EA201900312A1 - Способы лечения пролактин-рецептор положительного рака молочной железы - Google Patents

Способы лечения пролактин-рецептор положительного рака молочной железы

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Publication number
EA201900312A1
EA201900312A1 EA201900312A EA201900312A EA201900312A1 EA 201900312 A1 EA201900312 A1 EA 201900312A1 EA 201900312 A EA201900312 A EA 201900312A EA 201900312 A EA201900312 A EA 201900312A EA 201900312 A1 EA201900312 A1 EA 201900312A1
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EA
Eurasian Patent Office
Prior art keywords
prolactin
breast cancer
positive breast
methods
receptor
Prior art date
Application number
EA201900312A
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English (en)
Inventor
Маркус Келли
Джессика Р. Киршнер
Гэвин ТЕРСТОН
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Регенерон Фармасьютикалз, Инк.
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Application filed by Регенерон Фармасьютикалз, Инк. filed Critical Регенерон Фармасьютикалз, Инк.
Publication of EA201900312A1 publication Critical patent/EA201900312A1/ru

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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/57554—Prolactin
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

В настоящем документе представлены способы лечения рака молочной железы, положительного по отношению к рецептору пролактина, с использованием конъюгата антитело-лекарственное средство (ADC), содержащего антитело к рецептору пролактина или его антигенсвязывающий фрагмент, конъюгированный с цитотоксическим агентом. В некоторых вариантах осуществления антитело к рецептору пролактина или его антигенсвязывающий фрагмент конъюгированы с майтанзиноидом. В определенных вариантах осуществления способ лечения пролактин-рецептор положительного рака молочной железы включает введение конъюгата АЛС в комбинации с одним или несколькими химиотерапевтическими агентами.
EA201900312A 2016-11-29 2017-11-28 Способы лечения пролактин-рецептор положительного рака молочной железы EA201900312A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662427534P 2016-11-29 2016-11-29
PCT/US2017/063476 WO2018102304A1 (en) 2016-11-29 2017-11-28 Methods of treating prlr positive breast cancer

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EA201900312A1 true EA201900312A1 (ru) 2019-12-30

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US (1) US10925971B2 (ru)
EP (1) EP3548514A1 (ru)
JP (1) JP7174699B2 (ru)
KR (1) KR20190091290A (ru)
CN (1) CN110382534B (ru)
AU (1) AU2017366873A1 (ru)
CA (1) CA3044534A1 (ru)
EA (1) EA201900312A1 (ru)
IL (1) IL266917B2 (ru)
MX (1) MX2019006131A (ru)
WO (1) WO2018102304A1 (ru)

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CN110382534A (zh) 2019-10-25
CA3044534A1 (en) 2018-06-07
MX2019006131A (es) 2019-08-21
IL266917B1 (en) 2023-06-01
JP2019535797A (ja) 2019-12-12
IL266917A (en) 2019-07-31
EP3548514A1 (en) 2019-10-09
KR20190091290A (ko) 2019-08-05
JP7174699B2 (ja) 2022-11-17
AU2017366873A1 (en) 2019-06-13
WO2018102304A1 (en) 2018-06-07
IL266917B2 (en) 2023-10-01
US20180185504A1 (en) 2018-07-05
CN110382534B (zh) 2023-05-09
US10925971B2 (en) 2021-02-23

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