JP2020506177A - 新規エルゴステノールグリコシド誘導体 - Google Patents
新規エルゴステノールグリコシド誘導体 Download PDFInfo
- Publication number
- JP2020506177A JP2020506177A JP2019539762A JP2019539762A JP2020506177A JP 2020506177 A JP2020506177 A JP 2020506177A JP 2019539762 A JP2019539762 A JP 2019539762A JP 2019539762 A JP2019539762 A JP 2019539762A JP 2020506177 A JP2020506177 A JP 2020506177A
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- JP
- Japan
- Prior art keywords
- ergostenol
- dermatitis
- acid
- pharmaceutically acceptable
- compound represented
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims (12)
- 下記の化学式1で表示される化合物またはその薬学的に許容可能な塩。
-
- 下記の化学式1で表示される化合物またはその薬学的に許容可能な塩を有効性分に含む、皮膚炎の予防または治療用薬学組成物。
- 前記皮膚炎は、アトピー皮膚炎、接触性皮膚炎、または脂漏性皮膚炎からなる群より選択されるいずれか1つである、請求項3に記載の皮膚炎予防または治療用薬学組成物。
- 前記組成物は、軟膏、ゲル、クリーム、パッチ、及び噴霧剤からなる群より選択される剤形である、請求項3に記載の薬学組成物。
- 下記の化学式1で表示される化合物またはその薬学的に許容可能な塩を含む皮膚炎の改善または緩和用化粧料組成物。
- エルゴステロールをアルコール溶媒及び塩素系有機溶媒下にPd/C触媒と反応させてエルゴステノールを収得する段階を含む、下記の化学式1で表示される化合物の製造方法。
- 前記塩素系有機溶媒は、メチレンクロライド、クロロホルム、1,2−ジクロロエテインからなる群より選択されるものである、請求項7に記載の製造方法。
- エルゴステロールをアルコール溶媒及び塩素系有機溶媒下にPd/C触媒と反応させてエルゴステノールを収得する段階;及び
前記収得したエルゴステノールをOH基が保護された糖と塩素系有機溶媒下に混合した後、酸触媒存在下に撹拌する段階を含む、下記の化学式1を有する化合物の製造方法。
- 前記酸触媒はTMSOTf、BF3OEt2、Cu(OTf)2、Sc(OTf)3、SiO2−H2SO4、及びセルロース−HClO4からなる群より選択されたものである、請求項9に記載の製造方法。
- 下記の化学式1で表示される化合物またはその薬学的に許容可能な塩を含む組成物をこれを必要とする個体に投与する段階を含む、皮膚炎の予防または治療方法。
- 皮膚炎の予防または治療のための薬学組成物の製造のための、下記の化学式1で表示される化合物またはその薬学的に許容可能な塩の用途。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2017-0010639 | 2017-01-23 | ||
KR1020170010639A KR101900594B1 (ko) | 2017-01-23 | 2017-01-23 | 신규한 에르고스텐올 글리코시드 유도체 |
PCT/KR2017/003183 WO2018135699A1 (ko) | 2017-01-23 | 2017-03-24 | 신규한 에르고스텐올 글리코시드 유도체 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2020506177A true JP2020506177A (ja) | 2020-02-27 |
JP6851489B2 JP6851489B2 (ja) | 2021-03-31 |
Family
ID=62909158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019539762A Active JP6851489B2 (ja) | 2017-01-23 | 2017-03-24 | 新規エルゴステノールグリコシド誘導体 |
Country Status (6)
Country | Link |
---|---|
US (1) | US11059852B2 (ja) |
EP (1) | EP3572418A4 (ja) |
JP (1) | JP6851489B2 (ja) |
KR (1) | KR101900594B1 (ja) |
CN (1) | CN110198950B (ja) |
WO (1) | WO2018135699A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220164216A (ko) * | 2021-06-04 | 2022-12-13 | 에스티팜 주식회사 | 신규한 에르고스텐올 유도체 및 이의 용도 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009110612A1 (ja) * | 2008-03-06 | 2009-09-11 | 株式会社ファンケル | 発芽玄米由来の新規化合物及びそれを有効成分とする神経障害の予防又は改善剤 |
CN102940606A (zh) * | 2012-10-12 | 2013-02-27 | 江苏大学 | 一种金针菇甾醇提取物脂质体制剂及其制备方法 |
KR101740116B1 (ko) | 2014-04-07 | 2017-05-25 | 경희대학교 산학협력단 | 신규 5,6-다이하이드로에르고스테롤 글리코시드 유도체를 포함하는 조성물 |
-
2017
- 2017-01-23 KR KR1020170010639A patent/KR101900594B1/ko active IP Right Grant
- 2017-03-24 CN CN201780084248.2A patent/CN110198950B/zh active Active
- 2017-03-24 EP EP17892999.8A patent/EP3572418A4/en not_active Withdrawn
- 2017-03-24 WO PCT/KR2017/003183 patent/WO2018135699A1/ko active Application Filing
- 2017-03-24 JP JP2019539762A patent/JP6851489B2/ja active Active
-
2019
- 2019-07-22 US US16/518,478 patent/US11059852B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20180086777A (ko) | 2018-08-01 |
WO2018135699A1 (ko) | 2018-07-26 |
CN110198950B (zh) | 2022-06-14 |
EP3572418A1 (en) | 2019-11-27 |
US11059852B2 (en) | 2021-07-13 |
EP3572418A4 (en) | 2020-09-09 |
CN110198950A (zh) | 2019-09-03 |
JP6851489B2 (ja) | 2021-03-31 |
US20190337976A1 (en) | 2019-11-07 |
KR101900594B1 (ko) | 2018-09-19 |
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