CN100385012C - 生产二肽的方法 - Google Patents

生产二肽的方法 Download PDF

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Publication number
CN100385012C
CN100385012C CNB2004800213286A CN200480021328A CN100385012C CN 100385012 C CN100385012 C CN 100385012C CN B2004800213286 A CNB2004800213286 A CN B2004800213286A CN 200480021328 A CN200480021328 A CN 200480021328A CN 100385012 C CN100385012 C CN 100385012C
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CN
China
Prior art keywords
amino acid
cultured
cells
dna
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004800213286A
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English (en)
Chinese (zh)
Other versions
CN1826413A (zh
Inventor
横关健三
阿部巧
原诚一
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of CN1826413A publication Critical patent/CN1826413A/zh
Application granted granted Critical
Publication of CN100385012C publication Critical patent/CN100385012C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNB2004800213286A 2003-07-25 2004-07-26 生产二肽的方法 Expired - Fee Related CN100385012C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003201820A JP2005040037A (ja) 2003-07-25 2003-07-25 ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法
JP201820/2003 2003-07-25

Publications (2)

Publication Number Publication Date
CN1826413A CN1826413A (zh) 2006-08-30
CN100385012C true CN100385012C (zh) 2008-04-30

Family

ID=34100525

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800213286A Expired - Fee Related CN100385012C (zh) 2003-07-25 2004-07-26 生产二肽的方法

Country Status (7)

Country Link
US (1) US8084227B2 (enExample)
EP (1) EP1658375A4 (enExample)
JP (1) JP2005040037A (enExample)
KR (1) KR100760974B1 (enExample)
CN (1) CN100385012C (enExample)
RU (1) RU2006105494A (enExample)
WO (1) WO2005010196A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2180060B1 (en) * 2003-01-24 2012-08-29 Ajinomoto Co., Inc. Method for produding alpha-L-aspartyl-L-phenylalanine-beta-ester and method for producing alpha-L-aspartyl-L-phenylalanine-alpha-methyl ester
JP2005168405A (ja) 2003-12-11 2005-06-30 Ajinomoto Co Inc ジペプチドの製造方法
US20070190602A1 (en) * 2005-12-27 2007-08-16 Ajinomoto Co., Inc Mutant protein having the peptide-synthesizing activity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165311A (en) * 1977-01-27 1979-08-21 Toyo Soda Manufacturing Co. Ltd. Addition compound of dipeptide derivative and amino acid derivative
EP0278787A1 (en) * 1987-02-13 1988-08-17 Carlbiotech Ltd. A/S A process for enzymatic production of dipeptides
CN1353757A (zh) * 1999-03-29 2002-06-12 荷兰加甜剂公司 α－L－天冬氨酰－L－苯丙氨酸的微生物学生产方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5392729A (en) * 1977-01-27 1978-08-15 Toyo Soda Mfg Co Ltd Adduct of dipeptide derivatives and amino acid derivatives and process for their preparation
JPH0832717B2 (ja) 1987-10-07 1996-03-29 味の素株式会社 グルタミン誘導体の製造方法
DK163435C (da) * 1988-08-12 1992-07-20 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf
JP3473976B2 (ja) 1992-10-29 2003-12-08 協和醗酵工業株式会社 アラニルグルタミンの製造法
WO2003010189A1 (en) * 2001-07-26 2003-02-06 Ajinomoto Co., Inc. Process for producing dipeptide, peptide synthase to be used therein and process for producing peptide synthase
EP2298905B1 (en) * 2002-07-26 2014-02-12 Ajinomoto Co., Inc. Novel peptide-forming enzyme gene
EP2180060B1 (en) * 2003-01-24 2012-08-29 Ajinomoto Co., Inc. Method for produding alpha-L-aspartyl-L-phenylalanine-beta-ester and method for producing alpha-L-aspartyl-L-phenylalanine-alpha-methyl ester
JP2005168405A (ja) * 2003-12-11 2005-06-30 Ajinomoto Co Inc ジペプチドの製造方法
US20070190602A1 (en) * 2005-12-27 2007-08-16 Ajinomoto Co., Inc Mutant protein having the peptide-synthesizing activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165311A (en) * 1977-01-27 1979-08-21 Toyo Soda Manufacturing Co. Ltd. Addition compound of dipeptide derivative and amino acid derivative
EP0278787A1 (en) * 1987-02-13 1988-08-17 Carlbiotech Ltd. A/S A process for enzymatic production of dipeptides
CN1353757A (zh) * 1999-03-29 2002-06-12 荷兰加甜剂公司 α－L－天冬氨酰－L－苯丙氨酸的微生物学生产方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
peptide synthsis by chymotrypsin in frozen solutions.freeamino acis as nucleophiles.. Vello Tougu et al.febs letters,Vol.329 No.1-2. 1993 *
single-step synthesis of kyotorphin in frozen solutions bychymotrypsin.. helle meos et al.tetrahedron:asymmetry,Vol.4 No.7. 1993 *

Also Published As

Publication number Publication date
WO2005010196A1 (en) 2005-02-03
RU2006105494A (ru) 2006-07-10
EP1658375A4 (en) 2009-03-18
CN1826413A (zh) 2006-08-30
US8084227B2 (en) 2011-12-27
EP1658375A1 (en) 2006-05-24
US20060177893A1 (en) 2006-08-10
KR20060036470A (ko) 2006-04-28
JP2005040037A (ja) 2005-02-17
KR100760974B1 (ko) 2007-10-04

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CN100385012C (zh) 生产二肽的方法
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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20080430

Termination date: 20120726