|
JPS6032638B2
(ja)
|
1976-09-01 |
1985-07-29 |
武田薬品工業株式会社 |
3−アミノピラゾロ〔3,4−d〕ピリミジン誘導体
|
|
JPS58500966A
(ja)
|
1981-04-22 |
1983-06-09 |
ビイク グルデン ロンベルク ヒエ−ミツシエ フアブリ−ク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング |
新規ピラゾロ〔3,4−d〕ピリミジン、その製法及びこれを含有する医薬品
|
|
US4469868A
(en)
|
1982-05-24 |
1984-09-04 |
Warner-Lambert Company |
Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines
|
|
US4603203A
(en)
|
1983-12-14 |
1986-07-29 |
Takeda Chemical Industries, Ltd. |
3-aminopyrazolo[3,4-d]pyrimidine derivatives and production thereof
|
|
US4666908A
(en)
|
1985-04-05 |
1987-05-19 |
Warner-Lambert Company |
5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
|
|
KR920004437B1
(ko)
|
1989-09-12 |
1992-06-05 |
삼성전자 주식회사 |
금전등록기의 거래선 관리방법
|
|
ZA914727B
(en)
|
1990-06-21 |
1992-03-25 |
Schering Corp |
Polycyclic guanine derivatives
|
|
US5202328A
(en)
|
1991-03-06 |
1993-04-13 |
Merck & Co., Inc. |
Substituted fused pyrimidinones
|
|
US5294612A
(en)
|
1992-03-30 |
1994-03-15 |
Sterling Winthrop Inc. |
6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
|
|
NZ262797A
(en)
|
1993-02-26 |
1997-08-22 |
Schering Corp |
Polycyclic guanine derivatives, purine and pyrimidine precursors; medicaments
|
|
GB9304919D0
(en)
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
|
GB9315017D0
(en)
|
1993-07-20 |
1993-09-01 |
Glaxo Lab Sa |
Chemical compounds
|
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US5824683A
(en)
|
1995-11-28 |
1998-10-20 |
Schering Corporation |
2'- 4'-halo- 1,1'-biphenyl!-4-yl!methyl!-5'-methyl-spiro cyclopentane-1,7' (8'H)- 3H! imidazo 2,1-b!purin!-4' (5'H)-ones
|
|
GB9526245D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9622363D0
(en)
|
1996-10-28 |
1997-01-08 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
AU5330698A
(en)
|
1996-12-23 |
1998-07-17 |
Celltech Therapeutics Limited |
Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
|
|
SE9701398D0
(sv)
|
1997-04-15 |
1997-04-15 |
Astra Pharma Prod |
Novel compounds
|
|
IT1291372B1
(it)
|
1997-05-21 |
1999-01-07 |
Schering Plough S P A |
Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
|
|
US6013621A
(en)
|
1997-10-17 |
2000-01-11 |
The Rockfeller University |
Method of treating psychosis and/or hyperactivity
|
|
GB9722520D0
(en)
|
1997-10-24 |
1997-12-24 |
Pfizer Ltd |
Compounds
|
|
AU3053999A
(en)
|
1998-03-31 |
1999-10-25 |
Kyowa Hakko Kogyo Co. Ltd. |
Nitrogenous heterocyclic compounds
|
|
US6133273A
(en)
|
1998-05-08 |
2000-10-17 |
American Home Products Corporation |
Pyrazolopyrimidine-2,4-dione sulfonamides
|
|
US6459908B1
(en)
|
1998-12-31 |
2002-10-01 |
Qwest Communications International Inc. |
Method and system for supporting wireless features in a Generic C wireline architecture
|
|
GB9907658D0
(en)
|
1999-04-06 |
1999-05-26 |
Zeneca Ltd |
Chemical compounds
|
|
AU5636900A
(en)
|
1999-06-30 |
2001-01-31 |
Merck & Co., Inc. |
Src kinase inhibitor compounds
|
|
JP2003503354A
(ja)
|
1999-06-30 |
2003-01-28 |
メルク エンド カムパニー インコーポレーテッド |
Srcキナーゼ阻害剤化合物
|
|
DE19931206A1
(de)
|
1999-07-07 |
2001-01-11 |
Stief Christian |
Arzneimittel zur Erhöhung des cAMP-Spiegels und deren Verwendung
|
|
BR0013899A
(pt)
|
1999-09-10 |
2003-07-08 |
Merck & Co Inc |
Composto, composição farmacêutica, processos de tratamento ou prevenção de câncer, de uma doença em que a angiogênese esteja implicada, da vascularização retinal, da retinopatia diabética, da degeneração macular relacionada a idade, de doenças inflamatórias, de uma doença ou condições dependentes da tirosina quinase, de patologias associadas com ossos, e, processos para produzir uma composição farmacêutica, e de reduzir ou prevenir dano tecidual em seguida a um evento isquêmico cerebral
|
|
KR20020047198A
(ko)
|
1999-09-30 |
2002-06-21 |
해피 페너 ; 해리 에이치. 페너 2세 |
특정 알킬렌 디아민-치환된피라졸로[1,5-a]-1,5-피리미딘 및피라졸로[1,5-a]-1,3,5-트리아진
|
|
TWI265925B
(en)
|
1999-10-11 |
2006-11-11 |
Pfizer |
Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
|
|
EP1222190A1
(en)
|
1999-10-11 |
2002-07-17 |
Pfizer Limited |
5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors
|
|
IL139073A0
(en)
|
1999-10-21 |
2001-11-25 |
Pfizer |
Treatment of neuropathy
|
|
MY125533A
(en)
|
1999-12-06 |
2006-08-30 |
Bristol Myers Squibb Co |
Heterocyclic dihydropyrimidine compounds
|
|
GB0004890D0
(en)
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
|
CA2407031A1
(en)
|
2000-04-19 |
2001-10-25 |
Lilly Icos Llc |
Use of cyclic gmp-specific phosphodiesterase inhibitors for treatment of parkinson's disease
|
|
US6693099B2
(en)
|
2000-10-17 |
2004-02-17 |
The Procter & Gamble Company |
Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
|
|
ATE298238T1
(de)
|
2001-03-16 |
2005-07-15 |
Pfizer |
Pyrazolo(4,3-d)pyrimidinon-verbindungen als cgmp pde-inhibitoren
|
|
WO2002088079A2
(en)
|
2001-05-01 |
2002-11-07 |
Bristol-Myers Squibb Company |
Dual inhibitors of pde 7 and pde 4
|
|
SE0102315D0
(sv)
|
2001-06-28 |
2001-06-28 |
Astrazeneca Ab |
Compounds
|
|
MXPA04001891A
(es)
|
2001-08-28 |
2004-06-15 |
Schering Corp |
Inhibidores policiclicos de guanina fosfodiesterasa v.
|
|
WO2003020702A2
(en)
|
2001-08-31 |
2003-03-13 |
The Rockefeller University |
Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain
|
|
WO2003042216A1
(en)
|
2001-11-09 |
2003-05-22 |
Schering Corporation |
Polycyclic guanine derivative phosphodiesterase v inhibitors
|
|
WO2003070174A2
(en)
|
2002-02-15 |
2003-08-28 |
Sympore Gmbh |
Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
|
|
US20050153372A1
(en)
|
2002-02-21 |
2005-07-14 |
Paul Greengard |
Compositions and method for regulation of calcium-dependent signaling in brain
|
|
GB0230045D0
(en)
|
2002-12-23 |
2003-01-29 |
Glaxo Group Ltd |
Compounds
|
|
US7666843B2
(en)
|
2002-09-27 |
2010-02-23 |
Children's Medical Center Corporation |
Methods and compositions for treatment of neurological disorder
|
|
WO2004031375A2
(en)
*
|
2002-10-01 |
2004-04-15 |
Bayer Healthcare Ag |
Regulation of human 3’, 5’ cyclic nucleotide phosphodiesterase pde1c
|
|
EP1604202A2
(en)
*
|
2003-03-11 |
2005-12-14 |
Bayer HealthCare AG |
Diagnostics and therapeutics for diseases associated with phosphodiesterase 1a (pde1a)
|
|
WO2004087906A1
(en)
|
2003-03-31 |
2004-10-14 |
Pfizer Products Inc. |
Crystal structure of 3',5'-cyclic nucleotide phosphodiesterase 1b (pde1b) and uses thereof
|
|
EA200501548A1
(ru)
|
2003-04-01 |
2006-02-24 |
Апплайд Резеч Системз Арс Холдинг Н.В. |
Ингибиторы фосфодиэстераз при бесплодии
|
|
BRPI0414087A
(pt)
|
2003-09-05 |
2006-10-31 |
Neurogen Corp |
composto, métodos para tratar um distúrbio, para demostrar a presença de receptores de crf em amostras de célula ou tecido, e para inibir a ligação de crf a um receptor de crf1, composição farmacêutica, e, embalagem
|
|
US20050287665A1
(en)
*
|
2004-06-23 |
2005-12-29 |
Henrich Cheng |
Method for inducing neural differentiation
|
|
US20060052856A1
(en)
*
|
2004-09-08 |
2006-03-09 |
Kim Daniel H |
Stimulation components
|
|
WO2006133261A2
(en)
|
2005-06-06 |
2006-12-14 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
US20080194592A1
(en)
|
2005-08-23 |
2008-08-14 |
Intra-Cellular Therapies, Inc. |
Organic Compounds
|
|
JP5453086B2
(ja)
|
2006-06-06 |
2014-03-26 |
イントラ−セルラー・セラピーズ・インコーポレイテッド |
有機化合物
|
|
US20070286890A1
(en)
|
2006-06-07 |
2007-12-13 |
John Garnett Walt |
Eyelash applicator and method
|
|
US9198924B2
(en)
|
2006-11-13 |
2015-12-01 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
EP2089034A4
(en)
*
|
2006-12-05 |
2010-07-28 |
Intra Cellular Therapies Inc |
NEW USES
|
|
CN104370920A
(zh)
|
2007-12-06 |
2015-02-25 |
武田药品工业株式会社 |
有机化合物
|
|
WO2009073210A1
(en)
|
2007-12-06 |
2009-06-11 |
Intra-Cellular Therapies, Inc |
Organic compounds
|
|
BRPI0922700A2
(pt)
|
2008-12-06 |
2015-08-11 |
Intracellular Therapies Inc |
Compostos orgânicos
|
|
EA201170772A1
(ru)
|
2008-12-06 |
2012-03-30 |
Интра-Селлулар Терапиз, Инк. |
Органические соединения
|
|
WO2010065148A1
(en)
*
|
2008-12-06 |
2010-06-10 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
EA201170771A1
(ru)
|
2008-12-06 |
2012-01-30 |
Интра-Селлулар Терапиз, Инк. |
Органические соединения
|
|
JP5778582B2
(ja)
|
2008-12-06 |
2015-09-16 |
イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. |
有機化合物
|
|
MX2011005935A
(es)
|
2008-12-06 |
2011-12-16 |
Intra Cellular Therapies Inc |
Compuestos organicos.
|
|
EP2400970A4
(en)
*
|
2009-02-25 |
2012-07-18 |
Intra Cellular Therapies Inc |
PDE-1-HEMMER FOR EYE DRESSING
|
|
US9468637B2
(en)
|
2009-05-13 |
2016-10-18 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
JP2013507360A
(ja)
|
2009-10-08 |
2013-03-04 |
イントラ−セルラー・セラピーズ・インコーポレイテッド |
ホスホジエステラーゼ1−標的トレーサーおよび方法
|
|
RU2591194C2
(ru)
|
2010-04-22 |
2016-07-10 |
Интра-Селлулар Терапиз, Инк. |
Органические соединения
|
|
TW201206937A
(en)
|
2010-05-31 |
2012-02-16 |
Intra Cellular Therapies Inc |
Organic compounds
|
|
US9371327B2
(en)
|
2010-05-31 |
2016-06-21 |
Intra-Cellular Therapies, Inc. |
PDE1 inhibitor compounds
|
|
US9763948B2
(en)
|
2010-05-31 |
2017-09-19 |
Intra-Cellular Therapies, Inc. |
PDE1 inhibitory compounds and methods
|
|
US9434730B2
(en)
|
2010-05-31 |
2016-09-06 |
Intra-Cellular Therapies, Inc. |
PDE1 inhibitor compounds
|
|
WO2012171016A1
(en)
*
|
2011-06-10 |
2012-12-13 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
CA2845039A1
(en)
*
|
2011-08-18 |
2013-02-21 |
Shire Ag |
Combinations of a 5-ht4 receptor agonist and a pde4 inhibitor for use in therapy
|
|
AR091507A1
(es)
*
|
2012-06-21 |
2015-02-11 |
Intra Cellular Therapies Inc |
SALES DE (6aR,9aS)-5,6a,7,8,9,9a-HEXAHIDRO-5-METIL-3-(FENILAMINO)-2-((4-(6-FLUOROPIRIDIN-2-IL)FENIL)METIL)-CICLOPENT[4,5]IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(2H)-ONA
|
|
US9598426B2
(en)
|
2013-03-15 |
2017-03-21 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
US9545406B2
(en)
|
2013-03-15 |
2017-01-17 |
Intra-Cellular Therapies, Inc. |
Method of treating a CNS injury with a PDE1 inhibitor
|
|
EP3970719A1
(en)
|
2016-09-12 |
2022-03-23 |
Intra-Cellular Therapies, Inc. |
Pde1 inhibitor for use in a method of treatment or prophylaxis of inflammation and/or an inflammatory disease or disorder
|