JP2018514219A5 - - Google Patents
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- JP2018514219A5 JP2018514219A5 JP2017557142A JP2017557142A JP2018514219A5 JP 2018514219 A5 JP2018514219 A5 JP 2018514219A5 JP 2017557142 A JP2017557142 A JP 2017557142A JP 2017557142 A JP2017557142 A JP 2017557142A JP 2018514219 A5 JP2018514219 A5 JP 2018514219A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- snv
- natural nucleic
- optionally
- primer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 51
- 102000039446 nucleic acids Human genes 0.000 claims 51
- 108020004707 nucleic acids Proteins 0.000 claims 51
- 238000000034 method Methods 0.000 claims 49
- 108700028369 Alleles Proteins 0.000 claims 36
- 239000000523 sample Substances 0.000 claims 32
- 230000003321 amplification Effects 0.000 claims 12
- 238000003199 nucleic acid amplification method Methods 0.000 claims 12
- 238000012207 quantitative assay Methods 0.000 claims 12
- 238000012544 monitoring process Methods 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 238000007476 Maximum Likelihood Methods 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 230000003409 anti-rejection Effects 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- 238000003753 real-time PCR Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 206010019315 Heart transplant rejection Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 238000007847 digital PCR Methods 0.000 claims 1
- 238000009826 distribution Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 238000007481 next generation sequencing Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000002922 simulated annealing Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021127555A JP2022002508A (ja) | 2015-04-30 | 2021-08-03 | 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562155453P | 2015-04-30 | 2015-04-30 | |
| US62/155,453 | 2015-04-30 | ||
| PCT/US2016/030313 WO2016176662A1 (en) | 2015-04-30 | 2016-04-29 | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021127555A Division JP2022002508A (ja) | 2015-04-30 | 2021-08-03 | 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018514219A JP2018514219A (ja) | 2018-06-07 |
| JP2018514219A5 true JP2018514219A5 (https=) | 2019-08-29 |
Family
ID=56027193
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557142A Pending JP2018514219A (ja) | 2015-04-30 | 2016-04-29 | 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ |
| JP2021127555A Pending JP2022002508A (ja) | 2015-04-30 | 2021-08-03 | 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021127555A Pending JP2022002508A (ja) | 2015-04-30 | 2021-08-03 | 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20180142296A1 (https=) |
| EP (1) | EP3289102A1 (https=) |
| JP (2) | JP2018514219A (https=) |
| CN (1) | CN107849604A (https=) |
| AU (2) | AU2016255573A1 (https=) |
| BR (1) | BR112017023232A2 (https=) |
| CA (1) | CA2984352A1 (https=) |
| EA (1) | EA201792389A1 (https=) |
| HK (1) | HK1252152A1 (https=) |
| IL (2) | IL255301B (https=) |
| MX (1) | MX2017013878A (https=) |
| WO (1) | WO2016176662A1 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| WO2011146632A1 (en) | 2010-05-18 | 2011-11-24 | Gene Security Network Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| CN103608466B (zh) | 2010-12-22 | 2020-09-18 | 纳特拉公司 | 非侵入性产前亲子鉴定方法 |
| RU2671980C2 (ru) | 2011-02-09 | 2018-11-08 | Натера, Инк. | Способы неинвазивного пренатального установления плоидности |
| EP3741871A3 (en) | 2012-04-19 | 2021-02-17 | The Medical College of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| CA2945962C (en) | 2014-04-21 | 2023-08-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| WO2016176662A1 (en) * | 2015-04-30 | 2016-11-03 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| RU2760913C2 (ru) | 2016-04-15 | 2021-12-01 | Натера, Инк. | Способы выявления рака легкого |
| WO2017190106A1 (en) * | 2016-04-29 | 2017-11-02 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-target number |
| EP3449018A4 (en) * | 2016-04-29 | 2019-11-06 | The Medical College of Wisconsin, Inc. | REAL-TIME PCR WITH MULTIPLEXED OPTIMIZED MISMATCH AMPLIFICATION (MOMA) FOR THE EVALUATION OF FETAL WELL-BEING |
| WO2017190104A1 (en) * | 2016-04-29 | 2017-11-02 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cancer |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| WO2018085597A1 (en) * | 2016-11-02 | 2018-05-11 | Medical College Of Wisconsin, Inc. | Methods for assessing risk using mismatch amplification and statistical methods |
| JP2019534016A (ja) * | 2016-11-02 | 2019-11-28 | ザ メディカル カレッジ オブ ウィスコンシン，インコーポレイテッドＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． | 全および特異的な無細胞ｄｎａを使用しリスクを評価するための方法 |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| CA3067635A1 (en) * | 2017-06-20 | 2018-12-27 | The Medical College Of Wisconsin, Inc. | Transplant patient monitoring with cell-free dna |
| US11773434B2 (en) | 2017-06-20 | 2023-10-03 | The Medical College Of Wisconsin, Inc. | Assessing transplant complication risk with total cell-free DNA |
| US20210139988A1 (en) * | 2017-06-20 | 2021-05-13 | The Medical College Of Wisconsin, Inc. | Assessing conditions in transplant subjects using donor-specific cell-free dna |
| AU2018317875A1 (en) * | 2017-08-17 | 2020-03-05 | Tai Diagnostics, Inc. | Methods of determining donor cell-free DNA without donor genotype |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| AU2018383191B2 (en) * | 2017-12-15 | 2023-02-16 | Acrannolife Genomics Pvt. Ltd. | A non-invasive method for monitoring transplanted organ status in organ-transplant recipients |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| WO2020131955A1 (en) * | 2018-12-17 | 2020-06-25 | The Medical College Of Wisconsin, Inc. | Assessing risk with total cell-free dna |
| WO2020206290A1 (en) * | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using total cell-free dna |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| US12305235B2 (en) | 2019-06-06 | 2025-05-20 | Natera, Inc. | Methods for detecting immune cell DNA and monitoring immune system |
| WO2021236962A1 (en) | 2020-05-20 | 2021-11-25 | The Medical College Of Wisconsin, Inc. | Compositions and methods for inhibiting cytokine-release syndrome |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1325963B1 (en) * | 2001-12-24 | 2006-09-27 | Wolfgang Prof. Holzgreve | Method for non-invasive diagnosis of transplantations and transfusions |
| JP2013509883A (ja) * | 2009-11-06 | 2013-03-21 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 臓器移植患者における移植片拒絶反応の非侵襲的診断方法 |
| WO2011094646A1 (en) * | 2010-01-28 | 2011-08-04 | Medical College Of Wisconsin, Inc. | Methods and compositions for high yield, specific amplification |
| JP5842811B2 (ja) * | 2010-03-24 | 2016-01-13 | 凸版印刷株式会社 | 競合プライマーによる標的塩基配列の検出方法 |
| EP3741871A3 (en) * | 2012-04-19 | 2021-02-17 | The Medical College of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
| EP2959016A4 (en) * | 2013-02-21 | 2016-10-12 | Toma Biosciences Inc | METHOD, COMPOSITIONS AND NUCLEIC ACID ANALYSIS KITS |
| WO2014194113A2 (en) * | 2013-05-29 | 2014-12-04 | Chronix Biomedical | Detection and quantification of donor cell-free dna in the circulation of organ transplant recipients |
| WO2016176662A1 (en) * | 2015-04-30 | 2016-11-03 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
-
2016
- 2016-04-29 WO PCT/US2016/030313 patent/WO2016176662A1/en not_active Ceased
- 2016-04-29 JP JP2017557142A patent/JP2018514219A/ja active Pending
- 2016-04-29 HK HK18111543.9A patent/HK1252152A1/zh unknown
- 2016-04-29 EP EP16724189.2A patent/EP3289102A1/en active Pending
- 2016-04-29 AU AU2016255573A patent/AU2016255573A1/en not_active Abandoned
- 2016-04-29 MX MX2017013878A patent/MX2017013878A/es unknown
- 2016-04-29 EA EA201792389A patent/EA201792389A1/ru unknown
- 2016-04-29 CN CN201680039018.XA patent/CN107849604A/zh active Pending
- 2016-04-29 CA CA2984352A patent/CA2984352A1/en active Pending
- 2016-04-29 US US15/570,560 patent/US20180142296A1/en not_active Abandoned
- 2016-04-29 BR BR112017023232A patent/BR112017023232A2/pt not_active IP Right Cessation
-
2017
- 2017-10-29 IL IL255301A patent/IL255301B/en unknown
-
2021
- 2021-08-03 JP JP2021127555A patent/JP2022002508A/ja active Pending
- 2021-12-26 IL IL289404A patent/IL289404A/en unknown
-
2022
- 2022-05-23 AU AU2022203482A patent/AU2022203482A1/en not_active Abandoned
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