JPH09157116A - Miticidal agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a miticidal agent having low residual activity and suitable for indoor use by using a specific compound having high miticidal activity and low toxicity to human body and preferably adding a perfume consisting of a stimulating odor suppressing component to the agent. SOLUTION: This miticidal agent contains phenyl isothiocyanate as an active component. Since phenyl isothiocyanate has stimulating odor of WASABI (Japanese horseradish), it is preferable to use at least one kind of perfume selected from a susquiterpene compound, a natural essential oil containing a sesquiterpene compound, an alicyclic compound and an aromatic compound. The perfume is, e.g. cedrene, cedar wood oil, 4-(4-hydroxy-4-methylpentyl)-3- cyclohexene-1-carboxyaldehyde or phenylacetaldehyde glyceryl acetal. The compounding ratio of the perfume is preferably 1-10,000 pts.wt. based on 1 pt.wt. of phenyl isothiocyanate.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an anti-mitic agent. More specifically, the present invention relates to an anti-mitic agent having low residual property and suitable for indoor use.

[0002]

2. Description of the Related Art In recent years, it has been said that indoor dust mites (such as mites and dust mites) are allergens for bronchial asthma and atopic dermatitis, and the elimination of these mites becomes a serious problem. ing.

Conventionally, as an acaricide against mite and a growth inhibitor, an organophosphorus, carbamate or pyrethroid compound generally used as an insecticide has been used. It has also been proposed to use a substituted phenylisothiocyanate compound such as nitrophenylisothiocyanate as an anti-mite agent (Japanese Patent Publication No. 48-4).
523). As a method of using such an anti-mitic agent indoors, it is made to spray them on the surface or inside of a fold or carpet.

Further, as an indoor anti-mitic agent, one using an essential oil component of a cypress family (JP-A-4-13607) and one using an essential oil component such as cedar (JP-A-6-
239714).

[0005]

However, among the conventionally used anti-mitic agents, organic phosphorus compounds and carbamate compounds are highly toxic to the human body and are not suitable for use in a sealed space such as indoors. Not suitable.

Pyrethroid compounds are less toxic than organic phosphorus compounds or carbamate compounds,
Insufficient effect against indoor dust mites, especially dust mites.

Further, a substituted phenyl isothiocyanate compound such as nitrophenyl isothiocyanate (Japanese Patent Publication No.
No. 8-4523) has a low volatility, and therefore, when this compound is used indoors, it unnecessarily remains indoors for a long period of time, which is not preferable in terms of safety to human body.

On the other hand, those using natural essential oil ingredients are
It is considered to be preferable from the viewpoint of low toxicity to human body and easy volatility, but since the acaricidal effect is generally mild, a large amount must be used to obtain a sufficient acaricidal effect. In addition, since natural essential oil components generally have a peculiar irritating odor, there is a problem in that when they are used in a large amount, they are practically unsuitable from the viewpoint of odor.

The present invention is intended to solve the problems of the prior art as described above, and it is possible to obtain a sufficient anti-mite action even when used in a small amount, has low toxicity to the human body, and has an odor. The purpose is to obtain an anti-mite agent suitable for use in.

[0010]

To achieve the above object, the present invention provides an anti-mitic agent containing phenylisothiocyanate.

In particular, in addition to phenylisothiocyanate, a natural essential oil containing the following fragrances (A) to (D) (A) sesquiterpene compound (B) sesquiterpene compound as a stimulating odor reducing component (C) alicyclic ring An anti-mite agent containing at least one compound selected from the formula compound (D) aromatic compound is provided.

The phenylisothiocyanate contained as an anti-mite component in the present invention has a high anti-mite action and has low toxicity to the human body. Further, since phenylisothiocyanate has a high volatility, when it is sprayed on a fold or carpet, the sprayed phenylisothiocyanate does not remain unnecessarily. Therefore, the anti-mitic agent of the present invention is suitable for indoor use.

Further, although phenylisothiocyanate has a horseradish-like irritating odor, the anti-mitic agent of the present invention containing a specific fragrance as an irritating odor-relieving component is a specific fragrance which is used for indoor fittings such as folding and the like. An aroma that matches wooden furniture is emitted continuously for at least the remaining period of phenylisothiocyanate. Therefore, the anti-mitic agent of the present invention containing a specific fragrance as a stimulating odor reducing component is particularly excellent as an indoor anti-mitic agent also in terms of odor.

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail.

Phenylisothiocyanate contained in the present invention as an anti-mite component is represented by the following chemical formula.

[0016]

## STR1 ## C ₆ H ₅ -NCS This phenylisothiocyanate has an excellent anti-mite effect. Further, phenylisothiocyanate has a boiling point of 221 ° C. (760 mmHg) and is more volatile than substituted phenylisothiocyanates such as nitrophenyl isothiocyanate. Therefore, when this compound is sprayed indoors, it does not unnecessarily remain indoors as it is after achieving the anti-mite effect. Therefore, the anti-mitic agent of the present invention, from the viewpoint of anti-tick action and safety to the human body,
It becomes an excellent anti-mitic agent for indoor use.

The concentration of phenylisothiocyanate in the anti-mite agent varies depending on the dosage form imparted to the anti-mite agent, but is, for example, 0.01 to 10% by weight in the case of an oil solution for spraying. it can.

Further, phenylisothiocyanate has a horseradish-like pungent odor. Therefore, as the anti-mitic agent of the present invention, those containing a fragrance capable of alleviating this irritating odor are preferable, for example, according to the needs of the user of the anti-mitic agent. In this case, as the fragrance, from the viewpoint of making the anti-mitic agent of the present invention more suitable for indoor use, it can mask the wasabi-like irritating odor of phenylisothiocyanate and can match with indoor fittings such as folding and wooden furniture. It is preferable that the above-mentioned aroma is emitted, and that such aroma be maintained at least during the remaining period of phenylisothiocyanate. As such a fragrance, (A) sesquiterpene compound, (B) sesquiterpene compound-containing natural essential oil, (C) alicyclic compound or (D) aromatic compound can be used.

Of these, specific examples of the (A) sesquiterpene compound include, for example, sedren (CEDREN).
E), Cedrol, Tsuyopsen (TH
UJOPSENE, CEDRYL ACETATE (CEDRY)
L ACESTATE), Cedryl formate (CED
RYL FORMATE), ceryl methyl ether (CEDRYL METHYL ETHER), acetyl sedrene (ACETHYLCEDRENE), β-caryophyllene (β-CARYOPHYLLENE),
α, β-Santalol (α, β-SANTALOL),
2-Methyl-4- (2,2,3-trimethyl-3-cyclopenten-1-yl) -2-buten-1-ol (S
ANDAL MYSORE CORE, Kao Corporation
)), Vetiverol (VETIVEROL), or vetiveryl acetate (VETIVERYLACETAT)
E), patchouli alcohol (PATCHOURI AL
(CHOL) and the like. Since these sesquiterpene compounds have a woody odor such as cedar or sandalwood, or a grassy odor, it is possible to impart an odor to the anti-mitic agent that matches interior fittings such as folding and wooden furniture.

Examples of the natural essential oil (B) containing a sesquiterpene compound include cedar wood oil,
Examples thereof include cedar leaf oil, cypress oil, hiba oil, copaiba balsam oil, sandalwood oil, vetiver oil or patchouli oil.

As the alicyclic compound (C), for example, 4- (4-hydroxy-4-methylpentyl) -3-cyclohexene-1-carboxaldehyde (LYRAL, manufactured by IFF) having a mild floral odor. And iso-boronylcyclohexanol, iso-camphor cyclohexanol and i having a woody odor
Mixture of so-phencil cyclohexanol (SAN
DEOL and Soda Koryo Co., Ltd. can be mentioned.
The alicyclic compound having such a floral scent or woody scent can give an anti-mite agent an aroma that matches interior fittings such as folds and wooden furniture.

Examples of the aromatic compound (D) include those having the following mild green aroma and those having a mild floral aroma.

Examples of those having a mild green odor include phenylacetaldehyde glyceryl acetal, α-methyl-3,4-methylenedioxyhydrocinnamic aldehyde (HELIONAL, IFF).
Manufactured by K.K.), α-methyl-3,4-methylenedioxyhydrocinnamic aldehyde Schiff base, 2-methyl-3
-(P-Methoxyphenyl) propanal (CANTH
OXAL, manufactured by IFF) and the like.

Examples of those having a mild floral odor include cinnamates such as ethyl cinnamate, methyl cinnamate, cinnamyl acetate, cinnamic alcohol, hexyl cinnamic aldehyde and α-amyl cinnamic aldehyde. You can In addition, ethyl eugenol, methyl eugenol, pt-butyl-α-methylhydrocinnamic aldehyde (LILIAL, manufactured by Givaudanlur Co., Ltd.), ci
s-3-hexenyl salicylate, β-naphthol ethyl ether (NEROLIN BROMELIA, H &
R company), β-naphthol methyl ether (YARA
YARA, manufactured by IFF Co., Ltd.) and the like.

In the anti-mitic agent of the present invention, these flavors can be used alone or in combination of two or more. The proportion of the fragrance in the anti-mite agent depends on the type of the fragrance, but it is usually preferable to be 1 to 10000 parts by weight with respect to 1 part by weight of phenylisothiocyanate.

The anti-mite agent of the present invention may contain other insecticidal components and bactericidal components, if necessary. Also,
Additives such as an emulsifier, a dispersant, a spreading agent, a stabilizer, a propellant, and a volatilization regulator can be contained.

The dosage form of the anti-mitic agent of the present invention is not particularly limited. For example, it may be an oil, an emulsion, a wettable powder, a spray, an aerosol, a powder, a fumigant, a transpiration agent and the like. It can also be impregnated with resin, textiles, paper, unglazed products, and the like.

Various liquid or solid carriers can be used in molding the anti-mitic agent of the present invention into a desired dosage form. Here, as the liquid carrier, water, alcohols (methanol, ethanol, isopropanol, etc.), ketones (acetone, methyl ethyl ketone, cyclohexanone, etc.), ethers (tetrahydrofuran,
Dioxane, dimethyl ether, etc.), aliphatic hydrocarbons (hexane, kerosene, normal paraffin, solvent naphtha, etc.), halogenated hydrocarbons (dichloromethane, dichloroethane, etc.), esters (ethyl acetate, butyl acetate, etc.), etc. You can As the solid carrier, inorganic powder (silicic acid, kaolin, bentonite, diatomaceous earth, talc, clay, etc.), organic powder (soybean flour, wheat flour, starch, etc.), clathrate compound (cyclodextrin, microcapsules, etc.), Examples thereof include solids for impregnation (polypropylene, polyethylene, vinyl chloride, resins such as ethylene-polyvinyl alcohol copolymer, papers, non-woven fabrics, fibers, unglazed).

[0029]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be specifically described below based on embodiments.

Example 1, Comparative Examples 1, 2 Phenylisothiocyanate and the following compounded fragrance X
The anti-mitic agent of Example 1 was obtained by mixing (Forest bath) at a weight ratio of 1:19. Further, only phenylisothiocyanate was used as the anti-mitic agent of Comparative Example 1, and only compounded fragrance X containing no phenylisothiocyanate was used as the anti-mitic agent of Comparative Example 2.

[Formulation of blended perfume X] 40 parts by weight of CEDRENE 10 parts by weight of CEDARWOOD OIL 5 parts by weight of VETIVEROL 5 parts by weight of CARYOPHYLLENE HINOKI OIL 35 parts by weight

The effect of suppressing the proliferation of mites of the obtained anti-mitic agents of Example 1 and Comparative Examples 1 and 2 was evaluated by the following medium mixing method. That is, a medium (Example 1, Comparative Example 2: 250 mg of anti-mite agent / 50 g of medium, Comparative Example 1: 12.5 mg of anti-mite agent / 50 g of medium) and mite (about 20,000 animals / medium) were placed in a sealed 5 liter container. 50 g) was added, and the inhabiting mites were counted for 4 weeks at a temperature of 22 to 25 ° C. and a humidity of 75 to 85% RH, and the growth inhibition rate (%) was calculated according to the following formula. The results (average value of 2 times) are shown in Table 1.

[0033]

[Equation 1] Growth inhibition rate (%) = (1-T / C) × 100 (T: the number of live mites in the treatment group, C: the number of live mites in the control group)

Further, in order to evaluate the odor of the anti-mite agents of Example 1 and Comparative Examples 1 and 2, wood flooring (15) for flooring was used.
cm × 15 cm), each anti-mite agent of Example 1 and Comparative Examples 1 and 2 was sprayed with an atomizer (spray amount: about 0.2 g).
Then, it was allowed to stand at room temperature for 3 days and then smelled. When no irritating odor was felt, it was evaluated as ◯, and when irritating odor was felt, it was evaluated as x. The results are also shown in Table 1.

[0035]

[Table 1] Proliferation Suppression Rate (%) of Anti-Mite Agent Stimulative Odor Example 1 Phenylisothiocyanate / Prepared Fragrance X 100.0 ○ Comparative Example 1 Phenylisothiocyanate 100.0 × Comparative Example 2 Prepared Fragrance X 7.4 ○

From the results shown in Table 1, the anti-mitic agent of Example 1 was
It has the same anti-mitic activity as the anti-mitic agent of Comparative Example 1 containing no fragrance, and after spraying for 3 days at room temperature, no pungent odor is felt as in Comparative Example 2 containing no phenylisothiocyanate. I understand.

Example 2 An anti-mitic agent was prepared as an oil for spraying with the following formulation. Phenyl isothiocyanate 1 part by weight Ethanol 99 parts by weight

Example 3 A can was filled with the following formulation to obtain an anti-mite agent aerosol. Oil for spraying of Example 2 100 parts by weight Liquefied petroleum gas 50 parts by weight Dimethyl ether 50 parts by weight

Example 4 An anti-mite agent was prepared as a powder with the following formulation. Phenylisothiocyanate 1 part by weight Talc 54 parts by weight Clay 44.5 parts by weight Silicone 0.3 parts by weight Polyethylene alkyl ether 0.2 parts by weight

Example 5 An anti-mite agent was prepared as a powder with the following formulation. Phenylisothiocyanate 1 part by weight Sodium sulfate 70 parts by weight Sodium citrate 20 parts by weight Dextrin 5 parts by weight

Example 6 An emulsion stock solution was prepared according to the following formulation, and 100 parts of this was prepared with tap water.
The anti-mite agent was prepared as a spray emulsion by diluting it twice. [Emulsion stock solution] Phenyl isothiocyanate 10 parts by weight Dimethylformamide 50 parts by weight Xylene 40 parts by weight Polyoxyethylene alkyl ether 5 parts by weight

Example 7 An undiluted solution for impregnation was prepared according to the following formulation, and 100 parts by weight of this undiluted solution was impregnated in 1000 parts by weight of a bisque-coated plate to obtain a bisque-plate-supported anti-mitic agent. [Undiluted solution] Phenylisothiocyanate 1 part by weight Acetone 99 parts by weight

Example 8 A stock solution for embedding was prepared according to the following formulation, and 1 part by weight of the stock solution was incorporated into 100 parts by weight of a polypropylene resin to obtain a resin-embedded anti-mitic agent. [Stock solution for embedding] Phenyl isothiocyanate 0.1 part by weight Diethyl phthalate 0.9 part by weight

Example 9 A stock solution for paper impregnation was prepared by the following formulation, and 100 parts by weight of this stock solution was impregnated into 500 parts by weight of absorbent paper to obtain a paper-impregnated anti-mitic agent. [Undiluted solution for paper impregnation] Phenylisothiocyanate 1 part by weight Ethanol 38 parts by weight Water 60 parts by weight Polyoxyethylene alkyl ether 1 part by weight

Example 10 An anti-mite agent was prepared as an oil for spraying according to the following formulation. Anti-mite agent of Example 1 5 parts by weight Ethanol 95 parts by weight

Example 11 A can was filled with the following formulation to obtain an anti-mite agent aerosol agent. Oil for spraying of Example 10 100 parts by weight Liquefied petroleum gas 50 parts by weight Dimethyl ether 50 parts by weight

Example 12 An anti-mite agent was prepared as a powder with the following formulation. Anti-mitic agent of Example 1 5 parts by weight Talc 50 parts by weight Clay 44.5 parts by weight Silicon 0.3 parts by weight Polyethylene alkyl ether 0.2 parts by weight

Example 13 An anti-mitic agent was prepared as a powder with the following formulation. Anti-mitic agent of Example 1 5 parts by weight Sodium sulfate 70 parts by weight Sodium citrate 20 parts by weight Dextrin 5 parts by weight

Example 14 An emulsion stock solution was prepared according to the following formulation, and 100 parts of this was prepared with tap water.
The anti-mite agent was prepared as a spray emulsion by diluting it twice. [Emulsion stock solution] Anti-mitic agent of Example 1 20 parts by weight Dimethylformamide 40 parts by weight Xylene 35 parts by weight Polyoxyethylene alkyl ether 5 parts by weight

Example 15 An undiluted solution for impregnation was prepared according to the following formulation, and 1000 parts by weight of this undiluted solution was impregnated into 1000 parts by weight of the unbaked plate to obtain an anti-mitic agent of the type supported by the unbaked plate. [Stock solution for impregnation] Anti-mitic agent of Example 1 5 parts by weight Acetone 95 parts by weight

Example 16 A stock solution for embedding was prepared according to the following formulation, and 1 part by weight of this stock solution was incorporated into 100 parts by weight of a polypropylene resin to obtain a resin-embedded type anti-mitic agent. [Stock solution for embedding] Anti-mitic agent of Example 1 0.5 parts by weight Diethyl phthalate 9.5 parts by weight

Example 17 A stock solution for paper impregnation was prepared according to the following formulation, and 100 parts by weight of this stock solution was impregnated in 500 parts by weight of absorbent paper to obtain a paper-impregnated anti-mite agent. [Undiluted solution for paper impregnation] 5 parts by weight of anti-mitic agent of Example 1 30 parts by weight of ethanol 60 parts by weight of water 5 parts by weight of polyoxyethylene alkyl ether

Reference Example In order to evaluate the masking property of phenylisothiocyanate for pungent odor of various fragrances, as shown in Tables 2 to 4, phenylisothiocyanate and fragrances (A) to (D) described above were used. A fragrance belonging to the group or other fragrances were mixed at a weight ratio of 1:19, and the mixture was sprayed on a wood plate for flooring (15 cm × 15 cm) with an atomizer (spray amount: about 0.2 g), and left at room temperature for 3 days. . afterwards,
When the odor was smelled and no irritating odor was felt, it was evaluated as ◯, and when irritating odor was felt, it was evaluated as x. The results are shown in Tables 2-4.

[0054]

[Table 2] No. Fragrance masking property evaluation 1 (A) sedren (CEDRENE) ○ 2 (A) sedrol (CEDROL) ○ 3 (A) TSUJOPENE (THUJOPSENE) ○ 4 (A) sedryl acetate (CEDRYL ACETATE) ○ 5 (A) Cetryl formate (CEDRYL FORMATE) ○ 6 (A) Cetryl methyl ether (CEDRYL METHYL ETHER) ○ 7 (A) Acetyl acetylene (ACETHYL CEDRENE) ○ 8 (A) β-caryophyllene (β-CARYOPHYLLENE) ○ 9 (A) α, β-Santalol (α, β-SANTALOL) ○ 10 (A) 2-Methyl-4- (2,2,3-trimethyl-3-cyclopenten-1-yl) -2-butene -1- All (SANDAL MYSORE CORE, manufactured by Kao Corporation) ○ 11 (A) VETIVEROL ○ 12 (A) VETIVERYL ACETATE ○ 13 (A) PATCHOURI ALCHOL ○ 14 ( B) Cedar Wood Oil (CEDAR WOOD O IL) ○ 15 (B) CEDAR LEAF OIL ○ 16 (B) Hinoki oil (HINOKI OIL) ○ 17 (B) COPAIBA BALSAM OIL ○ 18 (B) Santa wood oil (SANDAL WOOD) OIL) ○ 19 (B) PACHOURI OIL ○

[0055]

[Table 3] No. Fragrance masking property evaluation 20 (C) 4- (4-Hydroxy-4-methylpentyl) -3-cyclohexene-1-carboxyaldechtate (LYRAL, manufactured by IFF) ○ 21 (C) iso-bornonyl , iso-camphor and iso-phensylcyclohexanol mixture (SANDEOL, manufactured by Soda Koryo Co., Ltd.) ○ 22 (D) ethyl cinnamate ○ 23 (D) methyl cinnamate ○ 24 (D) cinnamyl acetate ○ 25 ( D) Synthetic alcohol ○ 26 (D) Hexyl cinnamic aldehit ○ ○ 27 (D) α-amylcinnamic aldehit ○ ○ 28 (D) Ethyl eugenol ○ 29 (D) Methyl eugenol ○ 30 (D) Phenylaceto aldehyde glyceryl acetal ○ 31 (D) α-methyl-3,4-methylenedioxyhitrosine Mic Aldehit (HELIONAL, manufactured by IFF) ○ 32 (D) α-Methyl-3,4-methylene-dioxy-oxy-hitrosynamic Alchhit's Schiff base ○ 33 (D) pt-Butyl-α-methyl-homothin alkyhit (LILIAL) , (34) (D) cis-3-hexenyl salicylate ○ 35 (D) 2-methyl-3- (p-methoxyphenyl) propanal (CANTHOXAL, manufactured by IFF) ○ 36 (D) β-naphthol ethyl ether (NEROLIN BROMELIA, H & R) ○ 37 (D) β-naphthol methyl ether (YARA YARA, IFF) ○

[0056]

[Table 4] No. Fragrance masking property evaluation 38 (Other) LIMONENE × 39 (Other) iso-amyl acetate × 40 (Other) Diethyl phthalate × 41 None ×

As a fragrance, LIMONENE (No.
38) and iso-amyl acetate (No.39), the masking property was good immediately after spraying, but spraying 3
After the day, as shown in Table 4, no masking property was observed. Diethyl phthalate (No. 40) is an odorless solvent for diluting perfume.

From the results shown in Tables 2 to 4, it is possible to determine that (A) a sesquiterpene compound, (B) a sesquiterpene compound-containing natural essential oil, (C) an alicyclic compound or (D) an aromatic compound. It can be seen that it is excellent as a masking fragrance for thiocyanate.

[0059]

EFFECTS OF THE INVENTION According to the present invention, it is possible to obtain an anti-mitic agent having a high anti-miticity effect, low toxicity to the human body and also suitable for indoor use from the viewpoint of odor.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical indication C11B 9/00 C11B 9/00 A

Claims (7)

[Claims] 1. An anti-mite agent containing phenylisothiocyanate. 2. A natural essential oil containing the following fragrances (A) to (D) (A) sesquiterpene compound (B) sesquiterpene compound as a stimulating odor reducing component (C) alicyclic compound (D) aromatic The anti-mitic agent according to claim 1, containing at least one selected from the group consisting of compounds. 3. The fragrance (A) is cedrene, cedrol,
Tsuyopsen, cedolyl acetate, cedolyl formate, cedolyl methyl ether, acetyl cedrene, β-
Caryophyllene, α, β-santalol, 2-methyl-
4- (2,2,3-trimethyl-3-cyclopentene-
1-yl) -2-buten-1-ol, vetiverol,
The anti-mitic agent according to claim 2, which is selected from vetiveryl acetate and patchouli alcohol. 4. The anti-mitic agent according to claim 2, wherein the fragrance (B) is selected from cedar wood oil, cedar leaf oil, cypress oil, hiba oil, copaiba balsam oil, sandalwood oil, vetiver oil and patchouli oil. 5. The fragrance (C) is 4- (4-hydroxy-).
4-methylpentyl) -3-cyclohexene-1-carboxaldehyde, iso-boronyl cyclohexanol, iso-camphor cyclohexanol and iso
-Selected from -phensyl cyclohexanol.
The described anti-mite agent. 6. The Schiff base of fragrance (D) is phenylacetaldehyde glyceryl acetal, α-methyl-3,4-methylenedioxyhydrocinnamic aldehyde, α-methyl-3,4-methylenedioxyhydrocinnamic aldehyde. , 2-methyl-3- (p-methoxyphenyl) propanal, ethyl cinnamate, methyl cinnamate, cinnamyl acetate, cinnamic alcohol, hexyl cinnamic aldehyde, α-amyl cinnamic aldehyde, ethyl eugenol, methyl eugenol, The anti-mitic agent according to claim 2, which is selected from pt-butyl-α-methylhydrocinnamic aldehyde, cis-3-hexenyl salicylate, β-naphthol ethyl ether and β-naphthol methyl ether. 7. The anti-mitic agent according to claim 2, which contains a flavor as a pungent odor reducing component in an amount of 1 to 10000 parts by weight with respect to 1 part by weight of phenylisothiocyanate.