JP7246444B2 - 医療用セメント組成物 - Google Patents
医療用セメント組成物 Download PDFInfo
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- JP7246444B2 JP7246444B2 JP2021151629A JP2021151629A JP7246444B2 JP 7246444 B2 JP7246444 B2 JP 7246444B2 JP 2021151629 A JP2021151629 A JP 2021151629A JP 2021151629 A JP2021151629 A JP 2021151629A JP 7246444 B2 JP7246444 B2 JP 7246444B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/54—Filling; Sealing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/56—Apical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/871—Quartz; SiO2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/30—Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/84—Preparations for artificial teeth, for filling teeth or for capping teeth comprising metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/853—Silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/02—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing hydraulic cements other than calcium sulfates
- C04B28/04—Portland cements
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/18—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing mixtures of the silica-lime type
- C04B28/186—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing mixtures of the silica-lime type containing formed Ca-silicates before the final hardening step
- C04B28/188—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing mixtures of the silica-lime type containing formed Ca-silicates before the final hardening step the Ca-silicates being present in the starting mixture
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
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- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Organic Chemistry (AREA)
- Surgery (AREA)
- Dental Preparations (AREA)
Description
1)水酸化カルシウムによる遅延膨張を抑制して得られた優れた長期安定性
2)再治療が可能な低い圧縮強度
3)高い生体活性
DMSO溶液にヒドロキシプロピルメチルセルロースを2部添加して完全に溶かした。以後、三ケイ酸カルシウムとジルコニア(ZrO2)を1:7で混合した粉末成分と重量比で3:10で練り、リチウム塩添加剤の調節された量を追加して医療用セメント組成物を製造した。
(製造された医療用セメント組成物の三ケイ酸カルシウムの含有量は、全体組成物の9.6重量%であった。)
下記の表1のように、医療用セメント組成物のリチウム塩(炭酸リチウム)の含有量を全体医療用セメント組成物に含まれるケイ酸カルシウムの含有量を100重量%として、0.3、0.5、0.6、0.7、0.9、1.2および1.5重量%で添加したことを除き、製造例1の製造方法にしたがって、医療用セメント組成物を製造した。
三ケイ酸カルシウムとジルコニア(ZrO2)を1:3で混合した粉末を使用したことを除き、製造例1の製造方法にしたがって、医療用セメント組成物を製造した。つまり、比較例1には、リチウム塩が含まれていない。
(製造された医療用セメント組成物の三ケイ酸カルシウムの含有量は、全体組成物の20.03重量%であった。)
実施例1および比較例1の医療用セメント組成物硬化体の試片をそれぞれ製造し、圧縮強度を測定した(実施例1は、2つの試片を製造して測定し、比較例1は、4つの試片を製造して測定した)。
医療用セメント組成物硬化体の細胞毒性をMTT分析方法を用いて実験した。具体的な実験方法は、以下の通りである。
(図2のグラフに示した棒の値の最も左から最も右の順に、それぞれCON、OES、リチウム塩の含有量である0.3、0.5、0.6、0.7、0.9、1.2および1.5重量%含む医療用セメント組成物硬化体の細胞生存率の測定結果を示す。)
Claims (5)
- ケイ酸カルシウムが組成物全体質量の5質量%以上20質量%未満で含まれ、
前記ケイ酸カルシウムの含有量を100質量%基準として、リチウム塩を0.1質量%以上1.5質量%以下で含み、
N-メチル-2-ピロリドン(N-methyl-2-pyrrolidone、NMP)、ジメチルスルホキシド(dimethyl sulfoxide、DMSO)およびジエチレングリコールモノエチルエーテル(diethylene glycol monoethyl ether、DEGEE)の中から選択されたいずれか一つ以上をさらに含む、
医療用セメント組成物。 - 前記リチウム塩は、ケイ酸リチウム、窒化リチウム、炭酸リチウムおよび水酸化リチウムからなる群より選択されたいずれか一つ以上である、
請求項1に記載の医療用セメント組成物。 - 前記ケイ酸カルシウムは、三ケイ酸カルシウム(tricalcium silicate)である、
請求項1または2に記載の医療用セメント組成物。 - 硬化後の圧縮強度が3MPa以上であり、12MPa以下である、
請求項1~3のいずれか一項に記載の医療用セメント組成物。 - 前記医療用セメント組成物は、プレミックス(premix)されたものである、
請求項1~4のいずれか一項に記載の医療用セメント組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2020-0121240 | 2020-09-21 | ||
KR1020200121240A KR102452438B1 (ko) | 2020-09-21 | 2020-09-21 | 의료용 시멘트 조성물 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022051701A JP2022051701A (ja) | 2022-04-01 |
JP7246444B2 true JP7246444B2 (ja) | 2023-03-27 |
Family
ID=77912977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2021151629A Active JP7246444B2 (ja) | 2020-09-21 | 2021-09-17 | 医療用セメント組成物 |
Country Status (5)
Country | Link |
---|---|
US (1) | US11759406B2 (ja) |
EP (1) | EP3971152A1 (ja) |
JP (1) | JP7246444B2 (ja) |
KR (1) | KR102452438B1 (ja) |
CN (1) | CN114246803A (ja) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080214500A1 (en) | 2007-03-01 | 2008-09-04 | Leif Hermansson | Injectable cement composition for orthopaedic and dental use |
US20080210125A1 (en) | 2007-03-01 | 2008-09-04 | Doxa Ab | Stable cement composition for orthopaedic and dental use |
US20130025498A1 (en) | 2010-04-07 | 2013-01-31 | Gilles Richard | Dental Composition |
JP2017506648A (ja) | 2014-02-25 | 2017-03-09 | マルチMaruchi | 単一のペースト型の歯科用水硬性充填材組成物 |
US20170181931A1 (en) | 2014-09-16 | 2017-06-29 | Maruchi | Rapid-setting hydraulic binder composition |
JP2019535738A (ja) | 2016-11-21 | 2019-12-12 | マルチMaruchi | 根管貼薬剤組成物 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
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SE524334C2 (sv) * | 2002-09-30 | 2004-07-27 | Cerbio Tech Ab | Värmegenererande biokompatibla keramiska material och förfarande för dess framställning |
US9101436B2 (en) | 2005-10-21 | 2015-08-11 | Ada Foundation | Dental and endodontic filling materials and methods |
WO2008008184A2 (en) * | 2006-07-07 | 2008-01-17 | Dentsply International Inc. | Gutta-percha compositions for obturating dental root canals |
US7670427B2 (en) * | 2007-06-06 | 2010-03-02 | United States Gypsum Company | Very fast setting cementitious composition with high early-age compressive strength |
KR101000402B1 (ko) | 2008-04-24 | 2010-12-13 | 장성욱 | 치과 치료용 포졸란 시멘트 |
US20140322144A1 (en) * | 2011-07-27 | 2014-10-30 | Lj Walsh Dental Pty Ltd | Alkaline compositions and their dental and medical use |
KR101359073B1 (ko) | 2012-03-20 | 2014-02-05 | 장성욱 | 지르코니아 분말을 포함하는 치아 충전용 조성물 |
ITMI20132059A1 (it) * | 2013-12-10 | 2015-06-11 | Mapei Spa | Additivo accelerante per composizioni cementizie |
US10561583B2 (en) * | 2017-08-09 | 2020-02-18 | Shilpa Medicare Limited | Dental cement composition |
KR102040618B1 (ko) * | 2017-10-26 | 2019-11-06 | 주식회사 마루치 | 의료용 시멘트 조성물 |
KR102054296B1 (ko) * | 2017-11-09 | 2020-01-22 | 주식회사 마루치 | 의료용 충전재 조성물 |
KR102265378B1 (ko) * | 2018-10-12 | 2021-06-16 | 단국대학교 천안캠퍼스 산학협력단 | 치과 조직 재생용 이식체의 제조방법 |
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2020
- 2020-09-21 KR KR1020200121240A patent/KR102452438B1/ko active IP Right Grant
-
2021
- 2021-09-03 EP EP21194910.2A patent/EP3971152A1/en active Pending
- 2021-09-17 JP JP2021151629A patent/JP7246444B2/ja active Active
- 2021-09-18 CN CN202111111104.6A patent/CN114246803A/zh active Pending
- 2021-09-20 US US17/479,358 patent/US11759406B2/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080214500A1 (en) | 2007-03-01 | 2008-09-04 | Leif Hermansson | Injectable cement composition for orthopaedic and dental use |
US20080210125A1 (en) | 2007-03-01 | 2008-09-04 | Doxa Ab | Stable cement composition for orthopaedic and dental use |
US20130025498A1 (en) | 2010-04-07 | 2013-01-31 | Gilles Richard | Dental Composition |
JP2017506648A (ja) | 2014-02-25 | 2017-03-09 | マルチMaruchi | 単一のペースト型の歯科用水硬性充填材組成物 |
US20170181931A1 (en) | 2014-09-16 | 2017-06-29 | Maruchi | Rapid-setting hydraulic binder composition |
JP2017529349A (ja) | 2014-09-16 | 2017-10-05 | マルチMaruchi | 超速硬水硬性バインダー組成物 |
JP2019535738A (ja) | 2016-11-21 | 2019-12-12 | マルチMaruchi | 根管貼薬剤組成物 |
Also Published As
Publication number | Publication date |
---|---|
CN114246803A (zh) | 2022-03-29 |
JP2022051701A (ja) | 2022-04-01 |
US11759406B2 (en) | 2023-09-19 |
EP3971152A1 (en) | 2022-03-23 |
US20220087907A1 (en) | 2022-03-24 |
KR20220038887A (ko) | 2022-03-29 |
KR102452438B1 (ko) | 2022-10-11 |
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