|
US2779780A
(en)
|
1955-03-01 |
1957-01-29 |
Du Pont |
1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
JP2861087B2
(ja)
*
|
1989-08-08 |
1999-02-24 |
三菱化学株式会社 |
Ｎ―アシル‐５‐ピラゾールカルボキサミド類およびこれを有効成分とする殺虫、殺ダニ剤
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
AU675929B2
(en)
|
1992-02-06 |
1997-02-27 |
Curis, Inc. |
Biosynthetic binding protein for cancer marker
|
|
IT1255527B
(it)
*
|
1992-09-29 |
1995-11-09 |
Mini Ricerca Scient Tecnolog |
Pirazolcarbossammidi ad attivita' insetticida ed acaricida
|
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
EP0647450A1
(en)
|
1993-09-09 |
1995-04-12 |
BEHRINGWERKE Aktiengesellschaft |
Improved prodrugs for enzyme mediated activation
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
DK0821671T3
(da)
|
1995-04-20 |
2001-04-23 |
Pfizer |
Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
GB9520822D0
(en)
|
1995-10-11 |
1995-12-13 |
Wellcome Found |
Therapeutically active compounds
|
|
DE69624081T2
(de)
|
1995-12-20 |
2003-06-12 |
Agouron Pharmaceuticals, Inc. |
Matrix-metalloprotease Inhibitoren
|
|
DE19600097C1
(de)
|
1996-01-03 |
1997-07-31 |
Siemens Ag |
Verfahren und Vorrichtung zur Bestimmung einer Flüssigkeitshöhe mit Hilfe von Ultraschallimpulsen
|
|
US6291455B1
(en)
|
1996-03-05 |
2001-09-18 |
Zeneca Limited |
4-anilinoquinazoline derivatives
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
ES2191187T3
(es)
|
1996-07-13 |
2003-09-01 |
Glaxo Group Ltd |
Compuestos heteroaromaticos biciclicos como inhibidores de la proteina tirosin-quinasa.
|
|
ID19609A
(id)
|
1996-07-13 |
1998-07-23 |
Glaxo Group Ltd |
Senyawa-senyawa heterosiklik
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
EP0923585B1
(en)
|
1996-07-18 |
2002-05-08 |
Pfizer Inc. |
Phosphinate based inhibitors of matrix metalloproteases
|
|
WO1998007697A1
(en)
|
1996-08-23 |
1998-02-26 |
Pfizer Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
WO1998030566A1
(en)
|
1997-01-06 |
1998-07-16 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
EP0977733B1
(en)
|
1997-02-03 |
2003-09-03 |
Pfizer Products Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
JP2000507975A
(ja)
|
1997-02-07 |
2000-06-27 |
ファイザー・インク |
Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
|
|
EA002546B1
(ru)
|
1997-02-11 |
2002-06-27 |
Пфайзер Инк. |
Производные арилсульфонилгидроксамовой кислоты
|
|
EP0984930B1
(en)
|
1997-05-07 |
2005-04-06 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
CA2291709A1
(en)
|
1997-05-30 |
1998-12-03 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
AU730248B2
(en)
|
1997-08-08 |
2001-03-01 |
Pfizer Products Inc. |
Aryloxyarylsulfonylamino hydroxamic acid derivatives
|
|
WO1999010349A1
(en)
|
1997-08-22 |
1999-03-04 |
Zeneca Limited |
Oxindolylquinazoline derivatives as angiogenesis inhibitors
|
|
WO1999016755A1
(en)
|
1997-09-26 |
1999-04-08 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
CA2309690A1
(en)
|
1997-11-11 |
1999-05-20 |
Pfizer Products Inc. |
Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
RS49779B
(sr)
|
1998-01-12 |
2008-06-05 |
Glaxo Group Limited, |
Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
EA005032B1
(ru)
|
1998-05-29 |
2004-10-28 |
Сьюджен, Инк. |
Пирролзамещенные 2-индолиноны (варианты), фармацевтическая композиция (варианты), способ модулирования каталитической активности протеинкиназы, способ лечения или профилактики нарушения в организме, связанного с протеинкиназой
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
DK1004578T3
(da)
|
1998-11-05 |
2004-06-28 |
Pfizer Prod Inc |
5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater
|
|
AU776788C
(en)
|
1998-12-16 |
2005-10-27 |
Warner-Lambert Company |
Treatment of arthritis with MEK inhibitors
|
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
|
JP2001172261A
(ja)
*
|
1999-12-20 |
2001-06-26 |
Mitsubishi Chemicals Corp |
ピラゾールカルボン酸アミド類、およびこれを有効成分とする殺虫、殺ダニ剤
|
|
SI1255752T1
(sl)
|
2000-02-15 |
2007-12-31 |
Pharmacia & Upjohn Co Llc |
S pirolom substituirani zaviralci 2-indolinon protein kinaza
|
|
DZ3401A1
(fr)
|
2000-07-19 |
2002-01-24 |
Warner Lambert Co |
Esters oxygenes d'acides 4-iodophenylamino benzhydroxamiques
|
|
EP1317450B1
(en)
*
|
2000-09-15 |
2006-11-22 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6660731B2
(en)
|
2000-09-15 |
2003-12-09 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
WO2002083647A1
(en)
*
|
2001-04-06 |
2002-10-24 |
Nihon Nohyaku Co., Ltd. |
Pyrazolecarboxamide derivative, intermediate therefor, and pest control agent containing the same as active ingredient
|
|
JP2002363164A
(ja)
*
|
2001-04-06 |
2002-12-18 |
Mitsubishi Chemicals Corp |
ピラゾールカルボキサミド類、その中間体およびこれを有効成分とする有害生物防除剤
|
|
WO2004078163A2
(en)
|
2003-02-28 |
2004-09-16 |
Transform Pharmaceuticals, Inc. |
Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
|
|
AU2003224672B2
(en)
|
2002-03-08 |
2010-02-04 |
Eisai R&D Management Co., Ltd. |
Macrocyclic compounds useful as pharmaceuticals
|
|
SG2013013339A
(en)
|
2002-03-13 |
2014-12-30 |
Array Biopharma Inc |
N3 alkylated benzimidazole derivatives as mek inhibitors
|
|
US20070060589A1
(en)
|
2004-12-21 |
2007-03-15 |
Purandare Ashok V |
Inhibitors of protein arginine methyl transferases
|
|
ES2520015T3
(es)
*
|
2005-04-08 |
2014-11-11 |
Pfizer Products Inc. |
[3.1.0]Heteroaril amidas bicíclicas como inhibidores de transporte de glicina de tipo 1
|
|
EP1884513A4
(en)
*
|
2005-05-23 |
2010-04-28 |
Japan Tobacco Inc |
PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME
|
|
MX2008002114A
(es)
|
2005-07-21 |
2008-04-17 |
Ardea Biosciences Inc |
Inhibidores de n-(arilamino)-sulfonamida de mek.
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
WO2009025781A1
(en)
|
2007-08-16 |
2009-02-26 |
Beth Israel Deaconess Medical Center |
Activators of pyruvate kinase m2 and methods of treating disease
|
|
JPWO2009028280A1
(ja)
*
|
2007-08-29 |
2010-11-25 |
三井化学アグロ株式会社 |
ピラゾールカルボン酸誘導体及びその製造方法、並びに殺菌剤
|
|
AU2008298948B2
(en)
|
2007-09-12 |
2014-09-04 |
F. Hoffmann-La Roche Ag |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
US8354528B2
(en)
|
2007-10-25 |
2013-01-15 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
|
AU2009303335B2
(en)
*
|
2008-10-09 |
2016-05-19 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Activators of human pyruvate kinase
|
|
EP2346831B1
(en)
*
|
2008-11-17 |
2015-01-07 |
Boehringer Ingelheim International GmbH |
Heteroaryl diamide compounds useful as mmp-13 inhibitors
|
|
WO2010083246A1
(en)
|
2009-01-15 |
2010-07-22 |
Amgen Inc. |
Fluoroisoquinoline substituted thiazole compounds and methods of use
|
|
WO2010118063A2
(en)
*
|
2009-04-06 |
2010-10-14 |
Agios Pharmaceuticals, Inc. |
Therapeutic compositions and related methods of use
|
|
WO2010129596A1
(en)
|
2009-05-04 |
2010-11-11 |
Agios Pharmaceuticals, Inc. |
Pmk2 modulators for use in the treatment of cancer
|
|
US8349832B2
(en)
|
2009-09-02 |
2013-01-08 |
Canthera Therapeutics |
Compounds and compositions for treating cancer
|
|
WO2011069298A1
(en)
*
|
2009-12-11 |
2011-06-16 |
F. Hoffmann-La Roche Ag |
Novel cyclopropane indolinone derivatives
|
|
JP5902174B2
(ja)
|
2010-09-30 |
2016-04-13 |
ナショナル ヤン−ミン ユニバーシティ |
抗癌性抽出物及び化合物
|
|
EP2632920A1
(en)
|
2010-10-27 |
2013-09-04 |
Dynamix Pharmaceuticals Ltd. |
Sulfonamides for the modulation of pkm2
|
|
CA2821975A1
(en)
*
|
2010-12-17 |
2012-06-21 |
Shunqi Yan |
N-(4-(azetidine-1-carbonyl)phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase m2 pkm2 modulators
|
|
WO2012088314A1
(en)
|
2010-12-21 |
2012-06-28 |
Agios Pharmaceuticals, Inc. |
Bicyclic pkm2 activators
|
|
TWI549947B
(zh)
|
2010-12-29 |
2016-09-21 |
阿吉歐斯製藥公司 |
治療化合物及組成物
|
|
EP2497775A1
(en)
|
2011-03-11 |
2012-09-12 |
Ruprecht-Karls-Universität Heidelberg |
Ferrocene-based compounds and their use as ROS regulating prodrugs
|
|
WO2012160447A1
(en)
*
|
2011-05-25 |
2012-11-29 |
Dynamix Pharmaceuticals Ltd. |
3, 5 -diphenyl- substituted pyrazolines for the treatment of cancer, proliferative, inflammatory or autoimmune diseases
|
|
WO2013005157A1
(en)
|
2011-07-05 |
2013-01-10 |
Lupin Limited |
Sulfone derivatives and their use as pkm2 modulators for the treatment of cancer
|
|
DK2909181T3
(da)
*
|
2012-10-16 |
2017-11-20 |
Tolero Pharmaceuticals Inc |
PKM2-modulatorer og fremgangsmåder til anvendelse deraf
|
|
KR20150080619A
(ko)
|
2012-11-08 |
2015-07-09 |
아지오스 파마슈티컬스 아이엔씨. |
치료적 화합물 및 조성물
|
|
US9447054B2
(en)
|
2014-01-15 |
2016-09-20 |
Korea Institute Of Radiological & Medical Sciences |
Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient
|