JP2020037555A5 - - Google Patents

Download PDF

Info

Publication number
JP2020037555A5
JP2020037555A5 JP2019187271A JP2019187271A JP2020037555A5 JP 2020037555 A5 JP2020037555 A5 JP 2020037555A5 JP 2019187271 A JP2019187271 A JP 2019187271A JP 2019187271 A JP2019187271 A JP 2019187271A JP 2020037555 A5 JP2020037555 A5 JP 2020037555A5
Authority
JP
Japan
Prior art keywords
cdr
seq
sequence shown
light chain
heavy chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2019187271A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020037555A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2020037555A publication Critical patent/JP2020037555A/ja
Publication of JP2020037555A5 publication Critical patent/JP2020037555A5/ja
Ceased legal-status Critical Current

Links

JP2019187271A 2011-09-16 2019-10-11 クロストリジウム・ディフィシレの主要な外毒素TcdA及びTcdBに対する中和抗体 Ceased JP2020037555A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161535532P 2011-09-16 2011-09-16
US61/535,532 2011-09-16
US201261638731P 2012-04-26 2012-04-26
US61/638,731 2012-04-26

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2017104698A Division JP6603685B2 (ja) 2011-09-16 2017-05-26 クロストリジウム・ディフィシレの主要な外毒素TcdA及びTcdBに対する中和抗体

Publications (2)

Publication Number Publication Date
JP2020037555A JP2020037555A (ja) 2020-03-12
JP2020037555A5 true JP2020037555A5 (2) 2020-08-06

Family

ID=46881094

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2014530307A Expired - Fee Related JP6152107B2 (ja) 2011-09-16 2012-09-10 クロストリジウム・ディフィシレの主要な外毒素TcdA及びTcdBに対する中和抗体
JP2017104698A Expired - Fee Related JP6603685B2 (ja) 2011-09-16 2017-05-26 クロストリジウム・ディフィシレの主要な外毒素TcdA及びTcdBに対する中和抗体
JP2019187271A Ceased JP2020037555A (ja) 2011-09-16 2019-10-11 クロストリジウム・ディフィシレの主要な外毒素TcdA及びTcdBに対する中和抗体

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2014530307A Expired - Fee Related JP6152107B2 (ja) 2011-09-16 2012-09-10 クロストリジウム・ディフィシレの主要な外毒素TcdA及びTcdBに対する中和抗体
JP2017104698A Expired - Fee Related JP6603685B2 (ja) 2011-09-16 2017-05-26 クロストリジウム・ディフィシレの主要な外毒素TcdA及びTcdBに対する中和抗体

Country Status (30)

Country Link
US (2) US10752676B2 (2)
EP (2) EP2758432B1 (2)
JP (3) JP6152107B2 (2)
KR (1) KR20140063825A (2)
CN (2) CN103958544B (2)
AU (1) AU2012307157B2 (2)
BR (1) BR112014006175B1 (2)
CA (1) CA2848611A1 (2)
CL (1) CL2014000491A1 (2)
CO (1) CO6930310A2 (2)
CY (1) CY1121673T1 (2)
DK (1) DK2758432T3 (2)
EA (1) EA032475B1 (2)
EC (1) ECSP14013316A (2)
ES (1) ES2729278T3 (2)
HK (1) HK1199463A1 (2)
HR (1) HRP20190917T1 (2)
HU (1) HUE043661T2 (2)
IL (1) IL231167A0 (2)
LT (1) LT2758432T (2)
MX (1) MX2014002769A (2)
PE (1) PE20141547A1 (2)
PH (1) PH12014500456A1 (2)
PL (1) PL2758432T3 (2)
PT (1) PT2758432T (2)
SG (2) SG11201400193SA (2)
SI (1) SI2758432T1 (2)
TN (1) TN2014000101A1 (2)
WO (1) WO2013038156A1 (2)
ZA (1) ZA201402760B (2)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2758432T3 (pl) * 2011-09-16 2019-08-30 Ucb Biopharma Sprl Przeciwciała neutralizujące przeciw głównym egzotoksynom tcda i tcdb z clostridium difficile
CN109776676A (zh) * 2012-11-28 2019-05-21 Cnj控股公司 针对艰难梭菌的抗体
CN105451762A (zh) * 2013-04-22 2016-03-30 俄克拉荷马州大学评议会 艰难梭菌疫苗及使用方法
WO2015123767A1 (en) * 2014-02-18 2015-08-27 The Hospital For Sick Children Compositions and methods for treating or preventing clostridium infection
US9717711B2 (en) 2014-06-16 2017-08-01 The Lauridsen Group Methods and compositions for treating Clostridium difficile associated disease
WO2016178773A1 (en) * 2015-04-06 2016-11-10 Saureus, Inc. System and method for detecting clostridium difficile toxins
US20180085458A1 (en) * 2015-04-15 2018-03-29 Medimmune, Llc Methods for treating clostridium difficile infection and associated disease
HUE057952T2 (hu) 2015-06-24 2022-06-28 Hoffmann La Roche Anti-transzferrin receptor antitestek testreszabott affinitással
EP3344276B1 (en) 2015-09-03 2020-04-22 The Board of Regents of the University of Oklahoma Peptide inhibitors of clostridium difficile tcdb toxin
TWI873952B (zh) 2015-10-02 2025-02-21 瑞士商赫孚孟拉羅股份公司 雙特異性抗‐人類cd20/人類轉鐵蛋白受體抗體及使用方法
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
USD864160S1 (en) 2016-12-06 2019-10-22 Samsung Electronics Co., Ltd. Audio device
US12071666B2 (en) * 2016-12-14 2024-08-27 Merck Sharp & Dohme Llc Human genetic markers associated with response to treatments that target clostridium difficile toxin B
CN110607314B (zh) * 2019-10-31 2022-09-23 四川农业大学 一种TcdB RBD基因、重组RBD蛋白和应用
CN111763263A (zh) * 2020-07-09 2020-10-13 宁夏医科大学 一种艰难梭菌抗原及多克隆抗体的制备方法和检测试剂盒
CN112500484B (zh) * 2021-01-29 2021-06-08 迈杰转化医学研究(苏州)有限公司 一种抗trop2抗体及其应用
CN121379975B (zh) * 2025-12-25 2026-04-17 天津一瑞生物科技股份有限公司 抗TcdB毒素杂交瘤细胞株、单克隆抗体及应用

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4436727A (en) 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
DK336987D0 (da) 1987-07-01 1987-07-01 Novo Industri As Immobiliseringsmetode
CA1331443C (en) 1987-05-29 1994-08-16 Charlotte A. Kensil Saponin adjuvant
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
GB8720833D0 (en) 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8907617D0 (en) 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
EP0468520A3 (en) 1990-07-27 1992-07-01 Mitsui Toatsu Chemicals, Inc. Immunostimulatory remedies containing palindromic dna sequences
CA2090126C (en) 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
GB9112536D0 (en) 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
GB9113120D0 (en) 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
GB9120467D0 (en) 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
JP3723231B2 (ja) 1991-12-23 2005-12-07 ディミナコ アクチェンゲゼルシャフト アジュバント
CA2138997C (en) 1992-06-25 2003-06-03 Jean-Paul Prieels Vaccine composition containing adjuvants
US5776468A (en) 1993-03-23 1998-07-07 Smithkline Beecham Biologicals (S.A.) Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A
PL181241B1 (pl) 1993-11-17 2001-06-29 Deutsche Om Arzneimittel Gmbh Disacharydy beta(1 6)glukozoaminowe, sposób wytwarzania disacharydu beta(1 6) glukozoaminowego, zawierająca je kompozycja farmaceutyczna i środek immunomodulujący i/lub przeciwnowotworowy oraz szczepionka
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
FR2716640B1 (fr) 1994-02-28 1996-05-03 Procedes Machines Speciales Dispositif de centrage et de blocage d'une pièce en vue de son rodage à l'aide d'un rodoir à expansion.
EP1167379A3 (en) 1994-07-15 2004-09-08 University Of Iowa Research Foundation Immunomodulatory oligonucleotides
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
GB9620795D0 (en) 1996-10-05 1996-11-20 Smithkline Beecham Plc Vaccines
ATE292980T1 (de) 1996-10-11 2005-04-15 Univ California Immunostimulierende oligonucleotidekonjugate
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
GB9711990D0 (en) 1997-06-11 1997-08-06 Smithkline Beecham Biolog Vaccine
CA2302522C (en) 1997-08-29 2010-08-17 Antigenics Llc Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient
GB9718901D0 (en) 1997-09-05 1997-11-12 Smithkline Beecham Biolog Vaccine
AU1145699A (en) 1997-09-05 1999-03-22 Smithkline Beecham Biologicals (Sa) Oil in water emulsions containing saponins
GB9812545D0 (en) 1998-06-10 1998-08-05 Celltech Therapeutics Ltd Biological products
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
WO2004041857A2 (en) * 2002-06-17 2004-05-21 Ballard Jimmy D Mutant of clostridium difficile toxin b and methods of use
AU2002352938B8 (en) * 2002-11-26 2009-10-08 The University Of Chicago Materials and methods for preventing and treating microbe-mediated epithelial disorders
ES2374068T3 (es) 2002-12-03 2012-02-13 Ucb Pharma, S.A. Ensayo para identificar células productoras de anticuerpos.
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
ES2551439T5 (es) 2003-07-01 2018-11-08 Ucb Biopharma Sprl Fragmentos Fab de anticuerpos modificados
DK2270045T3 (en) * 2004-02-06 2015-04-07 Univ Massachusetts ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINES AND APPLICATIONS THEREOF
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
EP1830635B1 (en) 2004-12-27 2015-10-28 Huntsman Corporation Australia Pty Limited Reduced foam dispersions and formulations therefor
WO2006071877A2 (en) 2004-12-27 2006-07-06 Progenics Pharmaceuticals (Nevada), Inc. Orally deliverable and anti-toxin antibodies and methods for making and using them
WO2007146139A2 (en) * 2006-06-08 2007-12-21 Cornell Research Foundation, Inc. Codon-optimized dna molecules encoding the receptor binding domains of clostridium difficile toxins a and b
GB0619291D0 (en) 2006-09-29 2006-11-08 Ucb Sa Altered antibodies
EP2535349A1 (en) 2007-09-26 2012-12-19 UCB Pharma S.A. Dual specificity antibody fusions
BRPI0906060A2 (pt) * 2008-02-28 2015-12-01 3M Innovative Properties Co anticorpos isolados, métodos de preparo de um anticorpo anti-clostridium difficile, composição e método para a detecção da presença de um esporo de clostridium difficile em uma amostra
BRPI0914251B1 (pt) * 2008-06-25 2022-07-19 Novartis Ag Imunoligante recombinante, seu fragmento de ligação ao antígeno, uso dos mesmos, e composição
CA2737241C (en) 2008-09-26 2017-08-29 Ucb Pharma S.A. Multivalent antibody fusion proteins
AU2010215275B2 (en) * 2009-02-20 2016-03-31 Micropharm Limited Antibodies to Clostridium difficile toxins
US8986697B2 (en) * 2010-04-15 2015-03-24 Progenics Pharmaceuticals, Inc. Antibodies for the treatment of Clostridium difficile-associated infection and disease
EP2632949B1 (en) * 2010-10-25 2017-09-13 National Research Council of Canada Clostridium difficile-specific antibodies and uses thereof
US9815889B2 (en) * 2011-08-02 2017-11-14 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Antibodies for prevention and treatment of diseases caused by clostridium difficile
PL2758432T3 (pl) * 2011-09-16 2019-08-30 Ucb Biopharma Sprl Przeciwciała neutralizujące przeciw głównym egzotoksynom tcda i tcdb z clostridium difficile
UA112203C2 (uk) * 2011-11-11 2016-08-10 Юсб Фарма С.А. Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини
WO2014061783A1 (ja) * 2012-10-19 2014-04-24 株式会社イーベック クロストリジウム・ディフィシルの毒素に特異的なヒト抗体もしくはその抗原結合性断片
GB201411320D0 (en) * 2014-06-25 2014-08-06 Ucb Biopharma Sprl Antibody construct
GB201411420D0 (en) * 2014-06-26 2014-08-13 Ucb Biopharma Sprl Antibody constructs
US9107906B1 (en) * 2014-10-28 2015-08-18 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency

Similar Documents

Publication Publication Date Title
JP2020037555A5 (2)
HRP20190917T1 (hr) NEUTRALIZIRAJUĆA PROTUTIJELA NA GLAVNE EKSOTOKSINE TcdA i TcdB CLOSTRIDIUM DIFFICILE
IL266756A (en) Human monoclonal antibodies that bind to MASP 2 and suppress MASP-dependent complement activation, methods for their production and uses
JP6182152B2 (ja) 抗シュードモナス属(Pseudomonas)PslおよびPcrV結合分子を用いた併用治療
SI2857418T1 (en) Antibodies against Clostridium difficile toxins and uses thereof
HRP20190932T1 (hr) Molekule protutijela koje se vežu na il-17a i il-17f
JP2018507220A5 (2)
JP2021531254A5 (2)
JP2021501162A5 (2)
NZ585559A (en) Humanized antibodies against tl1a
FI3484915T3 (fi) Uusia zikavirusepitooppeihin spesifisesti sitoutuvia vasta-aineita ja niiden käyttöjä
RU2018106456A (ru) Антитело к epha4
JP2017534577A5 (2)
NZ596712A (en) Anti cxcr4 antibodies for the treatment of hiv
JP2016513682A5 (2)
RU2015115956A (ru) Антитела, специфичные в отношении фактора роста тромбоцитов в, и их композиции и применения
JP2013519364A5 (2)
JP2014529610A5 (2)
PE20221511A1 (es) Anticuerpos anti-ly6g6d y metodos de uso
CR20240482A (es) Anticuerpos anti-tl1a y métodos de uso de los mismos
UA108466C2 (en) Antibody antagonises c-Met
JP2021510523A5 (2)
CO6180454A2 (es) Anticuerpos de la egfl7 y metodos de uso
JP2021509012A5 (2)
JP2016501877A5 (2)