JP2020114818A5 - - Google Patents
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- JP2020114818A5 JP2020114818A5 JP2020035173A JP2020035173A JP2020114818A5 JP 2020114818 A5 JP2020114818 A5 JP 2020114818A5 JP 2020035173 A JP2020035173 A JP 2020035173A JP 2020035173 A JP2020035173 A JP 2020035173A JP 2020114818 A5 JP2020114818 A5 JP 2020114818A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hetero
- antibody
- glycosylation site
- linked glycosylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13188585 | 2013-10-14 | ||
| EP13188585.7 | 2013-10-14 | ||
| EP14165581.1 | 2014-04-23 | ||
| EP14165581 | 2014-04-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016547823A Division JP2016538878A (ja) | 2013-10-14 | 2014-10-14 | 糖鎖工学的に操作された抗体、抗体コンジュゲート、及びそれらの調製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020114818A JP2020114818A (ja) | 2020-07-30 |
| JP2020114818A5 true JP2020114818A5 (enExample) | 2020-09-10 |
| JP7041182B2 JP7041182B2 (ja) | 2022-03-23 |
Family
ID=51842732
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016547823A Pending JP2016538878A (ja) | 2013-10-14 | 2014-10-14 | 糖鎖工学的に操作された抗体、抗体コンジュゲート、及びそれらの調製方法 |
| JP2020035173A Expired - Fee Related JP7041182B2 (ja) | 2013-10-14 | 2020-03-02 | 糖鎖工学的に操作された抗体、抗体コンジュゲート、及びそれらの調製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016547823A Pending JP2016538878A (ja) | 2013-10-14 | 2014-10-14 | 糖鎖工学的に操作された抗体、抗体コンジュゲート、及びそれらの調製方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20160257764A1 (enExample) |
| EP (2) | EP2935611B1 (enExample) |
| JP (2) | JP2016538878A (enExample) |
| CN (1) | CN105829543B (enExample) |
| WO (1) | WO2015057066A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2991683T3 (da) | 2013-05-02 | 2019-11-04 | Glykos Finland Oy | Konjugater af et glykoprotein eller en glykan med en toksisk ladning |
| WO2015057065A1 (en) * | 2013-10-14 | 2015-04-23 | Synaffix B.V. | Glycoengineered antibody, antibody-conjugate and methods for their preparation |
| ES3060461T3 (en) | 2014-04-08 | 2026-03-26 | Univ Georgia | Site-specific antibody-drug glycoconjugates and methods |
| US10973920B2 (en) | 2014-06-30 | 2021-04-13 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| US11008601B2 (en) | 2016-01-15 | 2021-05-18 | University Of Maryland | Endo-S2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins |
| RU2018128784A (ru) * | 2016-01-27 | 2020-02-27 | МЕДИММЬЮН, ЭлЭлСи | Способы получения антител с заданным профилем гликозилирования |
| JP2017197512A (ja) * | 2016-02-08 | 2017-11-02 | シンアフィックス ビー．ブイ． | Ｃｄ３０腫瘍を標的化するための改善された治療指数を有する新規な抗体−コンジュゲート及び抗体−コンジュゲートの治療指数を改善するための方法 |
| WO2017137457A1 (en) * | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| JP2017200902A (ja) * | 2016-02-08 | 2017-11-09 | シンアフィックス ビー．ブイ． | Ｈｅｒ２腫瘍を標的化するための改善された治療指数を有する新規な抗体−コンジュゲート及び抗体−コンジュゲートの治療指数を改善するための方法 |
| WO2017137456A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Bioconjugates containing sulfamide linkers for use in treatment |
| US10874746B2 (en) | 2016-02-08 | 2020-12-29 | Synaffix B.V. | Sulfamide linkers for use in bioconjugates |
| WO2017137458A1 (en) * | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| US11590239B2 (en) | 2016-02-08 | 2023-02-28 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting CD30 tumours and method for improving therapeutic index of antibody-conjugates |
| US11617799B2 (en) | 2016-06-27 | 2023-04-04 | Tagworks Pharmaceuticals B.V. | Cleavable tetrazine used in bio-orthogonal drug activation |
| CN109715819A (zh) | 2016-08-10 | 2019-05-03 | 马里兰大学帕克分校 | 设计者α1,6-岩藻糖苷酶突变体实现完整N-糖肽和N-糖蛋白的直接核心岩藻糖基化 |
| CN109996543A (zh) * | 2016-11-14 | 2019-07-09 | 醣基生医股份有限公司 | 抗体药物复合体 |
| US11459380B2 (en) | 2017-06-29 | 2022-10-04 | University Of Maryland, College Park | Transglycosylation of endo-S and endo-S mutants for antibody glycosylation remodeling |
| CN107501388A (zh) * | 2017-09-22 | 2017-12-22 | 上海美吉医学检验有限公司 | 一种用于抗体‑分子定点偶联的方法及应用 |
| CA3177215C (en) | 2017-09-29 | 2026-06-09 | Daiichi Sankyo Company, Limited | Antibody-pyrrolobenzodiazepine derivative conjugate |
| WO2019090424A1 (en) | 2017-11-09 | 2019-05-16 | National Research Council Of Canada | Antibody glycoconjugates and methods of production and use |
| JP2021506842A (ja) | 2017-12-18 | 2021-02-22 | ヤンセン バイオテツク，インコーポレーテツド | ポリペプチドの放射性標識 |
| JP2019206491A (ja) * | 2018-05-29 | 2019-12-05 | 国立研究開発法人理化学研究所 | 乳がんまたは胃がんの治療のための抗体−薬物複合体 |
| CN118846110A (zh) | 2018-09-06 | 2024-10-29 | 第一三共株式会社 | 抗体药物偶联物 |
| GB201901608D0 (en) | 2019-02-06 | 2019-03-27 | Vib Vzw | Vaccine adjuvant conjugates |
| WO2020263943A1 (en) | 2019-06-24 | 2020-12-30 | University Of Georgia Research Foundation, Inc. | Dual drug antibody-drug conjugates |
| NL2023572B1 (en) * | 2019-07-25 | 2021-02-10 | Synaffix Bv | Synthesis of 6-azido-6-deoxy-2-N-acetyl-hexosamine-nucleoside diphosphate |
| AR124475A1 (es) | 2020-12-23 | 2023-03-29 | Univ Muenchen Ludwig Maximilians | Conjugados anticuerpo-droga mejorados dirigidos contra cd30 y usos de los mismos |
| WO2022136705A1 (en) * | 2020-12-24 | 2022-06-30 | Synaffix B.V. | Glycan-conjugated antibodies binding to fc-gamma receptor |
| EP4301782A1 (en) | 2021-03-05 | 2024-01-10 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
| WO2022217022A1 (en) | 2021-04-10 | 2022-10-13 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
| CA3216459A1 (en) | 2021-04-23 | 2022-10-27 | Profoundbio Us Co. | Anti-cd70 antibodies, conjugates thereof and methods of using the same |
| JP2024531915A (ja) | 2021-08-05 | 2024-09-03 | ジーオー セラピューティクス，インコーポレイテッド | 抗グリコｍｕｃ抗体およびその使用 |
| EP4433096A1 (en) | 2021-11-19 | 2024-09-25 | Ardeagen Corporation | Gpc3 binding agents, conjugates thereof and methods of using the same |
| WO2024102603A1 (en) * | 2022-11-07 | 2024-05-16 | Merck Sharp & Dohme Llc | Bisecting-glycan bridged conjugation for producing glycoprotein conjugates |
| EP4653020A1 (en) * | 2023-01-19 | 2025-11-26 | Shanghai Shengdi Pharmaceutical Co., Ltd | Tyrosinase-mediated protein site-specific conjugation and use thereof |
| WO2025027529A1 (en) | 2023-07-31 | 2025-02-06 | Advesya | Anti-il-1rap antibody drug conjugates and methods of use thereof |
| AR133955A1 (es) | 2023-09-26 | 2025-11-19 | Profoundbio Us Co | Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos |
| TW202530255A (zh) | 2023-12-15 | 2025-08-01 | 法商亞維西亞有限公司 | 抗ｉｌ－１ｒａｐ結合結構域及其抗體－藥物偶聯物 |
| WO2025181219A1 (en) | 2024-02-29 | 2025-09-04 | Genmab A/S | Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same |
| WO2026039642A1 (en) | 2024-08-16 | 2026-02-19 | Ardeagen Corporation | Anti-mesothelin antibody conjugates and methods of use thereof |
| CN120227472A (zh) * | 2024-11-12 | 2025-07-01 | 云舟生物科技(广州)股份有限公司 | 脂质纳米颗粒偶联物及其制备方法和用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6254868B1 (en) | 1996-03-20 | 2001-07-03 | Immunomedics, Inc. | Glycosylated humanized B-cell specific antibodies |
| US7355008B2 (en) * | 2003-01-09 | 2008-04-08 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| AU2004204463B2 (en) | 2003-01-10 | 2009-02-12 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health | Catalytic domains of beta(1,4)-galactosyltransferase I having altered donor and acceptor specificities, domains that promote in vitro protein folding, and methods for their use |
| US8431558B2 (en) | 2004-11-01 | 2013-04-30 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| JP2009531289A (ja) * | 2006-02-10 | 2009-09-03 | ライフ テクノロジーズ コーポレーション | オリゴ糖によるタンパク質の修飾及び標識方法 |
| US20070249014A1 (en) | 2006-02-10 | 2007-10-25 | Invitrogen Corporation | Labeling and detection of post translationally modified proteins |
| CA2647632C (en) | 2006-03-27 | 2017-06-27 | University Of Maryland Biotechnology Institute | Glycoprotein synthesis and remodeling by enzymatic transglycosylation |
| NZ576032A (en) * | 2006-10-12 | 2012-03-30 | Genentech Inc | Antibodies to lymphotoxin-alpha |
| US8425901B2 (en) | 2007-08-22 | 2013-04-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Alpha 1-3 N-galactosyltransferase with altered donor specificities |
| EP2907525B1 (en) | 2007-11-21 | 2018-05-16 | University Of Georgia Research Foundation, Inc. | Dibenzocyclooctene-compounds for bioorthogonal reactions |
| WO2009079242A2 (en) * | 2007-12-05 | 2009-06-25 | Massachusetts Institute Of Technology | Aglycosylated immunoglobulin mutants |
| WO2009102820A2 (en) | 2008-02-11 | 2009-08-20 | Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services | Modified sugar substrates and methods of use |
| US8519122B2 (en) | 2010-02-12 | 2013-08-27 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| US8859629B2 (en) | 2010-04-27 | 2014-10-14 | Synaffix B.V. | Fused cyclooctyne compounds and their use in metal-free click reactions |
| SG186451A1 (en) * | 2010-07-12 | 2013-01-30 | Covx Technologies Ireland Ltd | Multifunctional antibody conjugates |
| GB201115841D0 (en) | 2011-09-13 | 2011-10-26 | Genovis Ab | Protein and method |
| HRP20180268T4 (hr) * | 2012-10-23 | 2026-03-27 | Synaffix B.V. | Modificirano antitijelo, konjugat antitijela i postupak za njihovu pripremu |
| WO2015057065A1 (en) * | 2013-10-14 | 2015-04-23 | Synaffix B.V. | Glycoengineered antibody, antibody-conjugate and methods for their preparation |
| US11590239B2 (en) * | 2016-02-08 | 2023-02-28 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting CD30 tumours and method for improving therapeutic index of antibody-conjugates |
-
2014
- 2014-10-14 WO PCT/NL2014/050717 patent/WO2015057066A1/en not_active Ceased
- 2014-10-14 JP JP2016547823A patent/JP2016538878A/ja active Pending
- 2014-10-14 EP EP14790777.8A patent/EP2935611B1/en active Active
- 2014-10-14 CN CN201480068027.2A patent/CN105829543B/zh not_active Expired - Fee Related
- 2014-10-14 US US15/029,198 patent/US20160257764A1/en not_active Abandoned
- 2014-10-14 EP EP21184055.8A patent/EP3929301A1/en not_active Withdrawn
-
2020
- 2020-03-02 JP JP2020035173A patent/JP7041182B2/ja not_active Expired - Fee Related
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