JP2018514219A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018514219A5 JP2018514219A5 JP2017557142A JP2017557142A JP2018514219A5 JP 2018514219 A5 JP2018514219 A5 JP 2018514219A5 JP 2017557142 A JP2017557142 A JP 2017557142A JP 2017557142 A JP2017557142 A JP 2017557142A JP 2018514219 A5 JP2018514219 A5 JP 2018514219A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- snv
- natural nucleic
- optionally
- primer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 51
- 102000039446 nucleic acids Human genes 0.000 claims 51
- 108020004707 nucleic acids Proteins 0.000 claims 51
- 238000000034 method Methods 0.000 claims 49
- 108700028369 Alleles Proteins 0.000 claims 36
- 239000000523 sample Substances 0.000 claims 32
- 230000003321 amplification Effects 0.000 claims 12
- 238000003199 nucleic acid amplification method Methods 0.000 claims 12
- 238000012207 quantitative assay Methods 0.000 claims 12
- 238000012544 monitoring process Methods 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 238000007476 Maximum Likelihood Methods 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 230000003409 anti-rejection Effects 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- 238000003753 real-time PCR Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 206010019315 Heart transplant rejection Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 238000007847 digital PCR Methods 0.000 claims 1
- 238000009826 distribution Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 238000007481 next generation sequencing Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000002922 simulated annealing Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021127555A JP2022002508A (ja) | 2015-04-30 | 2021-08-03 | 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562155453P | 2015-04-30 | 2015-04-30 | |
| US62/155,453 | 2015-04-30 | ||
| PCT/US2016/030313 WO2016176662A1 (en) | 2015-04-30 | 2016-04-29 | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021127555A Division JP2022002508A (ja) | 2015-04-30 | 2021-08-03 | 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018514219A JP2018514219A (ja) | 2018-06-07 |
| JP2018514219A5 true JP2018514219A5 (https=) | 2019-08-29 |
Family
ID=56027193
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557142A Pending JP2018514219A (ja) | 2015-04-30 | 2016-04-29 | 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ |
| JP2021127555A Pending JP2022002508A (ja) | 2015-04-30 | 2021-08-03 | 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021127555A Pending JP2022002508A (ja) | 2015-04-30 | 2021-08-03 | 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20180142296A1 (https=) |
| EP (1) | EP3289102A1 (https=) |
| JP (2) | JP2018514219A (https=) |
| CN (1) | CN107849604A (https=) |
| AU (2) | AU2016255573A1 (https=) |
| BR (1) | BR112017023232A2 (https=) |
| CA (1) | CA2984352A1 (https=) |
| EA (1) | EA201792389A1 (https=) |
| HK (1) | HK1252152A1 (https=) |
| IL (2) | IL255301B (https=) |
| MX (1) | MX2017013878A (https=) |
| WO (1) | WO2016176662A1 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| EP2572003A4 (en) | 2010-05-18 | 2016-01-13 | Natera Inc | METHOD FOR NONINVASIVE PRANATAL PLOIDIE ASSIGNMENT |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| WO2012088456A2 (en) | 2010-12-22 | 2012-06-28 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| AU2011358564B9 (en) | 2011-02-09 | 2017-07-13 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
| AU2013249012B2 (en) | 2012-04-19 | 2019-03-28 | The Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free DNA |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| EP3957749A1 (en) | 2014-04-21 | 2022-02-23 | Natera, Inc. | Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples |
| US20180173845A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| US20180142296A1 (en) * | 2015-04-30 | 2018-05-24 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
| WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
| WO2017181202A2 (en) | 2016-04-15 | 2017-10-19 | Natera, Inc. | Methods for lung cancer detection |
| BR112018072196A2 (pt) * | 2016-04-29 | 2019-02-12 | Medical College Wisconsin Inc | amplificação de incompatibilidade otimizada multiplexadas (moma) - número do alvo |
| EP3449018A4 (en) * | 2016-04-29 | 2019-11-06 | The Medical College of Wisconsin, Inc. | REAL-TIME PCR WITH MULTIPLEXED OPTIMIZED MISMATCH AMPLIFICATION (MOMA) FOR THE EVALUATION OF FETAL WELL-BEING |
| JP2019518437A (ja) * | 2016-04-29 | 2019-07-04 | ザ メディカル カレッジ オブ ウィスコンシン インクＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ Ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． | 多重／最適化ミスマッチ増幅（ｍｏｍａ）−がんの評価のためのリアルタイムｐｃｒ |
| US11485996B2 (en) | 2016-10-04 | 2022-11-01 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| CN110114477A (zh) * | 2016-11-02 | 2019-08-09 | 威斯康星州立大学医学院 | 用于使用总的和特异性无细胞dna评估风险的方法 |
| CA3042722A1 (en) * | 2016-11-02 | 2018-05-11 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using mismatch amplification and statistical methods |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| AU2018288835A1 (en) | 2017-06-20 | 2020-01-16 | The Medical College Of Wisconsin, Inc. | Assessing conditions in transplant subjects using donor-specific cell-free DNA |
| CA3067635A1 (en) * | 2017-06-20 | 2018-12-27 | The Medical College Of Wisconsin, Inc. | Transplant patient monitoring with cell-free dna |
| AU2018288832B2 (en) | 2017-06-20 | 2025-03-06 | The Medical College Of Wisconsin, Inc. | Assessing transplant complication risk with total cell-free DNA |
| JP2020531050A (ja) * | 2017-08-17 | 2020-11-05 | ティーエーアイ ダイアグノスティックス インコーポレイテッドＴａｉ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． | ドナー遺伝子型なしでドナー無細胞ｄｎａを決定する方法 |
| JP2021506342A (ja) | 2017-12-14 | 2021-02-22 | ティーエーアイ ダイアグノスティックス インコーポレイテッドＴａｉ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． | 移植のための移植片適合性の評価 |
| SG11202005474RA (en) * | 2017-12-15 | 2020-07-29 | Acrannolife Genomics Pvt Ltd | A non-invasive method for monitoring transplanted organ status in organ-transplant recipients |
| CA3090426A1 (en) | 2018-04-14 | 2019-10-17 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| EP3899033A4 (en) * | 2018-12-17 | 2022-10-19 | The Medical College of Wisconsin, Inc. | Assessing risk with total cell-free dna |
| WO2020206290A1 (en) * | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using total cell-free dna |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| EP3980559A1 (en) | 2019-06-06 | 2022-04-13 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| WO2021236962A1 (en) | 2020-05-20 | 2021-11-25 | The Medical College Of Wisconsin, Inc. | Compositions and methods for inhibiting cytokine-release syndrome |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1325963B1 (en) * | 2001-12-24 | 2006-09-27 | Wolfgang Prof. Holzgreve | Method for non-invasive diagnosis of transplantations and transfusions |
| HUE052213T2 (hu) * | 2009-11-06 | 2021-04-28 | Univ Leland Stanford Junior | Grafitkilökõdés nem invazív diagnosztizálása szervátültetett betegekben |
| US20130143219A1 (en) * | 2010-01-28 | 2013-06-06 | Medical College of Wisconsin Inc. | Methods and compositions for high yield, specific amplification |
| CN102892901B (zh) * | 2010-03-24 | 2015-11-25 | 凸版印刷株式会社 | 利用竞争性引物的目标碱基序列的检测方法 |
| AU2013249012B2 (en) * | 2012-04-19 | 2019-03-28 | The Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free DNA |
| CN105339507A (zh) * | 2013-02-21 | 2016-02-17 | 托马生物科学公司 | 用于核酸分析的方法、组合物和试剂盒 |
| DK3004388T4 (da) * | 2013-05-29 | 2023-08-28 | Chronix Biomedical | Påvisning og kvantificering af cellefrit dna fra donor i kredsløbet hos organtransplantatmodtagere |
| US20180142296A1 (en) * | 2015-04-30 | 2018-05-24 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
-
2016
- 2016-04-29 US US15/570,560 patent/US20180142296A1/en not_active Abandoned
- 2016-04-29 WO PCT/US2016/030313 patent/WO2016176662A1/en not_active Ceased
- 2016-04-29 CA CA2984352A patent/CA2984352A1/en active Pending
- 2016-04-29 EA EA201792389A patent/EA201792389A1/ru unknown
- 2016-04-29 AU AU2016255573A patent/AU2016255573A1/en not_active Abandoned
- 2016-04-29 CN CN201680039018.XA patent/CN107849604A/zh active Pending
- 2016-04-29 HK HK18111543.9A patent/HK1252152A1/zh unknown
- 2016-04-29 MX MX2017013878A patent/MX2017013878A/es unknown
- 2016-04-29 EP EP16724189.2A patent/EP3289102A1/en active Pending
- 2016-04-29 JP JP2017557142A patent/JP2018514219A/ja active Pending
- 2016-04-29 BR BR112017023232A patent/BR112017023232A2/pt not_active IP Right Cessation
-
2017
- 2017-10-29 IL IL255301A patent/IL255301B/en unknown
-
2021
- 2021-08-03 JP JP2021127555A patent/JP2022002508A/ja active Pending
- 2021-12-26 IL IL289404A patent/IL289404A/en unknown
-
2022
- 2022-05-23 AU AU2022203482A patent/AU2022203482A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018514219A5 (https=) | ||
| JP2022002508A5 (https=) | ||
| JP2022180384A5 (https=) | ||
| Bachtrog et al. | Massive gene amplification on a recently formed Drosophila Y chromosome | |
| JP2019534017A5 (https=) | ||
| JP2019518438A5 (https=) | ||
| Macia et al. | Epigenetic control of retrotransposon expression in human embryonic stem cells | |
| JP2019514387A5 (https=) | ||
| ES2704682T3 (es) | Detección y cuantificación de ADN extracelular del donante en la circulación de receptores de trasplantes de órganos | |
| KR102393608B1 (ko) | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 | |
| JP2022002508A (ja) | 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ | |
| JP2019518437A5 (https=) | ||
| CN107206043A (zh) | 使用机器学习和高维转录数据在经支气管活检上诊断特发性肺纤维化的系统和方法 | |
| JP2014073134A5 (ja) | 標的増幅及びシークエンシングを使用した非侵襲的な胎児遺伝子型スクリーニング | |
| US10533214B2 (en) | Method for measuring mutational load | |
| No et al. | Comparison of targeted next-generation sequencing for whole-genome sequencing of Hantaan orthohantavirus in Apodemus agrarius lung tissues | |
| TWI715900B (zh) | 次世代定序儀用引子以及其製造方法、使用次世代定序儀用引子之ｄｎａ庫以及其製造方法，及使用ｄｎａ庫之基因體ｄｎａ解析方法 | |
| Zhou et al. | A noninvasive and donor-independent method simultaneously monitors rejection and infection in patients with organ transplant | |
| Keller et al. | miRNAs in ancient tissue specimens of the Tyrolean Iceman | |
| CN101955996A (zh) | 一种单碱基Indel突变的检测方法 | |
| CN103898231A (zh) | 一种与猪肉pH性状相关的SNP分子标记及其应用 | |
| US20150337377A1 (en) | Method of diagnosis of complement-mediated thrombotic microangiopathies | |
| CN103421769A (zh) | 一种与猪胴体性状相关的snp分子标记及其应用 | |
| Hidayat et al. | Feasibility of the salivary transcriptome as a novel biomarker in determining disease susceptibility | |
| US11884983B2 (en) | Method for predicting resistance |