JP2020049265A - 光硬化性接着剤を用いた硬化療法のための組成物およびデバイス - Google Patents
光硬化性接着剤を用いた硬化療法のための組成物およびデバイス Download PDFInfo
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M2005/1401—Functional features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0082—Catheter tip comprising a tool
- A61M25/0084—Catheter tip comprising a tool being one or more injection needles
Abstract
Description
好ましい態様では、上記組成物は、治療される静脈セグメント100mmにつき、0.001〜1.0gの接着剤、好ましくは0.001〜0.5、さらに好ましくは、0.001〜0.1g/100mmを含む。
より好ましい態様では、上記組成物は、治療される静脈セグメント100mmにつき、0.01〜1.0gの接着剤、好ましくは0.05〜0.5、さらに好ましくは、0.005〜0.1g/100mmを含む。
好ましくは、静脈疾患は静脈不全、膨張静脈、静脈瘤、拡張症または動脈瘤の群から選択される。
さらに好ましい実施形態では、接着剤およびガスは、本発明の注入カテーテル装置に負荷され、その後のボーラスに適用される。好ましくは、接着剤は、薬学的に許容される組織接着剤である。好ましくは、接着剤はまた、光硬化または光活性化接着剤であり、ガスは、静脈内使用のために許容される医療ガスである。
a.より小さい管をより大きな管内に配置して機能ユニットを形成する、大きな管および小さな管であって、
b.両方の管は、任意に再配置可能および取り外し可能であり、
c.両方の管は、両端に開口部を有し、
d.一つの開口部が先端から5mmと40mmとの間の距離に位置する外管の壁に設けられるか、またはいくつかの開口部が先端から5mm〜250mmのセグメントに位置し、ここで一つの開口の直径は外管の内径の70%と120%との間であり、またはいくつかの開口部の場合には各開口部につき、外管の内径の30%〜60%であり;いくつかの開口部の場合には:サイズ、形状および配給は、(フォーム)硬化薬の均一な展開を提供するように設けられているもの、
e.および光源または光伝導体を含み、
f.内管の外径は0.6mmと2.0mmとの間であり、内径は0.3〜1.6mm、より好ましくは0.4〜1.0mm、さらにより好ましくは0.5〜0.8mmであり、
g.外管の外径は、1.3mmと3.3mmとの間であり、内径は1.1〜3.0mm、好ましくは1.1〜2.8mm、さらにより好ましくは1.1〜2.7mmであり、内管の外壁と外管の内壁との間の距離は、0.1mmから3.0mmとの間であり、好ましくは1.1〜2.5mm、さらにより好ましくは0.1〜2.0mmである。
・外管の外径:1.3〜2.8mm、好ましくは1.5〜2.6mm、より好ましくは1.7〜2.4mm。
・外管の内径:1.0〜2.4mm、好ましくは1.4〜2.0mm、より好ましくは1.2〜1.8mm。
外管の壁の直径/厚み:0.1〜1.5mm、0.1〜0.3mm、好ましくは0.125〜0.25mm、より好ましくは0.15〜0.2mm。
D (mm) = Fr/3または、Fr = D (mm) × 3
Claims (18)
- 硬化療法における使用のための組成物であって、
a)薬学的に許容される組織接着剤、
b)好ましくはフォームの形態の、硬化薬、および
c)任意に、静脈内使用のために許容される医療ガスを含み、
前記薬学的に許容される組織接着剤が、注射可能であり、光硬化性または光活性化性であり、生分解性および/または生体適合性であり、ならびに好ましくは硬化後柔軟である組成物。 - 前記接着剤が、粘性流体、ゲル、フォームまたはエマルジョンの形態である請求項1に記載の組成物。
- 静脈セグメント100mmにつき、0.001〜1.0gの接着剤、好ましくは0.001〜0.5、さらに好ましくは、0.001〜0.1g/100mmの接着剤を含む請求項1または2に記載の組成物。
- 前記医療ガスが、二酸化炭素、酸素、空気、またはそれらの混合物のリストから選択される請求項1〜3のいずれかに記載の組成物。
- 光源を含む注入カテーテルデバイス。
- 前記光源が、光ファイバーまたは他の光伝送素子である請求項5に記載の注入カテーテルデバイス。
- 前記光源が、紫外光、可視光、または赤外光を発生、伝送、または発光し、紫外光は10〜380nmの間の波長の光であり、可視光は381〜780nmの間の波長の光であり、赤外光は781nm〜1mmの間の波長の光である請求項5または6に記載の注入カテーテルデバイス。
- 接着剤およびガスが、前記カテーテル内に負荷され、その後の塊で適用される請求項5〜7のいずれかに記載の注入カテーテルデバイス。
- 前記カテーテルが0.6〜2.2mmの内径、0.8〜2.8mmの外径、および、少なくとも一つの内腔を有する請求項5〜8のいずれかに記載の注入カテーテルデバイス。
- さらに接着剤用の容器を含む請求項5〜9のいずれかに記載の注入カテーテルデバイス。
- 前記カテーテルが二重管カテーテルである請求項5〜10のいずれかに記載の注入カテーテルデバイス。
- 前記光源が前記カテーテルの壁および/または前記カテーテルの1つの内腔内に一体化されている請求項5〜11のいずれかに記載の注入カテーテルデバイス。
- さらに分離システムを含む請求項5〜12のいずれかに記載の注入カテーテルデバイス。
- さらにセンサシステムを含む請求項5〜13のいずれかに記載の注入カテーテルデバイス。
- 請求項1〜4のいずれかに記載の組成物を含むキットであって、前記接着剤が薬学的に許容されるおよび/または生体適合性の光硬化性接着剤であるキット、ならびに請求項6〜14のいずれかに記載のカテーテル。
- 静脈が光硬化性接着剤を用いて閉塞される硬化療法のための方法。
- 静脈疾患の治療での使用のための光硬化性接着剤。
- 静脈疾患が静脈不全、膨張静脈、静脈瘤、拡張症または動脈瘤から選択される請求項17に記載の使用。
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US10542996B2 (en) | 2017-06-27 | 2020-01-28 | Covidien Lp | Vessel closure device |
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10502267A (ja) * | 1994-06-24 | 1998-03-03 | フォーカル,インコーポレイテッド | 内腔用光重合体ゲル注入器具およびその方法 |
JP2004524094A (ja) * | 2001-03-06 | 2004-08-12 | サイムド ライフ システムズ, インコーポレイテッド | 組織修復のためのデバイスおよび方法 |
JP2006523471A (ja) * | 2003-02-05 | 2006-10-19 | ベインアールエックス,インコーポレイティド | 血管の内部を治療する方法及び装置 |
JP2009082728A (ja) * | 2004-11-16 | 2009-04-23 | Microvention Inc | 血管の障害を治療するための組成物、システムおよび方法 |
US20120109191A1 (en) * | 2011-12-13 | 2012-05-03 | Vascular Insights Llc | Adhesive-based varicose vein treatment |
JP2012518482A (ja) * | 2009-02-20 | 2012-08-16 | サフェオン・インコーポレーテッド | 静脈不全の治療のための静脈閉鎖に対する方法および装置 |
WO2013160180A2 (en) * | 2012-04-24 | 2013-10-31 | Angioclinic Ag | Method and device for treating venous insufficiency and varicose veins |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2265896A (en) * | 1938-12-22 | 1941-12-09 | Suzanne Rosalie Mathot | Focusing device for motion and still picture cameras |
US5000740A (en) * | 1989-04-10 | 1991-03-19 | Critikon, Inc. | Catheter with needle guard |
US5948427A (en) * | 1996-04-25 | 1999-09-07 | Point Medical Corporation | Microparticulate surgical adhesive |
US20050107738A1 (en) * | 2000-07-21 | 2005-05-19 | Slater Charles R. | Occludable intravascular catheter for drug delivery and method of using the same |
US20080275432A1 (en) * | 2006-05-11 | 2008-11-06 | Ceramoptec Industries, Inc. | Photodynamic foam composition and sclerosis treatment |
WO2008086375A2 (en) * | 2007-01-08 | 2008-07-17 | Light Sciences Oncology, Inc. | Non-invasive vascular treatment systems, devices, and methods of using the same |
WO2008086376A2 (en) * | 2007-01-08 | 2008-07-17 | Light Sciences Oncology, Inc. | Therapeutic devices for the treatment of varicosity |
US20110035174A1 (en) * | 2008-04-07 | 2011-02-10 | Nxp B.V. | Time synchronization in an image processing circuit |
KR20130072907A (ko) * | 2011-12-22 | 2013-07-02 | 주식회사 케이티 | 단축 url 생성 방법 및 이를 지원하는 시스템 |
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Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10502267A (ja) * | 1994-06-24 | 1998-03-03 | フォーカル,インコーポレイテッド | 内腔用光重合体ゲル注入器具およびその方法 |
JP2004524094A (ja) * | 2001-03-06 | 2004-08-12 | サイムド ライフ システムズ, インコーポレイテッド | 組織修復のためのデバイスおよび方法 |
JP2006523471A (ja) * | 2003-02-05 | 2006-10-19 | ベインアールエックス,インコーポレイティド | 血管の内部を治療する方法及び装置 |
JP2009082728A (ja) * | 2004-11-16 | 2009-04-23 | Microvention Inc | 血管の障害を治療するための組成物、システムおよび方法 |
JP2012518482A (ja) * | 2009-02-20 | 2012-08-16 | サフェオン・インコーポレーテッド | 静脈不全の治療のための静脈閉鎖に対する方法および装置 |
US20120109191A1 (en) * | 2011-12-13 | 2012-05-03 | Vascular Insights Llc | Adhesive-based varicose vein treatment |
WO2013160180A2 (en) * | 2012-04-24 | 2013-10-31 | Angioclinic Ag | Method and device for treating venous insufficiency and varicose veins |
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