JP2020182486A5 - - Google Patents

Info

Publication number

JP2020182486A5

JP2020182486A5 JP2020123157A JP2020123157A JP2020182486A5 JP 2020182486 A5 JP2020182486 A5 JP 2020182486A5 JP 2020123157 A JP2020123157 A JP 2020123157A JP 2020123157 A JP2020123157 A JP 2020123157A JP 2020182486 A5 JP2020182486 A5 JP 2020182486A5

Authority

JP

Japan

Prior art keywords

antigen

conjugation

subject

cell

molecule

Prior art date

2020-07-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000427 antigen Substances 0.000 claims 50
• 102000036639 antigens Human genes 0.000 claims 50
• 108091007433 antigens Proteins 0.000 claims 50
• 210000004027 cell Anatomy 0.000 claims 32
• 239000003504 photosensitizing agent Substances 0.000 claims 27
• 230000021615 conjugation Effects 0.000 claims 25
• 108090000695 Cytokines Proteins 0.000 claims 24
• 102000004127 Cytokines Human genes 0.000 claims 24
• 238000000034 method Methods 0.000 claims 19
• 230000028993 immune response Effects 0.000 claims 18
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
• 210000000612 antigen-presenting cell Anatomy 0.000 claims 9
• 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 7
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 7
• 239000000203 mixture Substances 0.000 claims 7
• 206010028980 Neoplasm Diseases 0.000 claims 6
• 201000011510 cancer Diseases 0.000 claims 6
• PBHVCRIXMXQXPD-UHFFFAOYSA-N chembl2369102 Chemical compound C1=CC(S(=O)(=O)O)=CC=C1C(C1=CC=C(N1)C(C=1C=CC(=CC=1)S(O)(=O)=O)=C1C=CC(=N1)C(C=1C=CC(=CC=1)S(O)(=O)=O)=C1C=CC(N1)=C1C=2C=CC(=CC=2)S(O)(=O)=O)=C2N=C1C=C2 PBHVCRIXMXQXPD-UHFFFAOYSA-N 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 229960005486 vaccine Drugs 0.000 claims 6
• 229940124856 vaccine component Drugs 0.000 claims 6
• 101100537798 Arabidopsis thaliana TPS11 gene Proteins 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 5
• 208000035475 disorder Diseases 0.000 claims 5
• 208000015181 infectious disease Diseases 0.000 claims 5
• 238000002255 vaccination Methods 0.000 claims 5
• 229940079593 drug Drugs 0.000 claims 4
• 239000003085 diluting agent Substances 0.000 claims 3
• 239000000546 pharmaceutical excipient Substances 0.000 claims 3
• 239000000825 pharmaceutical preparation Substances 0.000 claims 3
• 229940127557 pharmaceutical product Drugs 0.000 claims 3
• 230000004936 stimulating effect Effects 0.000 claims 3
• 239000000969 carrier Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 229920001661 Chitosan Polymers 0.000 claims 1
• 230000030741 antigen processing and presentation Effects 0.000 claims 1
• 230000000890 antigenic effect Effects 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 210000000172 cytosol Anatomy 0.000 claims 1
• 210000004443 dendritic cell Anatomy 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 230000001678 irradiating effect Effects 0.000 claims 1
• 210000004698 lymphocyte Anatomy 0.000 claims 1
• 210000002540 macrophage Anatomy 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000000638 stimulation Effects 0.000 claims 1
• AVWQQPYHYQKEIZ-UHFFFAOYSA-K trisodium;2-dodecylbenzenesulfonate;3-dodecylbenzenesulfonate;4-dodecylbenzenesulfonate Chemical compound [Na+].[Na+].[Na+].CCCCCCCCCCCCC1=CC=C(S([O-])(=O)=O)C=C1.CCCCCCCCCCCCC1=CC=CC(S([O-])(=O)=O)=C1.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O AVWQQPYHYQKEIZ-UHFFFAOYSA-K 0.000 claims 1
• 0 CCC(CO[C@@](C)[C@](C1O)NC(C*(C)(C)C)=O)[C@@]1(*)O[C@@](C)(C(C1O)N(C)C(CN2CCN(CC(Nc(cc3)ccc3C(C(C=C3)=NC3=C(C3=CC[C@](C(c4ccccc4)=C4N=C5C=C4)N3)c3ccccc3)=C(C=C3)NC3=C5c3ccccc3)=O)CC2)=O)OC(CO)[C@]1ON Chemical compound CCC(CO[C@@](C)[C@](C1O)NC(C*(C)(C)C)=O)[C@@]1(*)O[C@@](C)(C(C1O)N(C)C(CN2CCN(CC(Nc(cc3)ccc3C(C(C=C3)=NC3=C(C3=CC[C@](C(c4ccccc4)=C4N=C5C=C4)N3)c3ccccc3)=C(C=C3)NC3=C5c3ccccc3)=O)CC2)=O)OC(CO)[C@]1ON 0.000 description 5