-04-06 | 2023-07-18 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carba-nucleoside analogs |
| AU2021281351A1 (en) | 2020-05-29 | 2023-01-19 | Gilead Sciences, Inc. | Remdesivir treatment methods |
| PH12022553530A1 (en) | 2020-06-24 | 2024-06-24 | Gilead Sciences Inc | 1'-cyano nucleoside analogs and uses thereof |
| CR20230100A (es) | 2020-08-24 | 2023-04-28 | Gilead Sciences Inc | Compuestos fosfolípidos y usos de los mismos |
| CN116568688B (zh) | 2020-08-27 | 2025-11-21 | 吉利德科学公司 | 用于治疗病毒感染的化合物和方法 |
| TWI811812B (zh) | 2020-10-16 | 2023-08-11 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| EP4346772A1 (en) | 2021-05-26 | 2024-04-10 | Gilead Sciences, Inc. | Phospholipid formulations of 1'-cyano substituted carba-nucleoside analogs |
| JP7719954B2 (ja) | 2021-08-18 | 2025-08-06 | ギリアード サイエンシーズ， インコーポレイテッド | リン脂質化合物並びにその製造方法及び使用方法 |
| US20250009713A1 (en) * | 2021-11-24 | 2025-01-09 | Biotron Limited | Methods of treating sars-cov-2 infection |
| WO2023167938A1 (en) | 2022-03-02 | 2023-09-07 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
| JP2025508942A (ja) | 2022-03-02 | 2025-04-10 | ギリアード サイエンシーズ， インコーポレイテッド | ウイルス感染症の治療のための化合物及び方法 |
| IL314961A (en) | 2022-03-03 | 2024-10-01 | Gilead Sciences Inc | Antiviral compounds and methods of making and using the same |
| CA3252904A1 (en) | 2022-03-03 | 2023-09-07 | Gilead Sciences, Inc. | ANTIVIRAL COMPOUNDS, THEIR PRODUCTION AND USE PROCESSES |
| US20240009220A1 (en) | 2022-06-06 | 2024-01-11 | Gilead Sciences, Inc. | Methods for treatment of viral infections |
| US20240051962A1 (en) | 2022-06-29 | 2024-02-15 | Gilead Sciences, Inc. | Solid forms of a nucleoside analogue and uses thereof |
| EP4547665A1 (en) | 2022-06-30 | 2025-05-07 | Gilead Sciences, Inc. | Solid forms of a nucleoside analogue and uses thereof |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
| WO2024173458A1 (en) | 2023-02-16 | 2024-08-22 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| US20250090537A1 (en) | 2023-08-31 | 2025-03-20 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| US20250084088A1 (en) | 2023-08-31 | 2025-03-13 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| US20250099476A1 (en) | 2023-09-06 | 2025-03-27 | Gilead Sciences, Inc. | Solid forms of a nucleoside analogue and uses thereof |
| TW202517647A (zh) | 2023-09-28 | 2025-05-01 | 美商基利科學股份有限公司 | 用於治療病毒感染的化合物及方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2491217T3 (es) * | 2005-06-24 | 2014-09-05 | Biotron Limited | Compuestos de acilguanidina antivirales |
| KR101558403B1 (ko) * | 2007-08-03 | 2015-10-07 | 바이오트론 리미티드 | Ｃ형 간염 바이러스 조성물 및 방법 |
| KR101369584B1 (ko) * | 2011-04-19 | 2014-03-06 | 일양약품주식회사 | 페닐-이속사졸 유도체 및 그의 제조방법 |
| KR20170063512A (ko) * | 2014-07-07 | 2017-06-08 | 프로필락시스 엘엘씨 | 바이러스 예방 치료 방법 및 사전-노출 예방 키트 |
| CN110870864B (zh) * | 2018-08-29 | 2021-09-24 | 复旦大学 | 马来酸卡比沙明在制备抗流感病毒药物中的应用 |
-
2018
- 2018-02-07 EP EP18751710.7A patent/EP3579833B1/en active Active
- 2018-02-07 JP JP2019563650A patent/JP7019727B2/ja active Active
- 2018-02-07 SG SG11201907034PA patent/SG11201907034PA/en unknown
- 2018-02-07 MX MX2019009443A patent/MX387115B/es unknown
- 2018-02-07 US US16/483,958 patent/US10918623B2/en active Active
- 2018-02-07 WO PCT/AU2018/050085 patent/WO2018145148A1/en not_active Ceased
- 2018-02-07 KR KR1020197024919A patent/KR102607599B1/ko active Active
- 2018-02-07 CA CA3052503A patent/CA3052503A1/en active Pending
- 2018-02-07 CN CN201880010492.9A patent/CN110325187B/zh active Active
- 2018-02-07 AU AU2018218179A patent/AU2018218179B2/en active Active
- 2018-02-07 RU RU2019126746A patent/RU2769317C2/ru active
- 2018-02-07 BR BR112019016316-6A patent/BR112019016316A2/pt not_active Application Discontinuation
- 2018-02-07 ES ES18751710T patent/ES2910136T3/es active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020506243A5 (enExample) | ||
| RU2019126746A (ru) | Способы лечения гриппа | |
| Liao et al. | Germacrone inhibits early stages of influenza virus infection | |
| Hayden | Antivirals for influenza: historical perspectives and lessons learned | |
| IL321503A (en) | Recombinant virus, composition comprising the same, and uses thereof | |
| IN2012DN01254A (enExample) | ||
| Haasbach et al. | The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus | |
| Liu et al. | A small-molecule compound has anti-influenza A virus activity by acting as a ‘‘PB2 inhibitor” | |
| Meseko et al. | Antiviral options and therapeutics against influenza: history, latest developments and future prospects | |
| HRP20130163T1 (hr) | Ljudske molekule za vezanje koje mogu neutralizirati virus influence h5n1 i njihova uporaba | |
| JP2014510130A5 (enExample) | ||
| JP2012531420A5 (enExample) | ||
| Govorkova et al. | Therapeutics against influenza | |
| Kumar et al. | Oseltamivir analogs with potent anti-influenza virus activity | |
| Kiselev et al. | A new antiviral drug Triazavirin: results of phase II clinical trial | |
| US20140121237A1 (en) | Methods for Inhibiting Virus Replication | |
| Tian et al. | Dihydromyricetin is a new inhibitor of influenza polymerase PB2 subunit and influenza-induced inflammation | |
| Yang et al. | Influenza virus entry inhibitors | |
| Leyva-Grado et al. | Aerosol administration increases the efficacy of oseltamivir for the treatment of mice infected with influenza viruses | |
| WO2017201030A1 (en) | Methods of treating viral infection | |
| Park et al. | Antiviral agents against influenza viruses | |
| CN110870864B (zh) | 马来酸卡比沙明在制备抗流感病毒药物中的应用 | |
| NZ755900B2 (en) | Methods of treating influenza | |
| Bavagnoli et al. | The 2009 influenza pandemic: promising lessons for antiviral therapy for future outbreaks | |
| JPWO2020212478A5 (enExample) |