RU2006105494A - Способ получения дипептидов - Google Patents
Способ получения дипептидов Download PDFInfo
- Publication number
- RU2006105494A RU2006105494A RU2006105494/13A RU2006105494A RU2006105494A RU 2006105494 A RU2006105494 A RU 2006105494A RU 2006105494/13 A RU2006105494/13 A RU 2006105494/13A RU 2006105494 A RU2006105494 A RU 2006105494A RU 2006105494 A RU2006105494 A RU 2006105494A
- Authority
- RU
- Russia
- Prior art keywords
- microorganism
- amino acid
- ester
- isolated
- dipeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (4)
1. Способ получения дипептидов, включающий взаимодействие эфира аминокислоты с аминокислотой с образованием дипептида в присутствии, по крайней мере, одного, выбранного из группы, состоящей из культуры микроорганизма, выделенных из культуры клеток микроорганизма, продукты обработанных клеток микроорганизма, пептидпродуцирующего фермента, выделенного из микроорганизма, в котором микроорганизм обладает способностью образовывать дипептид из эфира аминокислоты и аминокислоты, и принадлежит к родам, выбранным из группы, состоящей из Cellulophaga, Weeksella, Pedobacter, Persicobacter, Flexithrix, Chitinophaga, Cyclobacterium, Runella, Thermonema, Psychroserpens, Gelidibacter, Dyadobacter, Flammeovirga, Spirosoma, Flectobacillus, Tenacibaculum, Rhodothermus, Zobellia, Muncauda, Salegentibacter, Taxeobacter, Cytophaga, Marinilabilia, Lewinella, Saprospira, и Haliscomenobacter.
2. Способ по п.1, дополнительно включающий добавление ингибитора металлоферментов в реакционную смесь до образования дипептида из эфира аминокислоты и аминокислоты в присутствии, по крайней мере, одного, выбранного из группы, состоящей из культуры микроорганизма, выделенных из культуры клеток микроорганизма, продуктов обработанных клеток микроорганизма, и пептидпродуцирующего фермента, выделенного из микроорганизма.
3. Способ по п.1, в котором эфиром аминокислоты является эфир L-аланина.
4. Способ по п.1, в котором аминокислотой является L-глутамин.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003-201820 | 2003-07-25 | ||
| JP2003201820A JP2005040037A (ja) | 2003-07-25 | 2003-07-25 | ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006105494A true RU2006105494A (ru) | 2006-07-10 |
Family
ID=34100525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006105494/13A RU2006105494A (ru) | 2003-07-25 | 2004-07-26 | Способ получения дипептидов |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8084227B2 (ru) |
| EP (1) | EP1658375A4 (ru) |
| JP (1) | JP2005040037A (ru) |
| KR (1) | KR100760974B1 (ru) |
| CN (1) | CN100385012C (ru) |
| RU (1) | RU2006105494A (ru) |
| WO (1) | WO2005010196A1 (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2157188B1 (en) | 2003-01-24 | 2012-05-02 | Ajinomoto Co., Inc. | Method for producing alpha-L-Aspartyl-L-phenylalanine-Beta-ester and method for producing alpha-L-aspartyl-L-phenylalanine-alpha-methyl ester |
| JP2005168405A (ja) * | 2003-12-11 | 2005-06-30 | Ajinomoto Co Inc | ジペプチドの製造方法 |
| US20070190602A1 (en) * | 2005-12-27 | 2007-08-16 | Ajinomoto Co., Inc | Mutant protein having the peptide-synthesizing activity |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2801238C2 (de) * | 1977-01-27 | 1986-06-05 | (Zaidanhojin) Sagami Chemical Research Center, Tokio/Tokyo | Verfahren zur Herstellung von Salzen aus L,L-Dipeptiden und Phenylalaninestern |
| JPS5392729A (en) * | 1977-01-27 | 1978-08-15 | Toyo Soda Mfg Co Ltd | Adduct of dipeptide derivatives and amino acid derivatives and process for their preparation |
| DK72587D0 (da) * | 1987-02-13 | 1987-02-13 | Carlsberg Biotechnology Ltd | Fremgangsmaade til enzymatisk fremstilling af dipeptider |
| JPH0832717B2 (ja) | 1987-10-07 | 1996-03-29 | 味の素株式会社 | グルタミン誘導体の製造方法 |
| DK163435C (da) * | 1988-08-12 | 1992-07-20 | Carlsberg Biotechnology Ltd | Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf |
| JP3473976B2 (ja) | 1992-10-29 | 2003-12-08 | 協和醗酵工業株式会社 | アラニルグルタミンの製造法 |
| EP1165799A1 (en) * | 1999-03-29 | 2002-01-02 | Holland Sweetener Company V.o.F. | Microbiological production method for alpha-l-aspartyl-l-phenylalanine |
| RU2280077C2 (ru) * | 2001-07-26 | 2006-07-20 | Адзиномото Ко., Инк. | Ген пептидообразующего фермента, пептидообразующий фермент и способ получения дипептида |
| EP1541688B1 (en) * | 2002-07-26 | 2012-09-05 | Ajinomoto Co., Inc. | Peptide synthase gene |
| EP2157188B1 (en) * | 2003-01-24 | 2012-05-02 | Ajinomoto Co., Inc. | Method for producing alpha-L-Aspartyl-L-phenylalanine-Beta-ester and method for producing alpha-L-aspartyl-L-phenylalanine-alpha-methyl ester |
| JP2005168405A (ja) * | 2003-12-11 | 2005-06-30 | Ajinomoto Co Inc | ジペプチドの製造方法 |
| US20070190602A1 (en) * | 2005-12-27 | 2007-08-16 | Ajinomoto Co., Inc | Mutant protein having the peptide-synthesizing activity |
-
2003
- 2003-07-25 JP JP2003201820A patent/JP2005040037A/ja active Pending
-
2004
- 2004-07-26 KR KR1020067001652A patent/KR100760974B1/ko not_active IP Right Cessation
- 2004-07-26 RU RU2006105494/13A patent/RU2006105494A/ru not_active Application Discontinuation
- 2004-07-26 EP EP04748149A patent/EP1658375A4/en not_active Withdrawn
- 2004-07-26 WO PCT/JP2004/010990 patent/WO2005010196A1/en active Application Filing
- 2004-07-26 CN CNB2004800213286A patent/CN100385012C/zh not_active Expired - Fee Related
-
2006
- 2006-01-12 US US11/330,076 patent/US8084227B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1826413A (zh) | 2006-08-30 |
| KR20060036470A (ko) | 2006-04-28 |
| US20060177893A1 (en) | 2006-08-10 |
| JP2005040037A (ja) | 2005-02-17 |
| EP1658375A1 (en) | 2006-05-24 |
| KR100760974B1 (ko) | 2007-10-04 |
| CN100385012C (zh) | 2008-04-30 |
| EP1658375A4 (en) | 2009-03-18 |
| WO2005010196A1 (en) | 2005-02-03 |
| US8084227B2 (en) | 2011-12-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7754466B2 (en) | Method for producing dipeptides | |
| Stein et al. | Kinetic studies of isopeptidase T: modulation of peptidase activity by ubiquitin | |
| JP2011139667A (ja) | プロリンおよびβ−アラニンをＮ末端に有するジペプチド、及びその環化ジペプチドの酵素合成法 | |
| EP2145630A3 (en) | Angiotensin-converting enzyme inhibitory peptides | |
| WO1979000602A1 (en) | Easily split substrates for the quantification of proteases | |
| DE3244030A1 (de) | Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung | |
| CA2509765A1 (en) | Novel peptide-producing enzyme, microbe producing the enzyme and method for dipeptide synthesis using them | |
| Kato et al. | First stereoselective synthesis of D-amino acid N-alkyl amide catalyzed by D-aminopeptidase | |
| RU2006105494A (ru) | Способ получения дипептидов | |
| WO2014067746A1 (en) | Process for the enzymatic formation of amide bonds | |
| Morihara et al. | On the specificity of Bacillus subtilis neutral protease in relation to the compound active site | |
| CA2342072A1 (en) | Kunitz domain polypeptide zkun6 | |
| Xing et al. | Influence of reaction conditions on syntheses of sweetener precursors catalyzed by thermolysin in tert‐amyl alcohol | |
| Salam et al. | Protease-catalyzed dipeptide synthesis from N-protected amino acid carbamoylmethyl esters and free amino acids in frozen aqueous solutions | |
| US4425428A (en) | Novel peptide and peptolide substrates for mammalian collagenase | |
| CN101245094B (zh) | 肽醛的一种液相合成法 | |
| Makowski et al. | Synthesis of Tetrapeptide p‐nitrophenylanilides containing dehydroalanine and dehydrophenylalanine and their influence on cathepsin C activity | |
| Salam et al. | α-Chymotrypsin-catalyzed peptide synthesis using N-protected D-amino acid carbamoylmethyl esters as acyl donors | |
| CA1059938A (en) | Process for producing a peptide | |
| JPH01501118A (ja) | 酵素的方法 | |
| JP2005040037A5 (ru) | ||
| Kamarudheen et al. | An overview of protease inhibitors from Actinobacteria | |
| Kise et al. | Enantiospecificity of. ALPHA.-Chymotrypsin at S'1 Site for Peptide Synthesis in Aqueous-Organic Media. | |
| JP3621271B2 (ja) | アスパルチルフェニルアラニン低級アルキルエステルの製造方法 | |
| CN101245096B (zh) | N-苄氧羰基异亮氨酰-δ-叔丁基谷氨酰-丙氨酰-亮氨基醛的一种液相合成法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20071015 |