JP2020168015A5 - - Google Patents
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- JP2020168015A5 JP2020168015A5 JP2020114302A JP2020114302A JP2020168015A5 JP 2020168015 A5 JP2020168015 A5 JP 2020168015A5 JP 2020114302 A JP2020114302 A JP 2020114302A JP 2020114302 A JP2020114302 A JP 2020114302A JP 2020168015 A5 JP2020168015 A5 JP 2020168015A5
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- JP
- Japan
- Prior art keywords
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- stem cells
- medicament
- epithelial
- chir99021
- Prior art date
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- 239000003814 drug Substances 0.000 claims 12
- 210000000130 stem cell Anatomy 0.000 claims 7
- AQGNHMOJWBZFQQ-UHFFFAOYSA-N CT 99021 Chemical compound CC1=CNC(C=2C(=NC(NCCNC=3N=CC(=CC=3)C#N)=NC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 AQGNHMOJWBZFQQ-UHFFFAOYSA-N 0.000 claims 4
- 101001063456 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 5 Proteins 0.000 claims 4
- 102100031036 Leucine-rich repeat-containing G-protein coupled receptor 5 Human genes 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 210000003027 ear inner Anatomy 0.000 claims 4
- 210000000981 epithelium Anatomy 0.000 claims 4
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical class [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 claims 2
- -1 sodium valproic acid salt Chemical class 0.000 claims 2
- 210000002768 hair cell Anatomy 0.000 claims 1
- 210000002985 organ of corti Anatomy 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361783245P | 2013-03-14 | 2013-03-14 | |
| US61/783,245 | 2013-03-14 | ||
| JP2018158354A JP6764909B2 (ja) | 2013-03-14 | 2018-08-27 | 上皮幹細胞の増殖および培養のための組成物および方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018158354A Division JP6764909B2 (ja) | 2013-03-14 | 2018-08-27 | 上皮幹細胞の増殖および培養のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020168015A JP2020168015A (ja) | 2020-10-15 |
| JP2020168015A5 true JP2020168015A5 (enExample) | 2021-02-12 |
| JP6919032B2 JP6919032B2 (ja) | 2021-08-11 |
Family
ID=51625153
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501170A Expired - Fee Related JP6469643B2 (ja) | 2013-03-14 | 2014-03-11 | 上皮幹細胞の増殖および培養のための組成物および方法 |
| JP2018158354A Expired - Fee Related JP6764909B2 (ja) | 2013-03-14 | 2018-08-27 | 上皮幹細胞の増殖および培養のための組成物および方法 |
| JP2020114302A Expired - Fee Related JP6919032B2 (ja) | 2013-03-14 | 2020-07-01 | 上皮幹細胞の増殖および培養のための組成物および方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501170A Expired - Fee Related JP6469643B2 (ja) | 2013-03-14 | 2014-03-11 | 上皮幹細胞の増殖および培養のための組成物および方法 |
| JP2018158354A Expired - Fee Related JP6764909B2 (ja) | 2013-03-14 | 2018-08-27 | 上皮幹細胞の増殖および培養のための組成物および方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US10041046B2 (enExample) |
| EP (3) | EP4056677A1 (enExample) |
| JP (3) | JP6469643B2 (enExample) |
| KR (1) | KR102168088B1 (enExample) |
| CN (2) | CN108865972B (enExample) |
| AU (1) | AU2014240603B2 (enExample) |
| BR (1) | BR112015023261A2 (enExample) |
| CA (2) | CA3184040A1 (enExample) |
| CY (1) | CY1122934T1 (enExample) |
| DK (2) | DK2970890T3 (enExample) |
| ES (2) | ES2908026T3 (enExample) |
| HR (1) | HRP20200692T1 (enExample) |
| HU (2) | HUE057521T2 (enExample) |
| IL (1) | IL241572B (enExample) |
| LT (1) | LT2970890T (enExample) |
| NZ (1) | NZ713219A (enExample) |
| PL (2) | PL3702443T3 (enExample) |
| PT (2) | PT2970890T (enExample) |
| RS (1) | RS60371B1 (enExample) |
| SI (1) | SI2970890T1 (enExample) |
| SM (1) | SMT202000223T1 (enExample) |
| WO (1) | WO2014159356A1 (enExample) |
| ZA (1) | ZA201904258B (enExample) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010509919A (ja) | 2006-11-15 | 2010-04-02 | マサチューセッツ・アイ・アンド・イア・インファーマリー | 内耳細胞の生成 |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| EP3061808B1 (en) | 2009-02-03 | 2020-08-12 | Koninklijke Nederlandse Akademie van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells |
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP3970725B1 (en) | 2012-09-07 | 2025-08-20 | Massachusetts Eye & Ear Infirmary | A gamma secretase inhibitor for treating hearing loss |
| CN104822827B (zh) | 2012-12-06 | 2020-01-21 | 干细胞生物科技公司 | Lgr5+体干细胞 |
| CA3184040A1 (en) | 2013-03-14 | 2014-10-02 | The Brigham And Women's Hospital, Inc. | Compositions and methods for epithelial stem cell expansion comprising a wnt agonist and a histone deacetylase inhibitor |
| US10597633B2 (en) | 2014-05-16 | 2020-03-24 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture method for organoids |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| WO2016022776A2 (en) | 2014-08-06 | 2016-02-11 | Massachusetts Eye And Ear Infirmary | Increasing atoh1 life to drive sensorineural hair cell differentiantion |
| WO2016037016A1 (en) * | 2014-09-03 | 2016-03-10 | The Brigham And Women's Hospital, Inc. | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法 |
| GB201421094D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| US10926001B2 (en) * | 2014-12-02 | 2021-02-23 | Polarityte, Inc. | Methods related to minimally polarized functional units |
| WO2017019850A1 (en) * | 2015-07-28 | 2017-02-02 | StemBios Technologies, Inc. | Composition and method for inhibiting histone deacetylase |
| KR101756337B1 (ko) | 2015-08-12 | 2017-07-10 | 고려대학교 산학협력단 | Cxcr2 억제를 통한 인간 전분화능 줄기세포의 내배엽 및 중배엽 분화 방법 |
| WO2017096233A1 (en) | 2015-12-04 | 2017-06-08 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| AU2017205194A1 (en) * | 2016-01-08 | 2018-07-19 | Massachusetts Institute Of Technology | Production of differentiated enteroendocrine cells and insulin producing cells |
| WO2017123806A1 (en) | 2016-01-12 | 2017-07-20 | Cedars-Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| AU2017212655B2 (en) | 2016-01-29 | 2024-01-18 | Decibel Therapeutics, Inc. | Expansion and differentiation of inner ear supporting cells and methods of use thereof |
| WO2017136462A2 (en) | 2016-02-01 | 2017-08-10 | EMULATE, Inc. | Systems and methods for growth of intestinal cells in microfluidic devices |
| GB201603569D0 (en) | 2016-03-01 | 2016-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved differentiation method |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| CN109689052A (zh) * | 2016-03-02 | 2019-04-26 | 频率治疗公司 | 使用GSK-3-α抑制剂的受控增殖干细胞/产生内耳毛细胞的方法 |
| US9968615B2 (en) | 2016-03-02 | 2018-05-15 | Frequency Therapeutics, Inc. | Methods for controlled proliferation of stem cells / generating inner ear hair cells using 3-(pyridin-2-yl)-1H-indol-2-ol based compounds |
| US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
| US9913848B2 (en) | 2016-03-02 | 2018-03-13 | Frequency Therapeutics, Inc. | Methods for controlled proliferation of stem cells / generating inner ear hair cells using 1,2,3,4-tetrahydro-[1,4]diazepino[6,7, 1-hi]indolyl based compounds |
| US9913835B2 (en) | 2016-03-02 | 2018-03-13 | Frequency Therapeutics, Inc. | Methods for controlled proliferation of stem cells / generating inner ear hair cells using N-(alkylcarbamoyl)-1H-pyrazol-4-yl)-nicotinamide based compounds |
| US20190060371A1 (en) * | 2016-03-02 | 2019-02-28 | Frequency Therapeutics, Inc. | Methods for controlled proliferation of vestibular stem cells / generating inner ear hair cells using wnt and tgfbeta-inhibition |
| US10016507B2 (en) | 2016-03-02 | 2018-07-10 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: III |
| EP3447126A4 (en) * | 2016-04-20 | 2019-11-13 | Kyoto Prefectural Public University Corporation | METHOD FOR PRODUCING A LAYER OF CULTURED EPITHELIAL CELLS |
| EP4177335A1 (en) * | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| EP3690022A1 (en) * | 2016-05-18 | 2020-08-05 | Keio University | Cell culture medium for culturing organoid, culture method, and organoid |
| CA3066107A1 (en) | 2016-06-03 | 2017-12-07 | Hough Ear Institute | Combination therapies for inner ear sensory hair cell regeneration/replacement |
| GB201610748D0 (en) * | 2016-06-20 | 2016-08-03 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved diffrentation method |
| EP3534976A4 (en) | 2016-11-04 | 2020-09-16 | Children's Hospital Medical Center | PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE |
| WO2018088856A2 (ko) * | 2016-11-10 | 2018-05-17 | 재단법인 아산사회복지재단 | 마이크로유체칩, 삼차원 채널 구조물, 이를 이용한 세포 배양 방법 및 이를 이용한 생리활성 물질의 활성평가 방법 |
| EP3323882A1 (en) * | 2016-11-18 | 2018-05-23 | Ecole Polytechnique Fédérale de Lausanne | Organoid tissue engineering |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| CN110392686A (zh) | 2016-12-30 | 2019-10-29 | 频率治疗公司 | 1h-吡咯-2,5-二酮化合物以及使用它们来诱导干/祖支持细胞自我更新的方法 |
| US10383881B2 (en) | 2016-12-30 | 2019-08-20 | Frequency Therapeutics, Inc. | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same |
| US11913022B2 (en) | 2017-01-25 | 2024-02-27 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| WO2018151307A1 (ja) * | 2017-02-20 | 2018-08-23 | 公立大学法人名古屋市立大学 | 人工多能性幹細胞由来腸管幹細胞の維持培養 |
| US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
| US11414648B2 (en) | 2017-03-24 | 2022-08-16 | Cedars-Sinai Medical Center | Methods and compositions for production of fallopian tube epithelium |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
| EP3622068B1 (en) | 2017-05-10 | 2024-02-28 | The Broad Institute, Inc. | Methods for determination of mutations in single replication events |
| KR101966523B1 (ko) * | 2017-05-29 | 2019-04-05 | 차의과학대학교 산학협력단 | 오가노이드 배양을 위한 조성물 및 방법 |
| EP3630949A4 (en) * | 2017-05-29 | 2021-03-10 | Stemcell Technologies Canada Inc. | COMPOSITIONS AND PROCESSES FOR OBTAINING ORGANOIDS |
| CN107189981B (zh) * | 2017-06-07 | 2020-01-21 | 广东医科大学 | Hdac6抑制剂在骨髓间充质干细胞移植中的应用 |
| WO2019018440A1 (en) * | 2017-07-17 | 2019-01-24 | The Broad Institute, Inc. | HUMAN COLON CELL ATLAS IN GOOD HEALTH AND WITH HEMORRHAGIC RECTO-COLITIS |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| EP3732285A1 (en) * | 2017-12-28 | 2020-11-04 | Tract Pharmaceuticals, Inc. | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
| US11994512B2 (en) | 2018-01-04 | 2024-05-28 | Massachusetts Institute Of Technology | Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity |
| CN108085296B (zh) * | 2018-01-29 | 2021-04-13 | 清华大学 | 肠上皮类器官无生长因子培养方法 |
| US12161676B2 (en) | 2018-03-23 | 2024-12-10 | Cedars-Sinai Medical Center | Methods of use of islet cells |
| EP3775161A4 (en) | 2018-04-06 | 2022-04-06 | Cedars-Sinai Medical Center | NEURODEGENERATIVE DISEASE MODELS DERIVED FROM HUMAN PLURIPOTENTIC STEM CELLS ON A MICROFLUIDIC CHIP |
| US11981918B2 (en) | 2018-04-06 | 2024-05-14 | Cedars-Sinai Medical Center | Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
| CN110205283B (zh) * | 2018-04-18 | 2021-04-23 | 浙江大学 | 一种诱导人羊膜上皮细胞向视网膜色素上皮细胞分化的方法及其应用 |
| KR102099402B1 (ko) * | 2018-06-28 | 2020-04-09 | 오가노이드사이언스 주식회사 | 타액선 줄기세포의 기능 강화용 배양 조성물 및 이를 이용한 타액선 줄기세포 기능 강화 방법 |
| KR102887406B1 (ko) | 2018-07-26 | 2025-11-19 | 칠드런즈 호스피탈 메디칼 센터 | 간-담도-췌장 조직 및 이를 제조하는 방법 |
| WO2020037326A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
| US11162071B2 (en) | 2018-08-17 | 2021-11-02 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by upregulating JAG-1 |
| WO2020056158A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| WO2020097555A1 (en) * | 2018-11-09 | 2020-05-14 | Children's Hospital Medical Center | In vitro cell culture system for producing hepatocyte-like cells and uses thereof |
| US20220008433A1 (en) * | 2018-11-30 | 2022-01-13 | Massachusetts Eye And Ear Infirmary | Inhibition of Lysine Demethylase 1 (Lsd1) Induces Differentiation of Hair Cells |
| CN109576225A (zh) * | 2018-12-23 | 2019-04-05 | 山西医科大学 | 利用Rspo1抑制骨髓间充质干细胞凋亡的方法 |
| CN109679893A (zh) * | 2019-01-17 | 2019-04-26 | 浙江工商大学 | 基于小鼠肠道干细胞的肠上皮单层培养及表征方法 |
| WO2020159609A1 (en) * | 2019-01-30 | 2020-08-06 | MEAD, Benjamin Elliott | Small molecule enhancers of paneth cell function and differentiation |
| KR102050223B1 (ko) * | 2019-04-04 | 2019-11-29 | 포항공과대학교 산학협력단 | 배아줄기세포로부터 소장 오가노이드의 제조방법 |
| KR102334245B1 (ko) * | 2019-05-29 | 2021-12-03 | 연세대학교 산학협력단 | 인간 미뢰 오가노이드의 배양용 조성물 |
| WO2020247836A1 (en) * | 2019-06-07 | 2020-12-10 | Massachusetts Institute Of Technology | Methods and compositions for differentiating stem cells |
| EP3789049A1 (en) * | 2019-09-06 | 2021-03-10 | QGel SA | Method for obtaining healthy intestinal organoids |
| US12451250B2 (en) | 2019-10-22 | 2025-10-21 | Tempus Ai, Inc. | Systems and methods for predicting therapeutic sensitivity |
| US11629385B2 (en) | 2019-11-22 | 2023-04-18 | Tempus Labs, Inc. | Tumor organoid culture compositions, systems, and methods |
| JP7744340B2 (ja) | 2019-12-05 | 2025-09-25 | テンパス・エーアイ・インコーポレイテッド | ハイスループット薬物スクリーニングのためのシステムおよび方法 |
| CR20220325A (es) | 2019-12-20 | 2022-08-19 | Tenaya Therapeutics Inc | Fluoroalquil-oxadiazoles y sus usos |
| KR102315866B1 (ko) * | 2020-03-24 | 2021-10-21 | 한국원자력의학원 | 섬유화 질환 복합 치료제 개발 |
| CN111471643B (zh) * | 2020-04-09 | 2020-12-29 | 创芯国际生物科技(广州)有限公司 | 一种通用型上呼吸道粘膜类器官的培养基及培养方法 |
| US11561178B2 (en) | 2020-04-20 | 2023-01-24 | Tempus Labs, Inc. | Artificial fluorescent image systems and methods |
| CN111411083B (zh) * | 2020-04-22 | 2020-11-03 | 创芯国际生物科技(广州)有限公司 | 一种胃癌类器官的培养基及培养方法 |
| CN111849860B (zh) * | 2020-06-01 | 2021-12-21 | 浙江大学 | 一种利用铁元素调控肠道干细胞分化的方法及应用 |
| CN112592896B (zh) * | 2020-11-22 | 2024-06-25 | 深圳市第二人民医院(深圳市转化医学研究院) | 一种肺腺癌类器官的培养液及其培养方法 |
| JP7602932B2 (ja) * | 2021-02-26 | 2024-12-19 | 株式会社マンダム | 汗腺筋上皮細胞の幹細胞性維持剤、汗腺筋上皮細胞の幹細胞性を維持する方法および皮膚外用剤 |
| IL307883A (en) | 2021-04-23 | 2023-12-01 | Tenaya Therapeutics Inc | HDAC6 inhibitors for use in the treatment of dilated myocardial disease |
| CA3216768A1 (en) | 2021-05-04 | 2022-11-10 | Jin Yang | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
| WO2022261293A1 (en) * | 2021-06-09 | 2022-12-15 | The Regents Of The University Of California | Lung organoid model and method of use |
| KR20230073997A (ko) | 2021-11-19 | 2023-05-26 | 연세대학교 산학협력단 | 인간 타액선 상피성 줄기세포 또는 전구세포 유래 단일클론세포 분리, 유지, 증식 및 분화 방법 및 타액선 질환 치료용 세포외소포체 생산 방법 |
| US20250034523A1 (en) * | 2021-12-09 | 2025-01-30 | The Trustees Of Indiana University | Methods of generating human cochlear hair cells |
| CN114480274A (zh) * | 2021-12-30 | 2022-05-13 | 中国人民解放军海军军医大学第一附属医院 | 肠道类器官定向分化潘氏细胞的方法 |
| CN115637251A (zh) * | 2022-11-04 | 2023-01-24 | 中国人民解放军海军军医大学第一附属医院 | 一种诱导肠道类器官定向分化为肠吸收细胞的方法及其应用 |
| KR102693565B1 (ko) * | 2022-11-30 | 2024-08-08 | 오가노이드사이언스 주식회사 | 암 오가노이드 제조용 배지 조성물 |
| CN116478912A (zh) | 2023-06-07 | 2023-07-25 | 合肥工业大学 | 一种诱导小鼠肠道类器官定向分化为肠内分泌细胞的培养基及其应用 |
| WO2025152110A1 (zh) * | 2024-01-18 | 2025-07-24 | 五邑大学 | 用于阿尔兹海默症治疗的联合用药及其药物组合物 |
| WO2025215092A1 (en) | 2024-04-10 | 2025-10-16 | Institut National de la Santé et de la Recherche Médicale | Selective hdac6 inhibitors for use in the treatment of myotonic dystrophy type 1 |
Family Cites Families (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5059591B1 (en) | 1983-05-26 | 2000-04-25 | Liposome Co Inc | Drug preparations of reduced toxicity |
| US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
| US5731424A (en) | 1990-06-11 | 1998-03-24 | Nexstar Pharmaceuticals, Inc. | High affinity TGFβ nucleic acid ligands and inhibitors |
| US5731144A (en) | 1990-06-11 | 1998-03-24 | Nexstar Pharmaceuticals, Inc. | High affinity TGFβ nucleic acid ligands |
| US6124449A (en) | 1990-06-11 | 2000-09-26 | Nexstar Pharmaceuticals, Inc. | High affinity TGFβ nucleic acid ligands and inhibitors |
| US5561163A (en) | 1990-08-31 | 1996-10-01 | Deprenyl Animal Health, Inc. | Treating hearing loss with deprenyl |
| US5421818A (en) | 1993-10-18 | 1995-06-06 | Inner Ear Medical Delivery Systems, Inc. | Multi-functional inner ear treatment and diagnostic system |
| GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
| US5837681A (en) | 1996-02-23 | 1998-11-17 | Amgen Inc. | Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product |
| US6593290B1 (en) | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
| US6045528A (en) | 1997-06-13 | 2000-04-04 | Intraear, Inc. | Inner ear fluid transfer and diagnostic system |
| US6806358B1 (en) | 1997-12-16 | 2004-10-19 | University Of California San Diego | Peptide inhibitor of TGF-β growth factors |
| US6177434B1 (en) | 1997-12-16 | 2001-01-23 | The United States Of America As Represented By The Secretary Of The Navy | Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms |
| CA2321307A1 (en) | 1998-02-27 | 1999-09-02 | Venkatachala L. Narayanan | Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs |
| GB9809869D0 (en) | 1998-05-09 | 1998-07-08 | Medical Res Council | Inhibition of protein kinases |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| ES2146552B1 (es) | 1998-11-24 | 2001-04-16 | Inst Cientifico Tecnol Navarra | Peptidos inhibidores de tgf/31 |
| WO2000059939A1 (en) | 1999-04-05 | 2000-10-12 | Adherex Technologies Inc. | COMPOUNDS AND METHODS FOR STIMULATING β-CATENIN MEDIATED GENE EXPRESSION AND DIFFERENTIATION |
| US6492497B1 (en) | 1999-04-30 | 2002-12-10 | Cambridge Antibody Technology Limited | Specific binding members for TGFbeta1 |
| AU783615B2 (en) | 2000-05-11 | 2005-11-17 | Consejo Superior De Investigaciones Cientificas | Heterocyclic inhibitors of glycogen synthase kinase GSK-3 |
| US6509318B1 (en) | 2000-09-29 | 2003-01-21 | The Regents Of The University Of California | TGF-B inhibitors and methods |
| US20050287128A1 (en) | 2001-05-18 | 2005-12-29 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA) |
| US20050227936A1 (en) | 2001-05-18 | 2005-10-13 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA) |
| ES2289116T3 (es) | 2001-05-24 | 2008-02-01 | Eli Lilly And Company | Nuevos derivados de pirrol como agentes farmaceuticos. |
| US20030028905A1 (en) | 2001-07-31 | 2003-02-06 | Petra Knaus | Mutant forms of the TGF-beta type II receptor which bind all TGF-beta isoforms |
| CA2463822A1 (en) | 2001-11-01 | 2003-05-08 | Janssen Pharmaceutica N.V. | Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors) |
| SE0200979D0 (sv) | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
| US20040006030A1 (en) | 2002-07-02 | 2004-01-08 | Isis Pharmaceuticals Inc. | Antisense modulation of TGF-beta 2 expression |
| JP2005530800A (ja) | 2002-05-15 | 2005-10-13 | スミスクライン・ビーチャム・コーポレイション | ベンゾオキサジンおよびベンゾオキサジノン置換トリアゾール |
| US20040038856A1 (en) | 2002-05-17 | 2004-02-26 | Sarvajit Chakravarty | Treatment of fibroproliferative disorders using TGF-beta inhibitors |
| US7190468B2 (en) | 2002-07-17 | 2007-03-13 | Hewlett-Packard Development Company, L.P. | Background document rendering system and method |
| TW200417547A (en) | 2002-07-31 | 2004-09-16 | Smithkline Beecham Corp | Compounds |
| PL374967A1 (en) | 2002-08-02 | 2005-11-14 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of gsk-3 |
| SI1532145T1 (sl) | 2002-08-02 | 2007-02-28 | Vertex Pharma | Pirazolni sestavki, koristni kot inhibitorji GSK-3 |
| UA80296C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
| EP1543001B1 (en) | 2002-09-17 | 2007-08-15 | Eli Lilly And Company | Pyrazolopyridine derivatives as tgf beta signal transduction inhibitors for the treatment of cancer |
| KR20050057393A (ko) | 2002-09-18 | 2005-06-16 | 화이자 프로덕츠 인크. | 전환 성장 인자 (ｔｇｆ) 억제제로서 트리아졸 유도체 |
| EA200500286A1 (ru) | 2002-09-18 | 2005-08-25 | Пфайзер Продактс Инк. | Новые изотиазольные и изоксазольные соединения в качестве ингибиторов трансформирующего фактора роста (тфр) |
| AU2003291149A1 (en) | 2002-11-22 | 2004-06-18 | Scios, Inc. | USE OF TFG-Beta INHIBITORSTO COUNTERACT PATHOLOGIC CHANGES IN THE LEVEL OR FUNCTION OF STEROID/THYROID RECEPTORS |
| SE0203752D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| JP2006516603A (ja) | 2003-01-27 | 2006-07-06 | ファイザー・プロダクツ・インク | イソチアゾール誘導体 |
| WO2004081009A1 (en) | 2003-03-12 | 2004-09-23 | Millennium Pharmaceuticals, Inc. | Quinazoline derivatives as tgf-beta inhibitors |
| EP1608631A4 (en) | 2003-03-28 | 2008-08-20 | Scios Inc | BICYCLIC PYRIMIDININHIBITORS OF TGF BETA |
| US7314939B2 (en) | 2003-06-17 | 2008-01-01 | Millennium Pharmaceuticals, Inc. | Compositions and methods for inhibiting TGF-β |
| GB0316756D0 (en) | 2003-07-17 | 2003-08-20 | Bp Chem Int Ltd | Process |
| WO2005019422A2 (en) | 2003-08-13 | 2005-03-03 | The Board Of Trustees Of The University Of Illinois | Silencing of tgf-beta receptor type ii expression by sirna |
| US7387614B2 (en) | 2003-08-26 | 2008-06-17 | University Of Maryland, Baltimore | Drug delivery to the inner ear and methods of using same |
| JP4688680B2 (ja) | 2003-10-28 | 2011-05-25 | 独立行政法人理化学研究所 | ＴＧＦ−β情報伝達経路阻害剤 |
| US8673634B2 (en) | 2003-11-13 | 2014-03-18 | Massachusetts Eye & Ear Infirmary | Method for the treatment of hearing loss |
| GB0327908D0 (en) | 2003-12-02 | 2004-01-07 | Neuropharma Sa | GSK-3 inhibitors isolated from marine organisms |
| KR20070007055A (ko) | 2003-12-24 | 2007-01-12 | 사이오스 인코퍼레이티드 | Ｔｇｆ-베타 억제제를 이용한 악성 신경교종의 치료법 |
| EP1723146A1 (en) | 2004-03-01 | 2006-11-22 | Eli Lilly And Company | Fused pyrazole derivatives as tgf-beta signal transduction inhibitors for the treatment of fibrosis and neoplasms |
| AR048335A1 (es) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo |
| CA2568028A1 (en) | 2004-05-24 | 2005-12-08 | Auris Medical, Llc. | Combined otic aspirator and medication dispenser |
| GB0418328D0 (en) | 2004-08-17 | 2004-09-22 | Imp College Innovations Ltd | Cancer methods and medicaments |
| JP2007176795A (ja) | 2004-08-18 | 2007-07-12 | Univ Nihon | ＴＧＦ−β遺伝子発現抑制剤 |
| US8771754B2 (en) | 2004-09-17 | 2014-07-08 | Vanderbilt University | Use of GSK3 inhibitors in combination with radiation therapies |
| PT3520815T (pt) | 2005-02-08 | 2022-02-02 | Genzyme Corp | Anticorpos contra tgfbeta |
| GB0505970D0 (en) | 2005-03-23 | 2005-04-27 | Univ Edinburgh | Culture medium containing kinase inhibitor, and uses thereof |
| ES2369282T3 (es) | 2005-03-25 | 2011-11-29 | Tibotec Pharmaceuticals | Inhibidores heterobicíclicos de vhc. |
| WO2006105152A2 (en) | 2005-03-31 | 2006-10-05 | Stemnion, Inc. | Amnion-derived cell compositions, methods of making and uses thereof |
| NZ564179A (en) | 2005-06-30 | 2010-09-30 | Janssen Pharmaceutica Nv | Cyclic anilino - pyridinotriazines as GSK-3 inhibitors |
| SI1910370T1 (sl) | 2005-07-22 | 2015-06-30 | Eli Lilly And Company | Piridin kinolin substituirani pirolo(1,2-b)pirazol monohidrat kot tgf-beta inhibitor |
| EP1749523A1 (en) | 2005-07-29 | 2007-02-07 | Neuropharma, S.A. | GSK-3 inhibitors |
| CN101340927A (zh) | 2005-10-24 | 2009-01-07 | 西玛生物医学信息公司 | TGF-β1抑制性多肽在制备免疫反应调节剂上的用途 |
| US7951845B2 (en) | 2006-01-19 | 2011-05-31 | The Regents Of The University Of Michigan | Composition and method of treating hearing loss |
| ITMI20060181A1 (it) | 2006-02-03 | 2007-08-04 | Univ Padova | Modulatori del tgf-b e loro uso |
| TW200800203A (en) | 2006-03-08 | 2008-01-01 | Astrazeneca Ab | New use |
| US7846908B2 (en) | 2006-03-16 | 2010-12-07 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of TGF-beta and therapeutic uses thereof |
| KR20090052884A (ko) | 2006-08-23 | 2009-05-26 | 화이자 프로덕츠 인크. | Ｇｓｋ-3 억제제로서의 피리미돈 화합물 |
| JP2010509919A (ja) | 2006-11-15 | 2010-04-02 | マサチューセッツ・アイ・アンド・イア・インファーマリー | 内耳細胞の生成 |
| EP2125683B1 (en) | 2006-12-19 | 2013-10-23 | The Board of Trustees of the University of Illinois | 3-benzofuranyl-4-indolyl-maleimides as potent gsk-3 inhibitors for neurodegenerative disorders |
| WO2009017453A1 (en) | 2007-07-30 | 2009-02-05 | Astrazeneca Ab | New therapeutic combination of an antipsychotic and a gsk3 inhibitor 958 |
| WO2009017455A1 (en) | 2007-07-30 | 2009-02-05 | Astrazeneca Ab | A new combination of (a) an alpha-4-beta-2 -neuronal nicotinic agonist and (b) a gsk3 inhibitor |
| EP2197876A1 (en) | 2007-08-29 | 2010-06-23 | Glaxosmithkline LLC | Thiazole and oxazole kinase inhibitors |
| WO2009035522A1 (en) | 2007-09-14 | 2009-03-19 | Albert Einstein College Of Medicine Of Yeshiva University | Use of gamma secretase inhibitors and notch pathway inhibitors for treatment and prevention of renal disease |
| ES2690554T3 (es) | 2008-03-17 | 2018-11-21 | The Scripps Research Institute | Enfoques químicos y genéticos combinados para la generación de células madre pluripotentes inducidas |
| EP2278999B1 (en) | 2008-04-21 | 2025-01-29 | Dompé farmaceutici S.p.A. | Auris formulations for treating otic diseases and conditions |
| US20090270497A1 (en) | 2008-04-24 | 2009-10-29 | Pharmacyclics, Inc. | Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors |
| WO2009142719A2 (en) | 2008-05-19 | 2009-11-26 | Massachusetts Institute Of Technology | Tympanic membrane permeating ear drops and uses thereof |
| US8496957B2 (en) | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
| US8298825B1 (en) | 2008-08-25 | 2012-10-30 | The General Hospital Corporation | TGF-beta receptor inhibitors to enhance direct reprogramming |
| US20120059021A1 (en) | 2008-11-11 | 2012-03-08 | University Of Washington | Compositions and methods for treating cancer and methods for predicting a response to such treatments |
| CA2743436C (en) | 2008-11-24 | 2017-10-31 | Massachusetts Eye & Ear Infirmary | Pathways to generate hair cells |
| EP2376626A4 (en) * | 2008-12-13 | 2012-10-17 | Dna Microarray | MICRO-ENVIRONMENTAL NICHE ASSAY FOR SCREENING OF INDUCED PLURIPOTENT STEM CELLS (CIPS) |
| WO2010075551A1 (en) | 2008-12-24 | 2010-07-01 | Massachusetts Institute Of Technology | Compositions of modulators of the wnt/beta-catenin pathway and benzamide and/or hydroxamic acid derivatives to treat bipolar disorder |
| EP3061808B1 (en) * | 2009-02-03 | 2020-08-12 | Koninklijke Nederlandse Akademie van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells |
| GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| KR101748891B1 (ko) | 2009-03-11 | 2017-06-19 | 교린 세이야꾸 가부시키 가이샤 | Ｇｓｋ-3 억제제로서의 7-시클로알킬아미노퀴놀론 |
| WO2011019957A1 (en) * | 2009-08-12 | 2011-02-17 | University Of Southern California | Method for formation of induced pluripotent stem cells |
| AU2010312240B2 (en) * | 2009-10-31 | 2016-12-15 | Genesis Technologies Limited | Methods for reprogramming cells and uses thereof |
| US20110135756A1 (en) | 2009-12-08 | 2011-06-09 | University Of Washington | Compositions and methods for protecting sensory hair cells |
| CA2785233C (en) | 2009-12-28 | 2018-10-09 | Audiocure Pharma Gmbh | .beta.-carbolines for treatment of hearing damages and vertigo |
| WO2011089416A1 (en) | 2010-01-19 | 2011-07-28 | Astrazeneca Ab | Pyrazine derivatives |
| JP5897543B2 (ja) * | 2010-03-22 | 2016-03-30 | セルアーティス アーベー | Ｗｎｔシグナル経路の調節による多能性細胞から肝細胞様細胞への分化誘導と成熟 |
| CN103429739B (zh) | 2010-05-12 | 2018-11-13 | 哥伦比亚大学纽约管理委员会 | 制备产生和分泌胰岛素的肠内分泌细胞的方法 |
| KR20130101557A (ko) | 2010-11-02 | 2013-09-13 | 고꾸리쯔다이가꾸호오진 구마모또 다이가꾸 | 장세포의 제조 방법 |
| CA2823719A1 (en) | 2011-01-24 | 2012-08-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for generating inner ear cells in vitro |
| KR101807704B1 (ko) * | 2011-04-12 | 2017-12-13 | 차의과학대학교 산학협력단 | 역분화-증진제를 이용한 역분화 만능 줄기세포의 제조방법 |
| EP3473099A1 (en) | 2011-09-14 | 2019-04-24 | Samumed, LLC | Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors |
| US9347042B2 (en) | 2011-10-06 | 2016-05-24 | Keio University | Method for producing corneal endothelial cell |
| NZ630615A (en) | 2012-02-24 | 2015-09-25 | Asd Therapeutics Partners Llc | Thiadiazolidinediones as gsk-3 inhibitors |
| US9457009B2 (en) | 2012-05-31 | 2016-10-04 | The United States Of America As Represented By The Department Of Veterans Affairs | Methods and compositions for preventing and treating auditory dysfunctions |
| TW201406758A (zh) | 2012-06-28 | 2014-02-16 | Daiichi Sankyo Co Ltd | 三環性化合物 |
| GB201212960D0 (en) | 2012-07-20 | 2012-09-05 | Common Services Agency | Erythroid production |
| JP6486272B2 (ja) | 2012-09-07 | 2019-03-20 | マサチューセッツ・アイ・アンド・イア・インファーマリー | 有毛細胞および／または支持細胞再生のための方法および組成物 |
| WO2014050779A1 (ja) | 2012-09-25 | 2014-04-03 | 第一三共株式会社 | Ｇｓｋ３阻害剤と抗ｄｒ５抗体の組み合わせ |
| PL2909204T3 (pl) | 2012-10-12 | 2019-07-31 | The Broad Institute, Inc. | Inhibitory GSK3 i sposoby ich stosowania |
| EP2925859B1 (en) | 2012-11-29 | 2018-05-02 | Takara Bio Europe AB | Maturation of hepatocyte-like cells derived from human pluripotent stem cells |
| US20140248696A1 (en) * | 2013-03-01 | 2014-09-04 | Wisconsin Alumni Research Foundation | Methods of maintaining, expanding, and diffrentiating neuronal subtype specific progenitors |
| CA3184040A1 (en) | 2013-03-14 | 2014-10-02 | The Brigham And Women's Hospital, Inc. | Compositions and methods for epithelial stem cell expansion comprising a wnt agonist and a histone deacetylase inhibitor |
| WO2015168149A2 (en) | 2014-04-28 | 2015-11-05 | Massachusetts Eye & Ear Infirmary | Sensorineural hair cell differentiation |
| US10457915B2 (en) | 2014-05-15 | 2019-10-29 | International Stem Cell Corporation | Chemical differentiation of pluripotentstem cells into retinal epithelial cells |
| WO2016037016A1 (en) | 2014-09-03 | 2016-03-10 | The Brigham And Women's Hospital, Inc. | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
| AU2017205194A1 (en) | 2016-01-08 | 2018-07-19 | Massachusetts Institute Of Technology | Production of differentiated enteroendocrine cells and insulin producing cells |
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