JP2019535797A5 - - Google Patents
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- Publication number
- JP2019535797A5 JP2019535797A5 JP2019528685A JP2019528685A JP2019535797A5 JP 2019535797 A5 JP2019535797 A5 JP 2019535797A5 JP 2019528685 A JP2019528685 A JP 2019528685A JP 2019528685 A JP2019528685 A JP 2019528685A JP 2019535797 A5 JP2019535797 A5 JP 2019535797A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- antigen
- binding fragment
- prlr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662427534P | 2016-11-29 | 2016-11-29 | |
| US62/427,534 | 2016-11-29 | ||
| PCT/US2017/063476 WO2018102304A1 (en) | 2016-11-29 | 2017-11-28 | Methods of treating prlr positive breast cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535797A JP2019535797A (ja) | 2019-12-12 |
| JP2019535797A5 true JP2019535797A5 (https=) | 2021-02-25 |
| JP7174699B2 JP7174699B2 (ja) | 2022-11-17 |
Family
ID=60703124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019528685A Active JP7174699B2 (ja) | 2016-11-29 | 2017-11-28 | Ｐｒｌｒ陽性乳癌の治療方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10925971B2 (https=) |
| EP (1) | EP3548514A1 (https=) |
| JP (1) | JP7174699B2 (https=) |
| KR (1) | KR20190091290A (https=) |
| CN (1) | CN110382534B (https=) |
| AU (1) | AU2017366873A1 (https=) |
| CA (1) | CA3044534A1 (https=) |
| EA (1) | EA201900312A1 (https=) |
| IL (1) | IL266917B2 (https=) |
| MX (1) | MX2019006131A (https=) |
| WO (1) | WO2018102304A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX361875B (es) | 2012-03-14 | 2018-12-18 | Regeneron Pharma | Moléculas de unión de antígeno multiespecifícas y usos de las mismas. |
| WO2017190079A1 (en) | 2016-04-28 | 2017-11-02 | Regeneron Pharmaceuticals, Inc. | Methods of making multispecific antigen-binding molecules |
| CA3053348A1 (en) * | 2017-02-10 | 2018-08-16 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-lag3 antibodies for immuno-pet imaging |
| TW201836647A (zh) | 2017-04-06 | 2018-10-16 | 美商艾伯維有限公司 | 抗－ｐｒｌｒ抗體藥物軛合物（ａｄｃ）及其用途 |
| JP7779653B2 (ja) | 2018-02-07 | 2025-12-03 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 治療用タンパク質送達のための方法および組成物 |
| KR20240105964A (ko) * | 2022-12-29 | 2024-07-08 | 주식회사 삼양홀딩스 | 약동학적 특성이 우수한 풀베스트란트의 약학 조성물 및 그 제조 방법 |
| CN120842400A (zh) * | 2023-04-24 | 2025-10-28 | 深圳真实生物医药科技有限公司 | 泌乳素受体抗体及其用途 |
| WO2025192691A1 (ja) * | 2024-03-14 | 2025-09-18 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US6429186B1 (en) | 1991-05-10 | 2002-08-06 | Genentech, Inc. | Ligand antagonists for treatment of breast cancer |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| EP1079851B1 (en) | 1998-05-12 | 2007-07-04 | Greenville Hospital System | Use of anti-prolactin agents to treat cancer |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US6867187B2 (en) | 2000-12-22 | 2005-03-15 | Trustees Of The University Of Pennsylvania | Composition and method for modulating somatolactogenic function |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| WO2005058232A2 (en) | 2003-12-11 | 2005-06-30 | Tercica, Inc. | Methods and compositions for the treatment of prolactin-receptor related disorders |
| US8754031B2 (en) | 2004-03-08 | 2014-06-17 | Oncolix, Inc. | Use of prolactin receptor antagonists in combination with an agent that inactivates the HER2/neu signaling pathway |
| US7422899B2 (en) | 2005-10-05 | 2008-09-09 | Biogen Idec Ma Inc. | Antibodies to the human prolactin receptor |
| WO2007051112A2 (en) | 2005-10-24 | 2007-05-03 | Invitrogen Corporation | Serum prolactin binding protein in epithelial carcinoma |
| ES2398076T3 (es) | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
| WO2008002295A1 (en) | 2006-06-27 | 2008-01-03 | Thomson Licensing | Performance aware peer-to-peer video-on-demand |
| AR062435A1 (es) | 2006-08-18 | 2008-11-05 | Xoma Technology Ltd | Anticuerpo especifico prlr (receptor de prolactina) y sus usos |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| NO347649B1 (no) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| WO2009010398A1 (en) | 2007-07-18 | 2009-01-22 | Novo Nordisk A/S | Stabilized prolactin receptor antagonists |
| EP2276506A4 (en) | 2008-04-30 | 2014-05-07 | Immunogen Inc | EFFICIENT CONJUGATES AND HYDROPHILIC BINDER |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| EP2332995A1 (en) | 2009-12-10 | 2011-06-15 | Bayer Schering Pharma Aktiengesellschaft | Neutralizing prolactin receptor antibodies and their therapeutic use |
| WO2012136519A1 (en) | 2011-04-06 | 2012-10-11 | Bayer Pharma Aktiengesellschaft | Use of neutralizing prolactin receptor antibodies for the treatment and prevention of antiestrogen-resistant breast cancer |
| EP2530089A1 (en) | 2011-06-03 | 2012-12-05 | Bayer Pharma Aktiengesellschaft | Neutralising prolactin receptor antibody Mat3 and its therapeutical use |
| CN102746402A (zh) | 2012-07-09 | 2012-10-24 | 南京医科大学 | 全人源抗人催乳素受体单链抗体及其应用 |
| US8883979B2 (en) | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
| CN105102480B (zh) | 2012-12-24 | 2019-04-16 | 艾伯维公司 | 催乳素受体结合蛋白及其用途 |
| MX379256B (es) | 2013-03-15 | 2025-03-10 | Regeneron Pharma | Moleculas biologicamente activas, conjugados de las mismas, y usos terapeuticos. |
| EP2968538A1 (en) | 2013-03-15 | 2016-01-20 | Bayer HealthCare LLC | Anti-prolactin receptor antibody formulations |
| TWI641620B (zh) * | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | 抗－ｐｒｌｒ抗體及其用途 |
| US9545451B2 (en) * | 2013-08-21 | 2017-01-17 | Regeneron Pharmaceuticals, Inc. | Anti-PRLR antibodies and methods for killing PRLR-expressing cells |
| KR102252925B1 (ko) | 2013-08-26 | 2021-05-18 | 리제너론 파마슈티칼스 인코포레이티드 | 마크롤라이드 디아스테레오머를 포함하는 약제학적 조성물, 이의 합성 방법 및 치료학적 용도 |
| EA034950B1 (ru) | 2015-03-27 | 2020-04-09 | Регенерон Фармасьютикалз, Инк. | Производные майтанзиноида, их конъюгаты и способы использования |
-
2017
- 2017-11-28 WO PCT/US2017/063476 patent/WO2018102304A1/en not_active Ceased
- 2017-11-28 CN CN201780084656.8A patent/CN110382534B/zh not_active Expired - Fee Related
- 2017-11-28 IL IL266917A patent/IL266917B2/en unknown
- 2017-11-28 EP EP17817499.1A patent/EP3548514A1/en not_active Withdrawn
- 2017-11-28 US US15/824,546 patent/US10925971B2/en not_active Expired - Fee Related
- 2017-11-28 EA EA201900312A patent/EA201900312A1/ru unknown
- 2017-11-28 MX MX2019006131A patent/MX2019006131A/es unknown
- 2017-11-28 AU AU2017366873A patent/AU2017366873A1/en not_active Abandoned
- 2017-11-28 JP JP2019528685A patent/JP7174699B2/ja active Active
- 2017-11-28 KR KR1020197018219A patent/KR20190091290A/ko not_active Ceased
- 2017-11-28 CA CA3044534A patent/CA3044534A1/en active Pending
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