JP2021155342A - Mite repellent, and mite repellent method using the same - Google Patents

Abstract

To provide a repellent that uses ingredient contained in natural products, has sufficient repellent effect against mites as well as is highly safe for the human body and can be easily used in ordinary households.SOLUTION: Provided is a mite repellent that is characterized in containing the following components (A) and (B): (A) natural pyrethrin; and (B) one or more selected from the group consisting of (B-1) phellandrene, (B-2) basil oil, (B-3) moon peach (Alpinia speciosa) oil, (B-4) clove leaf oil, (B-5) black pepper oil, (B-6) particular aromatic ketone compound, (B-7) particular isothiocyanate compound, and (B-8) squeezed liquid, extract or distillate of plants belonging to the genus Abies of the Pinaceae family, as active ingredient.SELECTED DRAWING: Figure 1

Description

The present invention relates to a mite repellent and a method for repelling mites, and more particularly to a repellent for mites and a method for repelling mites against pests of the order Arachnida such as Dermatophagoides farinae, Dermatophagoides farinae, and Tyrophagus putrescentiae.

Conventionally, various repellents against mites have been proposed, and in recent years, pyrethroid compounds and the like have been widely used as mite repellent components.

It is also known that highly safe natural ingredients and food ingredients are used as anti-mite agents including repellents. For example, among the acaricide (Patent Document 1) obtained by steam-distilling the branches and leaves of Sugi with a water-containing polar organic solvent, and the essential oils extracted from the branches and leaves or roots of Hinoki, Taiwan Hinoki, Sugi, and Hiba. A hinoki cypress control agent for sanitary pests (Patent Document 2) containing at least one or a mixture thereof as an active ingredient is known.

However, the above-mentioned components have a weak effect on mites and have a problem that a sufficient repellent effect cannot be obtained. Therefore, there is a demand for a mite repellent that has a higher mite repellent effect and that can be easily used in ordinary households and has a high degree of safety.

JP-A-6-239714A Japanese Patent Application Laid-Open No. 1-193204

Therefore, it is an object of the present invention to provide a repellent that utilizes a component contained in a natural product, has a sufficient repellent effect against mites, is highly safe for the human body, and can be easily used in ordinary households. And.

The present inventors have been diligently studying the activity of components in natural products against mites in order to achieve the above-mentioned problems. We have found that it shows, and have completed the present invention.

（式中、Ｒ^１は炭素数１〜３のアルキル基を示す）
（Ｂ―７）次の一般式（２）で表されるイソチオシアネート化合物、

（式中、Ｒ^２はフェニル基又は炭素数１〜３の分岐していてもよいアルキル基若しくはアルキレン基を示す）、及び
（Ｂ−８）マツ科モミ属に属する植物の圧搾液、抽出物または蒸留物、よりなる群から選ばれる１種または２種以上
を有効成分として含有することを特徴とするダニ用忌避剤。 That is, the present invention describes the following components (A) and (B);
(A) Natural pyrethrin (B) (B-1) Phellandrene, (B-2) Basil oil, (B-3) Moon peach oil, (B-4) Clove leaf oil, (B-5) Black pepper oil , (B-6) Aromatic ketone compound represented by the following general formula (1),

(In the formula, R ¹ represents an alkyl group having 1 to 3 carbon atoms)
(B-7) The isothiocyanate compound represented by the following general formula (2),

(In the formula, R ² represents a phenyl group or an alkyl group or an alkylene group which may be branched with 1 to 3 carbon atoms), and (B-8) a pressed liquid or an extract of a plant belonging to the genus Fir of the Pinaceae family. Alternatively, a repellent for ticks, which comprises one or more selected from the group consisting of a distillate as an active ingredient.

Further, the present invention is a method for repelling mites by any of a method of releasing the above-mentioned repellent for mites into the environment, a method of applying the repellent to textile products, or a method of allowing the repellent for mites to act in contact with the mites.

The mite repellent of the present invention has an excellent repellent effect against pests of the order Arachnid, such as Dermatophagoides farinae, Dermatophagoides farinae, and Tyrophagus putrescentiae, and is a component in natural products, so it is extremely safe. It's expensive. Therefore, it can be easily used even in ordinary households, and the damage caused by mites can be effectively prevented and removed. Furthermore, indoor mites such as Kona leopard mites can cause allergies even if they are dead, so it is important to prevent them from dying while having a high repellent effect so that the dead will not remain. The mite repellent of the present invention has an excellent repellent effect, but has a low acaricidal effect, and therefore has an excellent allergen removing effect.

It is a figure which showed typically the cross section of the test apparatus used in Example 1. It is a figure which showed typically the plane of the test apparatus used in Example 1. FIG.

The mite repellent of the present invention (hereinafter referred to as "repellent") contains the component (A) and the component (B) as active ingredients.

Natural pyrethrin, which is the component (A) used in the present invention, is a general term for insecticidal components contained in the flowers of pyrethrin (Dalmatian pyrethrum), and the active ingredients are pyrethrin I, pyrethrin II, cinerin I, cinerin II, jasmorin I, jasmorin II. It is a mixture of 6 components of.
It is also possible to use one extracted from pyrethrum according to a conventional method, or it is also possible to use each compound alone or in combination. Examples of commercially available products include Sumitomo Natural Pyrethrin (manufactured by Sumitomo Chemical Co., Ltd.).

The component (B) used in the present invention includes the following components (B-1) to (B-8).

The basil oil which is the component (B-1) of the present invention is an oil whose component is already known, and an oil in which a synthetic product of each component is combined may be used, but an oil extracted from nature is used. It can also be used.

Conventionally known methods can be used as the extraction method of basil oil, and extraction methods such as squeezing, steam distillation, atmospheric distillation, vacuum distillation, and solvent extraction can be used. For example, in the steam distillation method, basil oil can be obtained by crushing basil leaves and fresh flowers, immersing them in alcohol or warm water for several hours, then performing steam distillation, and collecting the distillate oil. Steam distillation is preferable from the viewpoint of mite repellent effect and the like. Examples of commercially available products of such steam-distilled basil leaves and flowers include basil oil (HUILE ESSENTIELLE BASILIC GRAND VERT EGYPTE 100% pure et naturelle, manufactured by Albert Vieille SAS).

The shell ginger oil, which is the component (B-2) of the present invention, is an oil whose component is already known, and an oil in which a synthetic product of each component is combined may be used, but it is extracted from nature. Can also be used.

Conventionally known methods can be used as the extraction method of moon peach oil, and extraction methods such as squeezing, steam distillation, atmospheric distillation, vacuum distillation, and solvent extraction can be used. Steam distillation is preferable from the viewpoint of tick repellent effect. For example, in the steam distillation method, fresh flowers and leaves of moon peach are crushed and soaked in alcohol or warm water for several hours, and then steam distillation is performed to collect the distillate oil. Can obtain steam peach oil.

As the clove leaf oil which is the component (B-3) of the present invention, those extracted from the leaves of clove, which is a plant of the Myrtaceae family, can be used.

Conventionally known methods can be used as the extraction method of clove leaf oil, and extraction methods such as squeezing, steam distillation, atmospheric distillation, vacuum distillation, and solvent extraction can be used. Steam distillation is preferable from the viewpoint of tick repellent effect. For example, in the steam distillation method, clove leaves are crushed and soaked in alcohol or warm water for several hours, and then steam distillation is performed, and the distillate oil is collected to collect the distillate oil. You can get oil. Further, as such a steam distillation product, AT065 or AT173 sold by Tanemura & Co., Ltd. may be used.

The black pepper oil, which is the component (B-4) of the present invention, is made from black pepper, which is the fruit of a climbing plant belonging to the genus Piperaceae. Black pepper can be obtained by drying green pepper berries, which are collected before they are fully ripe, for a long period of time.

Examples of the method for obtaining black pepper oil from the fruit of black pepper include conventionally known methods such as a pressing method, a solvent extraction method, and a steam distillation method, but steam distillation is preferable from the viewpoint of mite repellent effect and the like.

As a general method for obtaining black pepper oil from the steam distillation method, black pepper oil is obtained by squeezing black pepper with a hydraulic machine, immersing it in warm water for several hours, then performing steam distillation, and collecting the distillate oil. Is obtained.

There are two types of phellandrene, which is the component (B-5) of the present invention, α-pherandrene and β-pherandrene, both of which can be used as the repellent of the present invention, but from the viewpoint of the effect of repelling mites and the like. To β-phellandrene is preferred. β-Phellandrene is expressed by the following equation.

Phellandrene is a known compound and can be obtained synthetically or by isolation from the essential oils of natural plants and the like.

The aromatic ketone compound which is the component (B-6) of the present invention is represented by the following formula (1).

（式中、Ｒ^１は炭素数１〜３のアルキル基を示す）

(In the formula, R ¹ represents an alkyl group having 1 to 3 carbon atoms)

Specific examples of the aromatic ketone of the above formula (1) include acetophenone, propiophenone, butyrophenone, and the like, and one or a mixture of two or more of these can be used.

These aromatic ketone compounds of the formula (1) are already known compounds, and synthetic products may be used, but those extracted from nature or naturally extracted containing the aromatic ketone compound of the formula (1). You can also use things.

で表されるアセトフェノンがダニ忌避効果等の観点から好ましい。アセトフェノンは、イチゴや茶などの天然植物から抽出することにより得られる化合物であり、例えば、イチゴなどを圧搾した後水蒸気蒸留し、その留出油分を採取すること等により得られる。 Of these, the following formula,

Acetophenone represented by is preferable from the viewpoint of mite repellent effect and the like. Acetophenone is a compound obtained by extracting from a natural plant such as strawberry or tea. For example, acetophenone is obtained by squeezing strawberry or the like and then steam-distilling it to collect the distillate oil.

（式中、Ｒ^２はフェニル基又は炭素数１〜３の分岐していてもよいアルキル基若しくはアルキレン基を示す） The isothiocyanate compound which is the component (B-7) of the present invention is represented by the following formula (2).

(In the formula, R ² represents a phenyl group or a branched alkyl group or alkylene group having 1 to 3 carbon atoms).

Specific examples of the isothiocyanate compound of the above formula (2) include methyl isothiocyanate, allyl isothiocyanate, phenyl isothiocyanate, ethyl isothiocyanate, vinyl isothiocyanate, propyl isothiocyanate, isopropyl isothiocyanate and the like. 1 type or a mixture of 2 or more types of the above can be used.

These isothiocyanate compounds of the formula (2) are already known compounds, and synthetic products may be used, but those extracted from nature or natural extracts containing the isothiocyanate compound of the above formula (2). Can also be used.

で表されるアリルイソチオシアネートがダニ忌避効果等の観点から好ましい。アリルイソチオシアネートは、ワサビやからしなどの天然植物から抽出することにより得られる化合物である。より具体的には、例えば、からしについて、水圧機で圧搾して脂肪油を除き、これを砕いて温湯に数時間浸した後水蒸気蒸留し、その留出油分を採取することにより得られる。 Of these, the following formula,

Allyl isothiocyanate represented by is preferable from the viewpoint of mite repellent effect and the like. Allyl isothiocyanate is a compound obtained by extracting from natural plants such as wasabi and mustard. More specifically, for example, mustard is obtained by pressing with a hydraulic press to remove fatty oil, crushing the mustard, immersing it in warm water for several hours, steam-distilling it, and collecting the distillate oil.

The blending ratio of the components (A) and (B) in the repellent of the present invention is not particularly limited, but from the viewpoint of the effect of repelling mites and the like, the component (A): the component (B) = 1: 1. ~ 1: 100 is preferable, 1: 10 to 1:80 is more preferable, and 1:20 to 1:60 is particularly preferable.

The repellent of the present invention may be a form in which only the above-mentioned components (A) and (B) are used as active ingredients, or a form in which an appropriate optional component is further combined and used as a preparation by a conventional method. You may.

As will be described later, the repellent of the present invention is used by a method of evaporating, a method of contacting with mites to act, and the like, and the active ingredient may be contained in an amount suitable for those methods. It is preferable to blend the component (A) and the component (B) in the agent so as to have a total content of 0.1 to 99.99% by mass (hereinafter, simply referred to as "%"), and 1 to 99.9. It is more preferable to blend so as to be%, and particularly preferably 10 to 90%.

The dosage form of the repellent of the present invention is not particularly limited, and may be in the form of a liquid agent, a gel agent, a solid agent, or the like, and any component corresponding thereto can be used.

One of the dosage forms of the repellent of the present invention is a liquid preparation, and a solvent is used to prepare this liquid preparation. The solvent used is not particularly limited, and a conventionally known liquid carrier can be used, but it is preferable to use a solvent having high safety to the body.

Specific examples of the solvent include water such as deionized water and distilled water; hydrocarbon compounds such as hexane, paraffin and isoparaffin; methanol, ethanol, 1-propanol, 2-propanol, 1-butanol and 2-butanol. , 2-Methyl-1-propanol, 2-methyl-2-propanol, Pentanol, Hexanol, Heptanol, Octanol, Nonanol, Decanol and other alkyl alcohols; Alkenyl alcohols such as allyl alcohol; Aromatic rings such as benzyl alcohol Alcohols contained; phenols such as eugenol; halogenated hydrocarbon compounds such as chloroform; ether compounds such as diethyl ether and diethylene glycol diethyl ether; ketone compounds such as acetone; fatty acid compounds such as acetic acid and oleic acid; acetic acid esters , Ester compounds such as propionic acid ester and benzoic acid ester; glycol compounds such as ethylene glycol and propylene glycol; glycol ether compounds such as 2-phenoxyethanol and 3-methyl-3-methoxybutanol; sesame oil, linole oil, salad oil Such as vegetable oils and the like. These can be used alone or in admixture of two or more.

The amount of these solvents used in the repellent is preferably 0.1 to 99.99% of the total repellent, and is preferably 1 to 99.9%. Is particularly preferred. More preferably, it is 10 to 90%.

In addition, a surfactant may be added as necessary in the preparation of this liquid preparation. Examples of the surfactant that can be used include conventionally known surfactants such as cationic surfactants, anionic surfactants, amphoteric surfactants, and nonionic surfactants, and one of them may be used. It can be used alone or in combination of two or more.

As another dosage form of the repellent of the present invention, a solid or sheet-like solid agent obtained by impregnating and supporting the above-mentioned liquid agent in an appropriate carrier can be mentioned. The carrier to be supported is not particularly limited, and examples thereof include resin pellets such as wood, paper, woven fabric, non-woven fabric, silica, talc, activated charcoal, silica gel, zeolite, cellulose beads, ceramics, and polypropylene.

Further, as a dosage form of another repellent of the present invention, a gel agent obtained by gelling the above-mentioned liquid agent with a gelling agent can be mentioned. Conventionally known gelling agents include, for example, carrageenan, gellan gum, agar, gelatin, guar gum, pectin, locust bean gum, xanthan gum, sodium alginate, cellulose derivatives, dibenzylidene-D-sorbitol, hydroxypropylation. Examples thereof include polysaccharides, highly water-absorbent resins such as inulin stearate and sodium acrylate, aluminum octylate, and the like, and these can be used alone or in admixture of two or more.

A preferred method of using the repellent of the present invention obtained as described above includes a method of releasing the repellent of the present invention into the environment for use.

Examples of the method of releasing into the environment include a method of naturally evaporating the active ingredient from the repellents of the present invention such as a liquid agent, a solid agent, and a gel agent at room temperature, and a method of forcibly evaporating. Examples of the method of forced transpiration include transpiration by heating, transpiration by blast, and fumigation. Further, as a method of releasing into the environment, a method of spraying or the like may be used.

Among the above-mentioned forced evaporation methods, as a method of evaporation by heating, for example, as disclosed in Japanese Patent Publication No. 2-78077, a repellent stored in a chemical solution bottle is sucked up by a sucking core and the upper part of the sucking core. The mat-like impregnated body as disclosed in Japanese Patent Publication No. 1-116072, etc. is impregnated with a repellent and heated. An example of this method is to use a heating steamer or the like that evaporates by placing it on a heater.

Further, for evaporation by blowing air, for example, a drug holder and a blower as disclosed in Japanese Patent Application Laid-Open No. 11-308955 are provided, and the drug holder is brought into contact with an air flow generated by the blower to repel the agent. Can be carried out using a fan-type repellent device or the like that discharges the water from the discharge port into the environment.

Further, evaporation by steaming is carried out by, for example, in a container having an upper opening as disclosed in Japanese Patent Publication No. 54-148267, an organic foaming agent such as an azo compound such as azodicarbonamide, a nitrogen compound, or a hydrazide compound. A storage chamber containing the repellent is formed, and a steaming device or the like that evaporates the repellent with nitrogen gas, carbon dioxide gas, etc. generated by decomposing the foaming agent by heating the bottom of the storage chamber with a heating means is used. Can be done.

Furthermore, spraying can be performed by using a sprayer to spray a liquid agent or by using an aerosol using an appropriate propellant. In the case of using a spray agent, the above-mentioned liquid agent may be combined with a spraying means such as a trigger spray or an atomizer. In the case of an aerosol agent, the above-mentioned liquid agent, an aerosol carrier such as LPG or isopentan, and an aerosol spraying means such as an aerosol can may be combined.

In addition, as another preferable method of using the repellent of the present invention, there is a method of allowing the repellent of the present invention to act in contact with mites in a liquid or solid state. In this case, the repellent effect can be exerted by contacting the installed repellent with the mites. For example, bedding such as futons, pillows and blankets, tatami mats, rugs, carpets, sofas, cushions, stuffed animals, clothing and other places where mites live, apply directly to objects, or use sprayers such as pump sprays and aerosols. And spray it.

The repellent of the present invention is an active ingredient by installing and applying it in a storage room, a chest of drawers, a closet, a closet, a clothes case, a clothing storage bag, a futon storage bag, a living room, a bedroom or the like, or a space such as an entrance. Can be effectively repelled by being released into the environment or by contacting the mites. Further, the repellent of the present invention is applied by directly spraying, spraying, applying, etc. to an object including textile products such as tatami mats, carpets, carpets, floors, futons, pillows, sofas, and clothing in which mites live. May be good.

The repellent of the present invention may contain other conventionally known mite control components, whereby a more excellent repellent effect can be exhibited.

Examples of these other tick control components include pyrethroid compounds such as empentrin, transfluthrin, alesulin, phenotrin, profluthrin, metoflutrin, and eminence; and organic phosphorus agents such as dichlorobos, diazinone, fenitrothione, and malathion; N, N. -Diethyl-m-toluamide (DEET), dimethylphthalate, dibutylphthalate, 2-ethyl-1,3-hexanediol, di-n-propylisosincomeronate, p-dichlorobenzene, di-n-butylsuccinate, Callan-3,4-diol, 1-methylpropyl2- (2-hydroxyethyl) -1-piperidincarboxylate, isopropyl myristate, isobornyl thiocyanoacetate, diphenyl, diphenylmethane, dibenzyl, benzylphenyl ether, benzylphenyl ethyl ether, Benzophenone, benzylphenylketone, dibenzylketone, benzalacetophenone, β-phenylethylbenzoate, γ-phenylpropylbenzoate, phenylacetate, benzylphenylacetate, β-phenylethylphenylacetate, phenylcinnamate, benzylcinnamete , Β-Phenylethyl cinnamate, β-phenylpropyl cinnamate, cinnamyl cinnamate, diphenylcarbinol, phenylbenzylcarbinol, dibenzylcarbinol, n-amylbenzoate, isoamylbenzoate, hexylbenzoate, heptylbenzoate, octylbenzoate , Nonylbenzoate, cis-3-hexenylbenzoate, n-amyl salicylate, iso-amyl salicylate, hexyl salicylate, cis-3-hexenyl salicylate, benzyl propionate, benzyl-n-butyrate, benzoluiso-butyrate, Compounds such as benzyl-n-valerate, benzylisovalerate, benzylcaproate, benzylheptanoate, benzylcaprilate, pentyldanylate, eugenol, methyleugenol, isoeugenol; α, β-pinene, α, β -Phenyl compounds such as terpinol, limonene, citronellal, linalol, citral; menthol, vetiver oil, pachori oil, etc. may be mentioned, and one of these may be used alone or in combination of two or more. You can also do it.

The repellent of the present invention described above can exert a synergistic repellent effect against pests of the order Mite such as Dermatophagoides farinae, Dermatophagoides farinae, Tyrophagus putrescentiae, Itch mite, Tick mites, Dermatophagoides farinae, Cheyletidae, and Dermatophagoides farinae. Among these, the repellent in the present invention has a high repellent effect, but has a low acaricidal effect, and the carcass does not remain at the place of application. On the other hand, it is preferably used. Furthermore, the squeezed liquid, extract or distillate of the plant belonging to the genus Fir of the Pinaceae family (B-8) also exhibits insecticidal, egg-laying inhibitory and egg hatching inhibitory effects on these mites. The combined repellent has a better tick control effect.

Next, the present invention will be described in more detail with reference to Examples and the like, but the present invention is not limited to these Examples and the like.

Manufacturing example 1
Production of shell ginger oil:
Using shell ginger leaves as a raw material, shell ginger oil was obtained as follows. That is, 100 g of shell ginger leaves were chopped into small pieces of about 5 mm square, soaked in 500 mL of hot water at about 80 ° C. for 2 hours, and then put into a distillation tank of a steam distillation apparatus for steam distillation. Then, the essential oil was separated from the distillate to obtain shell ginger oil.

Manufacturing example 2
Manufacture of black pepper oil:
Black pepper oil was obtained as follows. That is, 100 g of black pepper berries were sufficiently ground with a commercially available mortar and mortar, placed in a 1 L beaker, put in 500 mL of hot water at about 80 ° C., covered with a lid, soaked for 2 hours, and then crushed. The whole was put into the distillation tank of the steam distillation apparatus and steam distillation was performed. Then, the essential oil was separated from the distillate to obtain black pepper oil.

Manufacturing example 3
Using the leaves of Todomatsu as a raw material, about 50 kg of crushed by a crushing type crusher (manufactured by KYB Mfg. Co., Ltd.) was put into the distillation tank of the microwave distillation apparatus, and the pressure in the distillation tank was increased to about 20 KPa while stirring. It was kept under reduced pressure conditions (steam temperature was about 67 ° C.), irradiated with microwaves for 1 hour and distilled, and then the oily fraction was separated to obtain Todomatsu essential oil.

Example 1
Dermatophagoides farinae repellent test:
According to JIS L 1920 "Test method for anti-tick performance of textile products", mites were bred, the density was adjusted, and the repellent test was conducted with the devices shown in FIGS. 1 and 2.

That is, a sample was prepared according to the formulation shown in Table 1 below. 60 mg of each of these samples was applied to a cotton cloth having a diameter of 40 mm to obtain a specimen. As shown in FIGS. 1 and 2, the specimen (23) was placed in a small glass petri dish (22) having a diameter of 45 mm and a height of 17 mm, and 0.05 g of the citation feed (24) was placed in the center thereof. A large plastic petri dish (20) with a diameter of 90 mm and a height of 14 mm is uniformly mixed with a mite medium (21) containing about 10,000 live Dermatophagoides farinae (a mixture of powdered feed for breeding medium and dried yeast at a mass ratio of 1: 1). The small glass petri dish (22) was placed in the center of the medium. This was housed in a plastic container (25) containing a saturated saline solution (26) for humidity control.

The container was covered and sealed, and installed in a room having a temperature of 25 ° C. ± 1 ° C. After leaving for 20 hours after installation, the total number of surviving mites in the specimen and the citation medium was counted. This test was repeated 3 times, using a cotton cloth that had not been treated with chemicals as a blank. The total number of counts of the three tests was calculated, and the repellent rate was calculated by the following formula. The mortality rate was calculated by the following formula. The results are also shown in Table 1.

Repellent rate (%) = {(A1-A2) / A1} x 100
Mortality rate (%) = (A3 / A2) x 100
A1: Number of mites on blank cotton cloth and incentive medium A2: Number of mites on test piece and incentive medium in drug treatment group A3: Number of dead mites on test piece in drug treatment group and incentive medium

From the above results, it was shown that the product of the present invention has a high repellent effect on Dermatophagoides farinae. On the other hand, it was confirmed that the mortality rate was low and the allergen removal effect was also excellent.

Pharmaceutical example 1
Gel-like mite repellent:
To 85 g of isoparaffin, 10 g of an ethanol solution containing 0.1% natural pyrethrin and 1% basil oil was mixed, and 5 g of aluminum octylate was further added thereto, and the mixture was heated to 60 ° C. and stirred. This was filled in a container having a length of 35 mm, a width of 35 mm and a height of 75 mm, and allowed to stand at room temperature for 3 hours to obtain a gel-like mite repellent.

Pharmaceutical example 2
Room temperature volatilizing mite repellent:
0.6 g of an ethanol solution containing 0.1% natural pyrethrin and 1% phellandrene was impregnated into a 30 mm x 40 mm pulp filter paper, which was provided with a 9 mm x 22 mm vent and was breathable. A solid repellent was prepared by storing it in a plastic case (38 mm × 52 mm × 5 mm).

Pharmaceutical example 3
Aerosol:
An aerosol agent was prepared by filling a commercially available 200 ml aerosol can with the following formulation.
Active ingredient: Natural pyrethrin 0.4 ml
: Acetophenone 1.0 ml
Solvent: Ethanol 38.6 ml
Propellant: LPG 30.0 ml
Propellant: Isopentane 30.0 ml

Pharmaceutical example 4
Spray agent:
The following formulation was stored in a commercially available 150 ml trigger container to prepare a spray.
Active ingredient: Natural pyrethrin 0.1g
: Abies sachalinensis essential oil 1g
Solvent: Ethanol 10g
Fragrance 0.05g
Surfactant 0.1g
Ion-exchanged water 88.75g

Pharmaceutical example 5
Fumigant:
10 g of an ethanol solution containing 0.1% natural pyrethrin and 1% clove brief oil, 55 g of azodicarbonamide and 35 g of talc were kneaded, granulated and dried according to a conventional method to prepare a fumigant.

Pharmaceutical example 6
Heat transpiration agent:
A 3 cm × 3 cm pulp mat was impregnated with 100 mg of an ethanol solution containing 0.1% natural pyrethrin and 1% shell ginger oil to obtain a heat transpiration agent. This product evaporates the active ingredient by placing it in contact with a heater.

Pharmaceutical example 7
Granular repellent:
50 g of a granular impregnated body made of pulp (average particle size 5 mm) is impregnated with 50 mL of an ethanol solution containing 0.1% natural pyrethrin and 1% allyl isothiocyanate, and placed in a breathable non-woven fabric bag to form granules. Obtained a repellent.

Pharmaceutical example 8
Room temperature volatilizing mite repellent:
A 9.6 mm × 110 mm pulp filter paper was impregnated with 0.5 g of an ethanol solution containing 0.1% natural pyrethrin and 1% phellandrene and 0.01 g of Empentrin. This was stored in a breathable plastic case (130 mm × 138 mm × 9.5 mm) provided with a vent hole of 88 mm × 100 mm to prepare a solid repellent.

Pharmaceutical example 9
Modified Tick Repellent:
3 g of an ethanol solution containing 0.1% natural pyrethrin and 1% Abies sachalinensis essential oil was placed in a plastic container with a top opening (diameter 30 mm, depth 10 mm), and the opening was covered with a drug-permeable film for sustained release. Obtained a tick repellent.

Usage example 1
When the two room temperature volatilizing mite repellents obtained in Formulation Example 2 were placed together with clothes in a polyethylene clothing storage bag (75 cm × 80 cm × 32 cm), no mites were attached to the clothes for about one month.

Usage example 2
When the two room temperature volatilizing mite repellents obtained in Formulation Example 8 were placed together with the bedding in a polyethylene futon storage bag (150 cm × 100 cm), the bedding did not have mites for about 6 months.

Usage example 3
When the two room temperature volatilizing mite repellents obtained in Formulation Example 2 were placed in a 75 L (40 cm × 75 cm × 25 cm) costume case together with the clothes, the clothes did not get ticks for about 3 months.

Usage example 4
When the mite repellent of the spray agent obtained in Formulation Example 4 was sprayed evenly on the clothes, the clothes did not get ticks for about 1 week.

Usage example 5
When the mite repellent of the aerosol agent obtained in Formulation Example 3 was sprayed evenly on the carpet, the carpet was free of mites for about one month.

Usage example 6
When the sustained release tick repellent obtained in Formulation Example 9 was placed in a 30 liter polypropylene food storage container (355 mm × 472 mm × 253 mm), no mites invaded the storage container for about 1 year.

The repellent of the present invention has an excellent repellent effect against pests of the order Mite and is safe for the human body, so that it can be easily used even in ordinary households and is highly useful.

20 ……… Large petri dish 21 ……… Tick medium 22 ……… Small petri dish 23 ……… Sample piece 24 ……… Invited feed 25 ……… Plastic container 26 ……… Saturated saline solution

Claims (15)

The following components (A) and (B);
(A) Natural pyrethrin (B) (B-1) Phellandrene, (B-2) Basil oil, (B-3) Moon peach oil, (B-4) Clove leaf oil, (B-5) Black pepper oil , (B-6) Aromatic ketone compound represented by the following general formula (1),

(In the formula, R ¹ represents an alkyl group having 1 to 3 carbon atoms)
(B-7) The isothiocyanate compound represented by the following general formula (2) and

(In the formula, R indicates a phenyl group or an alkyl group or an alkylene group which may be branched with 1 to 3 carbon atoms).
(B-8) A repellent for mites, which comprises, as an active ingredient, one or more selected from the group consisting of pressed liquids, extracts or distilleds of plants belonging to the genus Fir of the Pinaceae family. (B-1) The mite repellent according to claim 1, wherein phellandrene is β-phellandrene. (B-2) The mite repellent according to claim 1, wherein the basil oil is an oil extracted from basil leaves and / or flowers. (B-3) The repellent for mites according to claim 1, wherein the shell ginger oil is an oil extracted from the leaves of shell ginger. (B-4) The mite repellent according to claim 1, wherein the clove leaf oil is a steam distilled product of clove leaves. (B-5) The repellent for mites according to claim 1, wherein the black pepper oil is a steam distilled product of black pepper. (B-6) The repellent for mites according to claim 1, wherein the aromatic ketone compound is acetophenone. (B-7) The repellent for mites according to claim 1, wherein the isothiocyanate compound is allyl isothiocyanate. (B-8) For ticks according to claim 1, wherein the squeezed liquid, extract or distillate of a plant belonging to the genus Fir of the Pinaceae family is a squeezed liquid, extract or distillate of a plant belonging to the genus Fir of the Pinaceae family. Repellent. A method for repelling mites, which comprises releasing the repellent for mites according to any one of claims 1 to 9 into the environment. The method for repelling mites according to claim 10, wherein the mite is released into the environment by natural transpiration at room temperature. The method for repelling mites according to claim 10, wherein the mite is forcibly released into the environment by transpiration by heating, transpiration by blowing air, or transpiration by fumigation. The method for repelling mites according to claim 10, wherein the mite is released into the environment by spraying. A method for repelling mites, which comprises applying the repellent for mites according to any one of claims 1 to 9 to a textile product. A method for repelling mites, which comprises bringing the mite repellent according to any one of claims 1 to 9 into contact with the mites to act.

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