JP2020050636A - Acarid repellent and method for repelling acarid using the same - Google Patents

Abstract

To provide a repellent that utilizes a component included in a natural product, has sufficient repelling efficacy against acarid, has high safety to human body and can be easily used even in general household.SOLUTION: The acarid repellent contains as an active ingredient an isothiocyanate compound represented by formula (1) and a method for repelling acarid utilizes the repellent. (In the formula, R represents a phenyl group or a 1-3C alkyl or alkylene group which may be branched).SELECTED DRAWING: None

Description

  The present invention relates to a repellent for mites and a method for repelling mites, and more particularly to a repellent for mites and a method for repelling mites against pests of the order Arachnida, such as Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Acarina mites.

  Conventionally, various repellents for mites have been proposed, and in recent years, pyrethroid compounds and the like have been widely used as mite repellent components.

  It is also known that highly safe natural ingredients and food ingredients are used as anti-mite agents including repellents. For example, among the acaricides obtained by extracting a cedar essential oil obtained by steam distillation of cedar branches and leaves with a water-containing polar organic solvent (Patent Document 1), and essential oils extracted from cypress, Taiwan cypress, cedar, hiba branches and roots BACKGROUND ART A mite control agent for sanitary pests containing at least one or a mixture thereof as an active ingredient is known (Patent Document 2).

  However, the above-mentioned components have a problem that the effect on mites is weak and sufficient repellency cannot be obtained. Therefore, there is a need for a tick repellent having a higher degree of safety, which has a higher mite repellent effect and can be easily used in ordinary households.

JP-A-6-239714 JP-A-1-193204

  Accordingly, an object of the present invention is to provide a repellent that uses components contained in natural products, has sufficient repellent effect against mites, is highly safe for the human body, and can be easily used even in ordinary households. And

  The present inventors have conducted intensive research on the activity of natural components for mites to achieve the above-mentioned problems, and found that a specific isothiocyanate compound exhibits an excellent repellent effect on mites, The present invention has been completed.

That is, the present invention provides the following general formula (1)
(Wherein, R represents a phenyl group or an optionally branched alkyl group or alkylene group having 1 to 3 carbon atoms)
A mite repellent containing an isothiocyanate compound represented by the following formula as an active ingredient.

  Further, the present invention is a method for repelling mites, comprising using the above-mentioned mite repellent to release an isocyanate compound into the environment.

  Further, the present invention is a method for repelling a tick using the above-mentioned mite repellent to bring an isocyanate compound into contact with a tick to act.

  The repellent for mites of the present invention is a pest of the order of the spider Acarina, for example, Dermatophagoides farinae, Dermatophagoides farinae, against mites such as Dermatophagoides farinae, and has an excellent repellent effect, because it is a component in natural products, it is extremely safe It is expensive. Therefore, it can be easily used in ordinary households, and can effectively prevent and eliminate damage caused by mites.

FIG. 2 is a diagram schematically illustrating a cross section of a test apparatus used in Example 1. FIG. 2 is a diagram schematically illustrating a plane of a test apparatus used in the first embodiment. FIG. 8 is a diagram schematically illustrating a cross section of a practical test device used in Example 2. FIG. 7 is a diagram schematically illustrating a plane of a practical test device used in Example 2.

  The repellent for mites of the present invention (hereinafter referred to as “repellent”) contains an isothiocyanate compound of the following formula (1) as an active ingredient.

(Wherein, R has the meaning described above)

  Specific examples of the isothiocyanate compound (1) include methyl isothiocyanate, allyl isothiocyanate, phenyl isothiocyanate, ethyl isothiocyanate, vinyl isothiocyanate, propyl isothiocyanate, and isopropyl isothiocyanate. Species or a mixture of two or more can be used.

  These isothiocyanate compounds (1) are already known compounds, and may be used in the form of a synthetic product. Alternatively, a natural extract or a natural extract containing the isothiocyanate compound (1) may be used. it can.

Of these, for example,
Is a compound obtained by extracting from a natural plant such as wasabi or mustard. More specifically, for example, for mustard, crushed with a hydraulic machine to remove fatty oils, crushed and immersed in hot water for several hours, then steam distilled, and the distillate oil was collected. Is obtained by

  The repellent of the present invention may be a form in which the above isothiocyanate compound (1) is used as a single active ingredient, or a form in which a suitable optional ingredient is further combined and used as a preparation by a conventional method. Is also good.

  As described later, the repellent of the present invention is used by a method of spontaneously evaporating at room temperature, a method of forcibly evaporating, a method of contacting with a tick and acting, and the like. The isothiocyanate compound (1) may be blended in the repellent.

  For example, in any of the method of naturally evaporating at room temperature and the method of forcibly evaporating, the amount of the isothiocyanate compound (1) in the environment is about 10 to 15 mg / day in 50 L during the use period. The repellent may be designed so that the amount can be maintained.

  In addition, if it is a method of contacting and acting on mites, it can be applied directly to places where mites inhabit, such as bedding such as futons, pillows, blankets, tatami mats, carpets, carpets, sofas, cushions, stuffed animals, clothing, etc. What is necessary is just to spray using a sprayer, such as a pump spray or an aerosol.

  The dosage form of the repellent of the present invention is not particularly limited, and may be in the form of a liquid preparation, a gel preparation, a solid preparation, or the like, and an optional component corresponding thereto may be used.

  One of the dosage forms of the repellent of the present invention is a liquid, and a solvent is used to prepare the liquid. The solvent used is not particularly limited, and a conventionally known liquid carrier can be used. However, it is preferable to use a solvent that is highly safe for the body.

  Specific examples of the solvent include water such as deionized water and distilled water; hydrocarbon compounds such as hexane, paraffin, and isoparaffin; methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, and 2-butanol. Alkyl alcohols such as, 2-methyl-1-propanol, 2-methyl-2-propanol, pentanol, hexanol, heptanol, octanol, nonanol, decanol; alkenyl alcohols such as allyl alcohol; aromatic rings such as benzyl alcohol Phenols such as eugenol; halogenated hydrocarbon compounds such as chloroform; ether compounds such as diethyl ether and diethylene glycol diethyl ether; ketone compounds such as acetone; fatty acid compounds such as acetic acid and oleic acid. Ester compounds such as acetate, propionate and benzoate; glycol compounds such as ethylene glycol and propylene glycol; glycol ether compounds such as 2-phenoxyethanol and 3-methyl-3-methoxybutanol; sesame oil and linol And vegetable oils such as oil and salad oil. These can be used alone or in combination of two or more.

  The amount of these solvents used in the repellent is preferably 0.1 to 99.9 mass / mass%, and more preferably 1 to 99 mass / mass%, based on the entire repellent. It is particularly preferable to mix them in such a manner. More preferably, the content is 10 to 90% by mass.

  In preparing the liquid preparation, a surfactant may be added as necessary. Examples of the surfactant that can be used include conventionally known surfactants such as a cationic surfactant, an anionic surfactant, an amphoteric surfactant, and a nonionic surfactant. They can be used alone or in combination of two or more.

  As another dosage form of the repellent of the present invention, a solid or sheet-like solid agent in which the above-mentioned liquid agent is impregnated and supported on a suitable carrier can be exemplified. The carrier to be supported is not particularly limited, and examples thereof include wood, paper, woven fabric, nonwoven fabric, silica, talc, activated carbon, silica gel, zeolite, cellulose beads, ceramic, and resin pellets such as polypropylene.

  Further, as another dosage form of the repellent of the present invention, there can be mentioned a gel prepared by gelling the above-mentioned liquid with a gelling agent. Known gelling agents include, for example, carrageenan, gellan gum, agar, gelatin, guar gum, pectin, locust bean gum, xanthan gum, sodium alginate, cellulose derivatives, dibenzylidene-D-sorbitol, and hydroxypropylated gelling agents. Examples thereof include polysaccharides, superabsorbent resins such as inulin stearate and sodium acrylate, and aluminum octylate. These can be used alone or in combination of two or more.

  As a preferred method of using the repellent of the present invention obtained as described above, a method of releasing the repellent of the present invention into the environment and using the same is exemplified.

  Examples of the method of releasing the compound into the environment include a method of naturally evaporating the isothiocyanate compound (1), which is an active ingredient, from the repellent of the present invention such as a liquid, a solid, and a gel at room temperature, and a method of forcibly releasing the compound. To evaporate. Examples of the method of forcibly evaporating include evaporation by heating, evaporation by air blowing, and evaporation by fumigation. Further, a method of spraying or the like may be used as a method of releasing into the environment.

  Among the above-mentioned forced transpiration methods, as a transpiration method by heating, for example, as disclosed in Japanese Utility Model Laid-Open No. 2-78077, etc. A repellent is impregnated in a heating evaporator that is made to evaporate by heating with a heating heater, or a mat-like impregnating body as disclosed in Japanese Utility Model Application Laid-Open No. 1-116072, and the mat is heated. A method using a heating evaporator or the like which is allowed to evaporate by being placed on a heater can be used.

  The transpiration by blowing is performed, for example, by providing a medicine holding body and a blower as disclosed in Japanese Patent Application Laid-Open No. H11-308955, and bringing the medicine holding body into contact with an air current generated by the blower to thereby prevent the repellent. Using a fan-type repelling device or the like that discharges into the environment from the discharge port.

  Further, the evaporation by fumigation is carried out, for example, by disposing an organic foaming agent such as an azo compound such as azodicarbonamide, a nitroso compound or a hydrazide compound in a container having an upper opening as disclosed in Japanese Utility Model Application Laid-Open No. 54-148267. A fumigation device or the like that evaporates the repellent by nitrogen gas, carbon dioxide gas, etc. generated by decomposing the foaming agent by heating the bottom of the storage chamber by heating means, and forming a storage chamber containing the repellent Can be done.

  Furthermore, spraying can be performed by a method of spraying a liquid agent using a sprayer or an aerosol using a suitable propellant. When a spray is used, the above-described liquid and a spraying means such as a trigger spray and an atomizer may be combined. When an aerosol is used, the above-mentioned liquid, an aerosol carrier such as LPG and isopentane, and an aerosol spraying means such as an aerosol can may be combined.

  Another preferable method of using the repellent of the present invention is a method in which the repellent of the present invention is brought into contact with a tick in a liquid or solid state to act. In this case, the repellent effect can be exhibited by the contact of the mites with the installed repellent.

  The repellent of the present invention is an active ingredient by installing and applying it in a storeroom, a closet, a closet, a closet, a costume case, a clothing storage bag, a futon storage bag, a room such as a living room, a bedroom, and a front door. Can be effectively repelled by being released into the environment or by contact with the mites. Further, the repellent of the present invention may be applied by directly spraying, spraying, applying, or the like to an object such as a tatami mat, a carpet, a carpet, a floor, a futon, a pillow, a sofa, and clothing in which mites inhabit.

  The repellent of the present invention may contain other conventionally known mite control components, whereby a more excellent repellent effect can be exhibited.

  Examples of these other mite controlling components include pyrethroid-based compounds such as empentrin, transfluthrin, allethrin, phenothrin, profluthrin, metofluthrin, and eminence; organic phosphorus agents such as dichlorvos, diazinon, fenitrothion, and malathion; -Diethyl-m-toluamide (DEET), dimethyl phthalate, dibutyl phthalate, 2-ethyl-1,3-hexanediol, di-n-propyl isosine comelonate, p-dichlorobenzene, di-n-butyl succinate, Curane-3,4-diol, 1-methylpropyl 2- (2-hydroxyethyl) -1-piperidinecarboxylate, isopropyl myristate, isobornyl thiocyanate, diphenyl, diphenylmethane, dibenzyl, ben Phenyl ether, benzyl phenyl ethyl ether, benzophenone, benzyl phenyl ketone, dibenzyl ketone, benzal acetophenone, β-phenylethyl benzoate, γ-phenylpropyl benzoate, phenyl phenylacetate, benzyl phenyl acetate, β-phenylethyl phenyl Acetate, phenyl cinnamate, benzyl cinnamate, β-phenylethyl cinnamate, β-phenylpropyl cinnamate, cinnamyl cinnamate, diphenylcarbinol, phenylbenzylcarbinol, dibenzylcarbinol, n-amylbenzoate, isoamylbenzoate , Hexyl benzoate, heptyl benzoate, octyl benzoate, nonyl benzoate, cis-3-hexenyl benzoate n-amyl salicylate, iso-amyl salicylate, hexyl salicylate, cis-3-hexenyl salicylate, benzyl propionate, benzyl-n-butyrate, benzoluiso-butyrate, benzyl-n-valerate, benzyl isovalerate, benzyl cap Compounds such as proate, benzylheptanoate, benzylcaprylate, pendyl danilate, eugenol, methyl eugenol, isoeugenol; α, β-pinene, α, β-terpinol, limonene, citronellal, linalool, citral, etc. Terpene compounds; menthol, vetiver oil, patchouli oil, clove oil, cedar, cypress, hinoki cypress, cypress essential oil, and other essential oils; pressed liquids, extracts or distillates of plants belonging to the genus Firaceae. , One of these may be used alone, or two or more may be used in combination.

  As a preferred embodiment of the mite repellent of the present invention, a combination with a squeezed liquid, extract or distillate of a plant belonging to the genus Pinaceae, disclosed in JP-A-2017-39677, is exemplified. The method for producing the squeezed liquid, extract or distillate is described in the patent publication. In this embodiment, the amount of the squeezed liquid or the like relative to 1 part by mass of the isothiocyanate compound (1) is preferably about 0.01 to 10 parts by mass, particularly preferably 0.1 to 1 part by mass.

  The repellent of the present invention described above exhibits an excellent repellent effect against insects of the order Acarina such as Dermatophagoides farinae, Dermatophagoides pteronyssinus, Dermatophagoides farinae, Dermatophagoides farinae, ticks, house dust mites, house dust mites, and southern house mites. Furthermore, the squeezed solution, extract or distillate of the above-mentioned plants belonging to the genus Pinaceae also exhibits insecticidal, egg-laying inhibition and egg hatching inhibitory effects against these mites. Has a better mite control effect.

  Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

Example 1
Repellent test for Dermatophagoides farinae:
According to JIS L 1920 "Testing method for mite-proofing performance of textile products", breeding of mite, adjustment of density and the like were performed, and repellency test was performed with the apparatus shown in Figs.

  That is, the isothiocyanate compounds shown in Table 1 below were applied to filter paper having a diameter of 40 mm to obtain test pieces. The test piece (23) was placed in a small glass Petri dish (22) having a diameter of 45 mm and a height of 17 mm, and 0.05 g of the recruiting feed (24) was placed at the center thereof. A tick culture medium (21) containing about 10,000 live Dermatophagoides farinae (mixed powder feed for breeding medium and dry yeast at a mass ratio of 1: 1) is uniformly distributed on a large plastic petri dish (20) having a diameter of 90 mm and a height of 14 mm. And the small glass Petri dish (22) was placed at the center. This was accommodated in a plastic container (25) containing a saturated saline solution (26) for humidity adjustment.

  The container was covered and sealed, and placed in a room at a temperature of 25 ° C. ± 1 ° C. After standing for 20 hours from the setting, the total number of living mites in the test piece and the attracting medium was counted. This test was repeated three times using a blank using filter paper without chemical treatment as a blank. The total count of the three tests was determined, and the repellency was determined by the following equation. Table 2 shows the results.

  From the above results, it was shown that all the products of the present invention have a high repellent effect against Dermatophagoides farinae.

Example 2
Repellent test for Acarina mites:
A repellency test was conducted in the same manner as in Example 1 except that Dermatophagoides farinae was replaced with Dermatophagoides farinae. Table 3 shows the results.

  From the above results, it was shown that the product 2 of the present invention also has a high repellent effect against Acarina acarina.

Example 3
Practical test for repelling Dermatophagoides farinae:
An evasion practical test was performed using the apparatus shown in FIGS. That is, a 50-L height drawer (25 mm) (commercial name: Fitz case (Long L), manufactured by Tenma Co., width 400 mm, depth 740 mm, height 230 mm) with a 50-L plastic drawer An opening (33) of 275 mm was provided, and a commercially available allyl isothiocyanate preparation (Wasaace PS180, manufactured by Rengo Co., Ltd.) was placed therein as a test piece (23), and the sample was volatilized for one week.

  500 mg of the attractant feed (24) placed in a small glass dish of 45 mm in diameter and 17 mm in height was put in the costume case, and a plastic tub having an upper surface opening together with the tick culture medium (equivalent to about 10,000 heads) used in Example 1. (31) It was placed in (664 mm in width, 1024 mm in depth, and 200 mm in height), and a double-sided tape was applied to the upper end of the opening.

  The plastic tub was placed in a vinyl pool (32) containing a saturated saline solution (26) having a diameter of 122 cm and a height of 25 cm, left at a temperature of 25 ° C. and a humidity of 60% for 120 hours, and the number of living mites in the attracted feed was counted. . A blank in which no drug was placed in the costume case was used as a blank, and the repellency was calculated by the following equation. Table 2 shows the results.

  From the above results, it was confirmed that the allyl isothiocyanate preparation had an excellent repellent action against Dermatophagoides farinae.

Formulation Example 1
Gel mite repellent:
10 g of allyl isothiocyanate was mixed with 85 g of isoparaffin, 5 g of aluminum octylate was further added, and the mixture was heated to 60 ° C. and stirred. This was filled into a container having a length of 35 mm × a width of 35 mm × a height of 75 mm and allowed to stand at room temperature for 3 hours to obtain a gel-like mite repellent.

Preparation Example 2
Room temperature volatile mite repellent:
0.6 g of allyl isothiocyanate is impregnated into a pulp filter paper of 30 mm × 40 mm, which is stored in a plastic case (38 mm × 52 mm × 5 mm) having a ventilation hole of 9 mm × 22 mm and having air permeability. A repellent was prepared.

Preparation Example 3
Aerosol:
An aerosol was prepared by filling the following formulation into a commercially available 200 ml aerosol can.
Active ingredient: Allyl isothiocyanate 1ml
Solvent: ethanol 39.0ml
Propellant: LPG 30.0ml
Propellant: 30.0 ml of isopentane

Formulation Example 4
Spray agent:
The following formulation was stored in a commercially available 150 ml trigger container to prepare a spray.
Active ingredient: allyl isothiocyanate 0.1 g
Solvent: ethanol 10g
Spice 0.05g
Surfactant 0.1g
89.75 g of ion exchange water

Formulation Example 5
Fumigant:
10 g of allyl isothiocyanate, 55 g of azodicarbonamide and 35 g of talc were kneaded, granulated and dried according to a conventional method to prepare a fumigant.

Formulation Example 6
Heat evaporation agent:
100 mg of allyl isothiocyanate was impregnated into a pulp mat of 3 cm × 3 cm to obtain a heating evaporant. The substance evaporates the active ingredient by being brought into contact with a heater.

Formulation Example 7
Granular repellent:
50 g of pulp-made granular impregnated body (average particle size: 5 mm) was impregnated with 50 mL of allyl isothiocyanate, and placed in a breathable nonwoven bag to obtain a granular repellent.

Formulation Example 8
Room temperature volatile mite repellent:
0.5 g of allyl isothiocyanate and 0.01 g of empentrin were impregnated into 9.6 mm × 110 mm pulp filter paper. This was stored in a breathable plastic case (130 mm x 138 mm x 9.5 mm) provided with a vent hole of 88 mm x 100 mm to prepare a solid repellent.

Formulation Example 9
Sustained release mite repellent:
3 g of allyl isothiocyanate was placed in a plastic container (30 mm in diameter, 10 mm in depth) with an open top, and the opening was covered with a drug-permeable film to obtain a sustained-release mite repellent.

Usage example 1
When two room temperature volatile mite repellents obtained in Formulation Example 2 were put together with the clothes in a polyethylene garment storage bag (75 cm × 80 cm × 32 cm), the ticks did not adhere to the clothes for about one month.

Example 2
When two room-temperature volatilizable mite repellents obtained in Formulation Example 8 were put together with the bedding in a futon storage bag (150 cm × 100 cm) made of polyethylene, the mite did not stick to the bedding for about 6 months.

Usage example 3
When two room temperature volatile mite repellents obtained in Formulation Example 2 were put together with clothes in a 75 L (40 cm × 75 cm × 25 cm) costume case, no ticks were found on the clothes for about 3 months.

Example 4
When the mite repellent of the spray obtained in Formulation Example 4 was evenly sprayed on the clothes, the mites did not adhere to the clothes for about one week.

Usage example 5
When the aerosol tick repellent obtained in Formulation Example 3 was evenly sprayed on the carpet, no mite was attached to the carpet for about one month.

Usage example 6
When the sustained-release mite repellent obtained in Formulation Example 9 was placed in a 30-liter polypropylene storage container (355 mm x 472 mm x 253 mm) for food, no mites entered the storage container for about one year.

  The allyl isothiocyanate, which is an active ingredient of the repellent of the present invention, exhibits an excellent repellent effect against insects of the order Acarina, and is safe and highly stable to the human body. Therefore, the repellent of the present invention can be easily used in ordinary households and is highly useful.

20 large petri dish 21 mite culture medium 22 small petri dish 23 test piece 24 quoting feed 25… plastic container 26… saturated saline solution 30…… costume costume case 31… plastic tub 32…… Vinyl pool 33…… Opening

Claims (7)

The present invention provides the following general formula (1)
(Wherein, R represents a phenyl group or an optionally branched alkyl group or alkylene group having 1 to 3 carbon atoms)
A repellent for mites containing an isothiocyanate compound represented by the formula (1) as an active ingredient.   2. The repellent for mites according to claim 1, wherein the isothiocyanate compound is allyl isothiocyanate.   A method for repelling mites, comprising using the repellent according to claim 1 or 2 to release an isocyanate compound into the environment.   The method for repelling mites according to claim 3, wherein the release into the environment is performed by natural transpiration at room temperature.   4. The method for repelling mites according to claim 3, wherein the release into the environment is forcibly performed by transpiration by heating, transpiration by air blowing, or transpiration by fumigation.   The method for repelling mites according to claim 3, wherein the release into the environment is performed by spraying. A method for repelling mites, comprising using the repellent according to claim 1 or 2 to cause an isocyanate compound to act on the mites.