JP2020094010A - 外用組成物 - Google Patents
外用組成物 Download PDFInfo
- Publication number
- JP2020094010A JP2020094010A JP2018233993A JP2018233993A JP2020094010A JP 2020094010 A JP2020094010 A JP 2020094010A JP 2018233993 A JP2018233993 A JP 2018233993A JP 2018233993 A JP2018233993 A JP 2018233993A JP 2020094010 A JP2020094010 A JP 2020094010A
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Abstract
Description
(1)(a)ヘパリン類似物質、(b)プラセンタエキス、及び(c)無機電解質、及び(d)水を含有することを特徴とする外用組成物、
(2)(c)無機電解質が、ナトリウム塩、マグネシウム塩、カルシウム塩、及びカリウム塩からなる群から選択される少なくとも1種である、(1)に記載の外用組成物、
(3)(c)無機電解質が、塩化ナトリウム、塩化マグネシウム、塩化カルシウム、塩化カリウム、及び硫酸マグネシウムからなる群から選択される少なくとも1種である、(1)又は(2)に記載の外用組成物、
(4)剤形が、ローション、クリーム、乳液、ゲル、又はパックである、(1)〜(3)のいずれかに記載の外用組成物、
(5)外用組成物が、化粧品、医薬部外品又は医薬品である、(1)〜(4)のいずれかに記載の外用組成物、である。
本発明の外用組成物中におけるプラセンタエキスの由来としては、例えばヒト、ウシ、ブタ、ウマ、ヒツジなどが挙げられるが、好ましくはブタである。また、プラセンタエキスとして市販されている商品(例えばビオカタライザープラセンタAPF(SW)(M−PE−APF))を使用してもよい。
本発明における電解質は、塩化ナトリウム、塩化マグネシウム、塩化カルシウム、塩化カリウム、硫酸マグネシウム等が挙げられ、この中でも塩化ナトリウム、塩化マグネシウム、塩化カルシウム、硫酸マグネシウムが特に好ましい。本発明の外用組成物中における電解質の含有量は0.01〜10w/w%が好ましく、0.1〜5w/w%がより好ましい。また、ヘパリン類似物質1質量部に対して0.001〜1000質量部が好ましく、0.01〜500質量部がより好ましい。
以下表1、2に示す処方に従い、ヘパリン類似物質、プラセンタエキス(BIODELL BIOCHEMICAL S.A.製のビオカタライザープラセンタAPF(SW)(M−PE−APF))、電解質を精製水に均一に溶解し、実施例1〜8及び比較例1〜5の外用組成物を得た。
実施例1〜7、比較例1〜4の各外用組成物5mLを10mLのスクリュー管に充てんし、65℃2週間保管し、調製直後からのにおいの変化を3人のパネラーが官能評価で確認した。
(においの評価基準)
○:においの変化がない
×:においの変化がある(不快臭あり)
実施例1〜5、8、比較例1、5の各外用組成物5mLを10mLのスクリュー管に充てんし、65℃2週間保管した。調製直後と65℃2週間保管品を波長400nmで吸光度を測定し、着色を評価した。
(処方例)
以下表3に示す処方に従い、各成分を水に均一に溶解し、外用組成物を得た。なお、以下処方例1の数値は全て質量%を意味するものとする。
*2:テトラ2−ヘキシルデカン酸アスコルビル含有組成物は、商品名「SBG-24」(山川貿易株式会社製)を用いた。
Claims (5)
- (a)ヘパリン類似物質、(b)プラセンタエキス、(c)無機電解質、及び(d)水を含有することを特徴とする外用組成物。
- (c)無機電解質が、ナトリウム塩、マグネシウム塩、カルシウム塩、及びカリウム塩からなる群から選択される少なくとも1種である、請求項1に記載の外用組成物。
- (c)無機電解質が、塩化ナトリウム、塩化マグネシウム、塩化カルシウム、塩化カリウム、及び硫酸マグネシウムからなる群から選択される少なくとも1種である、請求項1又は2に記載の外用組成物。
- 剤形が、ローション、クリーム、乳液、ゲル、又はパックである、請求項1〜3のいずれかに記載の外用組成物。
- 外用組成物が、化粧品、医薬部外品、又は医薬品である、請求項1〜4のいずれかに記載の外用組成物。
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0725742A (ja) * | 1993-07-15 | 1995-01-27 | Kao Corp | 美白化粧料 |
JPH09309721A (ja) * | 1996-05-20 | 1997-12-02 | Co-Op Chem Co Ltd | 有機粘土 |
JP2000204014A (ja) * | 1999-01-11 | 2000-07-25 | Pola Chem Ind Inc | 敏感肌用の化粧料 |
JP2001089381A (ja) * | 1999-09-16 | 2001-04-03 | Taisho Pharmaceut Co Ltd | 皮膚外用剤 |
JP2012036174A (ja) * | 2010-07-12 | 2012-02-23 | Rohto Pharmaceutical Co Ltd | 外用組成物 |
JP2017057145A (ja) * | 2015-09-14 | 2017-03-23 | 小林製薬株式会社 | 外用組成物 |
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Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0725742A (ja) * | 1993-07-15 | 1995-01-27 | Kao Corp | 美白化粧料 |
JPH09309721A (ja) * | 1996-05-20 | 1997-12-02 | Co-Op Chem Co Ltd | 有機粘土 |
JP2000204014A (ja) * | 1999-01-11 | 2000-07-25 | Pola Chem Ind Inc | 敏感肌用の化粧料 |
JP2001089381A (ja) * | 1999-09-16 | 2001-04-03 | Taisho Pharmaceut Co Ltd | 皮膚外用剤 |
JP2012036174A (ja) * | 2010-07-12 | 2012-02-23 | Rohto Pharmaceutical Co Ltd | 外用組成物 |
JP2017057145A (ja) * | 2015-09-14 | 2017-03-23 | 小林製薬株式会社 | 外用組成物 |
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