JP6741572B2 - アシルアミノ酸の生成 - Google Patents

アシルアミノ酸の生成 Download PDF

Info

Publication number
JP6741572B2
JP6741572B2 JP2016502994A JP2016502994A JP6741572B2 JP 6741572 B2 JP6741572 B2 JP 6741572B2 JP 2016502994 A JP2016502994 A JP 2016502994A JP 2016502994 A JP2016502994 A JP 2016502994A JP 6741572 B2 JP6741572 B2 JP 6741572B2
Authority
JP
Japan
Prior art keywords
acid
engineered
domain
amino acid
peptide synthetase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016502994A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016512692A (ja
JP2016512692A5 (enExample
Inventor
ケビン エー． ジャレル，
ケビン エー． ジャレル，
ガブリエル オー． レズニク，
ガブリエル オー． レズニク，
プラシェンツ ビシュワナツ，
プラシェンツ ビシュワナツ，
ミシェル ピン，
ミシェル ピン，
Original Assignee
モジュラー ジェネティクス， インコーポレイテッド
モジュラー ジェネティクス， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by モジュラー ジェネティクス， インコーポレイテッド, モジュラー ジェネティクス， インコーポレイテッド filed Critical モジュラー ジェネティクス， インコーポレイテッド
Publication of JP2016512692A publication Critical patent/JP2016512692A/ja
Publication of JP2016512692A5 publication Critical patent/JP2016512692A5/ja
Application granted granted Critical
Publication of JP6741572B2 publication Critical patent/JP6741572B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2016502994A 2013-03-15 2014-03-14 アシルアミノ酸の生成 Active JP6741572B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361788346P 2013-03-15 2013-03-15
US61/788,346 2013-03-15
PCT/US2014/029150 WO2014144649A1 (en) 2013-03-15 2014-03-14 Generation of acyl amino acids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019154479A Division JP6803434B2 (ja) 2013-03-15 2019-08-27 アシルアミノ酸の生成

Publications (3)

Publication Number Publication Date
JP2016512692A JP2016512692A (ja) 2016-05-09
JP2016512692A5 JP2016512692A5 (enExample) 2017-04-20
JP6741572B2 true JP6741572B2 (ja) 2020-08-19

Family

ID=51537750

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016502994A Active JP6741572B2 (ja) 2013-03-15 2014-03-14 アシルアミノ酸の生成
JP2019154479A Active JP6803434B2 (ja) 2013-03-15 2019-08-27 アシルアミノ酸の生成
JP2020198057A Active JP7432489B2 (ja) 2013-03-15 2020-11-30 アシルアミノ酸の生成
JP2023020919A Pending JP2023053308A (ja) 2013-03-15 2023-02-14 アシルアミノ酸の生成

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2019154479A Active JP6803434B2 (ja) 2013-03-15 2019-08-27 アシルアミノ酸の生成
JP2020198057A Active JP7432489B2 (ja) 2013-03-15 2020-11-30 アシルアミノ酸の生成
JP2023020919A Pending JP2023053308A (ja) 2013-03-15 2023-02-14 アシルアミノ酸の生成

Country Status (7)

Country Link
US (4) US9970036B2 (enExample)
EP (1) EP2970928A4 (enExample)
JP (4) JP6741572B2 (enExample)
CN (2) CN105531367A (enExample)
BR (1) BR112015023453A2 (enExample)
CA (1) CA2907229A1 (enExample)
WO (1) WO2014144649A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015023453A2 (pt) 2013-03-15 2017-12-05 Modular Genetics Inc composição de acil aminoácidos, método para sua produção, célula manipulada e método de preparação de um produto
EP2843043A1 (en) * 2013-08-27 2015-03-04 Evonik Industries AG A method for producing acyl amino acids
WO2016049484A1 (en) * 2014-09-26 2016-03-31 Dow Agrosciences Llc Chimeric non-ribosomal peptide synthase
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
US12123004B2 (en) 2018-07-18 2024-10-22 Modular Genetics, Inc. Generation of acyl amino acids
CN111454338B (zh) * 2019-01-22 2024-10-01 四川复通科技有限公司 塞普霉素前体肽的突变体、其应用及制得的塞普霉素类似物
WO2020181779A1 (zh) 2019-03-14 2020-09-17 江南大学 一种基于低共熔溶剂的脂氨基酸类化合物的制备方法
CN111575251B (zh) * 2020-05-29 2022-03-11 上海交通大学 一种用于达托霉素生物合成的dptC1突变体的构建
JPWO2022201968A1 (enExample) 2021-03-26 2022-09-29
CN114891837B (zh) * 2022-04-26 2023-04-25 青岛普瑞邦生物工程有限公司 一种产虾夷扇贝毒素的海杆菌及虾夷扇贝毒素的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264712B1 (it) 1993-07-13 1996-10-04 Eniricerche Spa Metodo di sintesi biologica di peptidi
IT1277466B1 (it) 1995-08-09 1997-11-10 Eniricerche Spa Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi
WO2002059322A2 (en) 2000-10-17 2002-08-01 Cubist Pharmaceuticlas, Inc. Compositions and methods relating to the daptomycin biosynthetic gene cluster
EP1421097A4 (en) 2001-08-06 2005-07-06 Cubist Pharm Inc COMPOSITIONS AND METHODS RELATING TO THE BIOSYNTHETIC MULTIGENIC FAMILY OF DAPTOMYCIN
AU2002324580A1 (en) * 2001-08-06 2003-02-24 Cubist Pharmaceuticals, Inc. Compositions and methods relating to the daptomycin biosynthetic gene cluster
MXPA05007654A (es) * 2003-01-17 2005-09-30 Danisco Metodo.
JP2005132833A (ja) 2003-10-08 2005-05-26 Ajinomoto Co Inc Ｎ−長鎖アシルグリシン塩の結晶及びその製造方法、並びに、該ｎ−長鎖アシルグリシン塩の結晶を用いた洗浄料組成物
RU2335495C2 (ru) * 2005-06-15 2008-10-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств
WO2008131002A2 (en) 2007-04-16 2008-10-30 Modular Genetics, Inc. Generation of acyl amino acids
US20110030103A1 (en) * 2007-04-16 2011-02-03 Gabriel Reznik Lipopeptides and lipopeptide synthetases
US8470883B2 (en) 2010-07-12 2013-06-25 Conopco, Inc. Preservative system and composition based on glycinate and hydroxyethyl sulfonate salt combination
JP2013542995A (ja) 2010-11-18 2013-11-28 ザ プロクター アンド ギャンブル カンパニー Ｎ−アシルアミノ酸化合物及びヘキシルデカノールをベースにした化粧品組成物
JP5714359B2 (ja) 2011-02-28 2015-05-07 株式会社マンダム 半固体状洗浄剤
US8822711B2 (en) 2011-07-28 2014-09-02 Conopco, Inc. Method for preparing fatty acyl amido carboxylic acid based surfactants
BR112015023453A2 (pt) 2013-03-15 2017-12-05 Modular Genetics Inc composição de acil aminoácidos, método para sua produção, célula manipulada e método de preparação de um produto

Also Published As

Publication number Publication date
US11155843B2 (en) 2021-10-26
JP2023053308A (ja) 2023-04-12
CN117965408A (zh) 2024-05-03
JP2020000247A (ja) 2020-01-09
JP2021052771A (ja) 2021-04-08
BR112015023453A2 (pt) 2017-12-05
EP2970928A4 (en) 2017-02-15
US20160076065A1 (en) 2016-03-17
EP2970928A1 (en) 2016-01-20
JP2016512692A (ja) 2016-05-09
WO2014144649A1 (en) 2014-09-18
CN105531367A (zh) 2016-04-27
JP7432489B2 (ja) 2024-02-16
US20180340198A1 (en) 2018-11-29
US20210062234A1 (en) 2021-03-04
US12031167B2 (en) 2024-07-09
US20220259626A1 (en) 2022-08-18
US9970036B2 (en) 2018-05-15
US10640799B2 (en) 2020-05-05
JP6803434B2 (ja) 2020-12-23
CA2907229A1 (en) 2014-09-18

Similar Documents

Publication Publication Date Title
JP7432489B2 (ja) アシルアミノ酸の生成
US20230242923A1 (en) Generation of acyl amino acids
US20250270567A1 (en) Generation of acyl amino acids
US20250257376A1 (en) Generation of acyl alcohols
US20110030103A1 (en) Lipopeptides and lipopeptide synthetases
JP5587763B2 (ja) 二次代謝物の製造方法
Olmedo-Verd et al. Membrane anchoring of aminoacyl-tRNA synthetases by convergent acquisition of a novel protein domain
CN117425727A (zh) C-葡糖基转移酶变体及其用途
CN112513259A (zh) 肽大环化酶

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170313

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170313

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180301

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180531

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180731

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180831

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190227

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190524

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190726

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190827

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20191101

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200302

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20200327

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200625

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200727

R150 Certificate of patent or registration of utility model

Ref document number: 6741572

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250