JP2019535739A - ジメチルスルホキシドを含む単一のペースト型水硬性根管充填材のための組成物 - Google Patents
ジメチルスルホキシドを含む単一のペースト型水硬性根管充填材のための組成物 Download PDFInfo
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- JP2019535739A JP2019535739A JP2019527243A JP2019527243A JP2019535739A JP 2019535739 A JP2019535739 A JP 2019535739A JP 2019527243 A JP2019527243 A JP 2019527243A JP 2019527243 A JP2019527243 A JP 2019527243A JP 2019535739 A JP2019535739 A JP 2019535739A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/876—Calcium oxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/54—Filling; Sealing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/56—Apical treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/69—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
- A61K6/71—Fillers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
- A61K6/71—Fillers
- A61K6/73—Fillers comprising sulfur-containing compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
- A61K6/71—Fillers
- A61K6/76—Fillers comprising silicon-containing compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
- A61K6/818—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising zirconium oxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
- A61K6/824—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising transition metal oxides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/836—Glass
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/853—Silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/856—Pozzolans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/869—Zeolites
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/878—Zirconium oxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2/00—Lime, magnesia or dolomite
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/001—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing unburned clay
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/02—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing hydraulic cements other than calcium sulfates
- C04B28/10—Lime cements or magnesium oxide cements
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B40/00—Processes, in general, for influencing or modifying the properties of mortars, concrete or artificial stone compositions, e.g. their setting or hardening ability
- C04B40/0028—Aspects relating to the mixing step of the mortar preparation
- C04B40/0039—Premixtures of ingredients
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
Abstract
Description
[本発明の好ましい実施例]
図1は、本発明の一実施例に係る細胞毒性試験のグラフである。図1を参照して詳察することにする。
本発明の一実施例により、ジルコニウムオキサイド、3ケイ酸カルシウム、ベントナイト、ヒュームドシリカおよびヒドロキシプロピルメチルセルロースをDMSOと混合してペーストを作った。以上の成分を順に45:21:1:0.6:0.6:31.8の重量比で混合した。
図2は、本発明の一実施例に係る細胞毒性試験のグラフである。図2を参照して詳察することにする。
本実施例により製造されたペーストのpH変化を観察した。WESを実験群とし、レジン系物質であるAH plusを対照群とした。各材料を1mmの厚さおよび5mmの直径を有するモールドに注入した後に硬化させた。その後、10mlの蒸溜水に硬化した材料を入れてphメーターを利用して1時間から7日までpHを測定した。前記実験の結果については、図3の本発明の一実施例に係るpH変化実験グラフを参照することができる。WESは実験期間の間ずっと10以上のpHを維持したがAH plusは中性に該当するpHを示した。これはヒュームドシリカが強塩基性の水酸化カルシウムを消耗したためと考えられる。
根管充填材はできるだけ根管内で組織液などによって溶解しないことが好ましい。溶解度が高いと溶解した空間で細菌が増殖して再感染となり得るためである。すなわち、溶解度が低いほど密閉性が優秀となる。
根管充填材は、一度根管内に適用されると必ず本来の体積をそのまま維持しなければならず、できるだけ収縮してはならない。材料が収縮すると必然的に空いた空間を残すことになり、細菌が増殖し得る条件が造成されるためである。単一のペースト型MTAシーラーは体積変化が少ないことが最も重要な性質であって、2%内外の膨潤性がなければならない。
図4は、製造例の試料(FD170828)と製造例でベントナイトを900℃で熱処理した試料(FD170828PH)(熱処理の理由は膨張を調節して抗菌性を維持するためである)が、それぞれバイオフィルムを有するE.faecalisに対して適用された状況を示すグラフである。そして、図5は、前記のような試料がそれぞれバイオフィルムを有するP.endodontalisに対して適用された状況を示すグラフである。他の二種類の試料については便宜上説明を省略する。
Claims (8)
- ケイ酸カルシウム成分、および
DMSOを含む、単一のペースト型水硬性根管充填材組成物。 - ポゾラン物質をさらに含む、請求項1に記載の単一のペースト型水硬性根管充填材組成物。
- 前記ポゾラン物質はヒュームドシリカ、沈降シリカおよびコロイダルシリカのうち少なくとも一つである、請求項2に記載の単一のペースト型水硬性根管充填材組成物。
- メタカオリン、硅藻土および膨潤性粘土のうち少なくとも一つをさらに含む、請求項1に記載の単一のペースト型水硬性根管充填材組成物。
- 前記膨潤性粘土はベントナイト、ヘクトライトおよび合成膨潤性粘土のうち少なくとも一つを含む、請求項4に記載の単一のペースト型水硬性根管充填材組成物。
- 前記DMSOは前記単一のペースト型水硬性根管充填材組成物の液体成分の重量の70%以上を占める、請求項1に記載の単一のペースト型水硬性根管充填材組成物。
- 水、エタノール、ポリエチレングリコールおよびDEGEEで構成された群から選択された少なくとも一つを前記液体成分の重量の30%以下で含む、請求項6に記載の単一のペースト型水硬性根管充填材組成物。
- 放射線不透過性物質をさらに含み、
前記放射線不透過性物質は、バリウムチタネート、ビスマスチタネート、バリウムジルコネート、ジルコニウムオキサイド、カルシウムタングステート、タンタルオキサイドおよびこれらのうち二以上の混合物から選択される、請求項1に記載の単一のペースト型水硬性根管充填材組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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KR20160155276 | 2016-11-21 | ||
KR10-2016-0155276 | 2016-11-21 | ||
PCT/KR2017/013300 WO2018093241A2 (ko) | 2016-11-21 | 2017-11-21 | 디메틸술폭시드를 포함하는 단일 페이스트형 수경성 근관 충전재를 위한 조성물 |
Publications (2)
Publication Number | Publication Date |
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JP2019535739A true JP2019535739A (ja) | 2019-12-12 |
JP7083827B2 JP7083827B2 (ja) | 2022-06-13 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP2019527242A Active JP7138633B2 (ja) | 2016-11-21 | 2017-11-21 | 根管貼薬剤組成物 |
JP2019527243A Active JP7083827B2 (ja) | 2016-11-21 | 2017-11-21 | ジメチルスルホキシドを含む単一のペースト型水硬性根管充填材のための組成物 |
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JP2019527242A Active JP7138633B2 (ja) | 2016-11-21 | 2017-11-21 | 根管貼薬剤組成物 |
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US (2) | US11737956B2 (ja) |
EP (2) | EP3542778B1 (ja) |
JP (2) | JP7138633B2 (ja) |
KR (4) | KR20200017542A (ja) |
CN (2) | CN109982680B (ja) |
WO (2) | WO2018093239A2 (ja) |
Families Citing this family (7)
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KR102054296B1 (ko) * | 2017-11-09 | 2020-01-22 | 주식회사 마루치 | 의료용 충전재 조성물 |
CN110051541B (zh) * | 2019-06-06 | 2022-03-22 | 四川涑爽医疗用品有限公司 | 一种氢氧化钙根管消毒糊剂及其制备方法 |
CN110882166A (zh) * | 2019-12-10 | 2020-03-17 | 广州润虹医药科技股份有限公司 | 一种稳定的磷酸钙根管填充剂 |
KR102452438B1 (ko) * | 2020-09-21 | 2022-10-11 | 주식회사 마루치 | 의료용 시멘트 조성물 |
KR102615342B1 (ko) * | 2022-03-04 | 2023-12-19 | 주식회사 마루치 | 생체흡수성이 개선된 방사선 불투과성 물질을 포함하는 조성물 |
CN114767548A (zh) * | 2022-04-21 | 2022-07-22 | 昆明青橙医疗科技有限公司 | 具有高流动性的无水根管消毒剂基质及应用其的消毒剂和应用 |
WO2023205886A1 (en) * | 2022-04-26 | 2023-11-02 | Pds Inc. | An improved mineral trioxide aggregate filling material for dentistry and a device for its use |
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2017
- 2017-11-21 US US16/462,581 patent/US11737956B2/en active Active
- 2017-11-21 CN CN201780071936.5A patent/CN109982680B/zh active Active
- 2017-11-21 EP EP17872299.7A patent/EP3542778B1/en active Active
- 2017-11-21 KR KR1020207003340A patent/KR20200017542A/ko not_active Application Discontinuation
- 2017-11-21 KR KR1020207013572A patent/KR102233620B1/ko active IP Right Grant
- 2017-11-21 JP JP2019527242A patent/JP7138633B2/ja active Active
- 2017-11-21 EP EP17871996.9A patent/EP3542777A4/en active Pending
- 2017-11-21 US US16/462,927 patent/US11517508B2/en active Active
- 2017-11-21 JP JP2019527243A patent/JP7083827B2/ja active Active
- 2017-11-21 WO PCT/KR2017/013298 patent/WO2018093239A2/ko active Application Filing
- 2017-11-21 KR KR1020177035268A patent/KR20180071201A/ko not_active IP Right Cessation
- 2017-11-21 WO PCT/KR2017/013300 patent/WO2018093241A2/ko unknown
- 2017-11-21 KR KR1020177035273A patent/KR102203499B1/ko active IP Right Grant
- 2017-11-21 CN CN201780071906.4A patent/CN110022838B/zh active Active
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KR20100037979A (ko) * | 2008-10-02 | 2010-04-12 | 이노베이티브 바이오세라믹스 인코퍼레이티드 | 미리 혼합된 시멘트 페이스트 및 시멘트 특성 물질 제조방법 |
WO2012146832A2 (en) * | 2011-04-28 | 2012-11-01 | Oulun Yliopisto | A method for improving penetration or long term adhesion of compositions to dental tissues and compositions usable in said method |
KR20150100446A (ko) * | 2014-02-25 | 2015-09-02 | 주식회사 마루치 | 단일 페이스트형 치과용 수경성 충전재 조성물 |
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KR20180071202A (ko) | 2018-06-27 |
WO2018093239A2 (ko) | 2018-05-24 |
WO2018093239A8 (ko) | 2019-04-18 |
KR102203499B1 (ko) | 2021-01-15 |
EP3542778A4 (en) | 2020-07-29 |
US20190321267A1 (en) | 2019-10-24 |
KR102233620B1 (ko) | 2021-03-30 |
CN109982680B (zh) | 2022-06-21 |
KR20180071201A (ko) | 2018-06-27 |
JP2019535738A (ja) | 2019-12-12 |
EP3542777A4 (en) | 2020-07-29 |
KR20200063228A (ko) | 2020-06-04 |
CN109982680A (zh) | 2019-07-05 |
WO2018093239A3 (ko) | 2018-08-09 |
EP3542777A2 (en) | 2019-09-25 |
CN110022838A (zh) | 2019-07-16 |
WO2018093241A2 (ko) | 2018-05-24 |
WO2018093241A3 (ko) | 2018-08-09 |
JP7083827B2 (ja) | 2022-06-13 |
EP3542778B1 (en) | 2022-02-16 |
CN110022838B (zh) | 2022-05-13 |
US11517508B2 (en) | 2022-12-06 |
JP7138633B2 (ja) | 2022-09-16 |
EP3542778A2 (en) | 2019-09-25 |
KR20200017542A (ko) | 2020-02-18 |
US20200060947A1 (en) | 2020-02-27 |
US11737956B2 (en) | 2023-08-29 |
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