JP2020122016A5 - - Google Patents
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- Publication number
- JP2020122016A5 JP2020122016A5 JP2020086709A JP2020086709A JP2020122016A5 JP 2020122016 A5 JP2020122016 A5 JP 2020122016A5 JP 2020086709 A JP2020086709 A JP 2020086709A JP 2020086709 A JP2020086709 A JP 2020086709A JP 2020122016 A5 JP2020122016 A5 JP 2020122016A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- alkyl
- cycloalkyl
- compound
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims description 46
- 150000001875 compounds Chemical class 0.000 claims description 45
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 27
- 229910052799 carbon Inorganic materials 0.000 claims description 26
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 22
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 22
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 22
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 21
- 229910052760 oxygen Inorganic materials 0.000 claims description 20
- 229910052717 sulfur Inorganic materials 0.000 claims description 20
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 229910052757 nitrogen Inorganic materials 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 12
- 239000012453 solvate Substances 0.000 claims description 12
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 11
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims description 11
- 150000003852 triazoles Chemical class 0.000 claims description 11
- 208000015181 infectious disease Diseases 0.000 claims description 8
- 230000000813 microbial effect Effects 0.000 claims description 8
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 claims description 6
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 6
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 claims description 3
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 3
- 230000002924 anti-infective effect Effects 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 229930192474 thiophene Natural products 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 description 18
- 125000003118 aryl group Chemical group 0.000 description 12
- 125000005843 halogen group Chemical group 0.000 description 10
- 125000000623 heterocyclic group Chemical group 0.000 description 10
- 0 CCCCCCCNc(c(C)c1)c(C=*)cc1N(CC(C*)O1)C1=O Chemical compound CCCCCCCNc(c(C)c1)c(C=*)cc1N(CC(C*)O1)C1=O 0.000 description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 8
- -1 C 1 to C 6 alkoxy Chemical group 0.000 description 6
- 238000000034 method Methods 0.000 description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021143166A JP2021183647A (ja) | 2015-07-17 | 2021-09-02 | 抗微生物治療のための置換フェニルオキサゾリジノン |
| JP2023127905A JP7585405B2 (ja) | 2015-07-17 | 2023-08-04 | 抗微生物治療のための置換フェニルオキサゾリジノン |
| JP2024140841A JP2024152930A (ja) | 2015-07-17 | 2024-08-22 | 抗微生物治療のための置換フェニルオキサゾリジノン |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562193963P | 2015-07-17 | 2015-07-17 | |
| US62/193,963 | 2015-07-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521488A Division JP6786598B2 (ja) | 2015-07-17 | 2016-07-15 | 抗微生物治療のための置換フェニルオキサゾリジノン |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021143166A Division JP2021183647A (ja) | 2015-07-17 | 2021-09-02 | 抗微生物治療のための置換フェニルオキサゾリジノン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020122016A JP2020122016A (ja) | 2020-08-13 |
| JP2020122016A5 true JP2020122016A5 (OSRAM) | 2021-10-14 |
| JP7232212B2 JP7232212B2 (ja) | 2023-03-02 |
Family
ID=57834866
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521488A Active JP6786598B2 (ja) | 2015-07-17 | 2016-07-15 | 抗微生物治療のための置換フェニルオキサゾリジノン |
| JP2020086709A Active JP7232212B2 (ja) | 2015-07-17 | 2020-05-18 | 抗微生物治療のための置換フェニルオキサゾリジノン |
| JP2021143166A Withdrawn JP2021183647A (ja) | 2015-07-17 | 2021-09-02 | 抗微生物治療のための置換フェニルオキサゾリジノン |
| JP2023127905A Active JP7585405B2 (ja) | 2015-07-17 | 2023-08-04 | 抗微生物治療のための置換フェニルオキサゾリジノン |
| JP2024140841A Pending JP2024152930A (ja) | 2015-07-17 | 2024-08-22 | 抗微生物治療のための置換フェニルオキサゾリジノン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521488A Active JP6786598B2 (ja) | 2015-07-17 | 2016-07-15 | 抗微生物治療のための置換フェニルオキサゾリジノン |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021143166A Withdrawn JP2021183647A (ja) | 2015-07-17 | 2021-09-02 | 抗微生物治療のための置換フェニルオキサゾリジノン |
| JP2023127905A Active JP7585405B2 (ja) | 2015-07-17 | 2023-08-04 | 抗微生物治療のための置換フェニルオキサゾリジノン |
| JP2024140841A Pending JP2024152930A (ja) | 2015-07-17 | 2024-08-22 | 抗微生物治療のための置換フェニルオキサゾリジノン |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10550092B2 (OSRAM) |
| EP (2) | EP3932917A3 (OSRAM) |
| JP (5) | JP6786598B2 (OSRAM) |
| KR (1) | KR102511898B1 (OSRAM) |
| CN (2) | CN113603683B (OSRAM) |
| AU (3) | AU2016295165B2 (OSRAM) |
| BR (1) | BR112018000991A2 (OSRAM) |
| CA (1) | CA2990260A1 (OSRAM) |
| EA (2) | EA037643B1 (OSRAM) |
| ES (1) | ES2897973T3 (OSRAM) |
| WO (1) | WO2017015106A1 (OSRAM) |
| ZA (1) | ZA201800189B (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018000991A2 (pt) * | 2015-07-17 | 2018-12-04 | The Global Alliance For Tb Drug Development, Inc. | feniloxazolidinonas substituídas para terapia antimicrobiana |
| WO2017066964A1 (en) * | 2015-10-22 | 2017-04-27 | Merck Sharp & Dohme Corp. | Oxazolidinone compounds and methods of use thereof as antibacterial agents |
| CN108727406B (zh) * | 2017-03-28 | 2021-12-07 | 北京协和制药二厂 | 含氮杂环取代的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途 |
| CN112543756A (zh) | 2018-07-25 | 2021-03-23 | 卡迪拉保健有限公司 | 用于治疗哺乳动物感染的经取代噁唑烷酮类 |
| US12365656B2 (en) | 2019-01-18 | 2025-07-22 | Merck Sharp & Dohme Llc | Oxazolidinone compounds and methods of use thereof as antibacterial agents |
| WO2020234636A1 (en) | 2019-05-17 | 2020-11-26 | Cadila Healthcare Limited | Novel compounds for the treatment of mammalian infections |
| CN110922411B (zh) * | 2019-11-27 | 2021-06-04 | 合肥远志医药科技开发有限公司 | 一种药物中间体的合成方法 |
| WO2021184339A1 (en) * | 2020-03-20 | 2021-09-23 | Merck Sharp & Dohme Corp. | Oxazolidinone compound and methods of use thereof as an antibacterial agent |
| CN113999152B (zh) * | 2021-07-14 | 2023-05-09 | 上海凌富药物研究有限公司 | 一种顺式-1-苄基-2,4-二烷氧基羰基氮杂环丁烷的合成方法 |
| EP4568961A1 (en) * | 2022-08-10 | 2025-06-18 | Merck Sharp & Dohme LLC | Processes for preparing oxazolidinone compounds |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| KR100392216B1 (ko) * | 1994-11-15 | 2003-10-17 | 파마시아 앤드 업존 캄파니 | 이환상옥사진및티아진옥사졸리디논항세균물질 |
| DK0828741T3 (da) * | 1995-05-11 | 2001-11-26 | Upjohn Co | Spirocykliske og bicykliske diazinyl- og carbazinyloxazolidinoner |
| US6255304B1 (en) * | 1997-05-30 | 2001-07-03 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| AU764980B2 (en) * | 1998-11-27 | 2003-09-04 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| JP2005520782A (ja) * | 2001-07-12 | 2005-07-14 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 向上した水溶解度を有するアミド含有化合物およびアミド含有化合物の水溶解度を向上させる方法 |
| WO2003072575A1 (en) | 2002-02-28 | 2003-09-04 | Astrazeneca Ab | 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents |
| WO2003093247A2 (en) * | 2002-04-30 | 2003-11-13 | Orchid Chemicals & Pharmaceuticals Ltd | Antibacterial agents |
| TW200403240A (en) * | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
| US6875784B2 (en) * | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| CN1237056C (zh) * | 2002-12-25 | 2006-01-18 | 中国科学院上海药物研究所 | 噁唑烷酮类化合物、其制备方法和用途 |
| JP2007503426A (ja) * | 2003-08-25 | 2007-02-22 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | 新規な抗微生物性アリールオキサゾリジノン化合物 |
| WO2006056875A1 (en) | 2004-11-29 | 2006-06-01 | Pharmacia & Upjohn Company Llc | Thiazepine oxazolidinones as antibacterial agents |
| CA2607660A1 (en) * | 2005-05-06 | 2006-11-16 | University Of South Florida | N-thiolated 2-oxazolidone antibiotics |
| WO2007000644A1 (en) * | 2005-06-29 | 2007-01-04 | Pharmacia & Upjohn Company Llc | Homomorpholine oxazolidinones as antibacterial agents |
| EP1902048A1 (en) | 2005-07-06 | 2008-03-26 | Pharmacia & Upjohn Company LLC | Oxazolidinone carboxamides containing azetidine and cyclobutane as antibacterial agents |
| EP2254892B1 (en) * | 2008-03-26 | 2014-04-23 | Global Alliance For Tb Drug Development | Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones |
| KR100980681B1 (ko) * | 2008-09-16 | 2010-09-07 | 한국과학기술연구원 | 디플루오로페닐 유도체를 갖는 신규한 옥사졸리디논 유도체또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 하는 항생제 조성물 |
| US20110053916A1 (en) * | 2009-08-14 | 2011-03-03 | Vertex Pharmaceuticals Incorporated | Pyrimidine compounds as tuberculosis inhibitors |
| BR112018000991A2 (pt) | 2015-07-17 | 2018-12-04 | The Global Alliance For Tb Drug Development, Inc. | feniloxazolidinonas substituídas para terapia antimicrobiana |
| JP2023127905A (ja) * | 2022-03-02 | 2023-09-14 | パナソニックＩｐマネジメント株式会社 | 物品管理システム、物品管理方法及びプログラム |
-
2016
- 2016-07-15 BR BR112018000991A patent/BR112018000991A2/pt not_active Application Discontinuation
- 2016-07-15 EP EP21185896.4A patent/EP3932917A3/en active Pending
- 2016-07-15 KR KR1020187003093A patent/KR102511898B1/ko active Active
- 2016-07-15 EA EA201792566A patent/EA037643B1/ru unknown
- 2016-07-15 JP JP2018521488A patent/JP6786598B2/ja active Active
- 2016-07-15 EA EA202190167A patent/EA202190167A1/ru unknown
- 2016-07-15 WO PCT/US2016/042486 patent/WO2017015106A1/en not_active Ceased
- 2016-07-15 ES ES16828300T patent/ES2897973T3/es active Active
- 2016-07-15 AU AU2016295165A patent/AU2016295165B2/en active Active
- 2016-07-15 US US15/738,503 patent/US10550092B2/en active Active
- 2016-07-15 EP EP16828300.0A patent/EP3307268B1/en active Active
- 2016-07-15 CN CN202111073361.5A patent/CN113603683B/zh active Active
- 2016-07-15 CA CA2990260A patent/CA2990260A1/en active Pending
- 2016-07-15 CN CN201680054227.1A patent/CN108348507B/zh active Active
-
2018
- 2018-01-10 ZA ZA2018/00189A patent/ZA201800189B/en unknown
-
2020
- 2020-01-13 US US16/740,660 patent/US11964949B2/en active Active
- 2020-05-18 JP JP2020086709A patent/JP7232212B2/ja active Active
-
2021
- 2021-07-16 AU AU2021205116A patent/AU2021205116B2/en active Active
- 2021-09-02 JP JP2021143166A patent/JP2021183647A/ja not_active Withdrawn
-
2022
- 2022-11-11 AU AU2022268387A patent/AU2022268387A1/en not_active Abandoned
-
2023
- 2023-08-04 JP JP2023127905A patent/JP7585405B2/ja active Active
-
2024
- 2024-08-22 JP JP2024140841A patent/JP2024152930A/ja active Pending
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