CN109963579A - 用于治疗软骨损伤和关节炎的方法和组合物 - Google Patents

用于治疗软骨损伤和关节炎的方法和组合物 Download PDF

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Publication number
CN109963579A
CN109963579A CN201780068935.5A CN201780068935A CN109963579A CN 109963579 A CN109963579 A CN 109963579A CN 201780068935 A CN201780068935 A CN 201780068935A CN 109963579 A CN109963579 A CN 109963579A
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CN
China
Prior art keywords
polypeptide
composition
amino acid
intra
articular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780068935.5A
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English (en)
Chinese (zh)
Inventor
C·斯科蒂
I·沃斯蒂尔
K·约翰逊
J·高德翰
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Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Priority to CN202311759624.7A priority Critical patent/CN117860868A/zh
Publication of CN109963579A publication Critical patent/CN109963579A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201780068935.5A 2016-11-14 2017-11-13 用于治疗软骨损伤和关节炎的方法和组合物 Pending CN109963579A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311759624.7A CN117860868A (zh) 2016-11-14 2017-11-13 用于治疗软骨损伤和关节炎的方法和组合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662421534P 2016-11-14 2016-11-14
US62/421,534 2016-11-14
US201762560301P 2017-09-19 2017-09-19
US62/560,301 2017-09-19
PCT/IB2017/057081 WO2018087727A1 (en) 2016-11-14 2017-11-13 Methods and compositions for treatment of cartilage damage and arthritis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202311759624.7A Division CN117860868A (zh) 2016-11-14 2017-11-13 用于治疗软骨损伤和关节炎的方法和组合物

Publications (1)

Publication Number Publication Date
CN109963579A true CN109963579A (zh) 2019-07-02

Family

ID=60629753

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201780068935.5A Pending CN109963579A (zh) 2016-11-14 2017-11-13 用于治疗软骨损伤和关节炎的方法和组合物
CN202311759624.7A Pending CN117860868A (zh) 2016-11-14 2017-11-13 用于治疗软骨损伤和关节炎的方法和组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202311759624.7A Pending CN117860868A (zh) 2016-11-14 2017-11-13 用于治疗软骨损伤和关节炎的方法和组合物

Country Status (10)

Country Link
US (3) US11351223B2 (enExample)
EP (1) EP3538127A1 (enExample)
JP (2) JP2019535707A (enExample)
KR (2) KR20190084287A (enExample)
CN (2) CN109963579A (enExample)
AU (2) AU2017357785A1 (enExample)
CA (1) CA3043667A1 (enExample)
IL (1) IL266361B2 (enExample)
MX (2) MX2019005621A (enExample)
WO (1) WO2018087727A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4346876A1 (en) 2021-05-24 2024-04-10 Novartis AG Methods for the treatment of osteoarthritis
TW202306970A (zh) 2021-05-24 2023-02-16 瑞士商諾華公司 用於治療骨關節炎之方法
WO2023084388A1 (en) * 2021-11-10 2023-05-19 Novartis Ag Methods for determining the biological activity of angptl polypeptides

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102307902A (zh) * 2008-12-10 2012-01-04 埃博灵克斯股份有限公司 用于治疗与血管发生相关的疾病和病症的针对血管生成素/Tie系统的氨基酸序列和包括其的多肽
CN102770451A (zh) * 2009-10-28 2012-11-07 雅培制药有限公司 双重可变结构域免疫球蛋白及其用途
CN104487095A (zh) * 2012-05-16 2015-04-01 巴克斯特国际公司 用于肟键联的亲核性催化剂
CN105025917A (zh) * 2013-03-08 2015-11-04 诺华股份有限公司 用于治疗关节损坏的肽和组合物
CN105228626A (zh) * 2013-03-15 2016-01-06 加州生物医学研究所 用于诱导软骨形成的化合物和方法
CN106459076A (zh) * 2014-05-13 2017-02-22 诺华股份有限公司 用于诱导软骨发生的化合物和组合物

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JP2005502322A (ja) 2001-04-19 2005-01-27 ザ スクリップス リサーチ インスティテュート 非天然アミノ酸のインビボ組込み
EP1558747B1 (en) 2002-10-16 2009-10-14 The Scripps Research Institute Glycoprotein synthesis
JP4444113B2 (ja) 2002-10-16 2010-03-31 ザ スクリップス リサーチ インスティテュート ケトアミノ酸の部位特異的蛋白質組込み方法
CN103215227B (zh) 2003-04-17 2015-09-16 斯克利普斯研究院 扩展真核生物遗传密码
WO2005007624A2 (en) 2003-07-07 2005-01-27 The Scripps Research Institute Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof
ES2301099T3 (es) 2003-07-07 2008-06-16 The Scripps Research Institute Composiciones de parejas ortogonales lisil-arnt y aminoacil-arnt sintetasa y usos de las mismas.
EP1704242A4 (en) 2003-07-07 2008-06-18 Scripps Research Inst COMPOSITIONS WITH PAIRS OF ORTHOGONAL LEUCYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF
CN101151366B (zh) 2004-09-21 2012-12-19 斯克利普斯研究院 将炔基氨基酸体内掺入真细菌的蛋白
US8216804B2 (en) 2004-10-27 2012-07-10 The Scripps Research Institute Orthogonal translation components for the in vivo incorporation of unnatural amino acids
CN101400796B (zh) 2006-03-09 2013-03-27 斯克利普斯研究院 在真细菌宿主细胞内表达正交翻译组分的系统
US8575397B2 (en) 2007-02-14 2013-11-05 Biocompatibles Uk Limited Derivatisation of biological molecules
BR112012000914B8 (pt) * 2009-07-14 2021-05-25 Irm Llc uso de polipeptídeo com atividade condrogênica, método in vitro de indução da diferenciação de células-tronco mesenquimais em condrócitos, e composição farmacêutica para aplicação intra-articular
MA38369B1 (fr) * 2013-03-08 2018-10-31 Novartis Ag Peptides et compositions pour le traitement d'une lesion de l'articulation

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CN102307902A (zh) * 2008-12-10 2012-01-04 埃博灵克斯股份有限公司 用于治疗与血管发生相关的疾病和病症的针对血管生成素/Tie系统的氨基酸序列和包括其的多肽
CN102770451A (zh) * 2009-10-28 2012-11-07 雅培制药有限公司 双重可变结构域免疫球蛋白及其用途
CN104487095A (zh) * 2012-05-16 2015-04-01 巴克斯特国际公司 用于肟键联的亲核性催化剂
CN105025917A (zh) * 2013-03-08 2015-11-04 诺华股份有限公司 用于治疗关节损坏的肽和组合物
CN105228626A (zh) * 2013-03-15 2016-01-06 加州生物医学研究所 用于诱导软骨形成的化合物和方法
CN106459076A (zh) * 2014-05-13 2017-02-22 诺华股份有限公司 用于诱导软骨发生的化合物和组合物

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DAR-MING LAI等: "Angiopoietin‐like protein 1 expression is related to intermuscular connective tissue and cartilage development", 《DEVELOPMENTAL DYNAMICS》 *

Also Published As

Publication number Publication date
JP2023039962A (ja) 2023-03-22
MX2019005621A (es) 2019-08-12
US20190269754A1 (en) 2019-09-05
EP3538127A1 (en) 2019-09-18
US11351223B2 (en) 2022-06-07
AU2017357785A1 (en) 2019-04-11
AU2020281098A1 (en) 2021-01-14
WO2018087727A1 (en) 2018-05-17
JP2019535707A (ja) 2019-12-12
AU2017357785A2 (en) 2019-05-02
RU2019117884A3 (enExample) 2021-02-05
CA3043667A1 (en) 2018-05-17
US20220331398A1 (en) 2022-10-20
MX2022011897A (es) 2022-10-18
CN117860868A (zh) 2024-04-12
IL266361B2 (en) 2024-02-01
IL266361A (en) 2019-06-30
US20250302915A1 (en) 2025-10-02
KR20240045351A (ko) 2024-04-05
IL266361B1 (en) 2023-10-01
KR20190084287A (ko) 2019-07-16
RU2019117884A (ru) 2020-12-14
AU2020281098B2 (en) 2024-05-02

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