JP2019534017A5 - - Google Patents
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- JP2019534017A5 JP2019534017A5 JP2019523633A JP2019523633A JP2019534017A5 JP 2019534017 A5 JP2019534017 A5 JP 2019534017A5 JP 2019523633 A JP2019523633 A JP 2019523633A JP 2019523633 A JP2019523633 A JP 2019523633A JP 2019534017 A5 JP2019534017 A5 JP 2019534017A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- amount
- unnatural
- results
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 40
- 102000039446 nucleic acids Human genes 0.000 claims 37
- 108020004707 nucleic acids Proteins 0.000 claims 37
- 238000000034 method Methods 0.000 claims 31
- 230000003321 amplification Effects 0.000 claims 20
- 238000003199 nucleic acid amplification method Methods 0.000 claims 20
- 238000012207 quantitative assay Methods 0.000 claims 14
- 108700028369 Alleles Proteins 0.000 claims 8
- 238000002054 transplantation Methods 0.000 claims 3
- 238000012544 monitoring process Methods 0.000 claims 2
- 238000003753 real-time PCR Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 238000012935 Averaging Methods 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 238000007476 Maximum Likelihood Methods 0.000 claims 1
- 230000002924 anti-infective effect Effects 0.000 claims 1
- 230000003409 anti-rejection Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000007847 digital PCR Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662416696P | 2016-11-02 | 2016-11-02 | |
| US62/416,696 | 2016-11-02 | ||
| US201762546789P | 2017-08-17 | 2017-08-17 | |
| US62/546,789 | 2017-08-17 | ||
| PCT/US2017/059802 WO2018085597A1 (en) | 2016-11-02 | 2017-11-02 | Methods for assessing risk using mismatch amplification and statistical methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019534017A JP2019534017A (ja) | 2019-11-28 |
| JP2019534017A5 true JP2019534017A5 (https=) | 2020-12-17 |
Family
ID=62076123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523633A Pending JP2019534017A (ja) | 2016-11-02 | 2017-11-02 | ミスマッチ増幅を使用するリスクを評価するための方法および統計方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20190360033A1 (https=) |
| EP (1) | EP3535391A4 (https=) |
| JP (1) | JP2019534017A (https=) |
| CN (1) | CN110177874A (https=) |
| AU (1) | AU2017355458A1 (https=) |
| CA (1) | CA3042722A1 (https=) |
| WO (1) | WO2018085597A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| RU2671980C2 (ru) | 2011-02-09 | 2018-11-08 | Натера, Инк. | Способы неинвазивного пренатального установления плоидности |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| RU2760913C2 (ru) | 2016-04-15 | 2021-12-01 | Натера, Инк. | Способы выявления рака легкого |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US11773434B2 (en) | 2017-06-20 | 2023-10-03 | The Medical College Of Wisconsin, Inc. | Assessing transplant complication risk with total cell-free DNA |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| WO2019217918A1 (en) * | 2018-05-10 | 2019-11-14 | The Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-cancer risk assessment with non-cancer associated targets |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE61148B1 (en) * | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| EP1325963B1 (en) * | 2001-12-24 | 2006-09-27 | Wolfgang Prof. Holzgreve | Method for non-invasive diagnosis of transplantations and transfusions |
| WO2011094646A1 (en) * | 2010-01-28 | 2011-08-04 | Medical College Of Wisconsin, Inc. | Methods and compositions for high yield, specific amplification |
| JP5842811B2 (ja) * | 2010-03-24 | 2016-01-13 | 凸版印刷株式会社 | 競合プライマーによる標的塩基配列の検出方法 |
| EP3741871A3 (en) * | 2012-04-19 | 2021-02-17 | The Medical College of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
| WO2014194113A2 (en) * | 2013-05-29 | 2014-12-04 | Chronix Biomedical | Detection and quantification of donor cell-free dna in the circulation of organ transplant recipients |
| WO2016176662A1 (en) * | 2015-04-30 | 2016-11-03 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
| EP3449018A4 (en) * | 2016-04-29 | 2019-11-06 | The Medical College of Wisconsin, Inc. | REAL-TIME PCR WITH MULTIPLEXED OPTIMIZED MISMATCH AMPLIFICATION (MOMA) FOR THE EVALUATION OF FETAL WELL-BEING |
| WO2017190106A1 (en) * | 2016-04-29 | 2017-11-02 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-target number |
| WO2017190104A1 (en) * | 2016-04-29 | 2017-11-02 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cancer |
| JP2019534016A (ja) * | 2016-11-02 | 2019-11-28 | ザ メディカル カレッジ オブ ウィスコンシン，インコーポレイテッドＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． | 全および特異的な無細胞ｄｎａを使用しリスクを評価するための方法 |
-
2017
- 2017-11-02 WO PCT/US2017/059802 patent/WO2018085597A1/en not_active Ceased
- 2017-11-02 US US16/347,185 patent/US20190360033A1/en not_active Abandoned
- 2017-11-02 CA CA3042722A patent/CA3042722A1/en not_active Abandoned
- 2017-11-02 AU AU2017355458A patent/AU2017355458A1/en not_active Abandoned
- 2017-11-02 JP JP2019523633A patent/JP2019534017A/ja active Pending
- 2017-11-02 EP EP17868449.4A patent/EP3535391A4/en not_active Withdrawn
- 2017-11-02 CN CN201780080316.8A patent/CN110177874A/zh active Pending
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