JP2021054740A - Mite repellant and mite repelling method - Google Patents

Abstract

To provide a repellant that uses a component contained in a natural product, has a sufficient repelling effect on mites, has high safety for human bodies, and can be used conveniently even at ordinary households.SOLUTION: The present invention relates to a mite repellant containing black pepper oil as an active ingredient and a mite repelling method using the same.SELECTED DRAWING: None

Description

The present invention relates to a mite repellent and a method for repelling mites, and more particularly to a repellent for mites and a method for repelling mites against pests of the order Arachnida such as Dermatophagoides farinae, Dermatophagoides farinae, and Tyrophagus putrescentiae.

Conventionally, various repellents against mites have been proposed, and in recent years, pyrethroid compounds and the like have been widely used as mite repellent components.

It is also known that highly safe natural ingredients and food ingredients are used as anti-mite agents including repellents. For example, among the acaricide (Patent Document 1) obtained by steam-distilling the branches and leaves of Sugi with a water-containing polar organic solvent, and the essential oils extracted from the branches and leaves or roots of hinoki, Taiwan hinoki, sugi, and hiba. A tick control agent for sanitary pests (Patent Document 2) containing at least one or a mixture thereof as an active ingredient is known.

However, the above-mentioned components have a weak effect on mites and have a problem that a sufficient repellent effect cannot be obtained. Therefore, there is a demand for a mite repellent that has a higher mite repellent effect and that can be easily used in ordinary households and has a high degree of safety.

JP-A-6-239714A Japanese Patent Application Laid-Open No. 1-193204

Therefore, it is an object of the present invention to provide a repellent that utilizes a component contained in a natural product, has a sufficient repellent effect against mites, is highly safe for the human body, and can be easily used in ordinary households. And.

The present inventors have conducted intensive studies on the activity of components in natural products against mites in order to achieve the above-mentioned problems, and found that black pepper oil has an excellent repellent effect on mites. The present invention has been completed.

That is, the present invention is a repellent for mites containing black pepper oil as an active ingredient.

Further, the present invention is a method for repelling mites by releasing the above-mentioned mite repellent into the environment or allowing it to act in contact with mites.

The mite repellent of the present invention has an excellent repellent effect against pests of the order Arachnid, such as Dermatophagoides farinae, Dermatophagoides farinae, and Tyrophagus putrescentiae, and is a component in natural products, so it is extremely safe. It's expensive. Therefore, it can be easily used even in ordinary households, and the damage caused by mites can be effectively prevented and removed.

It is a figure which showed typically the cross section of the test apparatus used in Example 1. FIG. It is a figure which showed typically the plane of the test apparatus used in Example 1. FIG.

The mite repellent of the present invention (hereinafter referred to as "repellent") contains black pepper oil as an active ingredient.

Black pepper, which is the raw material of black pepper oil, is made from the fruits of climbing plants of the genus Piperaceae. Black pepper can be obtained by drying the green pepper berries, which are collected before they are fully ripe, for a long period of time.

As a method for obtaining black pepper oil from black pepper nuts, conventionally known methods such as squeezing method, solvent extraction method, steam distillation method and the like can be mentioned, but stable extraction is possible so as not to break the substance. The method by steam distillation is preferable because isolation after extraction is relatively easy.

As a general method for obtaining black pepper oil from the steam distillation method, black pepper oil is obtained by pressing the black pepper with a hydraulic press, immersing it in warm water for several hours, then performing steam distillation, and collecting the distillate oil. Is obtained.

The repellent of the present invention may be in the form of using the above black pepper oil as a single active ingredient, or in the form of combining an appropriate optional ingredient and using it as a preparation by a conventional method.

As will be described later, the repellent of the present invention is used by a method of evaporating, a method of contacting with mites to act, and the like, and an amount of black pepper oil suitable for these methods may be added to the repellent.

For example, if it is a method of contacting and acting on mites, it is applied directly to the place where mites live, such as bedding such as futons, pillows and blankets, tatami mats, rugs, carpets, sofas, cushions, stuffed animals and clothing. Or you can spray it with a sprayer such as a pump spray or aerosol.

The dosage form of the repellent of the present invention is not particularly limited, and may be in the form of a liquid agent, a gel agent, a solid agent, or the like, and any component corresponding thereto can be used.

One of the dosage forms of the repellent of the present invention is a liquid preparation, and a solvent is used to prepare this liquid preparation. The solvent used is not particularly limited, and a conventionally known liquid carrier can be used, but it is preferable to use a solvent having high safety to the body.

Specific examples of the solvent include water such as deionized water and distilled water; hydrocarbon compounds such as hexane, paraffin and isoparaffin; methanol, ethanol, 1-propanol, 2-propanol, 1-butanol and 2-butanol. , 2-Methyl-1-propanol, 2-Methyl-2-propanol, Pentanol, Hexanol, Heptanol, Octanol, Nonanol, Decanol and other alkyl alcohols; Alkenyl alcohols such as allyl alcohol; Aromatic rings such as benzyl alcohol Alcohol-containing alcohols; phenols such as eugenol; halogenated hydrocarbon compounds such as chloroform; ether compounds such as diethyl ether and diethylene glycol diethyl ether; ketone compounds such as acetone; fatty acid compounds such as acetic acid and oleic acid; acetic acid esters , Ester compounds such as propionic acid ester and benzoic acid ester; glycol compounds such as ethylene glycol and propylene glycol; glycol ether compounds such as 2-phenoxyethanol and 3-methyl-3-methoxybutanol; sesame oil, linole oil, salad oil Such as vegetable oils and the like. These can be used alone or in admixture of two or more.

The amount of these solvents used in the repellent is preferably 0.1 to 99.9% by mass / mass% based on the total amount of the repellent, and is 1 to 99% by mass / mass%. It is particularly preferable to mix them in such a manner. More preferably, it is 10 to 90 mass / mass%.

In addition, a surfactant may be added as necessary in the preparation of this liquid preparation. Examples of the surfactant that can be used include conventionally known surfactants such as cationic surfactants, anionic surfactants, amphoteric surfactants, and nonionic surfactants, and one of them may be used. It can be used alone or in combination of two or more.

As another dosage form of the repellent of the present invention, a solid or sheet-like solid agent obtained by impregnating and supporting the above-mentioned liquid agent in an appropriate carrier can be mentioned. The carrier to be supported is not particularly limited, and examples thereof include resin pellets such as wood, paper, woven fabric, non-woven fabric, silica, talc, activated charcoal, silica gel, zeolite, cellulose beads, ceramics, and polypropylene.

Further, as a dosage form of another repellent of the present invention, a gel agent obtained by gelling the above-mentioned liquid agent with a gelling agent can be mentioned. Conventionally known gelling agents include, for example, carrageenan, gellan gum, agar, gelatin, guar gum, pectin, locust bean gum, xanthan gum, arabic gum, tara gum, tamarind seed gum, sodium alginate, cellulose derivatives, and di. Highly water-absorbent resins such as benziliden-D-sorbitol, hydroxypropylated polysaccharide, sodium stearate, dextrin palmitate, dextrin myristinate, inulin stearate, sodium acrylate, aluminum octylate, cellulose which is an ultrafine plant crystal fiber. Nanofiber (CNF) and the like can be mentioned, and these can be used alone or in admixture of two or more.

A preferred method of using the repellent of the present invention obtained as described above includes a method of releasing the repellent of the present invention into the environment for use.

Examples of the method of releasing into the environment include a method of naturally transpiring black pepper oil, which is an active ingredient, from the repellents of the present invention such as liquids, solids, and gels, or forcibly transpiring. The method can be mentioned. Examples of the method of forced transpiration include transpiration by heating, transpiration by blast, and fumigation. Further, as a method of releasing into the environment, a method of spraying or the like may be used.

Among the above-mentioned forced evaporation methods, as a method of evaporation by heating, for example, as disclosed in Japanese Patent Publication No. 2-78077, a repellent stored in a chemical solution bottle is sucked up by a sucking core and the upper part of the sucking core. A repellent is impregnated into a heat-transpiration device that evaporates the material by heating it with a heater, or a mat-like impregnated body as disclosed in Japanese Patent Publication No. 1-116072, etc., and the mat is heated. An example of this method is to use a heating steamer or the like that evaporates by placing it on a heater.

Further, for evaporation by blowing air, for example, a drug holder and a blower as disclosed in Japanese Patent Application Laid-Open No. 11-308955 are provided, and the drug holder is brought into contact with an air flow generated by the blower to repel the agent. Can be carried out using a fan-type repellent device or the like that discharges the water from the discharge port into the environment.

Further, evaporation by steaming is carried out by, for example, in a container having an upper opening as disclosed in Japanese Patent Publication No. 54-148267, an organic foaming agent such as an azo compound such as azodicarbonamide, a nitroso compound, or a hydrazide compound. A storage chamber containing the repellent is formed, and a smoker or the like is used to evaporate the repellent with nitrogen gas, carbon dioxide gas, etc. generated by decomposing the foaming agent by heating the bottom of the storage chamber with a heating means. Can be done.

Furthermore, spraying can be performed by using a sprayer to spray a liquid agent or by using an aerosol using an appropriate propellant. In the case of using a spray agent, the above-mentioned liquid agent may be combined with a spraying means such as a trigger spray or an atomizer. In the case of an aerosol agent, the above-mentioned liquid agent, an aerosol carrier such as LPG or isopentan, and an aerosol spraying means such as an aerosol can may be combined.

In addition, as another preferable method of using the repellent of the present invention, there is a method of allowing the repellent of the present invention to act in contact with mites in a liquid or solid state. In this case, the repellent effect can be exerted by contacting the installed repellent with the mites.

The repellent of the present invention is an active ingredient by installing and applying it in a storage room, a chest of drawers, a closet, a closet, a clothes case, a clothing storage bag, a futon storage bag, a living room, a bedroom or the like, or a space such as an entrance. Can be effectively repelled by being released into the environment or by contacting the mites. Further, the repellent of the present invention may be applied by directly spraying, spraying, applying or the like to an object such as a tatami mat, a carpet, a carpet, a floor, a futon, a pillow, a sofa, or clothing in which mites live.

The repellent of the present invention may contain other conventionally known mite control components, whereby a more excellent repellent effect can be exhibited.

Examples of these other tick control components include pyrethroid compounds such as empentrin, transfluthrin, aresulin, phenothrin, profluthrin, metoflutrin, and eminence; organic phosphorus agents such as dichlorobos, diadinone, fenitrothione, malathion, etc.; N, N. -Diethyl-m-toluamide (DEET), dimethylphthalate, dibutylphthalate, 2-ethyl-1,3-hexanediol, di-n-propylisosincomeronate, p-dichlorobenzene, di-n-butylsuccinate, Callan-3,4-diol, 1-methylpropyl2- (2-hydroxyethyl) -1-piperidincarboxylate, isopropyl myristate, isobornyl thiocyanoacetate, diphenyl, diphenylmethane, dibenzyl, benzylphenyl ether, benzylphenyl ethyl ether, Benzylphenone, benzylphenylketone, dibenzylketone, benzalacetophenone, β-phenylethylbenzoate, γ-phenylpropylbenzoate, phenylacetate, benzylphenylacetate, β-phenylethylphenylacetate, phenylcinnamate, benzylsinnamete , Β-phenylethyl cinnamate, β-phenylpropyl cinnamate, cinnamyl cinnamate, diphenylcarbinol, phenylbenzylcarbinol, dibenzylcarbinol, n-amylbenzoate, isoamylbenzoate, hexylbenzoate, heptylbenzoate, octylbenzoate , Nonylbenzoate, cis-3-hexenylbenzoate, n-amyl salicylate, iso-amyl salicylate, hexyl salicylate, cis-3-hexenyl salicylate, benzyl propionate, benzyl-n-butyrate, benzoluiso-butyrate, Compounds such as benzyl-n-valerate, benzylisovalerate, benzylcaproate, benzylheptanoate, benzylcaprilate, penzyldanylate, eugenol, methyleugenol, isoeugenol; α, β-pinene, α, β -Terpen compounds such as terpinol, limonene, citronellal, linalol, and citral; plant essential oils such as menthol, benzyl oil, pachori oil, clove oil, cedar, hinoki, Taiwan hinoki, and hiba essential oil, and plants belonging to the genus Fir of the pine family. Squeezed liquid, extract or benzyl, etc. Therefore, one of these types may be used alone, or two or more types may be used in combination.

Among the mite repellents of the present invention, one of preferred embodiments is a combination with a pressed liquid, an extract or a distilled product of a plant belonging to the genus Fir of the Pinaceae family disclosed in JP-A-2017-39677. A method for producing this squeezed liquid, extract or distilled product is described in the patent publication. Further, in this embodiment, the blending amount of the pressed liquid or the like with respect to 1 part by mass of black pepper oil is preferably about 0.01 to 10 parts by mass, and particularly preferably 0.1 to 1 part by mass.

The repellent of the present invention described above exerts an excellent repellent effect against pests of the order Tick such as Dermatophagoides farinae, Dermatophagoides farinae, Tyrophagus putrescentiae, Itch mite, Tick, House dust mite, Dermatophagoides farinae, and Dermatophagoides farinae. Furthermore, since the pressed liquid, extract or distillate of the plant belonging to the genus Fir of the Pinaceae family also exhibits insecticidal, egg-laying inhibitory and egg hatching inhibitory effects on these mites, a mite repellent that combines them. Has a better tick control effect.

Next, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples.

Manufacturing example Black pepper oil was obtained as follows. That is, 100 g of black pepper berries were sufficiently ground with a commercially available mortar and a mortar, placed in a 1 L beaker, put in 500 mL of hot water at about 80 ° C., covered with a lid, soaked for 2 hours, and then crushed. The whole was put into the distillation tank of the steam distillation apparatus and steam distilled. Then, the essential oil was separated from the distillate to obtain black pepper oil. The amount of the obtained essential oil was about 11 g, and the ratio of the essential oil to the input sample was 11%.

Example 1
Dermatophagoides farinae repellent test:
According to JIS L 1920 "Mite-proof performance test method for textile products", mites were bred, the density was adjusted, and the repellent test was conducted with the devices shown in FIGS. 1 and 2.

That is, the black pepper oil obtained in the production example was applied to a filter paper having a diameter of 40 mm to obtain a test piece. The test piece (23) was placed in a small glass petri dish (22) having a diameter of 45 mm and a height of 17 mm, and 0.05 g of the citation feed (24) was placed in the center thereof. A large plastic petri dish (20) with a diameter of 90 mm and a height of 14 mm is uniformly mixed with a mite medium (21) containing about 10,000 live Kona leopard mite (a mixture of powdered feed for breeding medium and dried yeast at a mass ratio of 1: 1). The small glass petri dish (22) was placed in the center of the medium. This was housed in a plastic container (25) containing a saturated saline solution (26) for humidity control.

The container was covered and sealed, and installed in a room having a temperature of 25 ° C. ± 1 ° C. After leaving for 20 hours after installation, the total number of surviving mites in the specimen and the reference medium was counted. This test was repeated 3 times, using a filter paper that was not treated with chemicals as a blank. The total number of counts of the three tests was calculated, and the repellent rate was calculated by the following formula. The results are shown in Table 2.

From the above results, it was shown that the product of the present invention has a high repellent effect on Dermatophagoides farinae.

Antacid example 1
Gel-like mite repellent:
10 g of the black pepper oil used in Example 1 was mixed with 85 g of isoparaffin, 5 g of aluminum octylate was further added thereto, and the mixture was heated to 60 ° C. and stirred. This was filled in a container having a length of 35 mm, a width of 35 mm and a height of 75 mm, and allowed to stand at room temperature for 3 hours to obtain a gel-like mite repellent.

Agent example 2
Room temperature volatilizing mite repellent:
A breathable plastic case (38 mm x 52 mm x 5 mm) in which 0.6 g of the black pepper oil used in Example 1 was impregnated into a 30 mm x 40 mm pulp filter paper and provided with a 9 mm x 22 mm vent hole. A solid repellent was prepared by storing in.

Antacid example 3
Aerosol:
An aerosol agent was prepared by filling a commercially available 200 ml aerosol can with the following formulation.
Active ingredient: 1 ml of black pepper oil used in Example 1
Solvent: Ethanol 39.0 ml
Propellant: LPG 30.0 ml
Propellant: Isopentane 30.0 ml

Antacid example 4
Spray agent:
The following formulation was stored in a commercially available 150 ml trigger container to prepare a spray.
Active ingredient: 0.1 g of black pepper oil used in Example 1
Solvent: Ethanol 10g
Fragrance 0.05g
Surfactant 0.1g
Ion-exchanged water 89.75g

Antacid example 5
Fumigant:
10 g of black pepper oil, 55 g of azodicarbonamide and 35 g of talc used in Example 1 were kneaded, granulated and dried according to a conventional method to prepare a fumigant.

Antacid example 6
Heat transpiration agent:
A 3 cm × 3 cm pulp mat was impregnated with 100 mg of black pepper oil used in Example 1 to obtain a heat transpiration agent. This product evaporates the active ingredient by placing it in contact with a heater.

Antacid example 7
Granular repellent:
50 g of a granular impregnated body made of pulp (average particle size 5 mm) was impregnated with 50 mL of the black pepper oil used in Example 1 and placed in a breathable non-woven fabric bag to obtain a granular repellent.

Agent Acid Example 8
Room temperature volatilizing mite repellent:
0.5 g of black pepper oil and 0.01 g of empentrin used in Example 1 were impregnated into a 9.6 mm × 110 mm pulp filter paper. This was stored in a breathable plastic case (130 mm × 138 mm × 9.5 mm) provided with a vent hole of 88 mm × 100 mm to prepare a solid repellent.

Antacid example 9
Sustained-release mite repellent:
3 g of the black pepper oil used in Example 1 was placed in a plastic container (diameter 30 mm, depth 10 mm) having a top opening, and the opening was covered with a drug-permeable film to obtain a sustained-release mite repellent.

Usage example 1
When the two room temperature volatilizing mite repellents obtained in Formulation Example 2 were placed together with clothes in a polyethylene clothing storage bag (75 cm × 80 cm × 32 cm), no mites were attached to the clothes for about one month.

Usage example 2
When the two room temperature volatilizing mite repellents obtained in Formulation Example 8 were placed in a polyethylene futon storage bag (150 cm × 100 cm) together with the bedding, the bedding did not have mites for about 6 months.

Usage example 3
When the two room temperature volatilizing mite repellents obtained in Preparation Example 2 were placed in a 75 L (40 cm × 75 cm × 25 cm) costume case together with the clothes, the clothes did not get ticks for about 3 months.

Usage example 4
When the mite repellent of the spray agent obtained in Preparation Example 4 was sprayed evenly on the clothes, the clothes did not get ticks for about 1 week.

Usage example 5
When the mite repellent of the aerosol agent obtained in Preparation Example 3 was sprayed evenly on the carpet, the carpet was free of mites for about one month.

Usage example 6
When the sustained-release mite repellent obtained in Formulation Example 9 was placed in a 30-liter polypropylene food storage container (355 mm × 472 mm × 253 mm), no mites invaded the storage container for about 1 year.

The black pepper oil, which is the active ingredient of the repellent of the present invention, exerts an excellent repellent effect against pests of the order Tick, is safe for the human body, and has high stability. Therefore, the repellent of the present invention can be easily used even in ordinary households and is highly useful.

20 ……… Large petri dish 21 ……… Tick medium 22 ……… Small petri dish 23 ……… Sample piece 24 ……… Invited feed 25 ……… Plastic container 26 ……… Saturated saline solution

Claims (7)

A repellent for mites that contains black pepper oil as an active ingredient. The mite repellent according to claim 1, wherein the black pepper oil is an oil extracted from black pepper. A method for repelling mites, which comprises releasing black pepper oil into the environment using the repellent according to claim 1 or 2. The method for repelling mites according to claim 3, wherein the mite is released into the environment by natural transpiration at room temperature. The method for repelling mites according to claim 3, wherein the mite is forcibly released into the environment by transpiration by heating, transpiration by blast, or fumigation. The method for repelling mites according to claim 3, wherein the mite is released into the environment by spraying. A method for repelling mites, which comprises contacting black pepper oil with mites to act by using the repellent according to claim 1 or 2.

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