JP2019535643A5 - - Google Patents
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- Publication number
- JP2019535643A5 JP2019535643A5 JP2019512895A JP2019512895A JP2019535643A5 JP 2019535643 A5 JP2019535643 A5 JP 2019535643A5 JP 2019512895 A JP2019512895 A JP 2019512895A JP 2019512895 A JP2019512895 A JP 2019512895A JP 2019535643 A5 JP2019535643 A5 JP 2019535643A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- composition
- carbamate hydrochloride
- phenylpropyl carbamate
- phenylpropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KAOVAAHCFNYXNJ-SBSPUUFOSA-N [(2r)-2-amino-3-phenylpropyl] carbamate;hydrochloride Chemical compound Cl.NC(=O)OC[C@H](N)CC1=CC=CC=C1 KAOVAAHCFNYXNJ-SBSPUUFOSA-N 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 24
- 208000005793 Restless legs syndrome Diseases 0.000 claims 10
- 239000012453 solvate Substances 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 6
- 208000020925 Bipolar disease Diseases 0.000 claims 5
- -1 phenylpropyl carbamate hydrochloride Chemical compound 0.000 claims 5
- 208000001573 Cataplexy Diseases 0.000 claims 4
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 4
- 206010041349 Somnolence Diseases 0.000 claims 4
- 201000003631 narcolepsy Diseases 0.000 claims 4
- 239000006260 foam Substances 0.000 claims 3
- 208000001640 Fibromyalgia Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 201000001880 Sexual dysfunction Diseases 0.000 claims 2
- RDUWMEXOUFLPOE-SBSPUUFOSA-N [(2R)-2-amino-3-phenylpropyl]carbamic acid hydrochloride Chemical compound Cl.N[C@@H](CNC(O)=O)CC1=CC=CC=C1 RDUWMEXOUFLPOE-SBSPUUFOSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 206010013663 drug dependence Diseases 0.000 claims 2
- 206010016256 fatigue Diseases 0.000 claims 2
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 2
- ULYZAYCEDJDHCC-UHFFFAOYSA-N isopropyl chloride Chemical compound CC(C)Cl ULYZAYCEDJDHCC-UHFFFAOYSA-N 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 239000006186 oral dosage form Substances 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 231100000872 sexual dysfunction Toxicity 0.000 claims 2
- 239000002002 slurry Substances 0.000 claims 2
- 230000000391 smoking effect Effects 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 238000011109 contamination Methods 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 238000000113 differential scanning calorimetry Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 208000013403 hyperactivity Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- SNMVRZFUUCLYTO-UHFFFAOYSA-N n-propyl chloride Chemical compound CCCCl SNMVRZFUUCLYTO-UHFFFAOYSA-N 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 1
- 208000015891 sexual disease Diseases 0.000 claims 1
- 238000007614 solvation Methods 0.000 claims 1
- 239000011877 solvent mixture Substances 0.000 claims 1
- 238000003828 vacuum filtration Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021155292A JP7642506B2 (ja) | 2016-09-06 | 2021-09-24 | （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム |
| JP2024161956A JP2024178291A (ja) | 2016-09-06 | 2024-09-19 | （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662383822P | 2016-09-06 | 2016-09-06 | |
| PCT/US2017/050233 WO2018048871A1 (en) | 2016-09-06 | 2017-09-06 | Solvate form of (r)-2-amino-3-phenylpropyl carbamate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021155292A Division JP7642506B2 (ja) | 2016-09-06 | 2021-09-24 | （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535643A JP2019535643A (ja) | 2019-12-12 |
| JP2019535643A5 true JP2019535643A5 (enExample) | 2020-09-24 |
| JP7219213B2 JP7219213B2 (ja) | 2023-02-07 |
Family
ID=61562003
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019512895A Active JP7219213B2 (ja) | 2016-09-06 | 2017-09-06 | （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム |
| JP2021155292A Active JP7642506B2 (ja) | 2016-09-06 | 2021-09-24 | （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム |
| JP2024161956A Pending JP2024178291A (ja) | 2016-09-06 | 2024-09-19 | （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021155292A Active JP7642506B2 (ja) | 2016-09-06 | 2021-09-24 | （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム |
| JP2024161956A Pending JP2024178291A (ja) | 2016-09-06 | 2024-09-19 | （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10829443B2 (enExample) |
| EP (2) | EP4364794A3 (enExample) |
| JP (3) | JP7219213B2 (enExample) |
| KR (1) | KR102513800B1 (enExample) |
| CN (2) | CN109996540A (enExample) |
| CA (1) | CA3036071A1 (enExample) |
| DK (1) | DK3509582T3 (enExample) |
| ES (1) | ES2970887T3 (enExample) |
| FI (1) | FI3509582T3 (enExample) |
| MY (1) | MY197630A (enExample) |
| PH (1) | PH12019500493A1 (enExample) |
| SG (1) | SG11201901998WA (enExample) |
| WO (1) | WO2018048871A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| JP7219213B2 (ja) * | 2016-09-06 | 2023-02-07 | ジャズ ファーマスティカルズ アイルランド リミテッド | （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム |
| US11447448B2 (en) | 2018-08-14 | 2022-09-20 | Glenmark Life Sciences Limited | Process for the preparation of solriamfetol and salt thereof |
| AU2020231916B2 (en) | 2019-03-01 | 2025-08-28 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| WO2021001457A1 (en) | 2019-07-04 | 2021-01-07 | Sandoz Ag | Crystalline (r)-2-amino-3-phenylpropylcarbamate acid addition salts |
| IT202000013855A1 (it) * | 2020-06-10 | 2021-12-10 | Flamma Spa | Un processo per la purificazione del (r)-2-ammino-3-fenilpropil carbammato |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| EP4615426A1 (en) * | 2022-11-07 | 2025-09-17 | Axsome Therapeutics | Compositions and methods for treating insomnia |
| EP4642446A2 (en) * | 2022-12-30 | 2025-11-05 | Axsome Malta Ltd. | Methods of administering solriamfetol to lactating women |
| WO2024194718A1 (en) | 2023-03-22 | 2024-09-26 | Unichem Laboratories Limited | A stable pharmaceutical composition and process for preparing thereof |
| WO2024249560A1 (en) | 2023-05-30 | 2024-12-05 | Axsome Therapeutics, Inc. | Solriamfetol for treating cognitive impairment in a subject with impaired cognition associated with obstructive sleep apnea and excessive daytime sleepiness |
| WO2025006965A1 (en) | 2023-06-29 | 2025-01-02 | Axsome Therapeutics, Inc. | Methods of administering solriamfetol to lactating women |
| WO2025042959A1 (en) | 2023-08-21 | 2025-02-27 | Axsome Therapeutics, Inc. | Use of solriamfetol for the treatment of orphan diseases |
| WO2025165760A1 (en) * | 2024-01-29 | 2025-08-07 | Axsome Therapeutics, Inc. | Phenylalkylamino carbamates for use in the treatment of attention deficit/hyperactivity disorder |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100197892B1 (ko) * | 1994-09-09 | 1999-06-15 | 남창우 | 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법 |
| KR0173862B1 (ko) | 1995-02-11 | 1999-04-01 | 조규향 | O-카바모일-(d)-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| US5756817C1 (en) | 1995-02-11 | 2001-04-17 | Sk Corp | O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same |
| KR0173863B1 (ko) | 1995-04-10 | 1999-04-01 | 조규향 | 페닐에 치환체가 있는 o-카바모일-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| JP4374441B2 (ja) | 1998-12-23 | 2009-12-02 | ジェイピーアイ コマーシャル，リミティド ライアビリティ カンパニー | 睡眠発作治療のための、ガンマ−ヒドロキシ酪酸塩の微生物的に安全で安定な液剤 |
| RU2202607C2 (ru) * | 2000-03-03 | 2003-04-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Штамм бактерий methylophilus methylotrophus - продуцент l-фенилаланина (варианты), способ получения l-фенилаланина |
| US20050080268A1 (en) * | 2003-10-08 | 2005-04-14 | Yong-Moon Choi | Process of preparing O-carbamoyl compounds in the presence of active amine group |
| WO2006050037A1 (en) | 2004-10-28 | 2006-05-11 | Sk Corporation | Adjunctive therapy for depression |
| PL1890684T3 (pl) * | 2005-06-08 | 2014-05-30 | Sk Biopharmaceuticals Co Ltd | Leczenie zaburzeń snu i czuwania |
| ATE459393T1 (de) * | 2005-06-22 | 2010-03-15 | Sk Holdings Co Ltd | Behandlung der sexuellen dysfunktion |
| WO2011005473A2 (en) | 2009-06-22 | 2011-01-13 | Shionogi Pharma, Inc. | Methods for treating or preventing fatigue |
| US8232315B2 (en) | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
| ES2447295T3 (es) | 2009-11-06 | 2014-03-11 | Sk Biopharmaceuticals Co., Ltd. | Métodos para el tratamiento del trastorno de déficit de atención/hiperactividad |
| RU2557533C2 (ru) | 2009-11-06 | 2015-07-20 | Ск Биофармасъютиклс Ко., Лтд. | Способы лечения синдрома фибромиалгии |
| US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
| US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
| US9050302B2 (en) | 2013-03-01 | 2015-06-09 | Jazz Pharmaceuticals Ireland Limited | Method of administration of gamma hydroxybutyrate with monocarboxylate transporters |
| BR112015022197B1 (pt) | 2013-03-13 | 2022-06-07 | Sk Biopharmaceuticals Co., Ltd. | Uso de um composto para o tratamento de cataplexia |
| US20150018414A1 (en) | 2013-07-12 | 2015-01-15 | Jazz Pharmaceuticals International lll Limited | Promotion of Smoking Cessation |
| CN105873576B (zh) * | 2013-07-18 | 2019-07-19 | 爵士制药国际Iii有限公司 | 治疗肥胖 |
| TWI655179B (zh) | 2014-02-28 | 2019-04-01 | 南韓商愛思開生物製藥股份有限公司 | 胺基羰基胺基甲酸酯化合物 |
| HK1257569A1 (zh) | 2016-02-16 | 2019-10-25 | The University Of Queensland | 磺醯脲和相关化合物及其用途 |
| JP7219213B2 (ja) * | 2016-09-06 | 2023-02-07 | ジャズ ファーマスティカルズ アイルランド リミテッド | （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム |
| KR101950254B1 (ko) | 2016-09-21 | 2019-02-20 | 유상신 | 차량탑승자의 부재를 감지하는 지능형 카시트 |
| US11447448B2 (en) * | 2018-08-14 | 2022-09-20 | Glenmark Life Sciences Limited | Process for the preparation of solriamfetol and salt thereof |
-
2017
- 2017-09-06 JP JP2019512895A patent/JP7219213B2/ja active Active
- 2017-09-06 FI FIEP17849432.4T patent/FI3509582T3/fi active
- 2017-09-06 DK DK17849432.4T patent/DK3509582T3/da active
- 2017-09-06 US US16/331,069 patent/US10829443B2/en active Active
- 2017-09-06 ES ES17849432T patent/ES2970887T3/es active Active
- 2017-09-06 MY MYPI2019001180A patent/MY197630A/en unknown
- 2017-09-06 WO PCT/US2017/050233 patent/WO2018048871A1/en not_active Ceased
- 2017-09-06 CN CN201780065192.6A patent/CN109996540A/zh active Pending
- 2017-09-06 KR KR1020197011279A patent/KR102513800B1/ko active Active
- 2017-09-06 EP EP23218015.8A patent/EP4364794A3/en active Pending
- 2017-09-06 CA CA3036071A patent/CA3036071A1/en not_active Abandoned
- 2017-09-06 CN CN202510706413.XA patent/CN120574152A/zh active Pending
- 2017-09-06 SG SG11201901998WA patent/SG11201901998WA/en unknown
- 2017-09-06 EP EP17849432.4A patent/EP3509582B1/en active Active
-
2019
- 2019-03-06 PH PH12019500493A patent/PH12019500493A1/en unknown
-
2020
- 2020-11-06 US US17/091,222 patent/US11560354B2/en active Active
-
2021
- 2021-09-24 JP JP2021155292A patent/JP7642506B2/ja active Active
-
2022
- 2022-12-14 US US18/066,000 patent/US12384743B2/en active Active
-
2024
- 2024-09-19 JP JP2024161956A patent/JP2024178291A/ja active Pending
-
2025
- 2025-07-11 US US19/266,767 patent/US20250340509A1/en active Pending
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