JP2005040037A5 - - Google Patents
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- Publication number
- JP2005040037A5 JP2005040037A5 JP2003201820A JP2003201820A JP2005040037A5 JP 2005040037 A5 JP2005040037 A5 JP 2005040037A5 JP 2003201820 A JP2003201820 A JP 2003201820A JP 2003201820 A JP2003201820 A JP 2003201820A JP 2005040037 A5 JP2005040037 A5 JP 2005040037A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- ester
- ammonium
- glutamine
- alanyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 amino acid ester Chemical class 0.000 description 9
- 229940024606 amino acid Drugs 0.000 description 8
- 235000001014 amino acid Nutrition 0.000 description 8
- 150000001413 amino acids Chemical class 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- HJCMDXDYPOUFDY-WHFBIAKZSA-N Ala-Gln Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O HJCMDXDYPOUFDY-WHFBIAKZSA-N 0.000 description 3
- 229960002648 alanylglutamine Drugs 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 2
- 108010016626 Dipeptides Proteins 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 229960003767 alanine Drugs 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 239000001729 Ammonium fumarate Substances 0.000 description 1
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 125000003412 L-alanyl group Chemical group [H]N([H])[C@@](C([H])([H])[H])(C(=O)[*])[H] 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 241000605114 Pedobacter heparinus Species 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 235000019297 ammonium fumarate Nutrition 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- CKKXWJDFFQPBQL-SEPHDYHBSA-N azane;(e)-but-2-enedioic acid Chemical compound N.N.OC(=O)\C=C\C(O)=O CKKXWJDFFQPBQL-SEPHDYHBSA-N 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000002897 organic nitrogen compounds Chemical class 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003201820A JP2005040037A (ja) | 2003-07-25 | 2003-07-25 | ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法 |
| CNB2004800213286A CN100385012C (zh) | 2003-07-25 | 2004-07-26 | 生产二肽的方法 |
| RU2006105494/13A RU2006105494A (ru) | 2003-07-25 | 2004-07-26 | Способ получения дипептидов |
| PCT/JP2004/010990 WO2005010196A1 (en) | 2003-07-25 | 2004-07-26 | Method for producing dipeptides |
| EP04748149A EP1658375A4 (en) | 2003-07-25 | 2004-07-26 | PROCESS FOR THE PREPARATION OF DIPEPTIDES |
| KR1020067001652A KR100760974B1 (ko) | 2003-07-25 | 2004-07-26 | 디펩티드의 제조 방법 |
| US11/330,076 US8084227B2 (en) | 2003-07-25 | 2006-01-12 | Method for producing dipeptides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003201820A JP2005040037A (ja) | 2003-07-25 | 2003-07-25 | ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005040037A JP2005040037A (ja) | 2005-02-17 |
| JP2005040037A5 true JP2005040037A5 (enExample) | 2006-09-07 |
Family
ID=34100525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003201820A Pending JP2005040037A (ja) | 2003-07-25 | 2003-07-25 | ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8084227B2 (enExample) |
| EP (1) | EP1658375A4 (enExample) |
| JP (1) | JP2005040037A (enExample) |
| KR (1) | KR100760974B1 (enExample) |
| CN (1) | CN100385012C (enExample) |
| RU (1) | RU2006105494A (enExample) |
| WO (1) | WO2005010196A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2180060B1 (en) * | 2003-01-24 | 2012-08-29 | Ajinomoto Co., Inc. | Method for produding alpha-L-aspartyl-L-phenylalanine-beta-ester and method for producing alpha-L-aspartyl-L-phenylalanine-alpha-methyl ester |
| JP2005168405A (ja) | 2003-12-11 | 2005-06-30 | Ajinomoto Co Inc | ジペプチドの製造方法 |
| US20070190602A1 (en) * | 2005-12-27 | 2007-08-16 | Ajinomoto Co., Inc | Mutant protein having the peptide-synthesizing activity |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2857828C2 (enExample) * | 1977-01-27 | 1990-06-07 | Toyo Soda Mfg. Co., Ltd., Shinnanyo, Yamaguchi, Jp | |
| JPS5392729A (en) * | 1977-01-27 | 1978-08-15 | Toyo Soda Mfg Co Ltd | Adduct of dipeptide derivatives and amino acid derivatives and process for their preparation |
| DK72587D0 (da) * | 1987-02-13 | 1987-02-13 | Carlsberg Biotechnology Ltd | Fremgangsmaade til enzymatisk fremstilling af dipeptider |
| JPH0832717B2 (ja) | 1987-10-07 | 1996-03-29 | 味の素株式会社 | グルタミン誘導体の製造方法 |
| DK163435C (da) * | 1988-08-12 | 1992-07-20 | Carlsberg Biotechnology Ltd | Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf |
| JP3473976B2 (ja) | 1992-10-29 | 2003-12-08 | 協和醗酵工業株式会社 | アラニルグルタミンの製造法 |
| CA2365594A1 (en) * | 1999-03-29 | 2000-10-05 | Holland Sweetener Company V.O.F. | Microbiological production method for .alpha.-l-aspartyl-l-phenylalanine |
| WO2003010189A1 (en) * | 2001-07-26 | 2003-02-06 | Ajinomoto Co., Inc. | Process for producing dipeptide, peptide synthase to be used therein and process for producing peptide synthase |
| EP2298905B1 (en) * | 2002-07-26 | 2014-02-12 | Ajinomoto Co., Inc. | Novel peptide-forming enzyme gene |
| EP2180060B1 (en) * | 2003-01-24 | 2012-08-29 | Ajinomoto Co., Inc. | Method for produding alpha-L-aspartyl-L-phenylalanine-beta-ester and method for producing alpha-L-aspartyl-L-phenylalanine-alpha-methyl ester |
| JP2005168405A (ja) * | 2003-12-11 | 2005-06-30 | Ajinomoto Co Inc | ジペプチドの製造方法 |
| US20070190602A1 (en) * | 2005-12-27 | 2007-08-16 | Ajinomoto Co., Inc | Mutant protein having the peptide-synthesizing activity |
-
2003
- 2003-07-25 JP JP2003201820A patent/JP2005040037A/ja active Pending
-
2004
- 2004-07-26 WO PCT/JP2004/010990 patent/WO2005010196A1/en not_active Ceased
- 2004-07-26 KR KR1020067001652A patent/KR100760974B1/ko not_active Expired - Fee Related
- 2004-07-26 RU RU2006105494/13A patent/RU2006105494A/ru not_active Application Discontinuation
- 2004-07-26 CN CNB2004800213286A patent/CN100385012C/zh not_active Expired - Fee Related
- 2004-07-26 EP EP04748149A patent/EP1658375A4/en not_active Withdrawn
-
2006
- 2006-01-12 US US11/330,076 patent/US8084227B2/en not_active Expired - Fee Related
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