JP2796588B2 - Indoor acaricide - Google Patents

Description

The present invention relates to an indoor acaricide characterized by containing a cinnamic acid derivative as an active ingredient.

[Conventional technology]

An extremely large variety of mites inhabit the earth, and for example, citrus spider mites and spider mites, which are parasitic on plants, cause great damage to agricultural crops. These acaricides for agricultural use have been developed for a long time, and new promising compounds have recently been discovered one after another.

On the other hand, due to changes in the living environment in recent years, household mites,
Dust mites, dust mites, and the like are generated, causing not only discomfort but also problems such as causing allergic asthma and rash. It has been known that organophosphorus agents such as sumithion and diazinon are effective against these indoor mites, but there are obstacles in practical use due to safety and resistance to humans and animals, The establishment of an extermination method has been eagerly awaited.

Recently, the application of highly safe pyrethroids and acaricides using terpene compounds have been disclosed in JP-A-63-104905 and JP-A-1-163104, but the control effect is not necessarily. Unsatisfactory, and attempts to use acaricides instead of acaricides are not a fundamental extermination method because they only move the habitat, and the development of an accurate acaricide is desired. That is the current situation.

[Problems to be solved by the invention]

The present invention solves the problem of toxicity to humans and animals having the conventional indoor acaricide, disadvantages such as insufficient control effect,
An object of the present invention is to provide an indoor acaricide that is excellent in safety and effectiveness, and is inexpensive and easy to use.

[Means for solving the problem]

The present inventors have conducted intensive studies to achieve the above object, and as a result, the general formula (I) (Wherein, R ₁ represents a hydrogen atom or a methyl group, R ₂ represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and R represents an aldehyde group, a hydroxymethyl group, a C 1-4 alkyl group. Alkoxycarbonyl group or carbon atom number 1
Wherein R ₁ and R ₂ both represent a hydrogen atom, R does not represent an aldehyde group), and the cinnamic acid derivative represented by the formula (1) is used as an active ingredient. It has been found that the acaricide exhibits a high acaricidal effect on mites, such as Dermatophagoides, Acarina, and Dust mites, which live in the house and has low toxicity, and thus completed the present invention.

The cinnamic acid derivative used in the present invention is widely used as a fragrance, but is known not to exhibit insecticidal properties,
The present invention having an acaricidal effect was completely unexpected.

Specific examples represented by the general formula (I) are as follows, but are not limited thereto.

In the general formula (I), when R ₂ is an alkyl group, there are two kinds of geometric isomers based on a carbon-carbon double bond, and each of them or a mixture thereof is included in the present invention.

The active ingredient of the acaricide for indoor use of the present invention is usually a liquid or a solid, and it is possible to apply the active ingredient as it is. However, it is usually preferable to use an appropriate carrier or other compounding agent according to the purpose of use. And various forms such as emulsions, wettable powders, powders, oils, aerosols, coatings, tablets and the like.

In addition, the above-mentioned active ingredient has a higher volatility than the conventional acaricide, so-called heating which is impregnated in a room temperature sustained-release preparation or a suitable holding material such as a pulp plate and then heated and evaporated by a suitable heating evaporator. It can also be applied as a transpirant or fumigant. As a liquid carrier, for example,
Water, alcohols (methyl alcohol, ethyl alcohol, ethylene glycol, etc.), ketones (acetone,
Methyl ethyl ketone, cyclohexanone, etc.), ethers (ethyl ether, dioxane, cellosolves, etc.),
Aliphatic hydrocarbons (gasoline, kerosene, kerosene, etc.),
Aromatic hydrocarbons (benzene, toluene, xylene, methylnaphthalene, etc.), halogenated hydrocarbons (dichloromethane, trichlorobenzene, Freon 113, Freon 114B
Etc.), esters, acid amides, nitriles and the like are suitable, and one or a mixture of two or more thereof is used. Examples of the solid carrier include clays (kaolin, pentonite, etc.), talc, silicas, calcium carbonate, alumina powder, activated carbons, wood flour, starch, vegetable powders such as flour, cyclodextrin and the like. Suitable and mixtures of one or more of these are used. Further, as the compounding agent, an emulsifier, a dispersant, a spreading agent, a propellant, a penetrant, a surfactant, a stabilizer, a film forming agent, a volatilization modifier, and the like are appropriate, and one or more of these may be used. Is used.

Examples of the coating film forming agent include cellulose derivatives, vinyl resins, alkyd resins, urea resins, silicon resins, urethane resins, epoxy resins, and the like. Decane,
Sublimable carriers such as cyclododecane, 2,4,6-triisopropyl-1,3,5-trioxane, trimethylene norbornene, higher fatty acid esters such as butyl stearate, isopropyl myristate, etc. Ronyl butoxide, Sinepirin 500 and the like can be exemplified.

Further, the indoor acaricide of the present invention may contain various insecticides, synergists, antioxidants, fungicides, fungicides, repellents, fragrances, coloring agents, and the like. As pesticides that can be blended,
Aresulin, d-T80-aresulin, praletrin, d
-T80-Flamethrin, d-T80-phthalsulin, d-T8
0-resmethrin, phenothrin, permethrin, cyphenothrin, cypermethrin, fenvalerate,
Pyrethroid compounds such as etofenprox,
Examples include organic phosphorus compounds such as fenitrothion, diazinon, and pyridafenthion, and carbamate compounds such as NAC, MTMC, and PHC.

In addition, empentrin and DD are used as indoor acaricides in the present invention.
VP, or a combination of volatile insect repellents such as paradichlorobenzene, naphthalene, and camphor;
A repellent such as butylacetanilide and N, N-diethylsuccinamate may be appropriately mixed to obtain a multipurpose acaricide having an excellent effect.

The amount of the active ingredient and the amount used in the indoor acaricide of the present invention are appropriately determined according to the dosage form, the application target, the application method, the application place, and the like. For example, for the control of mites that live in mats such as mites, per tatami, 0.1 mg or more, preferably 1 mg to 2 g of the active ingredient, and for the control of house dust mites that live in carpets, 0.5 mg to ² g per square meter. Of the active ingredient.

The present invention also provides a miticide obtained by holding the above-mentioned acaricide on a substrate. The mite control material is used as a film, a sheet, a cushion, a filler for bedding, a building material, and a construction material having mite control properties by utilizing the properties of the base material. Here, as the base, for example,
Synthetic resin sheets such as polyethylene, polypropylene, polyester, ethylene-vinyl acetate, animal and plant or inorganic fibrous sheets, and natural cotton, synthetic fiber cotton, feathers, buckwheat hulls, foam plastic, etc. as cushioning and bedding fillers Is raised.

One preferred embodiment of the tick control material provided by the present invention is a tick control carpet. The mite control carpet is an indoor carpet of the present invention having a liquid form in which, for example, a normal carpet including a pile, a first base cloth, a packing agent, and a second base cloth is prepared, and then a film forming agent is added as necessary. Spray-applying the acaricide or prior to the preparation of the carpet, at least one of paryl, the first base fabric and the second base fabric is treated with the indoor acaricide of the present invention, and the carpet is used using these. Is obtained. The mite control carpet prepared as described above preferably holds about 0.1 to 10 g of the active ingredient per 1 m ^{2 of} carpet area.

The acaricide for indoor use of the present invention thus obtained or a mite control material obtained by retaining the same exhibits a high extermination effect on various mites, particularly, tracheal asthma, atopic dermatitis, nasal allergy and the like. Eradication of house dust mites such as Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are said to cause terrestrial mite, Dermatophagoides farinae and Dermatophagoides farinae, which are considered to be pathogenic for allergic diseases and mite mites in the human body. Is extremely useful.

Hereinafter, the present invention will be described in more detail with reference to Test Examples and Examples, but the present invention is not limited to the following Examples as long as the gist is not exceeded.

Test Example 1 0.5 ml of a 10 mM acetone solution of a test compound was dropped on a 5 cm × 10 cm rectangular filter paper, air-dried, and 50 to 150 Dermatophagoides farinae were released between two folds. Put these two fold papers in 2
Acrylic cylinders (inner diameter 4.1cm, height 2cm) sandwiched and fixed with rubber bands.
% RH), and after standing for 24 hours, the number of live mites and the number of dead mites were counted, and the acaricidal efficacy of each test compound was examined.

As a control compound, d of the pyrethroid compound was used.
-T80-resmethrin and citral and carvone disclosed in JP-A-1-163104 were used.

As a result of the test, the cinnamic acid derivative used in the present invention shows high contact acaricidal activity against Dermatophagoides farinae, and is very superior to the control compounds d-T80-resmethrin and citral and carvone disclosed in JP-A-1-163104. Was.

Test Example 2 A test was conducted using the same apparatus as in Test Example 1 in order to examine the acaricide efficacy of the test compound on volatile compounds. 100 μl of a 100 mM acetone solution of the test compound (200 μl in the case of P. aeruginosa) was dropped onto about 1 cm square cloth, air-dried, and placed on the bottom of the lower acrylic cylinder. And placed in one container. After standing for 24 hours, the number of live mites and the number of dead mites were counted, and the lethal efficacy of each test compound volatilized was determined, as shown in the table below. As control compounds, empentrin, which is a volatile volatile pyrethroid, and citral, citronellal, and trans-cinnamic acid were used.

As a result of the test, it was confirmed that the cinnamic acid derivative used in the present invention has an extremely high acaricidal effect on volatile molecules and is useful for application to sustained-release preparations and heat-evaporation preparations.

On the other hand, it was also revealed that empentrin, which is widely used as an insect repellent, citral and citronellal disclosed in JP-A-1-163104, and cinnamic acid itself have very weak acaricidal efficacy.

Example 1 To 10 g of each of the above compound Nos. (2), (6), (8), (10) and (13), a very small amount of fragrance and kerosene were added to make a total of 120 ml, which was combined with liquefied petroleum gas and dimethyl ether. After filling 180 ml of the mixture (1: 1 volume ratio) into a pressure-resistant can for aerosol, an injection device was attached to obtain an acaricide for indoor use of the present invention in the form of an aerosol.

20ml per 1m ² in the carpet house dust mite has occurred
One day after the injection, the number of mites in the carpet was observed. The ratio of the number of dead mites to the number of collected mites was 90% or more.

Example 2 A carpet treated with the indoor acaricide of the present invention according to the specifications shown in the following table was produced.

The compound numbers are the same as those of the above compound examples.

The carpet treated with the acaricide of the present invention is cut into a size of 20 × 20 cm, a tick culture medium containing about 5,000 Dermatophagoides farinae is placed in the center, stored at 25 ° C. and 60% RH for 2 days, and then carpeted with a vacuum cleaner. Suck the mites on the front or back, count the number of live mites according to the prescribed method, X: Number of surviving mites in the carpet untreated carpet Y; The mortality was determined by the number of surviving mites in the carpet treated with the acaridide.

In addition, these carpets confirmed the usefulness of the indoor acaricide of the present invention without any problem in terms of odor and irritation.

Example 3 Compound Nos. (2), (4), (7) and (11)
8 g of a gelling agent was added to 2 g of each, and the acaricide for indoor use of the present invention in the form of a tablet was prepared by a conventional method.

When two of the above tablets (packed with Japanese paper) were stored in a cloth bag containing the futon and stored, no ticks were found on the futon.

〔The invention's effect〕

INDUSTRIAL APPLICABILITY The indoor acaricide of the present invention is excellent in safety and usability and exhibits high acaricidal efficacy based on containing a cinnamic acid derivative of the general formula (I) as an active ingredient.

Claims (1)

(57) [Claims] 1. The compound of the general formula (I) Wherein R ₁ represents a hydrogen atom or a methyl group, R ₂ represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and R represents an aldehyde group, a hydroxymethyl group,
Represents an alkoxycarbonyl group having 1 to 4 carbon atoms or an alkylcarboxymethyl group having 1 to 4 carbon atoms, provided that when R ₁ and R ₂ both represent a hydrogen atom, R does not represent an aldehyde group) An indoor acaricide comprising the cinnamic acid derivative represented as an active ingredient.