JP2020114818A5 - - Google Patents
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- JP2020114818A5 JP2020114818A5 JP2020035173A JP2020035173A JP2020114818A5 JP 2020114818 A5 JP2020114818 A5 JP 2020114818A5 JP 2020035173 A JP2020035173 A JP 2020035173A JP 2020035173 A JP2020035173 A JP 2020035173A JP 2020114818 A5 JP2020114818 A5 JP 2020114818A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hetero
- antibody
- glycosylation site
- linked glycosylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13188585.7 | 2013-10-14 | ||
| EP13188585 | 2013-10-14 | ||
| EP14165581 | 2014-04-23 | ||
| EP14165581.1 | 2014-04-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016547823A Division JP2016538878A (ja) | 2013-10-14 | 2014-10-14 | 糖鎖工学的に操作された抗体、抗体コンジュゲート、及びそれらの調製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020114818A JP2020114818A (ja) | 2020-07-30 |
| JP2020114818A5 true JP2020114818A5 (enExample) | 2020-09-10 |
| JP7041182B2 JP7041182B2 (ja) | 2022-03-23 |
Family
ID=51842732
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016547823A Pending JP2016538878A (ja) | 2013-10-14 | 2014-10-14 | 糖鎖工学的に操作された抗体、抗体コンジュゲート、及びそれらの調製方法 |
| JP2020035173A Expired - Fee Related JP7041182B2 (ja) | 2013-10-14 | 2020-03-02 | 糖鎖工学的に操作された抗体、抗体コンジュゲート、及びそれらの調製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016547823A Pending JP2016538878A (ja) | 2013-10-14 | 2014-10-14 | 糖鎖工学的に操作された抗体、抗体コンジュゲート、及びそれらの調製方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20160257764A1 (enExample) |
| EP (2) | EP2935611B1 (enExample) |
| JP (2) | JP2016538878A (enExample) |
| CN (1) | CN105829543B (enExample) |
| WO (1) | WO2015057066A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2759503T3 (es) | 2013-05-02 | 2020-05-11 | Glykos Finland Oy | Conjugados de una glicoproteína o un glicano con una carga útil tóxica |
| US20160235861A1 (en) * | 2013-10-14 | 2016-08-18 | SynAffix. B.V. | Glycoengineered antibody, antibody-conjugate and methods for their preparation |
| AU2015243512B2 (en) | 2014-04-08 | 2020-06-04 | University Of Georgia Research Foundation Inc. | Site-specific antibody-drug glycoconjugates and methods |
| DK3160513T3 (da) | 2014-06-30 | 2020-04-06 | Glykos Finland Oy | Saccharidderivat af en toksisk payload og antistofkonjugater deraf |
| EP3402815B1 (en) | 2016-01-15 | 2023-12-06 | University of Maryland, College Park | Endo-s2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins |
| JP6991978B2 (ja) * | 2016-01-27 | 2022-02-03 | メディミューン，エルエルシー | 定められるグリコシル化パターンを有する抗体を調製するための方法 |
| WO2017137457A1 (en) * | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| JP2017197512A (ja) * | 2016-02-08 | 2017-11-02 | シンアフィックス ビー．ブイ． | Ｃｄ３０腫瘍を標的化するための改善された治療指数を有する新規な抗体−コンジュゲート及び抗体−コンジュゲートの治療指数を改善するための方法 |
| WO2017137423A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Improved sulfamide linkers for use in bioconjugates |
| WO2017137458A1 (en) * | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| WO2017137456A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Bioconjugates containing sulfamide linkers for use in treatment |
| JP2017200902A (ja) * | 2016-02-08 | 2017-11-09 | シンアフィックス ビー．ブイ． | Ｈｅｒ２腫瘍を標的化するための改善された治療指数を有する新規な抗体−コンジュゲート及び抗体−コンジュゲートの治療指数を改善するための方法 |
| EP3413915A1 (en) * | 2016-02-08 | 2018-12-19 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting her2 tumours and method for improving therapeutic index of antibody-conjugates |
| US11617799B2 (en) | 2016-06-27 | 2023-04-04 | Tagworks Pharmaceuticals B.V. | Cleavable tetrazine used in bio-orthogonal drug activation |
| US11193155B2 (en) | 2016-08-10 | 2021-12-07 | University Of Maryland, College Park | Designer α 6-fucosidase mutants enable direct core fucosylation of intact N-glycopeptides and N-glycoproteins |
| WO2018090045A1 (en) * | 2016-11-14 | 2018-05-17 | Cho Pharma Inc | Antibody-drug conjugates |
| US11459380B2 (en) | 2017-06-29 | 2022-10-04 | University Of Maryland, College Park | Transglycosylation of endo-S and endo-S mutants for antibody glycosylation remodeling |
| CN107501388A (zh) * | 2017-09-22 | 2017-12-22 | 上海美吉医学检验有限公司 | 一种用于抗体‑分子定点偶联的方法及应用 |
| TWI885539B (zh) | 2017-09-29 | 2025-06-01 | 日商第一三共股份有限公司 | 抗體－吡咯并苯二氮呯衍生物複合體 |
| US11591408B2 (en) | 2017-11-09 | 2023-02-28 | National Research Council Of Canada | Antibody glycoconjugates and methods of production and use |
| JP2021506842A (ja) | 2017-12-18 | 2021-02-22 | ヤンセン バイオテツク，インコーポレーテツド | ポリペプチドの放射性標識 |
| JP2019206491A (ja) * | 2018-05-29 | 2019-12-05 | 国立研究開発法人理化学研究所 | 乳がんまたは胃がんの治療のための抗体−薬物複合体 |
| AU2019337051B2 (en) | 2018-09-06 | 2023-11-23 | Daiichi Sankyo Company, Limited | Novel cyclic dinucleotide derivative and antibody-drug conjugate thereof |
| GB201901608D0 (en) | 2019-02-06 | 2019-03-27 | Vib Vzw | Vaccine adjuvant conjugates |
| KR20220024829A (ko) * | 2019-06-24 | 2022-03-03 | 유니버시티 오브 죠지아 리서치 파운데이션, 인코포레이티드 | 이중 약물 항체-약물 접합체 |
| NL2023572B1 (en) * | 2019-07-25 | 2021-02-10 | Synaffix Bv | Synthesis of 6-azido-6-deoxy-2-N-acetyl-hexosamine-nucleoside diphosphate |
| WO2022136555A1 (en) | 2020-12-23 | 2022-06-30 | Ludwig-Maximilians-Universitaet Muenchen | Improved cd30 targeting antibody drug conjugates and uses thereof |
| EP4267195A1 (en) * | 2020-12-24 | 2023-11-01 | Synaffix B.V. | Glycan-conjugated antibodies binding to fc-gamma receptor |
| EP4301782A1 (en) | 2021-03-05 | 2024-01-10 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
| WO2022217022A1 (en) | 2021-04-10 | 2022-10-13 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
| AU2022262644A1 (en) | 2021-04-23 | 2023-11-09 | Genmab A/S | Anti-cd70 antibodies, conjugates thereof and methods of using the same |
| WO2023014863A1 (en) | 2021-08-05 | 2023-02-09 | Go Therapeutics, Inc. | Anti-glyco-muc4 antibodies and their uses |
| EP4433096A1 (en) | 2021-11-19 | 2024-09-25 | Ardeagen Corporation | Gpc3 binding agents, conjugates thereof and methods of using the same |
| WO2024102603A1 (en) * | 2022-11-07 | 2024-05-16 | Merck Sharp & Dohme Llc | Bisecting-glycan bridged conjugation for producing glycoprotein conjugates |
| TW202434309A (zh) * | 2023-01-19 | 2024-09-01 | 大陸商上海盛迪醫藥有限公司 | 酪胺酸酶介導的蛋白定點偶聯及其應用 |
| WO2025027529A1 (en) | 2023-07-31 | 2025-02-06 | Advesya | Anti-il-1rap antibody drug conjugates and methods of use thereof |
| TW202535954A (zh) | 2023-09-26 | 2025-09-16 | 丹麥商珍美寶股份有限公司 | Ｐｔｋ７結合劑、其共軛物及使用彼等之方法 |
| WO2025126157A1 (en) | 2023-12-15 | 2025-06-19 | Advesya | Anti-il-1rap binding domains and antibody-drug conjugates thereof |
| US20250381289A1 (en) | 2024-02-29 | 2025-12-18 | Genmab A/S | Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same |
| CN120227472A (zh) * | 2024-11-12 | 2025-07-01 | 云舟生物科技(广州)股份有限公司 | 脂质纳米颗粒偶联物及其制备方法和用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997034632A1 (en) | 1996-03-20 | 1997-09-25 | Immunomedics, Inc. | Glycosylated humanized b-cell specific antibodies |
| ES2897506T3 (es) * | 2003-01-09 | 2022-03-01 | Macrogenics Inc | Identificación y modificación de anticuerpos con regiones Fc variantes y métodos de utilización de los mismos |
| WO2004063344A2 (en) | 2003-01-10 | 2004-07-29 | Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health | CATALYTIC DOMAINS OF β/1,4)-GALACTOSYLTRANSFERASE I HAVING ALTERED DONOR AND ACCEPTOR SPECIFICITIES, DOMAINS THAT PROMOTE IN VITRO PROTEIN FOLDING, AND METHODS FOR THEIR USE |
| US8431558B2 (en) | 2004-11-01 | 2013-04-30 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| JP2009531289A (ja) * | 2006-02-10 | 2009-09-03 | ライフ テクノロジーズ コーポレーション | オリゴ糖によるタンパク質の修飾及び標識方法 |
| EP2623610B1 (en) * | 2006-02-10 | 2015-04-29 | Life Technologies Corporation | Labeling and detection of post translationally modified proteins |
| EP2001358B1 (en) | 2006-03-27 | 2016-07-13 | University Of Maryland, Baltimore | Glycoprotein synthesis and remodeling by enzymatic transglycosylation |
| EP2084188A2 (en) * | 2006-10-12 | 2009-08-05 | Genentech, Inc. | Antibodies to lymphotoxin-alpha |
| WO2009025646A1 (en) | 2007-08-22 | 2009-02-26 | Government Of The U.S.A, As Represented By The Secretary, Department Of Health & Human Services | Alpha 1-3 n-galactosyltransferase with altered donor specificities |
| CN101925366B (zh) | 2007-11-21 | 2015-02-04 | 乔治亚大学研究基金公司 | 炔烃以及炔烃与1,3-偶极-官能化合物反应的方法 |
| EP2229410A4 (en) * | 2007-12-05 | 2012-07-04 | Massachusetts Inst Technology | AGLYCOSYLATED IMMUNOGLOBULIN MUTANES |
| WO2009102820A2 (en) | 2008-02-11 | 2009-08-20 | Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services | Modified sugar substrates and methods of use |
| US8519122B2 (en) | 2010-02-12 | 2013-08-27 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| US8859629B2 (en) | 2010-04-27 | 2014-10-14 | Synaffix B.V. | Fused cyclooctyne compounds and their use in metal-free click reactions |
| KR20130050966A (ko) * | 2010-07-12 | 2013-05-16 | 씨오브이엑스 테크놀로지스 아일랜드 리미티드 | 다기능적 항체 접합체 |
| GB201115841D0 (en) | 2011-09-13 | 2011-10-26 | Genovis Ab | Protein and method |
| RS56953B1 (sr) * | 2012-10-23 | 2018-05-31 | Synaffix Bv | Modifikovano antitelo, konjugat antitela i postupak za njihovu pripremu |
| US20160235861A1 (en) * | 2013-10-14 | 2016-08-18 | SynAffix. B.V. | Glycoengineered antibody, antibody-conjugate and methods for their preparation |
| EP3413915A1 (en) * | 2016-02-08 | 2018-12-19 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting her2 tumours and method for improving therapeutic index of antibody-conjugates |
-
2014
- 2014-10-14 EP EP14790777.8A patent/EP2935611B1/en active Active
- 2014-10-14 US US15/029,198 patent/US20160257764A1/en not_active Abandoned
- 2014-10-14 WO PCT/NL2014/050717 patent/WO2015057066A1/en not_active Ceased
- 2014-10-14 CN CN201480068027.2A patent/CN105829543B/zh not_active Expired - Fee Related
- 2014-10-14 JP JP2016547823A patent/JP2016538878A/ja active Pending
- 2014-10-14 EP EP21184055.8A patent/EP3929301A1/en not_active Withdrawn
-
2020
- 2020-03-02 JP JP2020035173A patent/JP7041182B2/ja not_active Expired - Fee Related
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