ES2910136T3 - Métodos de tratamiento de la gripe - Google Patents
Métodos de tratamiento de la gripe Download PDFInfo
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- ES2910136T3 ES2910136T3 ES18751710T ES18751710T ES2910136T3 ES 2910136 T3 ES2910136 T3 ES 2910136T3 ES 18751710 T ES18751710 T ES 18751710T ES 18751710 T ES18751710 T ES 18751710T ES 2910136 T3 ES2910136 T3 ES 2910136T3
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| AU2017900385A AU2017900385A0 (en) | 2017-02-08 | Methods of treating influenza | |
| PCT/AU2018/050085 WO2018145148A1 (en) | 2017-02-08 | 2018-02-07 | Methods of treating influenza |
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| ES2910136T3 true ES2910136T3 (es) | 2022-05-11 |
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| ES18751710T Active ES2910136T3 (es) | 2017-02-08 | 2018-02-07 | Métodos de tratamiento de la gripe |
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| PT2595980E (pt) | 2010-07-22 | 2014-11-27 | Gilead Sciences Inc | Métodos e compostos para tratar infeções pelo vírus da família paramyxoviridae |
| TWI698444B (zh) | 2014-10-29 | 2020-07-11 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
| DK3349758T3 (da) | 2015-09-16 | 2022-06-13 | Gilead Sciences Inc | Fremgangsmåder til behandling af arenaviridae-virusinfektioner |
| CN110869028B (zh) | 2017-03-14 | 2023-01-20 | 吉利德科学公司 | 治疗猫冠状病毒感染的方法 |
| EP4219513A1 (en) | 2017-05-01 | 2023-08-02 | Gilead Sciences, Inc. | Crystalline form of (s)-2-ethylbutyl 2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| CN111093627B (zh) | 2017-07-11 | 2024-03-08 | 吉利德科学公司 | 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物 |
| KR20220132608A (ko) | 2020-01-27 | 2022-09-30 | 길리애드 사이언시즈, 인코포레이티드 | SARS CoV-2 감염증을 치료하기 위한 방법 |
| TWI785528B (zh) | 2020-03-12 | 2022-12-01 | 美商基利科學股份有限公司 | 1’-氰基核苷之製備方法 |
| JP7482250B2 (ja) | 2020-04-06 | 2024-05-13 | ギリアード サイエンシーズ， インコーポレイテッド | １’－シアノ置換カルバヌクレオシド類似体の吸入製剤 |
| EP4157272B1 (en) | 2020-05-29 | 2025-07-02 | Gilead Sciences, Inc. | Remdesivir for the treatment of viral infections |
| IL299202A (en) | 2020-06-24 | 2023-02-01 | Gilead Sciences Inc | 1'-cyano nucleoside analogs and uses thereof |
| JP7559223B2 (ja) | 2020-08-24 | 2024-10-01 | ギリアード サイエンシーズ， インコーポレイテッド | リン脂質化合物及びその使用 |
| US11926645B2 (en) | 2020-08-27 | 2024-03-12 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
| TWI925033B (zh) | 2020-10-16 | 2026-05-11 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| US12427150B2 (en) | 2021-05-26 | 2025-09-30 | Gilead Sciences, Inc. | Phospholipid formulations of 1′-cyano substituted carba-nucleoside analogs |
| CA3228162A1 (en) | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| AU2022399231A1 (en) * | 2021-11-24 | 2024-05-23 | Biotron Limited | Methods of treating sars-cov-2 infection |
| JP2025508943A (ja) | 2022-03-02 | 2025-04-10 | ギリアード サイエンシーズ， インコーポレイテッド | ウイルス感染症の治療のための化合物及び方法 |
| KR20240154647A (ko) | 2022-03-02 | 2024-10-25 | 길리애드 사이언시즈, 인코포레이티드 | 바이러스성 감염 치료를 위한 화합물 및 방법 |
| US20230382940A1 (en) | 2022-03-03 | 2023-11-30 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| CN118843629A (zh) | 2022-03-03 | 2024-10-25 | 吉利德科学公司 | 抗病毒化合物及其制备和使用方法 |
| WO2023239665A1 (en) | 2022-06-06 | 2023-12-14 | Gilead Sciences, Inc. | Methods for treatment of viral infections including sars-cov-2 |
| EP4547334A1 (en) | 2022-06-29 | 2025-05-07 | Gilead Sciences, Inc. | Solid forms of a nucleoside analogue and uses thereof |
| EP4547665A1 (en) | 2022-06-30 | 2025-05-07 | Gilead Sciences, Inc. | Solid forms of a nucleoside analogue and uses thereof |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
| WO2024173458A1 (en) | 2023-02-16 | 2024-08-22 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| WO2025049699A1 (en) | 2023-08-31 | 2025-03-06 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| US20250084088A1 (en) | 2023-08-31 | 2025-03-13 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| EP4774275A1 (en) | 2023-09-06 | 2026-07-15 | Gilead Sciences, LLC | Solid forms of a nucleoside analogue and uses thereof |
| KR20260079626A (ko) | 2023-09-28 | 2026-06-02 | 길리애드 사이언시즈, 인코포레이티드 | 바이러스성 감염 치료를 위한 화합물 및 방법 |
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| KR101369584B1 (ko) * | 2011-04-19 | 2014-03-06 | 일양약품주식회사 | 페닐-이속사졸 유도체 및 그의 제조방법 |
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| CN110870864B (zh) | 2018-08-29 | 2021-09-24 | 复旦大学 | 马来酸卡比沙明在制备抗流感病毒药物中的应用 |
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| EP3579833A4 (en) | 2021-01-13 |
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| EP3579833B1 (en) | 2022-01-05 |
| JP7019727B2 (ja) | 2022-02-15 |
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