JP2019535707A - 軟骨損傷および関節炎の処置のための方法および組成物 - Google Patents

軟骨損傷および関節炎の処置のための方法および組成物 Download PDF

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JP2019535707A
JP2019535707A JP2019524328A JP2019524328A JP2019535707A JP 2019535707 A JP2019535707 A JP 2019535707A JP 2019524328 A JP2019524328 A JP 2019524328A JP 2019524328 A JP2019524328 A JP 2019524328A JP 2019535707 A JP2019535707 A JP 2019535707A
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Prior art keywords
polypeptide
composition
amino acid
seq
intra
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Japanese (ja)
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JP2019535707A5 (enExample
Inventor
ジョンソン，クリステン
ゴールドハーン，ヨルグ
スコッティ，セレステ
ボスティアー，イゴール
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ノバルティス アーゲー
ノバルティス アーゲー
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Publication of JP2019535707A publication Critical patent/JP2019535707A/ja
Publication of JP2019535707A5 publication Critical patent/JP2019535707A5/ja
Priority to JP2022193539A priority Critical patent/JP2023039962A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019524328A 2016-11-14 2017-11-13 軟骨損傷および関節炎の処置のための方法および組成物 Withdrawn JP2019535707A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022193539A JP2023039962A (ja) 2016-11-14 2022-12-02 軟骨損傷および関節炎の処置のための方法および組成物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662421534P 2016-11-14 2016-11-14
US62/421,534 2016-11-14
US201762560301P 2017-09-19 2017-09-19
US62/560,301 2017-09-19
PCT/IB2017/057081 WO2018087727A1 (en) 2016-11-14 2017-11-13 Methods and compositions for treatment of cartilage damage and arthritis

Related Child Applications (1)

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JP2022193539A Division JP2023039962A (ja) 2016-11-14 2022-12-02 軟骨損傷および関節炎の処置のための方法および組成物

Publications (2)

Publication Number Publication Date
JP2019535707A true JP2019535707A (ja) 2019-12-12
JP2019535707A5 JP2019535707A5 (enExample) 2020-12-24

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JP2019524328A Withdrawn JP2019535707A (ja) 2016-11-14 2017-11-13 軟骨損傷および関節炎の処置のための方法および組成物
JP2022193539A Pending JP2023039962A (ja) 2016-11-14 2022-12-02 軟骨損傷および関節炎の処置のための方法および組成物

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Country Status (10)

Country Link
US (3) US11351223B2 (enExample)
EP (1) EP3538127A1 (enExample)
JP (2) JP2019535707A (enExample)
KR (2) KR20190084287A (enExample)
CN (2) CN109963579A (enExample)
AU (2) AU2017357785A1 (enExample)
CA (1) CA3043667A1 (enExample)
IL (1) IL266361B2 (enExample)
MX (2) MX2019005621A (enExample)
WO (1) WO2018087727A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117355323A (zh) 2021-05-24 2024-01-05 诺华股份有限公司 用于治疗骨关节炎的方法
TW202306970A (zh) 2021-05-24 2023-02-16 瑞士商諾華公司 用於治療骨關節炎之方法
EP4430395A1 (en) * 2021-11-10 2024-09-18 Novartis AG Methods for determining the biological activity of angptl polypeptides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012533549A (ja) * 2009-07-14 2012-12-27 ザ スクリプス リサーチ インスティチュート 間葉幹細胞分化
JP2016510763A (ja) * 2013-03-08 2016-04-11 ノバルティス アーゲー 関節損傷の治療のためのペプチドおよび組成物

Family Cites Families (17)

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EP1490483B1 (en) 2001-04-19 2015-06-03 The Scripps Research Institute In vivo incorporation of unnatural amino acids
DK1578949T3 (da) 2002-10-16 2009-07-27 Scripps Research Inst Stedspecifik optagelse af keto-aminnosyrer hos proteiner
KR20050073559A (ko) 2002-10-16 2005-07-14 더 스크립스 리서치 인스티튜트 당단백질 합성
CN103289960B (zh) 2003-04-17 2017-04-26 斯克利普斯研究院 扩展真核生物遗传密码
WO2005007624A2 (en) 2003-07-07 2005-01-27 The Scripps Research Institute Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof
WO2005007870A2 (en) 2003-07-07 2005-01-27 The Scripps Research Institute COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF
DE602004011789T2 (de) 2003-07-07 2009-02-12 The Scripps Research Institute, La Jolla Zusammensetzungen der orthogonalen Lysyl-tRNA und Aminoacyl-tRNA Synthetase Paaren und ihre Verwendungen
EP1794323B1 (en) 2004-09-21 2014-08-06 The Scripps Research Institute In vivo incorporation of alkynyl amino acids into proteins in eubacteria
AU2005330514B2 (en) 2004-10-27 2011-05-12 The Scripps Research Institute Orthogonal translation components for the in vivo incorporation of unnatural amino acids
CA2638763A1 (en) 2006-03-09 2007-09-13 The Scripps Research Institute System for the expression of orthogonal translation components in eubacterial host cells
EP2118150B1 (en) 2007-02-14 2015-09-23 Biocompatibles UK Limited Derivatisation of biological molecules
CN102307902B (zh) * 2008-12-10 2016-02-24 埃博灵克斯股份有限公司 用于治疗与血管发生相关的疾病和病症的针对血管生成素/Tie系统的氨基酸序列和包括其的多肽
UY32979A (es) * 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
AU2013204754C1 (en) * 2012-05-16 2018-10-11 Takeda Pharmaceutical Company Limited Nucleophilic Catalysts for Oxime Linkage
US9301971B2 (en) * 2013-03-08 2016-04-05 Novartis Ag Peptides and compositions for treatment of joint damage
WO2014151953A1 (en) * 2013-03-15 2014-09-25 The California Institute For Biomedical Research Compounds and methods for inducing chondrogenesis
UY36118A (es) * 2014-05-13 2016-01-08 Novartis Ag Compuestos y composiciones para inducir condrogénesis

Patent Citations (2)

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JP2012533549A (ja) * 2009-07-14 2012-12-27 ザ スクリプス リサーチ インスティチュート 間葉幹細胞分化
JP2016510763A (ja) * 2013-03-08 2016-04-11 ノバルティス アーゲー 関節損傷の治療のためのペプチドおよび組成物

Non-Patent Citations (1)

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Title
DEV. DYN. (2007) VOL.236, ISSUE 9, P.2643-2652, JPN6021039990, ISSN: 0004613302 *

Also Published As

Publication number Publication date
RU2019117884A (ru) 2020-12-14
EP3538127A1 (en) 2019-09-18
US11351223B2 (en) 2022-06-07
CA3043667A1 (en) 2018-05-17
KR20190084287A (ko) 2019-07-16
MX2019005621A (es) 2019-08-12
US20190269754A1 (en) 2019-09-05
IL266361A (en) 2019-06-30
KR20240045351A (ko) 2024-04-05
MX2022011897A (es) 2022-10-18
IL266361B1 (en) 2023-10-01
AU2017357785A1 (en) 2019-04-11
CN109963579A (zh) 2019-07-02
US20250302915A1 (en) 2025-10-02
AU2020281098A1 (en) 2021-01-14
WO2018087727A1 (en) 2018-05-17
US20220331398A1 (en) 2022-10-20
AU2020281098B2 (en) 2024-05-02
RU2019117884A3 (enExample) 2021-02-05
AU2017357785A2 (en) 2019-05-02
CN117860868A (zh) 2024-04-12
IL266361B2 (en) 2024-02-01
JP2023039962A (ja) 2023-03-22

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