JP2020000247A5 - - Google Patents
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- Publication number
- JP2020000247A5 JP2020000247A5 JP2019154479A JP2019154479A JP2020000247A5 JP 2020000247 A5 JP2020000247 A5 JP 2020000247A5 JP 2019154479 A JP2019154479 A JP 2019154479A JP 2019154479 A JP2019154479 A JP 2019154479A JP 2020000247 A5 JP2020000247 A5 JP 2020000247A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- engineered
- acylamino
- bacillus subtilis
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004442 acylamino group Chemical group 0.000 claims 40
- 239000002253 acid Substances 0.000 claims 27
- 244000063299 Bacillus subtilis Species 0.000 claims 24
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 24
- 108090000364 Ligases Proteins 0.000 claims 18
- 102000003960 Ligases Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 16
- 238000012258 culturing Methods 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 11
- 108010046716 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) Proteins 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 8
- 235000014113 dietary fatty acids Nutrition 0.000 claims 7
- 229930195729 fatty acid Natural products 0.000 claims 7
- 239000000194 fatty acid Substances 0.000 claims 7
- 150000004665 fatty acids Chemical class 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 6
- 125000002252 acyl group Chemical group 0.000 claims 5
- 239000000758 substrate Substances 0.000 claims 3
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 claims 2
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 claims 2
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 claims 2
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 claims 2
- 108010013198 Daptomycin Proteins 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 2
- 229960005484 daptomycin Drugs 0.000 claims 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 2
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- UAXOELSVPTZZQG-UHFFFAOYSA-N tiglic acid Natural products CC(C)=C(C)C(O)=O UAXOELSVPTZZQG-UHFFFAOYSA-N 0.000 claims 2
- SXGMVGOVILIERA-NFJMKROFSA-N (2s)-2,3-diaminobutanoic acid Chemical compound CC(N)[C@H](N)C(O)=O SXGMVGOVILIERA-NFJMKROFSA-N 0.000 claims 1
- OGNSCSPNOLGXSM-UHFFFAOYSA-N 2,4-diaminobutyric acid Chemical compound NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 1
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims 1
- 101100257702 Bacillus subtilis (strain 168) srfAA gene Proteins 0.000 claims 1
- IJASURGZDJYQGF-UHFFFAOYSA-N C(10)-epi-mycalamide Natural products C12OC(CC(O)CO)C(C)(C)C(OC)C2OCOC1NC(=O)C(O)C1(OC)CC(=C)C(C)C(C)O1 IJASURGZDJYQGF-UHFFFAOYSA-N 0.000 claims 1
- AFWTZXXDGQBIKW-UHFFFAOYSA-N C14 surfactin Natural products CCCCCCCCCCCC1CC(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O1 AFWTZXXDGQBIKW-UHFFFAOYSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- 239000005639 Lauric acid Substances 0.000 claims 1
- 108010028921 Lipopeptides Proteins 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 235000021360 Myristic acid Nutrition 0.000 claims 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 102000056222 Peptide Synthases Human genes 0.000 claims 1
- 108700018928 Peptide Synthases Proteins 0.000 claims 1
- 102000001708 Protein Isoforms Human genes 0.000 claims 1
- 108010029485 Protein Isoforms Proteins 0.000 claims 1
- 102000012463 Thioesterase domains Human genes 0.000 claims 1
- 108050002018 Thioesterase domains Proteins 0.000 claims 1
- 230000006154 adenylylation Effects 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 235000021588 free fatty acids Nutrition 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- NJGWOFRZMQRKHT-UHFFFAOYSA-N surfactin Natural products CC(C)CCCCCCCCCC1CC(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O1 NJGWOFRZMQRKHT-UHFFFAOYSA-N 0.000 claims 1
- NJGWOFRZMQRKHT-WGVNQGGSSA-N surfactin C Chemical compound CC(C)CCCCCCCCC[C@@H]1CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O1 NJGWOFRZMQRKHT-WGVNQGGSSA-N 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 238000006177 thiolation reaction Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020198057A JP7432489B2 (ja) | 2013-03-15 | 2020-11-30 | アシルアミノ酸の生成 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361788346P | 2013-03-15 | 2013-03-15 | |
| US61/788,346 | 2013-03-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502994A Division JP6741572B2 (ja) | 2013-03-15 | 2014-03-14 | アシルアミノ酸の生成 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020198057A Division JP7432489B2 (ja) | 2013-03-15 | 2020-11-30 | アシルアミノ酸の生成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020000247A JP2020000247A (ja) | 2020-01-09 |
| JP2020000247A5 true JP2020000247A5 (enExample) | 2020-07-27 |
| JP6803434B2 JP6803434B2 (ja) | 2020-12-23 |
Family
ID=51537750
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502994A Active JP6741572B2 (ja) | 2013-03-15 | 2014-03-14 | アシルアミノ酸の生成 |
| JP2019154479A Active JP6803434B2 (ja) | 2013-03-15 | 2019-08-27 | アシルアミノ酸の生成 |
| JP2020198057A Active JP7432489B2 (ja) | 2013-03-15 | 2020-11-30 | アシルアミノ酸の生成 |
| JP2023020919A Pending JP2023053308A (ja) | 2013-03-15 | 2023-02-14 | アシルアミノ酸の生成 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502994A Active JP6741572B2 (ja) | 2013-03-15 | 2014-03-14 | アシルアミノ酸の生成 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020198057A Active JP7432489B2 (ja) | 2013-03-15 | 2020-11-30 | アシルアミノ酸の生成 |
| JP2023020919A Pending JP2023053308A (ja) | 2013-03-15 | 2023-02-14 | アシルアミノ酸の生成 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9970036B2 (enExample) |
| EP (1) | EP2970928A4 (enExample) |
| JP (4) | JP6741572B2 (enExample) |
| CN (2) | CN105531367A (enExample) |
| BR (1) | BR112015023453A2 (enExample) |
| CA (1) | CA2907229A1 (enExample) |
| WO (1) | WO2014144649A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015023453A2 (pt) | 2013-03-15 | 2017-12-05 | Modular Genetics Inc | composição de acil aminoácidos, método para sua produção, célula manipulada e método de preparação de um produto |
| EP2843043A1 (en) * | 2013-08-27 | 2015-03-04 | Evonik Industries AG | A method for producing acyl amino acids |
| WO2016049484A1 (en) * | 2014-09-26 | 2016-03-31 | Dow Agrosciences Llc | Chimeric non-ribosomal peptide synthase |
| US11371066B2 (en) | 2015-07-13 | 2022-06-28 | Modular Genetics, Inc. | Generation of acyl alcohols |
| US12123004B2 (en) | 2018-07-18 | 2024-10-22 | Modular Genetics, Inc. | Generation of acyl amino acids |
| CN111454338B (zh) * | 2019-01-22 | 2024-10-01 | 四川复通科技有限公司 | 塞普霉素前体肽的突变体、其应用及制得的塞普霉素类似物 |
| WO2020181779A1 (zh) | 2019-03-14 | 2020-09-17 | 江南大学 | 一种基于低共熔溶剂的脂氨基酸类化合物的制备方法 |
| CN111575251B (zh) * | 2020-05-29 | 2022-03-11 | 上海交通大学 | 一种用于达托霉素生物合成的dptC1突变体的构建 |
| JPWO2022201968A1 (enExample) | 2021-03-26 | 2022-09-29 | ||
| CN114891837B (zh) * | 2022-04-26 | 2023-04-25 | 青岛普瑞邦生物工程有限公司 | 一种产虾夷扇贝毒素的海杆菌及虾夷扇贝毒素的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1264712B1 (it) | 1993-07-13 | 1996-10-04 | Eniricerche Spa | Metodo di sintesi biologica di peptidi |
| IT1277466B1 (it) | 1995-08-09 | 1997-11-10 | Eniricerche Spa | Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi |
| WO2002059322A2 (en) | 2000-10-17 | 2002-08-01 | Cubist Pharmaceuticlas, Inc. | Compositions and methods relating to the daptomycin biosynthetic gene cluster |
| EP1421097A4 (en) | 2001-08-06 | 2005-07-06 | Cubist Pharm Inc | COMPOSITIONS AND METHODS RELATING TO THE BIOSYNTHETIC MULTIGENIC FAMILY OF DAPTOMYCIN |
| AU2002324580A1 (en) * | 2001-08-06 | 2003-02-24 | Cubist Pharmaceuticals, Inc. | Compositions and methods relating to the daptomycin biosynthetic gene cluster |
| MXPA05007654A (es) * | 2003-01-17 | 2005-09-30 | Danisco | Metodo. |
| JP2005132833A (ja) | 2003-10-08 | 2005-05-26 | Ajinomoto Co Inc | Ｎ−長鎖アシルグリシン塩の結晶及びその製造方法、並びに、該ｎ−長鎖アシルグリシン塩の結晶を用いた洗浄料組成物 |
| RU2335495C2 (ru) * | 2005-06-15 | 2008-10-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств |
| WO2008131002A2 (en) | 2007-04-16 | 2008-10-30 | Modular Genetics, Inc. | Generation of acyl amino acids |
| US20110030103A1 (en) * | 2007-04-16 | 2011-02-03 | Gabriel Reznik | Lipopeptides and lipopeptide synthetases |
| US8470883B2 (en) | 2010-07-12 | 2013-06-25 | Conopco, Inc. | Preservative system and composition based on glycinate and hydroxyethyl sulfonate salt combination |
| JP2013542995A (ja) | 2010-11-18 | 2013-11-28 | ザ プロクター アンド ギャンブル カンパニー | Ｎ−アシルアミノ酸化合物及びヘキシルデカノールをベースにした化粧品組成物 |
| JP5714359B2 (ja) | 2011-02-28 | 2015-05-07 | 株式会社マンダム | 半固体状洗浄剤 |
| US8822711B2 (en) | 2011-07-28 | 2014-09-02 | Conopco, Inc. | Method for preparing fatty acyl amido carboxylic acid based surfactants |
| BR112015023453A2 (pt) | 2013-03-15 | 2017-12-05 | Modular Genetics Inc | composição de acil aminoácidos, método para sua produção, célula manipulada e método de preparação de um produto |
-
2014
- 2014-03-14 BR BR112015023453A patent/BR112015023453A2/pt not_active Application Discontinuation
- 2014-03-14 CA CA2907229A patent/CA2907229A1/en active Pending
- 2014-03-14 JP JP2016502994A patent/JP6741572B2/ja active Active
- 2014-03-14 EP EP14764638.4A patent/EP2970928A4/en active Pending
- 2014-03-14 US US14/776,805 patent/US9970036B2/en active Active
- 2014-03-14 CN CN201480026841.8A patent/CN105531367A/zh active Pending
- 2014-03-14 CN CN202311749532.0A patent/CN117965408A/zh active Pending
- 2014-03-14 WO PCT/US2014/029150 patent/WO2014144649A1/en not_active Ceased
-
2018
- 2018-05-14 US US15/978,634 patent/US10640799B2/en active Active
-
2019
- 2019-08-27 JP JP2019154479A patent/JP6803434B2/ja active Active
-
2020
- 2020-03-18 US US16/823,173 patent/US11155843B2/en active Active
- 2020-11-30 JP JP2020198057A patent/JP7432489B2/ja active Active
-
2021
- 2021-09-21 US US17/481,290 patent/US12031167B2/en active Active
-
2023
- 2023-02-14 JP JP2023020919A patent/JP2023053308A/ja active Pending
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