CY1122934T1 - Συνθεσεις και μεθοδοι για τη διευρυνση και tην καλλιεργεια επιθηλιακων βλαστοκυτταρων - Google Patents
Συνθεσεις και μεθοδοι για τη διευρυνση και tην καλλιεργεια επιθηλιακων βλαστοκυτταρωνInfo
- Publication number
- CY1122934T1 CY1122934T1 CY20201100390T CY201100390T CY1122934T1 CY 1122934 T1 CY1122934 T1 CY 1122934T1 CY 20201100390 T CY20201100390 T CY 20201100390T CY 201100390 T CY201100390 T CY 201100390T CY 1122934 T1 CY1122934 T1 CY 1122934T1
- Authority
- CY
- Cyprus
- Prior art keywords
- stem cells
- epithelial
- epithelial stem
- culture
- compositions
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title 1
- 101150017554 LGR5 gene Proteins 0.000 abstract 2
- 210000004966 intestinal stem cell Anatomy 0.000 abstract 2
- 210000003463 organelle Anatomy 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 210000004347 intestinal mucosa Anatomy 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 239000002356 single layer Substances 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
- C12N5/068—Stem cells; Progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/065—Modulators of histone acetylation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/73—Hydrolases (EC 3.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
Περιγράφονται διαλύματα και συστήματα κυτταροκαλλιέργειας για τις καλλιέργειες επιθηλιακών βλαστοκυττάρων και οργανιδίων, η διαμόρφωση επιθηλιακών δομών καθώς και οι χρήσεις αυτών στη μεταμόσχευση. Ένα ενιαίο στρώμα επιθηλιακών βλαστοκυττάρων, το οποίο αυτοανανεώνεται δραστικώς και οργανώνεται σε κρύπτες και λάχνες, επενδύει το έντερο. Έχει πρόσφατα αποδειχθεί ότι η ανανέωση του εντερικού επιθηλίου οδηγείται από τα εντερικά βλαστοκύτταρα Lgr5+ (ISC), τα οποία βρίσκονται στη βάση αυτών των κρυπτών (Barker et al., 2007). Τα βλαστοκύτταρα Lgr5+ μπορούν να απομονωθούν και να καλλιεργηθούν in vitro, προκειμένου να διαμορφώσουν οργανίδια τα οποία περιέχουν δομές κρύπτης-λάχνης που ανακεφαλαιώνουν το φυσικό εντερικό επιθήλιο (Sato et al., 2009).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361783245P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/023197 WO2014159356A1 (en) | 2013-03-14 | 2014-03-11 | Compositions and methods for epithelial stem cell expansion and culture |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122934T1 true CY1122934T1 (el) | 2020-10-14 |
Family
ID=51625153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100390T CY1122934T1 (el) | 2013-03-14 | 2020-04-29 | Συνθεσεις και μεθοδοι για τη διευρυνση και tην καλλιεργεια επιθηλιακων βλαστοκυτταρων |
Country Status (23)
Country | Link |
---|---|
US (4) | US10041046B2 (el) |
EP (3) | EP3702443B1 (el) |
JP (3) | JP6469643B2 (el) |
KR (1) | KR102168088B1 (el) |
CN (2) | CN105358677B (el) |
AU (1) | AU2014240603B2 (el) |
BR (1) | BR112015023261A2 (el) |
CA (2) | CA3184040A1 (el) |
CY (1) | CY1122934T1 (el) |
DK (2) | DK3702443T3 (el) |
ES (2) | ES2786925T3 (el) |
HK (1) | HK1219754A1 (el) |
HR (1) | HRP20200692T1 (el) |
HU (2) | HUE057521T2 (el) |
IL (1) | IL241572B (el) |
LT (1) | LT2970890T (el) |
NZ (1) | NZ713219A (el) |
PL (2) | PL2970890T3 (el) |
PT (2) | PT3702443T (el) |
RS (1) | RS60371B1 (el) |
SI (1) | SI2970890T1 (el) |
WO (1) | WO2014159356A1 (el) |
ZA (1) | ZA201904258B (el) |
Families Citing this family (80)
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WO2008076556A2 (en) | 2006-11-15 | 2008-06-26 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
EP3441458B9 (en) | 2009-02-03 | 2023-08-23 | Koninklijke Nederlandse Akademie van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells |
US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
US20150209367A1 (en) | 2012-09-07 | 2015-07-30 | Massachusetts Eye & Ear Infirmary | Treating Hearing Loss |
JP6495174B2 (ja) | 2012-12-06 | 2019-04-03 | ステムバイオス テクノロジーズ,インコーポレイテッド | Lgr5+体性幹細胞 |
NZ713219A (en) | 2013-03-14 | 2017-04-28 | Massachusetts Inst Technology | Compositions and methods for epithelial stem cell expansion and culture |
US10597633B2 (en) | 2014-05-16 | 2020-03-24 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture method for organoids |
CA2949834A1 (en) | 2014-05-28 | 2015-12-03 | James Macormack Wells | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
WO2016022776A2 (en) | 2014-08-06 | 2016-02-11 | Massachusetts Eye And Ear Infirmary | Increasing atoh1 life to drive sensorineural hair cell differentiantion |
KR102493376B1 (ko) | 2014-09-03 | 2023-01-27 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 청력 손실의 치료를 위해 내이 털세포를 생성하기 위한 조성물, 시스템, 및 방법 |
JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のin vivoモデル、並びにそれを作製、及び使用する方法 |
GB201421094D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
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CN108779437A (zh) * | 2016-01-08 | 2018-11-09 | 麻省理工学院 | 分化的肠内分泌细胞和胰岛素产生细胞的制备 |
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- 2014-03-11 PT PT147747232T patent/PT2970890T/pt unknown
- 2014-03-11 CA CA2905842A patent/CA2905842C/en active Active
- 2014-03-11 LT LTEP14774723.2T patent/LT2970890T/lt unknown
- 2014-03-11 KR KR1020157029319A patent/KR102168088B1/ko active IP Right Grant
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2015
- 2015-09-10 IL IL241572A patent/IL241572B/en active IP Right Grant
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2016
- 2016-06-30 HK HK16107654.4A patent/HK1219754A1/zh unknown
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2017
- 2017-04-21 US US15/494,291 patent/US10041047B2/en active Active
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2018
- 2018-07-06 US US16/028,872 patent/US10954490B2/en active Active
- 2018-08-27 JP JP2018158354A patent/JP6764909B2/ja not_active Expired - Fee Related
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2019
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2020
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- 2020-07-01 JP JP2020114302A patent/JP6919032B2/ja active Active
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2021
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