JP2017518316A5 - - Google Patents
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- JP2017518316A5 JP2017518316A5 JP2016571246A JP2016571246A JP2017518316A5 JP 2017518316 A5 JP2017518316 A5 JP 2017518316A5 JP 2016571246 A JP2016571246 A JP 2016571246A JP 2016571246 A JP2016571246 A JP 2016571246A JP 2017518316 A5 JP2017518316 A5 JP 2017518316A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- complement
- seq
- acid sequence
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000623 proteins and genes Proteins 0.000 claims description 30
- 102000004169 proteins and genes Human genes 0.000 claims description 29
- 239000003814 drug Substances 0.000 claims description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 230000024203 complement activation Effects 0.000 claims description 13
- 102100031506 Complement C5 Human genes 0.000 claims description 11
- 108010028773 Complement C5 Proteins 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 11
- 230000000295 complement effect Effects 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 8
- 230000001404 mediated effect Effects 0.000 claims description 8
- 208000035913 Atypical hemolytic uremic syndrome Diseases 0.000 claims description 7
- 208000009329 Graft vs Host Disease Diseases 0.000 claims description 7
- 208000024908 graft versus host disease Diseases 0.000 claims description 7
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 claims description 6
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 claims description 6
- 208000035475 disorder Diseases 0.000 claims description 6
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 claims description 6
- 102000004856 Lectins Human genes 0.000 claims description 4
- 108090001090 Lectins Proteins 0.000 claims description 4
- 201000007023 Thrombotic Thrombocytopenic Purpura Diseases 0.000 claims description 4
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 4
- 229960002224 eculizumab Drugs 0.000 claims description 4
- 239000002523 lectin Substances 0.000 claims description 4
- 208000002780 macular degeneration Diseases 0.000 claims description 4
- 206010043561 Thrombocytopenic purpura Diseases 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 230000004044 response Effects 0.000 claims description 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 2
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 2
- 206010019860 Hereditary angioedema Diseases 0.000 claims description 2
- 208000023105 Huntington disease Diseases 0.000 claims description 2
- 208000034486 Multi-organ failure Diseases 0.000 claims description 2
- 208000010718 Multiple Organ Failure Diseases 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- 206010033647 Pancreatitis acute Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 206010063837 Reperfusion injury Diseases 0.000 claims description 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims description 2
- 206010040070 Septic Shock Diseases 0.000 claims description 2
- 208000006011 Stroke Diseases 0.000 claims description 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 2
- 201000003229 acute pancreatitis Diseases 0.000 claims description 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims description 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 238000001631 haemodialysis Methods 0.000 claims description 2
- 230000000322 hemodialysis Effects 0.000 claims description 2
- 208000007475 hemolytic anemia Diseases 0.000 claims description 2
- 206010022000 influenza Diseases 0.000 claims description 2
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims description 2
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 206010028417 myasthenia gravis Diseases 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 2
- 102000054765 polymorphisms of proteins Human genes 0.000 claims description 2
- 208000023504 respiratory system disease Diseases 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 102200094439 rs373359894 Human genes 0.000 claims description 2
- 102200094440 rs56040400 Human genes 0.000 claims description 2
- 230000036303 septic shock Effects 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 2
- 230000009529 traumatic brain injury Effects 0.000 claims description 2
- 230000002792 vascular Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 13
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 238000012252 genetic analysis Methods 0.000 claims 2
- 102000016574 Complement C3-C5 Convertases Human genes 0.000 claims 1
- 108010067641 Complement C3-C5 Convertases Proteins 0.000 claims 1
- 108010078546 Complement C5a Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 101100440311 Homo sapiens C5 gene Proteins 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000008482 dysregulation Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 201000001505 hemoglobinuria Diseases 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000001314 paroxysmal effect Effects 0.000 description 1
- 208000027232 peripheral nervous system disease Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1410116.6A GB201410116D0 (en) | 2014-06-06 | 2014-06-06 | Method of treatment |
| GB1410116.6 | 2014-06-06 | ||
| PCT/EP2015/062742 WO2015185760A1 (en) | 2014-06-06 | 2015-06-08 | Ornithodoros moubata complement inhibitor for use in the treatment of complement-mediated diseases in patients with c5 polymorphism |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518316A JP2017518316A (ja) | 2017-07-06 |
| JP2017518316A5 true JP2017518316A5 (enExample) | 2019-11-14 |
| JP7045133B2 JP7045133B2 (ja) | 2022-03-31 |
Family
ID=51266841
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016571246A Active JP7045133B2 (ja) | 2014-06-06 | 2015-06-08 | Ｃ５多型を有する患者における補体媒介性疾患の治療に使用するためのオルニトドロス・モウバタ（Ｏｒｎｉｔｈｏｄｏｒｏｓ ｍｏｕｂａｔａ）補体阻害剤 |
| JP2017563314A Expired - Fee Related JP6767396B2 (ja) | 2014-06-06 | 2015-12-09 | 急性移植片対宿主病の治療に使用するためのオルニトドロス・モウバタ補体阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017563314A Expired - Fee Related JP6767396B2 (ja) | 2014-06-06 | 2015-12-09 | 急性移植片対宿主病の治療に使用するためのオルニトドロス・モウバタ補体阻害剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11052129B2 (enExample) |
| EP (1) | EP3151851B1 (enExample) |
| JP (2) | JP7045133B2 (enExample) |
| KR (1) | KR102439717B1 (enExample) |
| CN (1) | CN106659767B (enExample) |
| AU (1) | AU2015270396B2 (enExample) |
| BR (1) | BR112016028446A2 (enExample) |
| CA (1) | CA2951175A1 (enExample) |
| DK (2) | DK3151851T3 (enExample) |
| ES (2) | ES2906630T3 (enExample) |
| GB (1) | GB201410116D0 (enExample) |
| IL (1) | IL249237B (enExample) |
| MX (1) | MX382757B (enExample) |
| PL (2) | PL3151851T3 (enExample) |
| RU (1) | RU2700932C2 (enExample) |
| WO (1) | WO2015185760A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3302519B1 (en) * | 2015-06-08 | 2021-12-01 | Volution Immuno Pharmaceuticals SA | Ornithodoros moubata complement inhibitor for use in the treatment of acute graft versus host disease |
| GB201410116D0 (en) | 2014-06-06 | 2014-07-23 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
| GB201602802D0 (en) * | 2016-02-17 | 2016-03-30 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
| CN109328197A (zh) * | 2016-06-07 | 2019-02-12 | 诺华股份有限公司 | 用于治疗具有补体c5多态性的患者的抗c5抗体 |
| SE540754C2 (en) * | 2016-11-30 | 2018-10-30 | Ikea Supply Ag | Molding of fiber blanks into three-dimensional fiber block |
| AU2018253960A1 (en) * | 2017-04-21 | 2019-10-31 | Volution Immuno Pharmaceuticals Sa | Coversin for the treatment of cicatrising eye inflammatory disorders |
| US11730792B2 (en) | 2017-04-21 | 2023-08-22 | Volution Immuno Pharmaceuticals Sa | Coversin (OmCI) for the treatment of autoimmune blistering diseases: bullous pemphigoid (BP) and epidermolysis bullosa acquisita (EBA) |
| WO2019186084A1 (en) * | 2018-03-26 | 2019-10-03 | The University Of Liverpool | Anti-complement histones |
| US20220047673A1 (en) * | 2018-09-10 | 2022-02-17 | Volution Immuno Pharmaceuticals Sa | Coversin for Use in the Treatment of Rheumatic Diseases |
| GB201905810D0 (en) * | 2019-04-25 | 2019-06-05 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
| GB202218084D0 (en) | 2022-12-01 | 2023-01-18 | Volution Immuno Pharmaceuticals Sa | Fusion proteins |
| GB202408081D0 (en) | 2024-06-06 | 2024-07-24 | Volution Immuno Pharmaceuticals Sa | Methods of removing impurities |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050054033A9 (en) * | 1995-08-30 | 2005-03-10 | Human Genome Sciences, Inc. | Methods and compositions for treating and preventing infection using human interferon regulatory factor 3 |
| ES2324993T3 (es) | 2003-06-02 | 2009-08-21 | Varleigh Limited | Inhibidores del complemento de garrapatas. |
| GB0312619D0 (en) * | 2003-06-02 | 2003-07-09 | Evolutec Ltd | Complement inhibitors |
| GB0518443D0 (en) | 2005-09-09 | 2005-10-19 | Evolutec Ltd | Method of treating myasthenia gravis |
| US20100105611A1 (en) * | 2006-09-08 | 2010-04-29 | John Hamer | Method of treating respiratory disorders |
| GB0617734D0 (en) * | 2006-09-08 | 2006-10-18 | Evolutec Ltd | Method of treating peripheral nerve disorders |
| GB0802116D0 (en) | 2008-02-05 | 2008-03-12 | Natural Enviromental Res Counc | Treatment |
| GB0906779D0 (en) | 2009-04-20 | 2009-06-03 | Natural Environment Res Council | Composition |
| EP2521562B1 (en) | 2010-01-08 | 2019-09-18 | Volution Immuno Pharmaceuticals SA | Ev576 for use in the treatment of viral infections of the respiratory tract |
| TW201418707A (zh) | 2012-09-21 | 2014-05-16 | Alexion Pharma Inc | 補體組分ｃ５拮抗劑之篩選分析 |
| GB201410116D0 (en) * | 2014-06-06 | 2014-07-23 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
| US11730792B2 (en) | 2017-04-21 | 2023-08-22 | Volution Immuno Pharmaceuticals Sa | Coversin (OmCI) for the treatment of autoimmune blistering diseases: bullous pemphigoid (BP) and epidermolysis bullosa acquisita (EBA) |
-
2014
- 2014-06-06 GB GBGB1410116.6A patent/GB201410116D0/en not_active Ceased
-
2015
- 2015-06-08 KR KR1020167036998A patent/KR102439717B1/ko active Active
- 2015-06-08 DK DK15728491.0T patent/DK3151851T3/da active
- 2015-06-08 CN CN201580040646.5A patent/CN106659767B/zh active Active
- 2015-06-08 RU RU2016151179A patent/RU2700932C2/ru active
- 2015-06-08 CA CA2951175A patent/CA2951175A1/en active Pending
- 2015-06-08 MX MX2016016139A patent/MX382757B/es unknown
- 2015-06-08 JP JP2016571246A patent/JP7045133B2/ja active Active
- 2015-06-08 PL PL15728491T patent/PL3151851T3/pl unknown
- 2015-06-08 EP EP15728491.0A patent/EP3151851B1/en active Active
- 2015-06-08 ES ES15728491T patent/ES2906630T3/es active Active
- 2015-06-08 BR BR112016028446A patent/BR112016028446A2/pt active Search and Examination
- 2015-06-08 AU AU2015270396A patent/AU2015270396B2/en not_active Ceased
- 2015-06-08 US US15/315,136 patent/US11052129B2/en active Active
- 2015-06-08 WO PCT/EP2015/062742 patent/WO2015185760A1/en not_active Ceased
- 2015-12-09 DK DK15807907.9T patent/DK3302519T3/da active
- 2015-12-09 PL PL15807907T patent/PL3302519T3/pl unknown
- 2015-12-09 US US15/577,906 patent/US20180193417A1/en not_active Abandoned
- 2015-12-09 JP JP2017563314A patent/JP6767396B2/ja not_active Expired - Fee Related
- 2015-12-09 ES ES15807907T patent/ES2906632T3/es active Active
-
2016
- 2016-11-27 IL IL249237A patent/IL249237B/en active IP Right Grant
-
2021
- 2021-05-28 US US17/333,675 patent/US20210283221A1/en not_active Abandoned
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