JP2019534017A5 - - Google Patents
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- JP2019534017A5 JP2019534017A5 JP2019523633A JP2019523633A JP2019534017A5 JP 2019534017 A5 JP2019534017 A5 JP 2019534017A5 JP 2019523633 A JP2019523633 A JP 2019523633A JP 2019523633 A JP2019523633 A JP 2019523633A JP 2019534017 A5 JP2019534017 A5 JP 2019534017A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- amount
- unnatural
- results
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 40
- 102000039446 nucleic acids Human genes 0.000 claims 37
- 108020004707 nucleic acids Proteins 0.000 claims 37
- 238000000034 method Methods 0.000 claims 31
- 230000003321 amplification Effects 0.000 claims 20
- 238000003199 nucleic acid amplification method Methods 0.000 claims 20
- 238000012207 quantitative assay Methods 0.000 claims 14
- 108700028369 Alleles Proteins 0.000 claims 8
- 238000002054 transplantation Methods 0.000 claims 3
- 238000012544 monitoring process Methods 0.000 claims 2
- 238000003753 real-time PCR Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 238000012935 Averaging Methods 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 238000007476 Maximum Likelihood Methods 0.000 claims 1
- 230000002924 anti-infective effect Effects 0.000 claims 1
- 230000003409 anti-rejection Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000007847 digital PCR Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662416696P | 2016-11-02 | 2016-11-02 | |
| US62/416,696 | 2016-11-02 | ||
| US201762546789P | 2017-08-17 | 2017-08-17 | |
| US62/546,789 | 2017-08-17 | ||
| PCT/US2017/059802 WO2018085597A1 (en) | 2016-11-02 | 2017-11-02 | Methods for assessing risk using mismatch amplification and statistical methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019534017A JP2019534017A (ja) | 2019-11-28 |
| JP2019534017A5 true JP2019534017A5 (https=) | 2020-12-17 |
Family
ID=62076123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523633A Pending JP2019534017A (ja) | 2016-11-02 | 2017-11-02 | ミスマッチ増幅を使用するリスクを評価するための方法および統計方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20190360033A1 (https=) |
| EP (1) | EP3535391A4 (https=) |
| JP (1) | JP2019534017A (https=) |
| CN (1) | CN110177874A (https=) |
| AU (1) | AU2017355458A1 (https=) |
| CA (1) | CA3042722A1 (https=) |
| WO (1) | WO2018085597A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| AU2011358564B9 (en) | 2011-02-09 | 2017-07-13 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US20180173845A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
| WO2017181202A2 (en) | 2016-04-15 | 2017-10-19 | Natera, Inc. | Methods for lung cancer detection |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| AU2018288832B2 (en) | 2017-06-20 | 2025-03-06 | The Medical College Of Wisconsin, Inc. | Assessing transplant complication risk with total cell-free DNA |
| JP2021506342A (ja) | 2017-12-14 | 2021-02-22 | ティーエーアイ ダイアグノスティックス インコーポレイテッドＴａｉ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． | 移植のための移植片適合性の評価 |
| CA3090426A1 (en) | 2018-04-14 | 2019-10-17 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| WO2019217918A1 (en) * | 2018-05-10 | 2019-11-14 | The Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-cancer risk assessment with non-cancer associated targets |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE61148B1 (en) * | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| EP1325963B1 (en) * | 2001-12-24 | 2006-09-27 | Wolfgang Prof. Holzgreve | Method for non-invasive diagnosis of transplantations and transfusions |
| US20130143219A1 (en) * | 2010-01-28 | 2013-06-06 | Medical College of Wisconsin Inc. | Methods and compositions for high yield, specific amplification |
| CN102892901B (zh) * | 2010-03-24 | 2015-11-25 | 凸版印刷株式会社 | 利用竞争性引物的目标碱基序列的检测方法 |
| AU2013249012B2 (en) * | 2012-04-19 | 2019-03-28 | The Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free DNA |
| DK3004388T4 (da) * | 2013-05-29 | 2023-08-28 | Chronix Biomedical | Påvisning og kvantificering af cellefrit dna fra donor i kredsløbet hos organtransplantatmodtagere |
| US20180142296A1 (en) * | 2015-04-30 | 2018-05-24 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
| JP2019518437A (ja) * | 2016-04-29 | 2019-07-04 | ザ メディカル カレッジ オブ ウィスコンシン インクＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ Ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． | 多重／最適化ミスマッチ増幅（ｍｏｍａ）−がんの評価のためのリアルタイムｐｃｒ |
| BR112018072196A2 (pt) * | 2016-04-29 | 2019-02-12 | Medical College Wisconsin Inc | amplificação de incompatibilidade otimizada multiplexadas (moma) - número do alvo |
| EP3449018A4 (en) * | 2016-04-29 | 2019-11-06 | The Medical College of Wisconsin, Inc. | REAL-TIME PCR WITH MULTIPLEXED OPTIMIZED MISMATCH AMPLIFICATION (MOMA) FOR THE EVALUATION OF FETAL WELL-BEING |
| CN110114477A (zh) * | 2016-11-02 | 2019-08-09 | 威斯康星州立大学医学院 | 用于使用总的和特异性无细胞dna评估风险的方法 |
-
2017
- 2017-11-02 CA CA3042722A patent/CA3042722A1/en not_active Abandoned
- 2017-11-02 CN CN201780080316.8A patent/CN110177874A/zh active Pending
- 2017-11-02 EP EP17868449.4A patent/EP3535391A4/en not_active Withdrawn
- 2017-11-02 US US16/347,185 patent/US20190360033A1/en not_active Abandoned
- 2017-11-02 AU AU2017355458A patent/AU2017355458A1/en not_active Abandoned
- 2017-11-02 WO PCT/US2017/059802 patent/WO2018085597A1/en not_active Ceased
- 2017-11-02 JP JP2019523633A patent/JP2019534017A/ja active Pending
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