CA2907229A1 - Generation of acyl amino acids - Google Patents

Generation of acyl amino acids

Info

Publication number
CA2907229A1
CA2907229A1 CA2907229A CA2907229A CA2907229A1 CA 2907229 A1 CA2907229 A1 CA 2907229A1 CA 2907229 A CA2907229 A CA 2907229A CA 2907229 A CA2907229 A CA 2907229A CA 2907229 A1 CA2907229 A1 CA 2907229A1
Authority
CA
Canada
Prior art keywords
acid
amino acid
domain
acyl
engineered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2907229A
Other languages
English (en)
French (fr)
Inventor
Kevin A. Jarrell
Gabriel O. Reznik
Prashanth Vishwanath
Michelle PYNN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Modular Genetics Inc
Original Assignee
Modular Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modular Genetics Inc filed Critical Modular Genetics Inc
Publication of CA2907229A1 publication Critical patent/CA2907229A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2907229A 2013-03-15 2014-03-14 Generation of acyl amino acids Pending CA2907229A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361788346P 2013-03-15 2013-03-15
US61/788,346 2013-03-15
PCT/US2014/029150 WO2014144649A1 (en) 2013-03-15 2014-03-14 Generation of acyl amino acids

Publications (1)

Publication Number Publication Date
CA2907229A1 true CA2907229A1 (en) 2014-09-18

Family

ID=51537750

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2907229A Pending CA2907229A1 (en) 2013-03-15 2014-03-14 Generation of acyl amino acids

Country Status (7)

Country Link
US (4) US9970036B2 (enExample)
EP (1) EP2970928A4 (enExample)
JP (4) JP6741572B2 (enExample)
CN (2) CN105531367A (enExample)
BR (1) BR112015023453A2 (enExample)
CA (1) CA2907229A1 (enExample)
WO (1) WO2014144649A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015023453A2 (pt) 2013-03-15 2017-12-05 Modular Genetics Inc composição de acil aminoácidos, método para sua produção, célula manipulada e método de preparação de um produto
EP2843043A1 (en) * 2013-08-27 2015-03-04 Evonik Industries AG A method for producing acyl amino acids
WO2016049484A1 (en) * 2014-09-26 2016-03-31 Dow Agrosciences Llc Chimeric non-ribosomal peptide synthase
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
US12123004B2 (en) 2018-07-18 2024-10-22 Modular Genetics, Inc. Generation of acyl amino acids
CN111454338B (zh) * 2019-01-22 2024-10-01 四川复通科技有限公司 塞普霉素前体肽的突变体、其应用及制得的塞普霉素类似物
WO2020181779A1 (zh) 2019-03-14 2020-09-17 江南大学 一种基于低共熔溶剂的脂氨基酸类化合物的制备方法
CN111575251B (zh) * 2020-05-29 2022-03-11 上海交通大学 一种用于达托霉素生物合成的dptC1突变体的构建
JPWO2022201968A1 (enExample) 2021-03-26 2022-09-29
CN114891837B (zh) * 2022-04-26 2023-04-25 青岛普瑞邦生物工程有限公司 一种产虾夷扇贝毒素的海杆菌及虾夷扇贝毒素的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264712B1 (it) 1993-07-13 1996-10-04 Eniricerche Spa Metodo di sintesi biologica di peptidi
IT1277466B1 (it) 1995-08-09 1997-11-10 Eniricerche Spa Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi
WO2002059322A2 (en) 2000-10-17 2002-08-01 Cubist Pharmaceuticlas, Inc. Compositions and methods relating to the daptomycin biosynthetic gene cluster
EP1421097A4 (en) 2001-08-06 2005-07-06 Cubist Pharm Inc COMPOSITIONS AND METHODS RELATING TO THE BIOSYNTHETIC MULTIGENIC FAMILY OF DAPTOMYCIN
AU2002324580A1 (en) * 2001-08-06 2003-02-24 Cubist Pharmaceuticals, Inc. Compositions and methods relating to the daptomycin biosynthetic gene cluster
MXPA05007654A (es) * 2003-01-17 2005-09-30 Danisco Metodo.
JP2005132833A (ja) 2003-10-08 2005-05-26 Ajinomoto Co Inc Ｎ−長鎖アシルグリシン塩の結晶及びその製造方法、並びに、該ｎ−長鎖アシルグリシン塩の結晶を用いた洗浄料組成物
RU2335495C2 (ru) * 2005-06-15 2008-10-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств
WO2008131002A2 (en) 2007-04-16 2008-10-30 Modular Genetics, Inc. Generation of acyl amino acids
US20110030103A1 (en) * 2007-04-16 2011-02-03 Gabriel Reznik Lipopeptides and lipopeptide synthetases
US8470883B2 (en) 2010-07-12 2013-06-25 Conopco, Inc. Preservative system and composition based on glycinate and hydroxyethyl sulfonate salt combination
JP2013542995A (ja) 2010-11-18 2013-11-28 ザ プロクター アンド ギャンブル カンパニー Ｎ−アシルアミノ酸化合物及びヘキシルデカノールをベースにした化粧品組成物
JP5714359B2 (ja) 2011-02-28 2015-05-07 株式会社マンダム 半固体状洗浄剤
US8822711B2 (en) 2011-07-28 2014-09-02 Conopco, Inc. Method for preparing fatty acyl amido carboxylic acid based surfactants
BR112015023453A2 (pt) 2013-03-15 2017-12-05 Modular Genetics Inc composição de acil aminoácidos, método para sua produção, célula manipulada e método de preparação de um produto

Also Published As

Publication number Publication date
US11155843B2 (en) 2021-10-26
JP2023053308A (ja) 2023-04-12
CN117965408A (zh) 2024-05-03
JP2020000247A (ja) 2020-01-09
JP2021052771A (ja) 2021-04-08
BR112015023453A2 (pt) 2017-12-05
EP2970928A4 (en) 2017-02-15
US20160076065A1 (en) 2016-03-17
EP2970928A1 (en) 2016-01-20
JP6741572B2 (ja) 2020-08-19
JP2016512692A (ja) 2016-05-09
WO2014144649A1 (en) 2014-09-18
CN105531367A (zh) 2016-04-27
JP7432489B2 (ja) 2024-02-16
US20180340198A1 (en) 2018-11-29
US20210062234A1 (en) 2021-03-04
US12031167B2 (en) 2024-07-09
US20220259626A1 (en) 2022-08-18
US9970036B2 (en) 2018-05-15
US10640799B2 (en) 2020-05-05
JP6803434B2 (ja) 2020-12-23

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