JP2615089B2 - Acaricide containing an alkyldiaminoalkylglycine and a salt thereof as an active ingredient - Google Patents

Description

The present invention relates to an acaricide and an acaricide.

[Conventional technology]

House dust mites are found everywhere indoors, and their habitat extends not only to tatami mats and carpets but also to sofas, stuffed animals and bedding. Conventionally, as acaricides against such house dust mites, phosphorus compounds such as fenitrothion, fenthion, DDVP and diazinon, propoxers, carbamate compounds such as NAC, and pyrethroid compounds such as resmethrin are known. I have.

[Problems to be solved by the invention]

These known acaricides are used on tatami mats, carpet repellent paper, or sprayed or sprayed as they are, but phosphorus-based and carbamate-based acaricides are highly toxic and have a low effect on Dermatophagoides. Therefore, the scope and amount of application are limited. Further, since pyrethroids are expensive and slow-acting, they have various drawbacks, such as being limited in their application method and application amount.

The inventors of the present invention have conducted intensive studies to solve the problems of the prior art, and as a result, when alkyldiaminoalkylglycine and a salt thereof are used as an active ingredient, the above-mentioned disadvantages of the conventional acaricide are completely eliminated. As a result, they have found an acaricide having low toxicity and excellent safety for the human body, and which is effective against all kinds of mites such as Dermatophagoides and have completed the present invention.

[Means for solving the problem]

The present invention relates to (1) an acaricide characterized by containing (1) alkyldiaminoalkylglycine and a salt thereof as an active ingredient.

(2) The present invention relates to a mite control material characterized in that a miticide containing an alkyldiaminoalkylglycine and a salt thereof as an active ingredient is held on a substrate.

The mites to be controlled in the present invention can be any type of target, but in particular, Dermatophagoides, such as Dermatophagoides farinae and Dermatophagoides pteronyssinus, mites, such as Dermatophagoides farinae and Dermatophagoides farinae; Examples include mites, such as stag mites and mite mites, and animal parasitic mites, such as house mites and common ticks. The alkyldiaminoalkylglycine of the present invention and a salt thereof are amphoteric surfactants widely used as germicidal disinfectants, and have low toxicity and extremely high safety. As the alkyl group include up to C ₁ -C ₆ the latter include C ₈ to the former to C _18, and as the salts, such as sodium salt, potassium salt, calcium salt, and hydrochloride or the like .

Although the acaricide of the present invention can be used as it is,
Usually held on a liquid carrier and a solid carrier, and if necessary, a film forming agent, an emulsifier, a dispersant, a spreading agent, a wetting agent, a stabilizer,
Add propellants, volatilization modifiers, etc. to oils, emulsions, aqueous solutions, wettable powders, sprays, aerosols, smokers, coatings,
It can be used in the form of powders, granules and the like.

Examples of the liquid carrier include water and alcohols such as methyl alcohol, ethyl alcohol and isopropyl alcohol, ketones such as acetone, methyl ethyl ketone and cyclohexanone, ethers such as tetrahydrofuran, dioxane and dimethyl ether, hexane, kerosene, normal paraffin and solvent. Aliphatic hydrocarbons such as naphtha, aromatic hydrocarbons such as benzene and toluene, halogenated hydrocarbons such as dichloromethane and dichloroethane, esters such as ethyl acetate and butyl acetate, and CFC-based solvents (CFC-133, CFC-114B2) , CFC 21, CFC 10, etc.). As the solid carrier, for example, mineral powders such as silicic acid, kaolin, activated carbon, bentonite, diatomaceous earth, talc, clay, calcium carbonate, ceramic powders, vegetable powders such as wood flour, soy flour, flour, starch, cyclodextrin And the like.

Examples of the coating film forming agent include cellulose derivatives, vinyl resins, alkyd resins, urea resins, epoxy resins, polyester resins, urethane resins, silicone resins, acrylic resins, chlorinated rubbers, polyvinyl alcohol, and the like. As emulsifiers, dispersants, and spreading agents, soaps, polyoxyethylene fatty alcohol ethers, polyoxyethylene alkyl allyl ethers, polyoxyethylene fatty acid esters, fatty acid glycerides, sorbitan fatty acid esters, sulfuric acid esters of higher alcohols, Surfactants such as alkyl allyl sulfonates, and propellants include liquefied petroleum gas, dimethyl ether, fluorocarbon and the like. Or, as a volatilization regulator, tricyclodecane, cyclododecane, 2,4,6-triisopropyl-1,3,5-trioxane, sublimable carriers such as trimethylene norbornene and paradichlorobenzene, sublimation such as naphthalene π-camphor Using an insect repellent, the mite control composition can be used as a sublimable solid agent, or empenthrin, DD
A volatile insecticide such as VP can be combined and used as a volatile mite control agent.

Furthermore, the acaricide of the present invention, various insect repellents, synergists,
Pest repellent, rodent repellent, participation inhibitor, decomposition inhibitor,
A bactericide, an antifungal agent, a fragrance, a coloring agent, and the like can be added. Insect repellents that can be blended include 3-allyl-2-methylcyclopent-2-en-4-one-1-yl dl-cis / transn-chrysanthemate, 3-allyl-2-
Methylcyclopenta-2-en-4-one-1-yl
d-cis / trans-chrysanthemate, d-3-allyl-2-methylcyclopenta-2-en-4-one-1
-Yl d-trans-chrysanthemate, 3-allyl-2-methylcyclopenta-2-en-4-one-1-
Il d-trans-chrysanthemate, N- (3.4
* 5.6-tetrahydrophthalimide) -methyl dl-cis / trans-chrysanthemate, 5-benzyl-3-
Furylmethyl d-cis / trans-chrysanthemate, 5- (2-propargyl) -3-furylmethylchrysanthemate, 3-phenoxybenzyl, 2.2-dimethyl-3- (2'.2'-dichloro) Vinylcyclopropanecarboxylate, 3-phenoxybenzyl d-cis / trans-chrysanthemate, α-cyanophenoxybenzyl isopropyl-4-chlorophenylacetate, d-3-allyl-2-methylcyclopenta-2-
Ene-4-one-1-yl d-trans-chrysanthemate, (S) -α-cyano-3-phenoxybenzyl (1R · cis) -3- (2.2-dichlorovinyl) -2 ·
2-dimethylcyclopropanecarboxylate, (R.
S) -α-cyano-3-phenoxybenzyl (1R · 1
S) -cis / trans-3- (2.2-dichlorovinyl) -2-2.2-dimethylcyclopropanecarboxylate, α-cyano-3-phenoxybenzyl d-cis /
Trans-chrysanthemate, 1-ethynyl-2-methyl-2-pentenyl cis / trans-chrysanthemate, 1-ethyl-2-methyl-2-pentenyl 2.2
-Dimethyl-3- (2-methyl-1-propenyl) cyclopropane-1-carboxylate, 1-ethynyl-2
-Methyl-2-pentenyl 2,2,3-tetramethylcyclopropanecarboxylate, 1-ethynyl-
2-methyl-2-pentenyl 2,2-dimethyl-3-
(2.2-dichlorovinyl) cyclopropane-1-carboxylate, 0.0-dimethyl 0- (2.2-dichloro) vinyl phosphate, 0-isopropoxyphenylmethylcarbamate, 0.0-dimethyl 0- (3 −
Methyl-4-nitrophenyl) thionophosphate,
0.0-diethyl 0-2-isopropyl-4-methyl-pyrimidyl- (6) -thiophosphate, 0.0-
Dimethyl S- (1,2-dicarbethoxyethyl)-
Dithiophosphate, benzyl benzoate and the like; synergistic agents such as 6- (propylpiperonyl) -butyl carbyl ether, N- (2-ethylhexyl) -1-
Isopropyl-4-methylbicyclo (2,2,2) oct-
5-ene-2,3-dicarboximide, isobonyl thiocyanoacetate, octachlorodipropyl ether and the like; N- (fluorodichloromethylthio) -phthalimide, N, N-dimethyl as fungicides and fungicides −
N'-phenyl-N '-(fluorodichloromethylthio) sulfamide, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 0-phenylphenol,
P-chloro-m-xylenol, 4-chlorophenyl-
3'-iodopropargyl formal and the like can be exemplified.

The amount of the active ingredient in the acaricide of the present invention may be appropriately determined according to the dosage form, application method, application place, etc., but an aqueous solution, a wettable powder, an emulsion or a coating agent, a powder, a granule may be used. When used in the form of an agent or the like, the active ingredient is preferably 0.1 to 35% by weight, and when used in the form of a spray, smoke, oil or aerosol, the active ingredient is preferably 0.1 to 10% by weight, its dose is about the active ingredient in an area 1 m ² per be processed 10m
g or more, it is desirable to present the active ingredient from about 1mg or more per application space 1 m ^2.

The present invention also provides a tick control material comprising the above-mentioned acaricide held on a substrate. The tick control material,
Utilizing the characteristics of the base material, it is used as a film, a sheet, a filler for cushion bedding, a building / construction material, etc., having mite control properties. Here, examples of the base material include synthetic resin sheets such as polyethylene, polypropylene, nylon, polyvinyl chloride, polyvinylidene chloride, and polyester, animal and plant or inorganic fiber sheets (paper, cloth, nonwoven fabric, leather, etc.), and these synthetic resins. Examples thereof include a mixed sheet or mixed fabric of inorganic fibers or powder, a mixed fabric or nonwoven fabric of the synthetic resin and animal and plant fibers, a metal foil or film of aluminum, stainless steel, zinc, or the like, and a laminated sheet of the above various sheets. As cushions and bedding fillers, natural cotton (cotton, cotton, etc.), synthetic fiber cotton (polyester cotton, nylon cotton, acrylic cotton, etc.), feathers and other animal hair, buckwheat hull, rice hull, grain straw, foam plastic (Polyethylene foam, urethane foam, etc.).

Further, as the above-mentioned base material, natural woods used as building / construction materials, such as drills, pencil ferns, and so on, and plastics, such as vinyl chloride resin, chlorinated polyethylene, polyethylene, and polypropylene, can be effectively used.
Means for holding the mite control agent of the present invention on these substrates is not particularly limited, and may be performed by, for example, application, impregnation, dropping, spraying, kneading, or the like. The retention amount is not particularly limited and can be appropriately determined. However, in the case where the substrate is impregnated, the amount is preferably up to the saturated impregnation amount.

As a preferred embodiment of the tick control material of the present invention,
A tick control carpet can be exemplified. The mite control carpet according to the present invention has a liquid form in which a normal carpet comprising, for example, a pile, a first base fabric, a packing agent and a second base fabric is prepared, and then a film-forming agent is added as required. Spray the agent or prior to making the carpet,
At least one of a pile, a first base cloth and a second base cloth
It is obtained by treating a seed with the acaricide of the present invention and using them to make a carpet. The mite control carpet prepared as described above desirably holds about 0.1 to 10 g of the active ingredient per 1 m ^{2 of} carpet area.
As another embodiment, a tick control futon and a pillow can be exemplified. The tick control quilt and pillow are made of natural cotton, synthetic fiber cotton,
It can be obtained by spray-coating a filler such as feathers and other animal hair, buckwheat hulls, rice hulls, cereal straw, foamed plastic, etc. with the shell mite agent of the present invention. The mite control futon and pillow prepared as described above are about 0.1 to 10 with respect to 1 kg of filler weight.
g of the active ingredient may be retained.

(Operation)

The acaricide and the acaricide of the present invention exhibit extremely excellent effects based on the fact that they contain alkyldiaminoalkylglycine and its salts as active ingredients.

<Examples> Hereinafter, the acaricide and the mite control material of the present invention will be described in detail based on examples.

Example 1 Efficacy against Dermatophagoides farinae A nonwoven fabric (made of polypropylene, 230 μm in thickness) is cut into a size of 5 × 5 cm, and impregnated with an acetone solution of a test compound to a predetermined concentration. After removing the solvent, apply this impregnated paper to about 30
Put it in a polyethylene bag (6 × 6 cm) together with 0 test mites, and make it close to all sides. After 48 hours, life and death were determined under a stereoscopic microscope. The results were obtained as mortality (%) by Abbott correction of the following formula, and are shown in Table 1.

x; Percentage of surviving insects in untreated plot y; Percentage of surviving insects in treated plot The acaricide of the present invention showed a higher effect than resmethrin.

Example 2 Specifications No. A to Table 2 below for the purpose of controlling insects on carpets
The mite control material of the present invention in the form of H carpet was produced.

Mite control carpet samples No. A to H obtained above
The following test was conducted.

<Test Method> A tick culture medium containing about 10,000 Dermatophagoides farinae was placed in the center of carpet sample Nos. A to H and a carpet without treatment (each 20 × 20 cm).
31 × 22cm) After put in the bottom, 2 ℃ under the condition of 25 ℃ and 64% RH
After storage for 2 days, 200mesh nylon goose 2
The mite on the front or back of the carpet was sucked off with a vacuum cleaner between the sheets. Next, remove the nylon goose from the vacuum cleaner,
The mites are dropped into a 300 ml beaker containing 100 ml of the Darling solution, transferred to a centrifuge tube after stirring, centrifuged at 1000 rpm, and the supernatant is transferred to a Puchner funnel with a mouthpiece and passed through a suction port. Surviving mites on this paper were counted, and the result was obtained as the mortality (%) from the following equation.

x: Number of surviving mites in the carpet untreated with drug y; Number of surviving mites in the mite-controlling carpet plot The above test was repeated three times, and the results are shown in Table 4 as average values.

As shown in Table 4 above, each sample showed sufficient mite control.

Example 3. To 10 g of each of the following test compound sample Nos. A to D, a small amount of a fragrance, 20 ml of ethyl alcohol, and distilled water were added to make a total of 150 ml, and a mixture of liquefied petroleum gas and dimethyl ether ( (1: 1 volume ratio) of 150 ml was filled into a pressure-resistant can for aerosol (contents: 400 ml), attached to an injection device, and sealed to obtain a mite control material of the present invention in the form of an aerosol.

Using each of the aerosols thus obtained, the mite control effect was tested in the same manner as in Example 1.

<Test method> Spray each aerosol on a high-quality paper (30 x 30 cm) for 3 seconds so as to be as uniform as possible. After storing at room temperature for 1 day,
A sheet having a size of 5 × 5 cm was cut out, and the mite control effect was tested according to the test method of Example 1 below.

The above test was repeated three times, and the results are shown in Table 4 as average values.

As shown in Table 4 above, each sample showed sufficient mite control.

Example 4. Nos. A to D of the test compound-mixed samples shown in Table 5 below were sprayed on futon cotton so that the test compound became 2 g / kg cotton, and then dried to obtain a tick controlling material of the present invention.

The following tests were carried out on the mite-proof futon cotton samples Nos. A to D obtained above.

<Test Method> 1 g of each of the futon cotton samples Nos. A to D is taken in a sample tube (30 ml), placed in about 500 Dermatophagoides farinae, covered, and placed at 25 ° C. After 48 hours, cotton was taken out of the sample tube, and live mites were collected by a heat expulsion method, and the insect repellency (%) was determined by the following equation.

x: Percentage of collected mites in the untreated area y; Percentage of collected mites in the treated area As a result, all the samples were able to obtain almost 100% insect repellency and showed sufficient mite control.

Example 5 The test compound of the present invention used in Example 3 was mixed with the same weight of silicon oxide, sufficiently stirred and mixed, and then powdered to obtain a powdered mite control material of the present invention.

The powder thus obtained was tested for its mite control effect by the following test method.

<Test method> After heat-killing a straw cut to a length of about 2 cm, put 5 g of the straw in a 100 ml Erlenmeyer flask, then add and mix 0.05 g of each powder and mix at 25 ° C and 85 to 90% RH. Save for one day. Into this Erlenmeyer flask, about 400 Acarina mites were charged, and after storage for 2 days under the same conditions, living mites were expelled by a heat expulsion method, the number was counted, and the mortality was determined according to the test method of Example 2. Calculated.

As a result, all powders were able to obtain almost 100% mortality and showed sufficient mite control.

Example 6 A paper pack of a vacuum cleaner was impregnated with an acetone solution of a test compound shown in Table 6 and then dried to obtain a tick controlling material of the present invention.

Tick control paper pack samples No.A to G obtained above
The following tests were conducted for

<Test method> After attaching the paper pack samples No.A to G and the untreated paper pack to a commercially available vacuum cleaner (suction power 160 W), loosen 20 g of cotton-like polyester short fiber as a substitute for indoor dust. After suction, the paper pack was taken out and sprayed with 3 ml of water. Further, about 200 mg of a tick breeding medium containing about 1000 Dermatophagoides farinae was placed in a paper pack, and then the paper pack was mounted again in a vacuum cleaner and placed at 25 ° C. and 75% RH for 2 weeks. Thereafter, the mites in the paper pack were collected by a saturated saline floatation method, and alive and dead were determined to determine the mortality (%).
The above test was repeated three times, and the results are shown in Table 7 as average values.

As shown in Table 7 above, each sample showed sufficient mite control.

〔The invention's effect〕

As described above, the acaricide and the acaricide according to the present invention can exhibit an extremely excellent acaricidal effect based on the fact that they contain alkyldiaminoalkylglycine and its salt as its active ingredient.

Claims (2)

(57) [Claims] 1. An acaricide comprising an alkyldiaminoalkylglycine and a salt thereof as an active ingredient. 2. A tick controlling material characterized by having an acaricide containing an alkyldiaminoalkylglycine and a salt thereof as an active ingredient retained on a base material.