JP2019533442A5 - - Google Patents
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- JP2019533442A5 JP2019533442A5 JP2019518063A JP2019518063A JP2019533442A5 JP 2019533442 A5 JP2019533442 A5 JP 2019533442A5 JP 2019518063 A JP2019518063 A JP 2019518063A JP 2019518063 A JP2019518063 A JP 2019518063A JP 2019533442 A5 JP2019533442 A5 JP 2019533442A5
- Authority
- JP
- Japan
- Prior art keywords
- stem cells
- medium
- hours
- less
- storage medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000000130 stem cell Anatomy 0.000 claims description 246
- 239000002609 medium Substances 0.000 claims description 211
- 238000003860 storage Methods 0.000 claims description 183
- 102000007562 Serum Albumin Human genes 0.000 claims description 150
- 108010071390 Serum Albumin Proteins 0.000 claims description 150
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 141
- 239000012595 freezing medium Substances 0.000 claims description 138
- 238000002360 preparation method Methods 0.000 claims description 112
- 238000000034 method Methods 0.000 claims description 87
- 102000009027 Albumins Human genes 0.000 claims description 37
- 108010088751 Albumins Proteins 0.000 claims description 37
- 210000004027 cell Anatomy 0.000 claims description 37
- 230000035939 shock Effects 0.000 claims description 34
- 150000001413 amino acids Chemical class 0.000 claims description 30
- 238000004321 preservation Methods 0.000 claims description 30
- DZTHIGRZJZPRDV-LBPRGKRZSA-N N-acetyl-L-tryptophan Chemical compound C1=CC=C2C(C[C@H](NC(=O)C)C(O)=O)=CNC2=C1 DZTHIGRZJZPRDV-LBPRGKRZSA-N 0.000 claims description 27
- DZTHIGRZJZPRDV-UHFFFAOYSA-N Nalpha-Acetyltryptophan Natural products C1=CC=C2C(CC(NC(=O)C)C(O)=O)=CNC2=C1 DZTHIGRZJZPRDV-UHFFFAOYSA-N 0.000 claims description 27
- 229940116191 n-acetyltryptophan Drugs 0.000 claims description 27
- 239000003599 detergent Substances 0.000 claims description 26
- 239000000872 buffer Substances 0.000 claims description 22
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims description 21
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 21
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 21
- 229920000053 polysorbate 80 Polymers 0.000 claims description 21
- 229940068968 polysorbate 80 Drugs 0.000 claims description 21
- 230000004083 survival effect Effects 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 18
- 102000004169 proteins and genes Human genes 0.000 claims description 18
- 108090000623 proteins and genes Proteins 0.000 claims description 18
- 238000001542 size-exclusion chromatography Methods 0.000 claims description 16
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 15
- 229930195729 fatty acid Natural products 0.000 claims description 15
- 239000000194 fatty acid Substances 0.000 claims description 15
- 150000004665 fatty acids Chemical class 0.000 claims description 15
- 239000001963 growth medium Substances 0.000 claims description 14
- 239000000178 monomer Substances 0.000 claims description 14
- 238000004113 cell culture Methods 0.000 claims description 13
- 239000007864 aqueous solution Substances 0.000 claims description 12
- 230000006872 improvement Effects 0.000 claims description 11
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 10
- 238000005138 cryopreservation Methods 0.000 claims description 10
- 230000014759 maintenance of location Effects 0.000 claims description 10
- 125000005474 octanoate group Chemical class 0.000 claims description 10
- 238000004007 reversed phase HPLC Methods 0.000 claims description 10
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 9
- 229910052782 aluminium Inorganic materials 0.000 claims description 9
- 239000000539 dimer Substances 0.000 claims description 9
- 150000002402 hexoses Chemical class 0.000 claims description 9
- 241000700605 Viruses Species 0.000 claims description 8
- 230000010261 cell growth Effects 0.000 claims description 8
- 230000035899 viability Effects 0.000 claims description 8
- 238000007710 freezing Methods 0.000 claims description 7
- 230000008014 freezing Effects 0.000 claims description 7
- 150000003278 haem Chemical class 0.000 claims description 7
- 239000002510 pyrogen Substances 0.000 claims description 7
- 235000000346 sugar Nutrition 0.000 claims description 7
- 108010071241 Factor XIIa Proteins 0.000 claims description 6
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims description 6
- 238000004949 mass spectrometry Methods 0.000 claims description 6
- 229920000136 polysorbate Polymers 0.000 claims description 6
- 229950008882 polysorbate Drugs 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 238000010257 thawing Methods 0.000 claims description 6
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 6
- 108010062580 Concanavalin A Proteins 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- 150000001450 anions Chemical class 0.000 claims description 5
- 150000001768 cations Chemical class 0.000 claims description 5
- 239000008103 glucose Substances 0.000 claims description 5
- 239000003102 growth factor Substances 0.000 claims description 5
- 229940088597 hormone Drugs 0.000 claims description 5
- 239000005556 hormone Substances 0.000 claims description 5
- 229910052742 iron Inorganic materials 0.000 claims description 5
- 229940088594 vitamin Drugs 0.000 claims description 5
- 239000011782 vitamin Substances 0.000 claims description 5
- 229930003231 vitamin Natural products 0.000 claims description 5
- 235000013343 vitamin Nutrition 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 4
- 230000036252 glycation Effects 0.000 claims description 3
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000007943 implant Substances 0.000 claims description 2
- 210000004748 cultured cell Anatomy 0.000 claims 3
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 239000003792 electrolyte Substances 0.000 description 16
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 12
- 229910019142 PO4 Inorganic materials 0.000 description 11
- 235000021317 phosphate Nutrition 0.000 description 11
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 9
- 239000011734 sodium Substances 0.000 description 9
- 229910052708 sodium Inorganic materials 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- -1 gluconate ions Chemical class 0.000 description 8
- 230000003204 osmotic effect Effects 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 230000006907 apoptotic process Effects 0.000 description 6
- 210000001185 bone marrow Anatomy 0.000 description 6
- 239000010452 phosphate Substances 0.000 description 6
- 210000001778 pluripotent stem cell Anatomy 0.000 description 6
- YXHLJMWYDTXDHS-IRFLANFNSA-N 7-aminoactinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=C(N)C=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 YXHLJMWYDTXDHS-IRFLANFNSA-N 0.000 description 5
- 108700012813 7-aminoactinomycin D Proteins 0.000 description 5
- 208000005176 Hepatitis C Diseases 0.000 description 5
- 150000001805 chlorine compounds Chemical class 0.000 description 5
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 5
- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 4
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical group [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 229940050410 gluconate Drugs 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 239000011777 magnesium Substances 0.000 description 4
- 229910052749 magnesium Inorganic materials 0.000 description 4
- 229910001425 magnesium ion Inorganic materials 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 229910001414 potassium ion Inorganic materials 0.000 description 4
- 229910001415 sodium ion Inorganic materials 0.000 description 4
- 102000000412 Annexin Human genes 0.000 description 3
- 108050008874 Annexin Proteins 0.000 description 3
- 210000004504 adult stem cell Anatomy 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000002338 cryopreservative effect Effects 0.000 description 3
- 210000001671 embryonic stem cell Anatomy 0.000 description 3
- 210000004700 fetal blood Anatomy 0.000 description 3
- 210000004602 germ cell Anatomy 0.000 description 3
- 210000001368 germline stem cell Anatomy 0.000 description 3
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 3
- 210000003494 hepatocyte Anatomy 0.000 description 3
- 210000004263 induced pluripotent stem cell Anatomy 0.000 description 3
- 210000001178 neural stem cell Anatomy 0.000 description 3
- 210000005259 peripheral blood Anatomy 0.000 description 3
- 239000011886 peripheral blood Substances 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 3
- 210000003954 umbilical cord Anatomy 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- 102000004121 Annexin A5 Human genes 0.000 description 2
- 108090000672 Annexin A5 Proteins 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- 150000001242 acetic acid derivatives Chemical class 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 230000003833 cell viability Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001860 citric acid derivatives Chemical class 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 2
- 230000002107 myocardial effect Effects 0.000 description 2
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 108090000113 Plasma Kallikrein Proteins 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 235000018343 nutrient deficiency Nutrition 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229940085991 phosphate ion Drugs 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021128733A JP7249387B2 (ja) | 2016-10-04 | 2021-08-05 | 組換え酵母由来血清アルブミンの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16192276.0 | 2016-10-04 | ||
| EP16192276 | 2016-10-04 | ||
| PCT/EP2017/075257 WO2018065491A1 (en) | 2016-10-04 | 2017-10-04 | Uses of recombinant yeast-derived serum albumin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021128733A Division JP7249387B2 (ja) | 2016-10-04 | 2021-08-05 | 組換え酵母由来血清アルブミンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019533442A JP2019533442A (ja) | 2019-11-21 |
| JP2019533442A5 true JP2019533442A5 (enExample) | 2021-03-25 |
| JP6928084B2 JP6928084B2 (ja) | 2021-09-01 |
Family
ID=57047137
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518063A Active JP6928084B2 (ja) | 2016-10-04 | 2017-10-04 | 組換え酵母由来血清アルブミンの使用 |
| JP2021128733A Active JP7249387B2 (ja) | 2016-10-04 | 2021-08-05 | 組換え酵母由来血清アルブミンの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021128733A Active JP7249387B2 (ja) | 2016-10-04 | 2021-08-05 | 組換え酵母由来血清アルブミンの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20190216079A1 (enExample) |
| EP (3) | EP3429345B1 (enExample) |
| JP (2) | JP6928084B2 (enExample) |
| KR (2) | KR102573478B1 (enExample) |
| CA (1) | CA3038422A1 (enExample) |
| DK (1) | DK3429345T3 (enExample) |
| ES (1) | ES2761854T3 (enExample) |
| WO (1) | WO2018065491A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3111273C (en) | 2018-09-06 | 2024-03-26 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| EP3982724A1 (en) | 2019-06-11 | 2022-04-20 | Axogen Corporation | Wet preservation of tissue |
| WO2021111143A1 (en) | 2019-12-04 | 2021-06-10 | Albumedix Limited | Methods and compositions produced thereby |
| JP7712284B2 (ja) | 2020-03-12 | 2025-07-23 | バヴァリアン・ノルディック・アクティーゼルスカブ | ポックスウイルスの安定性を改善する組成物 |
| CN113549653B (zh) * | 2020-04-23 | 2024-03-22 | 上海赛比曼生物科技有限公司 | 用于慢病毒载体长期存贮的组合试剂 |
| JP7280623B2 (ja) * | 2020-12-28 | 2023-05-24 | 株式会社アビー | 細胞凍結保存液、及び細胞凍結方法 |
| JP7318983B2 (ja) * | 2021-12-21 | 2023-08-01 | 株式会社アビー | 細胞凍結保存液、及び細胞凍結方法 |
| WO2024018452A1 (en) | 2022-07-18 | 2024-01-25 | Yeda Research And Development Co. Ltd. | Albumin protein variants, production thereof and uses of same |
| CN117783501B (zh) * | 2024-02-26 | 2024-05-10 | 四川大学华西第二医院 | 辛酸钠在注意缺陷与多动障碍中的应用及产品 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| FR2746109B1 (fr) * | 1996-03-12 | 1998-04-17 | Rhone Poulenc Rorer Sa | Milieu pour la conservation de materiel biologique |
| GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| JP4798832B2 (ja) | 2000-10-24 | 2011-10-19 | 一般財団法人化学及血清療法研究所 | ヒト血清アルブミン多量体の除去方法 |
| CN1275981C (zh) | 2000-10-24 | 2006-09-20 | 财团法人化学及血清疗法研究所 | 人血清白蛋白多聚体的单体化方法 |
| JP4798833B2 (ja) | 2000-10-24 | 2011-10-19 | 一般財団法人化学及血清療法研究所 | 加熱処理工程を含むヒト血清アルブミンの製造方法 |
| JP2004238392A (ja) * | 2003-01-14 | 2004-08-26 | Nipro Corp | 安定化された蛋白質性製剤 |
| GB0310347D0 (en) | 2003-05-07 | 2003-06-11 | Delta Biotechnology Ltd | Assay |
| AU2005205314B2 (en) | 2004-01-20 | 2010-12-09 | Km Biologics Co., Ltd. | Process for producing human serum albumin by heating in presence of divalent cation |
| WO2009057537A1 (ja) * | 2007-11-02 | 2009-05-07 | Jcr Pharmaceuticals Co., Ltd. | ヒト間葉系幹細胞含有医薬組成物 |
| KR101722961B1 (ko) | 2009-02-11 | 2017-04-04 | 알부메딕스 에이/에스 | 알부민 변이체 및 접합체 |
| CN102549012B (zh) * | 2009-05-07 | 2015-07-01 | 诺维信生物制药丹麦公司 | 纯化白蛋白的方法 |
| MX2012004793A (es) | 2009-10-30 | 2012-07-20 | Novozymes Biopharma Dk As | Variantes de albumina. |
| WO2011075686A2 (en) * | 2009-12-18 | 2011-06-23 | Ventria Bioscience | Methods & compositions comprising heat shock proteins |
| SG182618A1 (en) * | 2010-01-25 | 2012-08-30 | Ventria Bioscience | Methods & compositions for improving protein production |
| JP5969458B2 (ja) | 2010-04-09 | 2016-08-17 | アルブミディクス アクティーゼルスカブ | アルブミン誘導体及び変異体 |
| CN103649111B (zh) | 2011-07-05 | 2018-03-13 | 阿尔布梅迪克斯医疗公司 | 白蛋白制剂和用途 |
| EP2885969B1 (en) * | 2013-12-19 | 2018-06-27 | FertiPro N.V. | Cryopreservation tools and methods |
-
2017
- 2017-10-04 EP EP17786853.6A patent/EP3429345B1/en active Active
- 2017-10-04 ES ES17786853T patent/ES2761854T3/es active Active
- 2017-10-04 EP EP20189314.6A patent/EP3791719A1/en active Pending
- 2017-10-04 WO PCT/EP2017/075257 patent/WO2018065491A1/en not_active Ceased
- 2017-10-04 KR KR1020197010505A patent/KR102573478B1/ko active Active
- 2017-10-04 JP JP2019518063A patent/JP6928084B2/ja active Active
- 2017-10-04 EP EP19182203.0A patent/EP3603391A1/en not_active Withdrawn
- 2017-10-04 DK DK17786853T patent/DK3429345T3/da active
- 2017-10-04 KR KR1020237029284A patent/KR102662031B1/ko active Active
- 2017-10-04 CA CA3038422A patent/CA3038422A1/en active Pending
-
2019
- 2019-04-02 US US16/372,581 patent/US20190216079A1/en active Pending
-
2021
- 2021-08-05 JP JP2021128733A patent/JP7249387B2/ja active Active
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