JP7438704B2 - Tick repellent and tick repellent method using the same - Google Patents

Description

The present invention relates to a mite repellent and a mite repellent method, and more particularly to a mite repellent and a mite repellent method for insect pests of the order Araneae, such as Dermatophagoides nigricans, Dermatophagoides nigricans, and Araneae.

Conventionally, various repellents for ticks have been proposed, and in recent years, pyrethroid compounds and the like have been widely used as tick repellent ingredients.

It is also known that highly safe natural ingredients and food ingredients are used as anti-mite agents, including repellents. For example, there are acaricides made by extracting cedar essential oil obtained by steam distillation of cedar branches and leaves with a water-containing polar organic solvent (Patent Document 1), and essential oils extracted from the branches and leaves or roots of Japanese cypress, Taiwanese cypress, cedar, and hiba. A mite control agent for sanitary pests (Patent Document 2) containing at least one kind or a mixture thereof as an active ingredient is known.

However, the above-mentioned components had a problem in that they were weakly effective against mites and did not have sufficient repellent efficacy. Therefore, there is a need for a tick repellent that has a higher tick repelling effect, can be easily used in general households, and has a high degree of safety.

Japanese Patent Application Publication No. 6-239714 Japanese Patent Application Publication No. 1-193204

Therefore, it is an object of the present invention to provide a repellent that uses ingredients contained in natural products, has a sufficient repellent effect against ticks, is highly safe for the human body, and can be easily used at home. shall be.

In order to achieve the above-mentioned object, the present inventors have been conducting extensive research on the activity of ingredients in natural products against mites, and have discovered that moon peach oil exhibits an excellent repellent effect against mites. was completed.

That is, the present invention is a tick repellent containing moongweed oil as an active ingredient.

The present invention also provides a method for repelling mites, in which the above-mentioned mite repellent is released into the environment or brought into contact with mites to act.

The mite repellent of the present invention has an excellent repellent effect against pests of the order Acarinae, for example, mites such as Dermatophagoides nigricans, Dermatophagoides nigricans, and Dermatophagoides nigricans, and since it is a component of natural products, it is extremely safe. It's expensive. Therefore, it can be easily used in general households and can effectively prevent and eliminate damage caused by mites.

1 is a diagram schematically showing a cross section of a test device used in Example 1. FIG. 1 is a diagram schematically showing a plane of a test device used in Example 1. FIG.

The mite repellent (hereinafter referred to as "repellent") of the present invention contains moonshine oil as an active ingredient.

Moon peach oil is an oil whose components are already known, and an oil that is a combination of synthetic products of each component may be used, but it is also possible to use one extracted from nature.

Conventionally known methods can be used for extracting moon peach oil, and extraction methods such as compression, steam distillation, atmospheric distillation, vacuum distillation, and solvent extraction can be used. For example, in the steam distillation method, the fresh flowers and leaves of the moon peach are crushed and soaked in alcohol or hot water for several hours, followed by steam distillation, and the distilled oil is collected to obtain the moon peach oil.

The repellent of the present invention may be in a form in which the moonthorn oil is used as a sole active ingredient, or may be in a form in which it is used as a preparation by combining appropriate optional ingredients in a conventional manner.

As described later, the repellent of the present invention can be used by methods such as transpiration, contact with mites, and other methods, and it is sufficient to mix the repellent with an amount of moongwort oil that is suitable for these methods. .

For example, if the method involves contact with dust mites, it can be applied directly to areas where dust mites live, such as bedding such as futons, pillows, and blankets, tatami mats, rugs, carpets, sofas, cushions, stuffed animals, and clothing. Alternatively, you can use a sprayer such as a pump sprayer or aerosol to spray.

The dosage form of the repellent of the present invention is not particularly limited, and can be in the form of a liquid, gel, solid, etc., and arbitrary components can be used accordingly.

One of the dosage forms of the repellent of the present invention is a liquid formulation, and a solvent is used to prepare this liquid formulation. The solvent used is not particularly limited, and conventionally known liquid carriers can be used, but it is preferable to use a solvent that is highly safe for the body.

Examples of specific solvents include water such as deionized water and distilled water; hydrocarbon compounds such as hexane, paraffin, and isoparaffin; methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, and 2-butanol. , 2-methyl-1-propanol, 2-methyl-2-propanol, pentanol, hexanol, heptanol, octanol, nonanol, decanol, and other alkyl alcohols; allyl alcohol and other alkenyl alcohols; and benzyl alcohol and other aromatic rings. Containing alcohols; phenols such as eugenol; halogenated hydrocarbon compounds such as chloroform; ether compounds such as diethyl ether and diethylene glycol diethyl ether; ketone compounds such as acetone; fatty acid compounds such as acetic acid and oleic acid; acetic acid esters , propionate ester, benzoate ester, and other ester compounds; ethylene glycol, propylene glycol, and other glycol compounds; 2-phenoxyethanol, 3-methyl-3-methoxybutanol, and other glycol ether compounds; sesame oil, linole oil, salad oil and other vegetable oils. These can be used alone or in combination of two or more.

The amount of these solvents used in the repellent is preferably 0.1 to 99.9% by mass/mass, and 1 to 99% by mass/mass, based on the entire repellent. It is particularly preferable to blend them in this manner. More preferably, it is 10 to 90% by mass/mass.

Furthermore, in preparing this liquid agent, a surfactant may be added if necessary. Examples of surfactants that can be used include conventionally known surfactants such as cationic surfactants, anionic surfactants, amphoteric surfactants, and nonionic surfactants. They can be used alone or in combination of two or more.

Another dosage form of the repellent of the present invention includes a solid or sheet-like solid dosage form, which is obtained by impregnating and supporting the above-mentioned liquid medicine on a suitable carrier. The carrier to be supported is not particularly limited, but examples thereof include wood, paper, woven fabric, nonwoven fabric, silica, talc, activated carbon, silica gel, zeolite, cellulose beads, ceramic, resin pellets such as polypropylene, etc.

Further, as another formulation of the repellent of the present invention, a gel preparation obtained by gelling the above-mentioned liquid preparation with a gelling agent can be mentioned. The gelling agents used include those conventionally known, such as carrageenan, gellan gum, agar, gelatin, guar gum, pectin, locust bean gum, xanthan gum, sodium alginate, cellulose derivatives, dibenzylidene-D-sorbitol, and hydroxypropylation. Examples include polysaccharides, inulin stearate, superabsorbent resins such as sodium acrylate, aluminum octylate, etc., and these can be used alone or in combination of two or more.

A preferred method of using the repellent of the present invention obtained as described above includes a method of releasing the repellent of the present invention into the environment.

Examples of methods for releasing it into the environment include a method of naturally evaporating the active ingredient in the repellent of the present invention, such as a liquid, a solid, and a gel, at room temperature, or a method of forcibly evaporating it. There are several methods. Examples of methods for forced transpiration include transpiration by heating, transpiration by blowing air, and transpiration by fumigation. Furthermore, a spraying method or the like may be used as a method for releasing into the environment.

Among the above-mentioned forced transpiration methods, as a transpiration method by heating, for example, as disclosed in Utility Model Application Publication No. 2-78077, etc., a repellent stored in a chemical solution bottle is sucked up with a wick and the upper part of the wick is used. A repellent is impregnated into a mat-like impregnated body as disclosed in Japanese Utility Model Application Publication No. 1-116072, etc., and the mat is heated. Examples include a method using a heating evaporator or the like that is placed on a heater to evaporate.

In addition, transpiration by air blowing can be achieved by, for example, providing a drug holding body and a blower as disclosed in JP-A No. 11-308955, etc., and bringing the drug holding body into contact with the airflow generated by the blower. This can be done using a fan-type repellent device or the like that releases the air into the environment from a discharge port.

Furthermore, transpiration by fumigation can be achieved by placing an organic blowing agent such as an azo compound such as azodicarbonamide, a nitroso compound, or a hydrazide compound in a container with an opening at the top, as disclosed in, for example, Japanese Utility Model Application Publication No. 54-148267. A storage chamber containing the repellent is formed, and a fumigation device or the like is used to evaporate the repellent using nitrogen gas, carbon dioxide gas, etc. generated by the decomposition of the foaming agent by heating the bottom of the storage chamber with a heating means. It can be done by

Furthermore, dispersion by atomization can be carried out by spraying a liquid agent using an atomizer, or by using an aerosol using a suitable propellant. When preparing a spray agent, the above-mentioned liquid agent may be combined with a spraying means such as a trigger spray or an atomizer. Further, in the case of making an aerosol agent, the above-mentioned liquid agent, an aerosol carrier such as LPG or isopentane, and an aerosol spraying means such as an aerosol can may be combined.

Another preferable method for using the repellent of the present invention includes a method in which the repellent of the present invention is brought into contact with ticks in a liquid or solid state to act on them. In this case, when the mites come into contact with the installed repellent, the repellent effect can be exerted.

The repellent of the present invention can be installed and applied in spaces such as storerooms, drawers, closets, closets, costume cases, clothing storage bags, futon storage bags, living rooms, bedrooms, etc., entrances, etc. is released into the environment or comes into contact with mites, thereby effectively repelling mites. The repellent of the present invention may also be applied by directly spraying, scattering, coating, etc. on objects such as tatami mats, rugs, carpets, floors, futons, pillows, sofas, and clothing where mites live.

Note that the repellent of the present invention may also contain other conventionally known tick-controlling ingredients, thereby making it possible to exhibit an even more excellent repellent effect.

These other mite control ingredients include, for example, pyrethroid compounds such as empenthrin, transfluthrin, allethrin, phenothrin, profluthrin, metofluthrin, and eminence; organic phosphorus agents such as dichlorvos, diazinon, fenitrothion, malathion, etc.; -diethyl-m-toluamide (DEET), dimethyl phthalate, dibutyl phthalate, 2-ethyl-1,3-hexanediol, di-n-propylisocincomeronate, p-dichlorobenzene, di-n-butyl succinate, Karan-3,4-diol, 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate, isopropyl myristate, isobornyl thiocyanoacetate, diphenyl, diphenylmethane, dibenzyl, benzylphenyl ether, benzylphenylethyl ether, Benzophenone, benzyl phenyl ketone, dibenzyl ketone, benzalacetophenone, β-phenylethyl benzoate, γ-phenylpropyl benzoate, phenyl phenylacetate, benzyl phenyl acetate, β-phenylethyl phenyl acetate, phenyl cinnamate, benzyl cinnamate , β-phenylethylcinnamate, β-phenylpropylcinnamate, cinnamylcinnamate, diphenylcarbinol, phenylbenzylcarbinol, dibenzylcarbinol, n-amylbenzoate, isoamylbenzoate, hexylbenzoate, heptylbenzoate, octylbenzoate , nonyl benzoate, cis-3-hexenyl benzoate, n-amyl salicylate, iso-amyl salicylate, hexyl salicylate, cis-3-hexenyl salicylate, benzyl propionate, benzyl-n-butyrate, benzyl iso-butyrate, Compounds such as benzyl-n-valerate, benzyl isovalerate, benzyl caproate, benzyl heptanoate, benzyl caprylate, penzyl danilate, eugenol, methyleugenol, isoeugenol; α, β-pinene, α, β - Terpene compounds such as terpinol, limonene, citronellal, linalool, and citral; menthol, vetiver oil, patchouli oil, clove oil, plant essential oils such as cedar, cypress, Taiwanese cypress, and hiba essential oil; plants belonging to the genus Fir in the Pinaceae family; Pressed liquid, extract, distillate, etc. may be mentioned, and one type of these may be used alone, or two or more types may be used in combination.

Among the mite repellents of the present invention, one of the preferred embodiments includes a combination with a pressed liquid, an extract, or a distillate of a plant belonging to the genus Abies of the family Pinaceae, as disclosed in JP 2017-39677. The method for producing this press liquor, extract or distillate is described in the patent publication. Further, in this embodiment, the amount of squeezed liquid etc. to be blended with respect to 1 part by mass of the ethanol solution containing 1% shellfish oil is preferably about 0.01 to 10 parts by mass, particularly 0.1 to 1 part by mass. preferable.

The above-described repellent of the present invention exhibits an excellent repellent effect against insect pests of the order Acarinae, such as Dermatophagoides nigricans, Deterinary mites, Deterinary mites, Deterinary mites, Ixodes mites, House dust mites, Thin mites, and D. mites. Furthermore, the pressed liquid, extract or distillate of the above-mentioned plants belonging to the genus Fir in the Pinaceae family also exhibits insecticidal, oviposition inhibiting and egg hatching inhibiting effects against these mites, so a mite repellent containing these is used. has better mite control effect.

EXAMPLES Next, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited to these Examples in any way.

Production Example Using the leaves of the moon peach as a raw material, the moon peach oil was obtained in the following manner. That is, 100 g of moon peach leaves were chopped into small pieces of about 5 mm square, soaked in 500 mL of hot water at about 80° C. for 2 hours, and then placed in a distillation tank of a steam distillation apparatus to perform steam distillation. Thereafter, the essential oil was separated from the distillate to obtain shellfish oil. The amount of honey peach oil obtained was about 4 g, and the ratio of essential oil to the input sample was about 4%. The obtained moonshine oil was dissolved in ethanol, and various tests were conducted as an ethanol solution containing 1% moonshine oil.

Implementation example 1
Repellent test for Kona leopard mite:
In accordance with JIS L 1920 "Testing method for anti-mite performance of textile products", mites were reared, the density was adjusted, etc., and a repellent test was conducted using the apparatus shown in FIGS. 1 and 2.

That is, the moon peach oil shown in Table 1 below was applied to a filter paper having a diameter of 40 mm to obtain a test piece. The test piece (23) was placed in a small glass petri dish (22) with a diameter of 45 mm and a height of 17 mm, and 0.05 g of the attraction feed (24) was placed in the center. A mite culture medium (21) containing approximately 10,000 live Dermatophagoids mites (a mixture of powdered feed for rearing medium and dry yeast in a mass ratio of 1:1) was uniformly placed in a large plastic petri dish (20) with a diameter of 90 mm and a height of 14 mm. It was spread out, and the small glass Petri dish (22) was placed in the center. This was placed in a plastic container (25) containing saturated saline (26) for humidity adjustment.

The container was sealed with a lid and placed in a room at a temperature of 25°C±1°C. After being left for 20 hours after installation, the total number of living mites on the test piece and the attraction medium was counted. This test was repeated three times using filter paper that was not treated with chemicals as a blank. The total number of counts from the three tests was determined, and the repellency rate was determined using the following formula. The results are shown in Table 2.

From the above results, it was shown that the product of the present invention has a high repellent effect against Dermatophagoides mites.

Preparation example 1
Gel-like tick repellent:
85 g of isoparaffin was mixed with 10 g of an ethanol solution containing 1% bayberry oil, and 5 g of aluminum octylate was added thereto, and the mixture was heated to 60° C. and stirred. This was filled into a container measuring 35 mm long x 35 mm wide x 75 mm high, and allowed to stand at room temperature for 3 hours to obtain a gel-like tick repellent.

Preparation example 2
Room temperature volatile tick repellent:
A 30 mm x 40 mm pulp filter paper was impregnated with 0.6 g of an ethanol solution containing 1% moon peach oil, and the paper was placed in a breathable plastic case (38 mm x 52 mm x 5 mm) to prepare a solid repellent.

Preparation example 3
Aerosol:
An aerosol was prepared by filling a commercially available 200 ml aerosol can with the following formulation.
Active ingredient: Moon peach oil 0.4ml
Solvent: ethanol 39.6ml
Propellant: LPG 30.0ml
Propellant: Isopentane 30.0ml

Preparation example 4
Spray:
A spray was prepared by storing the following formulation in a commercially available 150 ml container manufactured by Trigger.
Active ingredient: Moon peach oil 0.1g
Solvent: ethanol 10g
Fragrance 0.05g
Surfactant 0.1g
Ion exchange water 89.75g

Preparation example 5
Fumigants:
A fumigation agent was prepared by kneading 10 g of an ethanol solution containing 1% moon peach oil, 55 g of azodicarbonamide, and 35 g of talc, followed by granulation and drying according to a conventional method.

Preparation example 6
Heating transpiration agent:
A 3 cm x 3 cm pulp mat was impregnated with 100 mg of an ethanol solution containing 1% bayberry oil to obtain a heating transpiration agent. This product evaporates the active ingredient by placing it in contact with a heater.

Preparation example 7
Granular repellent:
50 g of a granular impregnated body made of pulp (average particle size: 5 mm) was impregnated with 50 mL of an ethanol solution containing 1% honeysuckle oil, and placed in an air-permeable nonwoven fabric bag to obtain a granular repellent.

Preparation example 8
Room temperature volatile tick repellent:
A pulp filter paper of 9.6 mm x 110 mm was impregnated with 0.5 g of an ethanol solution containing 1% honeysuckle oil and 0.01 g of empenthrin. This was housed in an air permeable plastic case (130 mm x 138 mm x 9.5 mm) provided with a ventilation hole of 88 mm x 100 mm to prepare a solid repellent.

Preparation example 9
Sustained release tick repellent:
3 g of an ethanol solution containing 1% honeysuckle oil was placed in a plastic container (diameter 30 mm, depth 10 mm) with an open top, and the opening was covered with a drug-permeable film to obtain a sustained-release tick repellent.

Usage example 1
When two pieces of the room-temperature volatile mite repellent obtained in Formulation Example 2 were placed in a polyethylene clothing storage bag (75 cm x 80 cm x 32 cm) with clothing, no mites were attached to the clothing for about 1 month.

Usage example 2
When two pieces of the room-temperature volatile mite repellent obtained in Formulation Example 8 were placed in a polyethylene futon storage bag (150 cm x 100 cm) with bedding, no mites were attached to the bedding for about 6 months.

Usage example 3
When two pieces of the room-temperature volatile mite repellent obtained in Formulation Example 2 were placed in a 75 L (40 cm x 75 cm x 25 cm) clothing case with clothing, mites did not stick to the clothing for about 3 months.

Usage example 4
When the spray mite repellent obtained in Formulation Example 4 was evenly sprayed onto clothing, no mites were attached to the clothing for about a week.

Usage example 5
When the aerosol mite repellent obtained in Formulation Example 3 was evenly sprayed onto a carpet, no mites were attached to the carpet for about one month.

Usage example 6
When the sustained-release mite repellent obtained in Formulation Example 9 was placed in a 30 liter polypropylene food storage container (355 mm x 472 mm x 253 mm), no mites entered the storage container for about one year.

Moon peach oil, which is an active ingredient of the repellent of the present invention, exhibits an excellent repellent effect against pests of the order Acari, and is safe for the human body and highly stable. Therefore, the repellent of the present invention can be easily used in general households and is highly useful.

20 ... ... Large Petri dish 21 ... ... Mite medium 22 ... ... Small Petri dish 23 ... ... Test piece 24 ... ... Feed for attraction 25 ... ... Plastic container 26 ... ... Saturated saline solution

Claims (7)

A mite repellent containing as an active ingredient a steam-distilled moonthorn oil , wherein the mites are Dermatophagoids nigricans and/or Dermatophagoids pectus . 2. The tick repellent according to claim 1, wherein the moon peach oil is an oil extracted from the leaves of the moon peach. A method for repelling mites, which comprises using the repellent according to claim 1 or 2 and releasing moonshine oil into the environment. The method for repelling mites according to claim 3, wherein the release into the environment is carried out by natural transpiration at room temperature. The method for repelling mites according to claim 3, wherein the release into the environment is forcibly carried out by transpiration by heating, transpiration by blowing air, or transpiration by fumigation. The method for repelling mites according to claim 3, wherein the release into the environment is carried out by spraying. A method for repelling mites, which comprises using the repellent according to claim 1 or 2, and bringing moon peach oil into contact with the mites so as to act on the mites.